The Imperial University Was established in 1991 by the Pakistan Benevolence & Social Management Trust. The initial development of IU was supported by academic collaboration with the University of Hull, UK. In 2002, ICBS was chartered by the Govt. of Punjab as independent degree awarding institution .The University offers academic programs in multiple disciplines including Engineering, Management science, Computing, Information Technology, Applied Technology, Social science, Natural science, Commerce,Medicine, Architecture and Fashion Designing.The University has faculty members in each discipline.School of Business, Economics and Management science.School of Computing and Information science.School of Engineering and TechnologySchool of Architecture, Art and DesignSchool of Medicine Wikipedia.
Safi S.Z.,COMSATS Institute of Information Technology |
Noreen M.,Women University |
Imran M.,Imperial College of Business Studies |
Waheed Y.,Foundation University |
And 3 more authors.
International Eye Science | Year: 2017
Glaucoma is a multifactorial neurodegenerative disease that can result in permanent vision loss by damaging optic nerves due to higher pressure in the eye. Although most of the fundamental pathophysiological mechanisms involved in glaucoma are undetermined but alteration in ocular blood flow (OBF) in tissues such as optic nerve, retina, choroid and iris is an important risk factor for glaucoma. Various factors such as limited knowledge of the factors causing optic nerve damage, confusion in the measurement assays and lack of therapies, make hindrances in the understanding of glaucoma. Researchers are continuously accumulating evidence to suggest that alterations in OBF play important role in the pathogenesis of glaucoma but most of the times they have diverse and contradictory conclusions regarding changes in the OBF and risk of glaucoma. In this article we have reviewed different aspects of glaucoma and the effect of OBF in the disease progression Copyright 2017 by the IJO Press.
Imran M.,National University of Sciences and Technology |
Imran M.,Imperial College of Business Studies |
Manzoor S.,National University of Sciences and Technology |
Saalim M.,National University of Sciences and Technology |
And 4 more authors.
APMIS | Year: 2016
Human immunodeficiency virus (HIV) infection is a major health burden across the world which leads to the development of acquired immune deficiency syndrome (AIDS). This review article discusses the prevalence of HIV, its major routes of transmission, natural immunity, and evasion from the host immune system. HIV is mostly prevalent in Sub-Saharan Africa and low income countries. It is mostly transmitted by sharing syringe needles, blood transfusion, and sexual routes. The host immune system is categorized into three main types; the innate, the adaptive, and the intrinsic immune system. Regarding the innate immune system against HIV, the key players are mucosal membrane, dendritic cells (DCs), complement system, interferon, and host Micro RNAs. The major components of the adaptive immune system exploited by HIV are T cells mainly CD4+ T cells and B cells. The intrinsic immune system confronted by HIV involves (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G) APOBEC3G, tripartite motif 5-α (TRIM5a), terherin, and (SAM-domain HD-domain containing protein) SAMHD1. HIV-1 efficiently interacts with the host immune system, exploits the host machinery, successfully replicates and transmits from one cell to another. Further research is required to explore evasion strategies of HIV to develop novel therapeutic approaches against HIV. © 2016 APMIS. Published by John Wiley & Sons Ltd
Sohail M.U.,U.S. Department of Agriculture |
Sohail M.U.,Government College University at Faisalabad |
Hume M.E.,U.S. Department of Agriculture |
Byrd J.A.,U.S. Department of Agriculture |
And 4 more authors.
Avian Pathology | Year: 2015
The gastrointestinal tract commensal microbiome is important for host nutrition, health and immunity. Little information is available regarding the role of these commensals at other mucosal surfaces in poultry. Tracheal mucosal surfaces offer sites for first-line health and immunity promotion in broilers, especially under stress-related conditions. The present study is aimed at elucidating the effects of feed supplementations with mannanoligosaccharides (MOS) prebiotic and a probiotic mixture (PM) on the caecal and tracheal microbiome of broilers kept under chronic heat stress (HS; 35 ± 2°C). Day-old chickens were randomly divided into five treatment groups: thermoneutral control (TN-CONT), HS-CONT, HS-MOS, HS-PM and HS synbiotic (fed MOS and PM). Caecal digesta and tracheal swabs were collected at day 42 and subjected to DNA extraction, followed by polymerase chain reaction denaturing gradient gel electrophoresis (PCR-DGGE) and pyrosequencing. The PCR-DGGE dendrograms revealed significant (49.5% similarity coefficients) differences between caecal and tracheal microbiome. Tracheal microbiome pyrosequencing revealed 9 phyla, 17 classes, 34 orders, 68 families and 125 genera, while 11 phyla, 19 classes, 34 orders, 85 families and 165 genera were identified in caeca. An unweighted UniFrac distance metric revealed a distinct clustering pattern (analysis of similarities, P = 0.007) between caecal and tracheal microbiome. Lactobacillus was the most abundant genus in trachea and caeca and was more abundant in caeca and trachea of HS groups compared with the TN-CONT group. Distinct bacterial clades occupied the caecal and tracheal microbiomes, although some bacterial groups overlapped, demonstrating a core microbiome dominated by Lactobacillus. No positive effects of supplementations were observed on abundance of probiotic bacteria. © 2015 Houghton Trust Ltd.
