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Tel Aviv-yafo, Israel

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Horio T.,Kyoto University | Yasuda M.,Kyoto University | Yasuda M.,imp Inc | Matsusaka S.,Kyoto University
Drug Development and Industrial Pharmacy | Year: 2013

Background: The evaluation of lubricity or flowability of pharmaceutical powders is important for consistent production and quality control of drug products. However, there have been only a few studies on quantitative measurements of the properties of lubricated powders. Method: Magnesium stearate (MgSt) and sodium stearyl fumarate (SSF) were used as lubricants. Lubricated powders were prepared by adding lubricants to spray-dried lactose under different conditions. To evaluate flowability, the vibrating tube method was used. In this method, the vibration amplitude of the tube is increased at a constant rate, and the mass of the powder discharged from the tube is recorded. Flowability profiles, i.e. The relationships between the mass flow rate and vibration acceleration, were obtained experimentally. To characterize static and dynamic friction properties of powders, critical vibration acceleration required to make powder particles flow and the average mass flow rate were determined. Results: Addition of 0.5% MgSt was sufficient for the reduction of static friction between particles. Blending time of the lubricants had little effect on the average mass flow rate of lubricated powders. On the other hand, addition of SSF resulted in an increase in static friction at the beginning of blending, and after a certain blending time, flowability improved. The combination of MgSt and SSF improved both static and dynamic friction properties irrespective of the blending time. Conclusion: The vibrating tube method can be used to evaluate the flowability properties of lubricated powders, and the experimental results provide useful information on the production of pharmaceutical solid dosage forms. © 2013 Informa Healthcare USA, Inc.


Peters J.-M.,imp Inc | Nishiyama T.,imp Inc | Nishiyama T.,Nagoya University
Cold Spring Harbor Perspectives in Biology | Year: 2012

During S phase, not only does DNA have to be replicated, but also newly synthesized DNA molecules have to be connected with each other. This sister chromatid cohesion is essential for the biorientation of chromosomes on the mitotic or meiotic spindle, and is thus an essential prerequisite for chromosome segregation. Cohesion is mediated by cohesin complexes that are thought to embrace sister chromatids as large rings. Cohesin binds to DNA dynamically before DNA replication and is converted into a stably DNA-bound form during replication. This conversion requires acetylation of cohesin, which in vertebrates leads to recruitment of sororin. Sororin antagonizes Wapl, a protein that is able to release cohesin from DNA, presumably by opening the cohesin ring. Inhibition ofWapl by sororin therefore "locks" cohesin rings on DNA and allows them to maintain cohesion for long periods of time in mammalian oocytes, possibly for months or even years. © 2012 Cold Spring Harbor Laboratory Press; all rights reserved.


Trademark
imp Inc | Date: 2014-02-18

surgical support unit for knee and hip surgery.


Trademark
imp Inc | Date: 2014-09-23

Bracelets and jewelry featuring electronic chips for attracting energy to the body wherein the electronic chips increase in power in the presence of electromagnetic fields, for the purpose of re-balancing the human energy field.


H!

Trademark
imp Inc | Date: 2015-12-28

Computer software to enable uploading, downloading, accessing, posting, displaying, editing, tagging, blogging, streaming, linking, sharing or otherwise providing electronic media or information via computer and communication networks; software for sending and receiving electronic messages, graphics, images, audio and audio visual content via global communication networks; computer software for the collection, editing, organizing, modifying, transmission, storage and sharing of data and information; computer search engine software; computer software for accessing, browsing and searching online databases; computer software for personal information management, and data synchronization software. Marketing, advertising and promotion services; market research and information services; promoting the goods and services of others via computer and communication networks; facilitating the exchange and sale of services and products of third parties via computer and communication networks; arranging subscriptions of the online publications of others; online retail store services featuring gift cards and delivery of digital media, namely, pre-recorded music, video, images, text and audiovisual works; providing online marketplaces for sellers of goods and/or services; providing online business services via online facilities for connecting sellers with buyers; providing commercial information for consumers in the field of gifts via online facilities; business networking; providing a searchable online advertising guide featuring the goods and services of other on-line vendors on the internet. Telecommunications services, namely, electronic transmission of data, messages, graphics, images, audio, video and information; peer-to-peer photo sharing and video sharing services, namely, electronic transmission of digital photo files, videos and audio visual content among internet users; providing access to computer, electronic and online databases; online document delivery via a global computer network; providing online forums, email and online messaging services, and electronic bulletin boards; audio, text and video broadcasting services over computer or other communication networks namely, uploading, posting, displaying, modifying, tagging, and electronically transmitting data, information, audio and video; voice over IP services; providing access to computer databases in the fields of social networking, social introduction and dating.


Trademark
imp Inc | Date: 2015-04-27

Computer software to enable uploading, downloading, accessing, posting, displaying, editing, tagging, blogging, streaming, linking, sharing or otherwise providing electronic media or information via computer and communication networks; software for sending and receiving electronic messages, graphics, images, audio and audio visual content via global communication networks; computer software for the collection, editing, organizing, modifying, transmission, storage and sharing of data and information; computer search engine software; computer software for accessing, browsing and searching online databases; computer software for personal information management, and data synchronization software. Marketing, advertising and promotion services; market research and market research information services; promoting the goods and services of others via computer and communication networks; facilitating the exchange and sale of services and products of third parties via computer and communication networks; arranging subscriptions of the online publications of others; online retail store services featuring gift cards and downloadable pre-recorded music, video, images, text and audiovisual works; providing online marketplaces for sellers of goods and/or services; providing online business services via online facilities, namely, operating online marketplaces and online social networks, for connecting sellers with buyers; providing commercial information for consumers in the field of gifts via online an online website; business networking; providing a searchable online advertising guide featuring the goods and services of other on-line vendors on the internet. Telecommunications services, namely, electronic transmission of data, messages, graphics, images, audio, video and information; peer-to-peer photo sharing and video sharing services, namely, electronic transmission of digital photo files, videos and audio visual content among internet users; providing access to computerized, electronic, mobile and online databases; online document delivery via a global computer network; providing online forums for transmission of messages among computer users, electronic users, online or Internet users and mobile technology users; providing email and online messaging services, and electronic bulletin boards; audio, text and video broadcasting services over computer or other communication networks, namely, uploading, posting, displaying, modifying, tagging, and electronically transmitting data, information, audio and video; voice over IP services; providing access to computer databases in the fields of social networking, social introduction and dating.


