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Tel Aviv-yafo, Israel

Horio T.,Kyoto University | Yasuda M.,Kyoto University | Yasuda M.,imp Inc | Matsusaka S.,Kyoto University
Drug Development and Industrial Pharmacy | Year: 2013

Background: The evaluation of lubricity or flowability of pharmaceutical powders is important for consistent production and quality control of drug products. However, there have been only a few studies on quantitative measurements of the properties of lubricated powders. Method: Magnesium stearate (MgSt) and sodium stearyl fumarate (SSF) were used as lubricants. Lubricated powders were prepared by adding lubricants to spray-dried lactose under different conditions. To evaluate flowability, the vibrating tube method was used. In this method, the vibration amplitude of the tube is increased at a constant rate, and the mass of the powder discharged from the tube is recorded. Flowability profiles, i.e. The relationships between the mass flow rate and vibration acceleration, were obtained experimentally. To characterize static and dynamic friction properties of powders, critical vibration acceleration required to make powder particles flow and the average mass flow rate were determined. Results: Addition of 0.5% MgSt was sufficient for the reduction of static friction between particles. Blending time of the lubricants had little effect on the average mass flow rate of lubricated powders. On the other hand, addition of SSF resulted in an increase in static friction at the beginning of blending, and after a certain blending time, flowability improved. The combination of MgSt and SSF improved both static and dynamic friction properties irrespective of the blending time. Conclusion: The vibrating tube method can be used to evaluate the flowability properties of lubricated powders, and the experimental results provide useful information on the production of pharmaceutical solid dosage forms. © 2013 Informa Healthcare USA, Inc.

Lopez-Villa A.,imp Inc | Medina A.,ESIME Azcapotzalco | Higuera F.J.,Technical University of Madrid
Physics of Fluids | Year: 2011

The effect of partial confinement on the shape and volume of bubbles generated by injection of a constant flow rate of gas into a very viscous liquid is studied numerically and experimentally. Numerical solutions of the Stokes equations for the liquid and the evolution equation for the surface of a bubble, and experiments with two different liquids, show that cylindrical and conical walls concentric with a gas injection orifice in the horizontal bottom of the liquid may strongly affect the shape and volume of the bubbles, and can be used to control the size of the generated bubbles without changing the flow rate of gas. A well-known scaling law for the volume of the bubbles generated by injection of a high flow rate of gas in a very viscous unconfined liquid is extended to take into account the presence of cylindrical or conical walls around the injection orifice. © 2011 American Institute of Physics.

Horio T.,Kyoto University | Yasuda M.,Kyoto University | Yasuda M.,imp Inc | Matsusaka S.,Kyoto University
International Journal of Pharmaceutics | Year: 2014

Powder flowability of microcrystalline cellulose particles having different particle shapes, whose aspect ratios ranged from 1.8 to 6.4, was measured using the vibration shear tube method. Particles lubricated with magnesium stearate were also investigated in order to evaluate the effect of surface modification on powder flowability. Particles were discharged through a narrow gap between a vibrating tube edge and a flat bottom surface, where each particle experienced high shear forces, thus, overcoming adhesion and friction forces. Vibration amplitude was increased at a constant rate during measurement and the masses of the discharged particles were measured at consistent time intervals. Flowability profiles, i.e., the relationships between the mass flow rates of the discharged particles and their vibration accelerations, were obtained from these measurements. Critical vibration accelerations and characteristic mass flow rates were then determined from flowability profiles in order to evaluate static and dynamic friction properties. The results were compared with those obtained using conventional methods. It was found that angle of repose and compressibility were related to static and dynamic friction properties. Furthermore, it was found that particle aspect ratio more significantly affects powder flowability than does lubrication with magnesium stearate. © 2014 Elsevier B.V.

imp Inc | Date: 2016-04-28

Computer software to enable uploading, downloading, accessing, posting, displaying, editing, tagging, blogging, streaming, linking, sharing or otherwise providing electronic media or information via computer and communication networks; software for sending and receiving electronic messages, graphics, images, audio and audio visual content via global communication networks; computer software for the collection, editing, organizing, modifying, transmission, storage and sharing of data and information; computer search engine software; computer software for accessing, browsing and searching online databases; computer software for personal information management, and data synchronization software. Marketing, advertising and promotion services; market research and information services; promoting the goods and services of others via computer and communication networks; facilitating the exchange and sale of services and products of third parties via computer and communication networks; arranging subscriptions of the online publications of others; online retail store services featuring gift cards and delivery of digital media, namely, pre-recorded music, video, images, text and audiovisual works; providing online marketplaces for sellers of goods and/or services; providing online business services via online facilities for connecting sellers with buyers; providing commercial information for consumers in the field of gifts via online facilities; business networking; providing a searchable online advertising guide featuring the goods and services of other on-line vendors on the internet. Telecommunications services, namely, electronic transmission of data, messages, graphics, images, audio, video and information; peer-to-peer photo sharing and video sharing services, namely, electronic transmission of digital photo files, videos and audio visual content among internet users; providing access to computer, electronic and online databases; online document delivery via a global computer network; providing online forums, email and online messaging services, and electronic bulletin boards; audio, text and video broadcasting services over computer or other communication networks namely, uploading, posting, displaying, modifying, tagging, and electronically transmitting data, information, audio and video; voice over IP services; providing access to computer databases in the fields of social networking, social introduction and dating.

imp Inc | Date: 2014-09-23

Bracelets and jewelry featuring electronic chips for attracting energy to the body wherein the electronic chips increase in power in the presence of electromagnetic fields, for the purpose of re-balancing the human energy field.

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