Ter Wal A.L.J.,Imperial College of Business Studies |
Ter Wal A.L.J.,University Utrecht
Regional Studies | Year: 2013
Ter Wal A. L. J. Cluster emergence and network evolution: a longitudinal analysis of the inventor network in Sophia-Antipolis, Regional Studies. It is increasingly acknowledged that clusters do not necessarily exhibit networks of local collective learning. Through a case study of Sophia-Antipolis in France, this study investigates to what extent networks of collective learning emerged throughout the growth of the business park. A longitudinal analysis of the inventor networks of its two main sectors reveals that a local network of collective learning emerged only in Information Technology and not in the Life Sciences. Through the creation of spin-offs and high-technology start-up firms, the initial dominance of large multinationals decreased only in Information Technology. This suggests that small firms play an important role in establishing local networks. © 2013 Copyright Regional Studies Association.
Cantner U.,Friedrich - Schiller University of Jena |
Meder A.,Friedrich - Schiller University of Jena |
Ter Wal A.L.J.,Imperial College of Business Studies
Technovation | Year: 2010
Although network analysis has gained increasing attention over the last years, the literature on Regional Innovation Systems thus far has not embraced network methods. This study is an attempt to enrich the Regional Innovation System concept by applying social network methods to quantitatively assess the extent to which innovating actors in a region engage in systemic forms of knowledge exchange and collaboration. On the basis of a comparison of three rather different regional innovator networks, the paper suggests that regions with a strong knowledge base that are specialized in broad technology fields tend to have relatively fragmented network structures. © 2010 Elsevier Ltd. All rights reserved.
Hussain G.,University of Engineering and Technology Lahore |
Haydar S.,University of Engineering and Technology Lahore |
Bari A.J.,University of Engineering and Technology Lahore |
Aziz J.A.,Imperial College of Business Studies |
And 2 more authors.
Journal of the Chemical Society of Pakistan | Year: 2015
Efficiency of a household plastic biosand filter (BSF) for the removal of turbidity and fecal contamination was evaluated. Water of river Ravi was used as influent. Water filtered through BSF was further treated using Solar Disinfection (SODIS). The study was conducted for raw water with low pollution level (total coliforms <500 MPN/100 ml) and high pollution level (total coliforms between 500-20,000 MPN/100 ml). The average value of turbidity removal by BSF was 94.5% with 0.9 NTU as average turbidity of effluent. For raw water with low pollution level, the BSF was able to achieve a maximum of 2.2 log10 unit reduction (99.4%) for total coliforms (39 MPN/100 mL in effluent) and 1.95 log10 unit reduction (98.5%) for fecal coliforms (9 MPN/100 mL in effluent). While for raw water with high pollution level, the maximum removal of 1.5 log10 unit (97.5%) for total coliforms (1430 MPN/100 mL in effluent) and 1.8 log10 units (98.4%) for fecal coliforms (387 MPN/100 mL in effluent) was achieved in BSF. To make the effluent fit for drinking it was further treated using SODIS, which rendered the BSF effluent fit for drinking with zero fecal coliforms count (for full sunny and partially cloudy conditions). Newly proposed plastic BSF could be a good replacement of already used concrete household BSF (used in more than 63 countries) being cheaper in cost and lighter in weight by 85% and 80%, respectively than the concrete BSF. © 2015, Chemical Society of Pakistan. All rights reserved.
PubMed | University of Swabi, University of Jordan, Imperial College of Business Studies, Indiana University Bloomington and 2 more.
