Owerri, Nigeria

Imo State University

Owerri, Nigeria

The Imo State University in Owerri, Imo State, Nigeria was established in 1981 through law No. 4 passed by the Imo State House of Assembly.The university admitted the first intake of 392 pioneer students on October 23, 1981.After the creation of Abia State in 1991, the Uturu campus of the university became the Abia State University.Imo State University is a fully functional University. Most of the programmes of the University have obtained full accreditation from National Universities Commission of Nigeria.The result of the 1999/2000 accreditation exercise of the National Universities Commission confirmed that high rate and acceptance of the University by the Nigerian public. The University was ranked 1st among all State Universities in Nigeria and the 10th overall among both State and Federal Universities. The University scored 100% in 2006 and 2007 accreditation visit, with all programmes visited getting accreditation.Five years after being formally commissioned, by 2009 the Imo State University Teaching Hospital had failed to produce reasonable services of moderately acceptable standards.A report in February 2009 said that decaying infrastructure, endless workers strike and admission scandals were threatening to kill the University, once rated among the best ten in Nigeria.The vice chancellor and the university bursar had been suspended by the Imo State government, embarrassed by the extent of the admission scam. Wikipedia.

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Emetumah F.C.,Imo State University
Risk, Reliability and Safety: Innovating Theory and Practice - Proceedings of the 26th European Safety and Reliability Conference, ESREL 2016 | Year: 2017

Companies operating in process industries are always looking for ways of maximizing productivity with minimal risk to lives and property. This can be possible if these organizations can effectively identify pertinent risks and make arrangements for adequate protection from their effects. Integrated management systems (IMS) provide a framework for an organization to combine a number of international standards related to their area of operation. The overall aim of this paper is to evaluate the relevant issues an organization will have to deal with in order to effectively integrate ISO 9001 with ISO 14001 and OHSAS 18001; the essence of this integration is to efficiently manage applicable risks. © 2017 Taylor & Francis Group, London.

Background: The exploitation and utilization of vast varieties of herbal extracts may serve as alternative measures to deter aggregation of deoxygenated sickle cell hemoglobin (deoxyHbS) molecules. Objective: The present in vitro study ascertained the capacity of three medicinal plants, namely, Anacardium occidentale, Psidium guajava, and Terminalia catappa, to alter polymerization of HbS. Materials and Methods: Spectrophotometric method was used to monitor the level of polymerization of hemolysate HbS molecules treated with sodium metabisulfite (Na 2 S 2 O 5 ) at a regular interval of 30 s for a period of 180 s in the presence of separate aqueous extracts of A. occidentale, P. guajava, and T. catappa. At time intervals of 30 s, the level of polymerization was expressed as percentage of absorbance relative to the control sample at the 180th s. Results: Although extracts of the three medicinal plants caused significant (P < 0.05) reduction in polymerization of deoxyHbS molecules, the corresponding capacity in this regard diminished with increase in incubation time. Aqueous extract of P. guajava exhibited the highest capacity to reduced polymerization of deoxyHbS molecules. Whereas at t > 60 s, extract concentration of 400 mg% of A. occidentale activated polymerization of deoxyHbS molecules by 6.23±1.34, 14.53±1.67, 21.15±1.89, and 24.42±1.09%, 800 mg% of T. catappa at t > 30 s gave values of 2.50±1.93, 5.09±1.96, 10.00±0.99, 15.38±1.33, and 17.310.97%. Conclusion: The capacity of the three medicinal plants to interfere with polymerization of deoxyHbS molecules depended on the duration of incubation and concentration of the extracts.

Chikezie P.C.,Imo State University | Uwakwe A.A.,University of Port Harcourt
Pharmacognosy Magazine | Year: 2011

Background: Many reports showed that medicinal plant extracts cause alterations on the shape and physiology of erythrocytes. Objective: The present study seeks to ascertain the osmotic stability of sickle erythrocytes incubated in aqueous extracts of Anacardium occidentale, Psidium guajava, and Terminalia catappa. Materials and Methods: The fraction of erythrocytes lysed when suspended in saline solution of varying concentrations was investigated by spectrophotometric method. The percentage hemolysis of erythrocytes in the control and test samples showed a sigmoidal relationship with increasing concentrations of saline solution. Membrane stability was ascertained as mean corpuscular fragility (MCF) index of erythrocytes incubated in 400 and 800 mg/dL aqueous concentrations of the three plant extracts. Results: The two experimental concentrations of P. guajava and T. catappa protected the erythrocytes against osmotic stress, as evidenced by decreases in the values of MCF compared with the control sample (P < 0.05). However, 800 mg/dL of A. occidentale promoted significant (P < 0.05) distabilization of sickle erythrocytes. Conclusion: Whereas the two experimental concentrations of aqueous extracts of P. guajava and T. catappa stabilized erythrocyte membrane, higher concentration (800 mg/dL) of A. occidentale exhibited no membrane protective effect.