Trademark
imp Inc | Date: 2016-04-28

Computer software to enable uploading, downloading, accessing, posting, displaying, editing, tagging, blogging, streaming, linking, sharing or otherwise providing electronic media or information via computer and communication networks; software for sending and receiving electronic messages, graphics, images, audio and audio visual content via global communication networks; computer software for the collection, editing, organizing, modifying, transmission, storage and sharing of data and information; computer search engine software; computer software for accessing, browsing and searching online databases; computer software for personal information management, and data synchronization software. Marketing, advertising and promotion services; market research and information services; promoting the goods and services of others via computer and communication networks; facilitating the exchange and sale of services and products of third parties via computer and communication networks; arranging subscriptions of the online publications of others; online retail store services featuring gift cards and delivery of digital media, namely, pre-recorded music, video, images, text and audiovisual works; providing online marketplaces for sellers of goods and/or services; providing online business services via online facilities for connecting sellers with buyers; providing commercial information for consumers in the field of gifts via online facilities; business networking; providing a searchable online advertising guide featuring the goods and services of other on-line vendors on the internet. Telecommunications services, namely, electronic transmission of data, messages, graphics, images, audio, video and information; peer-to-peer photo sharing and video sharing services, namely, electronic transmission of digital photo files, videos and audio visual content among internet users; providing access to computer, electronic and online databases; online document delivery via a global computer network; providing online forums, email and online messaging services, and electronic bulletin boards; audio, text and video broadcasting services over computer or other communication networks namely, uploading, posting, displaying, modifying, tagging, and electronically transmitting data, information, audio and video; voice over IP services; providing access to computer databases in the fields of social networking, social introduction and dating.


Imp

Trademark
imp Inc | Date: 2013-04-01

MEERSCHAUM TOBACCO PIPES.


News Article | December 21, 2016
Site: www.marketwired.com

SYDNEY, AUSTRALIA--(Marketwired - Dec 21, 2016) - Prima BioMed Ltd ( : PRR) ( : PBMD) ("Prima" or the "Company") today announced interim data from the AIPAC Phase IIb clinical trial for IMP321 in metastatic breast cancer (Active Immunotherapy PAClitaxel). The initial data confirms previous trial results showing IMP321 is safe and well tolerated. In this Phase IIb study of IMP321 plus paclitaxel chemotherapy in patients with hormone receptor-positive metastatic breast cancer, data from all 15 patients in the safety run-in phase demonstrated that IMP321 is safe and well tolerated at both the 6mg and 30mg dosage levels. Immune monitoring data has also confirmed that IMP321, as an Antigen Presenting Cell (APC) activator, is working to generate the desired immune responses. The data demonstrated activation and an increased level of blood monocytes, dendritic cells and CD8 T-cells. Prima's Chief Medical Officer, Dr Frédéric Triebel, said: "Following the initial data released in June, we are now very pleased to confirm the safety, pharmacokinetics and pharmacodynamics of IMP321 across the initial patient cohorts at both dosage levels. This is another important step in de-risking our AIPAC trial as we look to commence the enlarged randomised and double-blind phase in the new year. We also look forward to providing further insights into efficacy of these safety run in patients by the middle of 2017." Subject to the confirmation of the dose escalation committee on the 30th December, Prima will now commence the randomised phase of the trial in January 2017. Patients will receive paclitaxel treatment plus placebo or paclitaxel in conjunction with IMP321. IMP321 is a first-in-class Antigen Presenting Cell (APC) activator based on the immune checkpoint LAG-3. IMP321 represents one of the first proposed active immunotherapy drugs in which the patient's own immune system is harnessed to respond to tumour antigenic debris created by chemotherapy. As an APC activator IMP321 boosts the network of dendritic cells in the body that can respond to tumour antigens for a better anti-tumour CD8 T cell response. IMP321 has been shown in an open-label Phase I study1, to be able to double the expected six-month response rate in HER-2 negative metastatic breast cancer patients receiving standard-of-care paclitaxel; from a 25% historic response rate2, to 50% when combined with IMP321. Prima BioMed is a globally active biotechnology company that is striving to become a leader in the development of immunotherapeutic products for the treatment of cancer. Prima BioMed is dedicated to leveraging its technology and expertise to bring innovative treatment options to market for patients and to maximise value to shareholders. Prima's current lead product is IMP321, based on the LAG-3 immune control mechanism which plays a vital role in the regulation of the T cell immune response. IMP321, which is a soluble LAG-3Ig fusion protein, is an APC activator boosting T cell responses. IMP321 is currently in a Phase II clinical trial as a chemoimmunotherapy for metastatic breast cancer termed AIPAC (clinicaltrials.gov identifier NCT 02614833) and in a Phase I combination therapy trial in metastatic melanoma termed TACTI-mel (clinicaltrials.gov identifier NCT 02676869). A number of additional LAG-3 products including antibodies for immune response modulation in autoimmunity and cancer are being developed by large pharmaceutical partners. Prima BioMed is listed on the Australian Securities Exchange and on the NASDAQ in the US. For further information please visit www.primabiomed.com.au.

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