Norcross, GA, United States
Norcross, GA, United States

Time filter

Source Type

Turnis M.E.,St Jude Childrens Research Hospital | Sawant D.V.,University of Pittsburgh | Sawant D.V.,St Jude Childrens Research Hospital | Szymczak-Workman A.L.,St Jude Childrens Research Hospital | And 12 more authors.
Immunity | Year: 2016

Regulatory T (Treg) cells pose a major barrier to effective anti-tumor immunity. Although Treg cell depletion enhances tumor rejection, the ensuing autoimmune sequelae limits its utility in the clinic and highlights the need for limiting Treg cell activity within the tumor microenvironment. Interleukin-35 (IL-35) is a Treg cell-secreted cytokine that inhibits T cell proliferation and function. Using an IL-35 reporter mouse, we observed substantial enrichment of IL-35+ Treg cells in tumors. Neutralization with an IL-35-specific antibody or Treg cell-restricted deletion of IL-35 production limited tumor growth in multiple murine models of human cancer. Limiting intratumoral IL-35 enhanced T cell proliferation, effector function, antigen-specific responses, and long-term T cell memory. Treg cell-derived IL-35 promoted the expression of multiple inhibitory receptors (PD1, TIM3, LAG3), thereby facilitating intratumoral T cell exhaustion. These findings reveal previously unappreciated roles for IL-35 in limiting anti-tumor immunity and contributing to T cell dysfunction in the tumor microenvironment. © 2016 Elsevier Inc.


Trademark
Immucor Inc. | Date: 2013-08-27

COMPUTER SOFTWARE AND MIDDLEWARE FOR USE IN FACILITATING DATA ACCESS AND ARCHIVING ACROSS INSTRUMENTS, PLATFORMS AND APPLICATIONS IN THE FIELD OF IMMUNOHEMATOLOGY.


Trademark
Immucor Inc. | Date: 2013-08-27

COMPUTER SOFTWARE AND MIDDLEWARE FOR USE IN FACILITATING DATA ACCESS AND ARCHIVING ACROSS INSTRUMENTS, PLATFORMS AND APPLICATIONS IN THE FIELD OF IMMUNOHEMATOLOGY.


Trademark
Immucor Inc. | Date: 2016-03-30

instruments used in blood bank laboratories for testing parameters useful in human blood transfusions.


Trademark
Immucor Inc. | Date: 2016-03-30

instruments used in blood bank laboratories for testing parameters useful in human blood transfusions, namely blood group typing apparatus.


Trademark
Immucor Inc. | Date: 2013-10-14

chemical and biochemical reagents, assays and kits comprising diagnostic reagents for research and clinical laboratory use. diagnostic reagents, diagnostic assays and kits comprising diagnostic reagents for medical diagnostic use; in-vitro diagnostic test kits comprising primarily immunodiagnostic reagents for use in measuring various blood parameters. laboratory instruments for analyzing blood and tissue samples for medical use.


Trademark
Immucor Inc. | Date: 2012-05-18

MEDICAL DIAGNOSTIC REAGENTS AND ASSAYS, NAMELY, REAGENTS AND ASSAYS FOR IMMUNOHEMATOLOGY AND IN VITRO DIAGNOSTIC GENOTYPING.


Trademark
Immucor Inc. | Date: 2010-11-09

INSTRUMENTS USED IN BLOOD BANK LABORATORIES FOR TESTING PARAMETERS USEFUL IN HUMAN BLOOD TRANSFUSIONS.


Trademark
Immucor Inc. | Date: 2012-10-02

DNA reference samples for evaluating the accuracy of assays used in hematology testing.


Trademark
Immucor Inc. | Date: 2015-04-21

hematology testing kits for use in the detection of human antigens comprised primarily of medical reagents and assays for the testing of body fluids for research purposes.

Loading Immucor Inc. collaborators
Loading Immucor Inc. collaborators