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Fierabracci V.,University of Pisa | Franzini M.,Sant'Anna School of Advanced Studies | Franzini M.,G Monasterio Foundation Cnrregione Toscana | Baggiani A.,University of Pisa | And 11 more authors.
Biomarkers | Year: 2012

Plasma samples from human cord blood, and fetuses, newborns, and adults of different mammalians species were analyzed by gel-filtration chromatography, to ascertain whether gamma-glutamyltransferase (GGT) fractions reflect liver maturation. Human cord blood plasma showed higher b-, m-, and s-GGT fraction as compared to adult women. In rat and mouse fetuses and in newborns, b-GGT was the most abundant fraction. As in adult humans, in adult rats, mice, rabbits, sheep, and mini pigs, f-GGT was the most abundant fraction. GGT fractions are a common feature of all mammalian species tested. Their pattern changes seem to reflect liver postnatal maturation, function. © 2012 Informa UK, Ltd.

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