Type: | Journal: Critical reviews in food science and nutrition | Year: 2016
Owing to their antimicrobial, antioxidant, and anti-inflammatory activity, grapes (Vitis vinifera L.) are the archetypal paradigms of fruits used not only for nutritional purposes but also for exclusive therapeutics. Grapes are a prominent and promising source of phytochemicals, especially resveratrol, a phytoalexin antioxidant found in red grapes which has both chemopreventive and therapeutic effects against various ailments. Resveratrols role in reducing different human cancers, including breast, cervical, uterine, blood, kidney, liver, eye, bladder, thyroid, esophageal, prostate, brain, lung, skin, gastric, colon, head and neck, bone, ovarian, and cervical, has been reviewed. This review covers the literature that deals with the anticancer mechanism of resveratrol with special reference to antioxidant potential. Furthermore, this article summarizes the literature pertaining to resveratrol as an anticancer agent.
PubMed | FHAS, The Women University Multan and Imperial College of Business Studies
Type: Journal Article | Journal: Viral immunology | Year: 2016
Viruses are the intracellular pathogens that reproduce only in the living cell and manipulate the cellular machinery to produce more viruses. Viral replications can affect cellular genes of the host in multiple cancerous ways. Approximately, 20% of all human oncogenesis is caused by cancer-causing viruses known as oncoviruses. Viral infection causes chronic inflammation leading to cell death, uncontrollable proliferation, and modulated expression of some of the regulatory proteins. Oncogenesis is a multistep phenomenon in which normal host cells are transformed into cancerous cells on the basis of host genetic variability. Oncogenic viruses encode genes that cause viral replication and transformation of the host cells to produce viral proteins and protein complexes. The phenomenon from basic viral infection to tumorigenesis is lengthy due to the involvement of factors like immunity complications, cellular mutations, and exposure to other cancerous agents. The viruses that are involved in human cancer development are Hepatitis B virus (HBV), Hepatitis C virus (HCV), Epstein-Barr virus (EBV), Human papilloma virus (HPV), Kaposis sarcoma herpes virus (KSHV), and Human T lymphotrophic virus 1 (HTLV-1). This review article summarizes advanced knowledge related to human oncogenic viruses and the molecular mechanisms that lead to tumorigenesis in humans.
PubMed | University of Queensland, University of Veterinary and Animal Sciences, COMSATS Institute of Information Technology, Imperial College of Business Studies and Government College University at Faisalabad
Type: | Journal: Critical reviews in food science and nutrition | Year: 2016
Cucurmin, a naturally yellow component isolated from turmeric, ability to prevent various life-style related disorders. The current review article mainly emphasizes on different anticancer perspectives of cucurmin i.e. colon, cervical, uterine, ovarian, prostate head and neck, breast, pulmonary, stomach and gastric, pancreatic, bladder oral, oesophageal and bone cancer. It holds a mixture of strong bioactive molecule known as cucurminoids that has ability to reduce cancer/tumor at initial, promotion and progression stages of tumor development. In particular, these compounds block several enzymes required for the growth of tumors and may therefore involve in tumor treatments. Moreover, it modulates an array of cellular progressions i.e. nitric oxide synthetase activity, protein kinase C activity, epidermal growth factor (EGF) receptor intrinsic kinase activity, nuclear factor kappa (NF-kB) activity, inhibiting lipid peroxidation and production of reactive oxygen species. However, current manuscript summarizes most of the recent investigations of cucurmin but still further research should be conducted to explore the role of curcumin to mitigate various cancers.
PubMed | Islam Dental College, National University of Sciences and Technology and Imperial College of Business Studies
Type: Journal Article | Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica | Year: 2016
Human immunodeficiency virus (HIV) infection is a major health burden across the world which leads to the development of acquired immune deficiency syndrome (AIDS). This review article discusses the prevalence of HIV, its major routes of transmission, natural immunity, and evasion from the host immune system. HIV is mostly prevalent in Sub-Saharan Africa and low income countries. It is mostly transmitted by sharing syringe needles, blood transfusion, and sexual routes. The host immune system is categorized into three main types; the innate, the adaptive, and the intrinsic immune system. Regarding the innate immune system against HIV, the key players are mucosal membrane, dendritic cells (DCs), complement system, interferon, and host Micro RNAs. The major components of the adaptive immune system exploited by HIV are T cells mainly CD4+ T cells and B cells. The intrinsic immune system confronted by HIV involves (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G) APOBEC3G, tripartite motif 5- (TRIM5a), terherin, and (SAM-domain HD-domain containing protein) SAMHD1. HIV-1 efficiently interacts with the host immune system, exploits the host machinery, successfully replicates and transmits from one cell to another. Further research is required to explore evasion strategies of HIV to develop novel therapeutic approaches against HIV.