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Paris, France

A method for performing an electrophysiological analysis implemented in a system includes: a series of electrodes to be placed on different regions of the human body; a DC voltage source controlled so as to produce DC voltage pulses; a switching circuit for selectively connecting the active electrodes to the voltage source, the active electrodes forming an anode and a cathode, and for connecting at least one other high-impedance passive electrode used to measure the potential reached by the body; and a measuring circuit for reading data representative of the current in the active electrodes, and data representative of the potentials generated on at least certain high-impedance electrodes in response to the application of the pulses, the data allowing a value to be determined for the electrochemical conductance of the skin. The method also regenerates a high-impedance electrode connected to the voltage source as a cathode.


Patent
Impeto Medical | Date: 2015-02-04

The disclosure relates to an electrophysiological analysis system which includes a plurality of electrodes, a power supply for successively applying a substantially continuous voltage ranging approximately from 1 to 5 volts and lasting from 0.1 to 5 seconds to different slotted electrode pairs, a collecting and storing device for recording the variation of a current flow in the electrode pairs to which the voltage slots are applied, a device enabling the current variations obtained by comparison between at least two current variations caused by supposed identical conditions and a device comparing data related to the current variations recorded for several electrode pairs and enabled with reference data. The system can be used for chronoamperometrically detecting pathologies, pathological areas and organ dysfunctions.


Patent
Impeto Medical | Date: 2013-08-27

The disclosure relates to an electrophysiological analysis system including: a series of electrodes intended to be placed in different regions of the human body; a direct current voltage source; a control device adapted (i) to selectively apply direct current pulses, generated by the voltage source, to a pair of so-called active electrodes, the active electrodes forming an anode and a cathode, and (ii) to connect at least one other so-called passive electrode with high-impedance, the electrode measuring the potential reached by the body; and a measurement device arranged to obtain data representative of the current at the cathode and the potentials on at least some of the electrodes connected with high impedance, in response to the application of the pulses, which data can be used to determine a value for the electrochemical conductance of the skin. The system also includes a device for controlling the difference between the potential at the anode and the potential reached by the body, according to the voltage delivered by the direct current voltage source.


A method for assessing sudomotor function of a patient for evaluating diabetic and autonomous neuropathy is disclosed. The method is performed in a system comprising electrodes intended to be placed on different regions of the patient body, and an adjustable DC source. The method includes applying on the electrodes DC voltage pulses of varying voltage values in order to stress sweat glands, the voltage pulses lasting given durations allowing the stabilization of electrochemical phenomena in the body, near the electrodes; collecting data representative of the current between the electrodes, and of the potential generated on the electrodes for the different DC voltages; from the data, computing results representative of the electrochemical skin conductance of the patient; reconciling the latter data with reference data obtained in the same conditions on patients identified as suffering or not from sudomotor, and identifying the patient as suffering or not from sudomotor dysfunction.


Calvet J.H.,Impeto Medical | Dupin J.,Impeto Medical | Winiecki H.,Arztehaus Blasewitz | Schwarz P.E.H.,TU Dresden
Experimental and Clinical Endocrinology and Diabetes | Year: 2013

Introduction: Sudomotor dysfunction is one of the earliest neurophysiologic abnormalities to manifest in distal small fiber neuropathy. SUDOSCAN ® was developed to provide a non invasive, quick, simple and quantitative measurement of sweat function. The aim of this observational study was to assess sweat function in a diabetes outpatient consult clinic in Germany. Methods: The study was conducted from February 2009 to March 2011 on patients of a diabetes outpatient clinic in Germany with type 1 and type 2 diabetes, and was conducted parallel to standard care. Sweat function was evaluated by measuring the electrochemical conductance (ESC) of the hands and feet. The method's reproducibility between 2 devices and a follow-up according to insulin administration were also assessed. Results: 52 patients with type 1 diabetes and 115 patients with type 2 diabetes (69 receiving insulin) were involved in this observational study. Hand and foot conductances were lower in patients with type 2 diabetes when compared to patients with type 1 diabetes. A slight decrease in hand and foot conductances was observed in patients with type 2 diabetes without insulin, while an increase was observed in patients receiving insulin (- 3.8±9.7 vs. 1.0±9.7 S, p=0.02 for the hands and - 2.2±7.5 vs. 4.1±8.8 S, p<0.001 for the feet). Coefficient of correlation between measurements performed with the 2 different devices was 0.85 for hands and 0.93 for feet, p<0.001. No safety concern was reported and none of the subjects experienced discomfort during the tests. Conclusion: This preliminary study shows that the assessment of small C fiber neuropathy can be performed non invasively, quickly and effectively in standard diabetes outpatient practice with very good reproducibility. The observation that electrochemical skin conductance improves with intensified insulin treatment must be confirmed in a clinical study performed on a larger population. © J. A. Barth Verlag inGeorg Thieme Verlag KG Stuttgart. New York. Source

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