Ekeanyanwu R.C.,Imo State University
Pakistan Journal of Nutrition | Year: 2013

Protein plays an important role in biochemical, biophysical and physiological processes. The deficiency of proteins leads to weakness, anaemia, protein energy malnutrition (Kwashiorkor and marasmus), delayed wound healing and fracture healing and also decreased resistance to infection. Proteins in the body come from both plant and animal source. Life without protein is not possible and amino acids are the building blocks of protein. The crude protein and amino acid composition of Monodora myristica seed was determined using standard analytical techniques with a view to further appraise the nutritive value. The results showed that crude protein content in percentage as 11.34%. The Total Amino Acid (TAA) of Monodora myristica seed was 65.60g/100g of crude protein. The Total Essential Amino Acid (TEAA, with Histidine) was calculated to be 47.64% of the crude protein while the Total non Essential Amino Acid (TNEAA) was calculated to be 52.36% of the crude protein. The predicted protein efficiency ratio (P-PER) was calculated to be 2.32. The content of total Essential Amino Acid (EAA) with value 26.85g/100g crude protein is lower than FAO/WHO recommended value of 36.0g/100g crude protein. Monodora myristica could be used as good sources of protein supplement in the human diet. Monodora myristica has been used as spice and condiment in food and also possess medicinal property. © Asian Network for Scientific Information, 2013.

Okwara E.C.,Imo State University
Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria | Year: 2012

Human immunodeficiency virus (HIV) infection is associated with increased nutrient requirement. Information on micro-mineral status in HIV infected in Nigerians is lacking. We evaluated the impact of HIV infection on selenium, zinc and magnesium status of HIV infected adults presenting at Imo State University Teaching Hospital. Fifty one (51) consecutive adult HIV patients (aged 18-56 years), presenting at the HIV treatment unit of the hospital over a period of 3-months who gave informed written consent participated. Also 48 HIV sero-negative adults (aged 19-59 years) were recruited as controls. Blood samples were collected from all subjects for mineral estimation by atomic absorption spectrophotometry. Results were presented as means (+/- SD) and variables compared using unpaired t-test. Selenium, zinc and magnesium levels in HIV patients were 0.23 +/- 0.08 mmol/L, 9.04 +/- 1.26 mmol/L and 104.61 +/- 24 mmol/L respectively. Minerals in controls were 0.29 +/- 0.09 mmol/L, 9.73 +/- 1.15 mmol/L and 125.57 +/- 29.55 mmol/L respectively. All minerals were significantly lower in HIV patients (P < 0.05). In male controls, mineral levels were 0.32 +/- 0.08 mmol/L, 9.97 +/- 2.96 mmol/L and 94.93 +/- 28.63 mmol/L respectively. In male HIV patients minerals were 0.02 +/- 0.06 mmol/L, 8.74 +/- 1.23 mmol/L and 93.42 +/- 19.79 mmol/L respectively. All minerals were significantly lower in male HIV patients than male controls. In female controls selenium, zinc and magnesium levels were 0.28 +/- 0.09 mml/L, 9.57 +/- 1.17 mmol/L and 121.39 +/- 29.89 mmol respectively. Minerals in female HIV patients were 0.25 +/- 0.08 mmol/L, 9.17 +/- 1.29 mmol/L and 110.77 +/- 24.42 mmol/L respectively. There were no significant differences in respective micro-mineral level between female controls and female HIV patients. Selenium, zinc and magnesium were depleted in HIV infected suburban Nigerian subjects. Depletion was predominant in males possibly due to better health seeking behavior of females than males causing early presentation in females.

Chineke T.C.,Imo State University | Ezike F.M.,Imo State University
Energy Policy | Year: 2010

Climate change, in particular rainfall variability, affects rain-dependent agriculture in Africa. The resulting food shortages, in combination with rising population and lack of access to electricity needed for development, require the governments and people of Africa to consider renewable energy sources. One example that has high potential in Africa is solar energy. Many African governments have begun discussions about renewable energy but tangible results have yet to materialize. This research contributes to the governmental efforts by presenting the solar electricity potentials for some African cities. Using photovoltaic geographical information system (PVGIS) data, it is clear that there is enough electricity for urban and rural dwellers if there is political will and if the solar panels are mounted at the suggested optimal angles ranging from 8-34°. The solar irradiation at all sites was higher than the typical daily domestic load requirement of 2324 Wh/m2 in urban and rural areas. We provide a strong rationale for political will, collaboration and transparent energy policies that will ensure that life is enhanced through the use of environmentally-friendly renewable energy technologies such as solar power. © 2009 Elsevier Ltd. All rights reserved.

Njoku V.O.,Imo State University
Journal of Environmental Chemical Engineering | Year: 2014

The potential of cocoa pod husk (CPH) as a biosorbent for the removal of Zn(II) from aqueous solution in a batch system was studied. The effects of contact time, initial concentration of Zn(II), temperature, pH and presence of other metal ions were investigated. The biosorption was relatively fast at 30 C and followed the Avrami kinetic model. The biosorption isotherm modeling showed that the equilibrium data fitted better to the Freundlich than the Langmuir model. The biosorption showed a pH dependent profile and optimum values at pH 6. Binary metal system experiments showed that the presence of coions had adverse effect on the biosorption capacity of CPH for Zn(II). The thermodynamic parameters indicated that the biosorption of Zn(II) on CPH was a spontaneous and endothermic process. High biosorption capacity obtained shows that CPH may be useful for the removal of Zn(II) from aqueous media. © 2014 Elsevier Ltd. All rights reserved.

Chikezie P.C.,Imo State University
Asian Journal of Biochemistry | Year: 2011

In vitro study was carried out to investigate levels of oxidative stress indicators of sickle erythrocytes incubated in aqueous extracts of Anacardium occidentale, Psidium guajava and Terminalia catappa for 12 h. At regular time intervals of 3 h, portions of the incubation mixtures were withdrawn and spectrophotometric method was used to assay for levels of erythrocyte Malondialdehyde (MDA) and methaemoglobin (Met. Hb%). The control analysis showed that within the experimental time, erythrocyte MDA increased from 2.45±0.35 to 3.13±0.59 mmol rnL -1 (p>0.05; pvalue = 0.801176). Erythrocyte MDA concentrations in the presence of the three extracts were higher than the control samples at t = 3 h (p>0.05; p value = 0.963253). Compared with the control samples at the given time (t) intervals, extract of T. catappa exhibited the highest capacity to cause reduction of erythrocyte MDA ([T. catappa] = 800 mg%; [MDA] = 2.89±0.33 mmol rnL -1; t = 12 h). Erythrocyte Met. Hb% increased from 2.42±0.55 to 2.51±0.49% (p>0.05; p value = 0.995171) in the control samples within 12 h. Incubation of sickle erythrocytes with extract of (P. guajava) = 800 mg% for 9 h caused reduction of Met. Hb% from 2.49±0.49 to 2.29±0.45%; p>0.05; p = 0.983519. Extracts of A. occidentale, P. guajava and T. catappa exhibited variable capacities to hinder lipid peroxidation but did not cause corresponding reduction in erythrocyte Met. Hb%, exemplified by negative correlation between the two oxidative stress indicators in the presence of T. catappa and higher concentrations of A. occidentale and P. guajava. © 2011 Academic Journals Inc.

The aim of the present in vitro study was to ascertain the tendency of two quinoline (quinine and chloroquine phosphate) drugs to interfere with osmotic stability of three human erythrocyte genotypes, namely, HbAA, HbAS and HbSS. Spectrophotometric method was used for determination of the capacity of the erythrocyte genotypes to withstand osmotic stress in the presence of separate increasing concentrations (0.2, 0.4, 0.6 and 0.8 mg%) of the two antimalarials. The Mean Corpuscular Fragility (MCF) index of the three genotypes was in the order: HbAA0.05) between the MCF values of non-malarious blood samples of HbAA and HbAS erythrocytes, values between HbAA and HbSS erythrocytes showed significant difference (p<0.05). In addition, parasitized erythrocytes exhibited significant (p<0.05) increased MCF values. Furthermore, at relative low experimental concentrations (approx<0.4 mg %) of the two drugs, parasitized erythrocytes and those of non-malarious human origin of HbAA and HbAS genotypes showed variable levels of stability. The HbSS erythrocytes did not exhibit osmotic stability within the range of experimental concentrations of the two drugs. The implications of these findings are discussed. © 2011 Academic Journals Inc.

Chikezie P.C.,Imo State University
Asian Journal of Biochemistry | Year: 2011

The aim of the present study was to ascertain methaemoglobin concentrations and levels of NADH-methaemoglobin reductase activity of three human erythrocyte genotypes, namely, HbAA, HbAS and HbSS. The cyanomethaemoglobin reaction was used for the determination of erythrocyte haemolysate methaemoglobin concentration. NADH-methaemoglobin reductase activity was measured by the rate of oxidation of NADH + H+ when, the erythrocyte enzyme was incubated in potassium ferrocyanide {K3Fe(CN)6}. Whereas, methaemoglobin concentrations in the three erythrocyte genotypes was in the range of 1.45±0.13 to 2.50±0.43%, in the order: HbAS

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