Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: NMP-2007-1.1-1 | Award Amount: 4.94M | Year: 2008
The cause of diseases is often unknown, but their origin can frequently be found at the biomolecular and cellular level situated on nm-scale. Early diagnostics combined with early intervention on that nanoscale is one of the holy grail of modern medicine. Inorganic nanoparticles are very promising agents in that respect. One of the promising biomedical applications of these nanoparticles is their use as agents for tumor hyperthermia. Hyperthermia is a form of cancer treatment that uses an elevated temperature to kill the tumor tissue. Compared to the more conventional surgical procedures, it is hailed as a less invasive approach that could be used for small, non-defined tumors. Well-designed instrumentation in combination with engineered inorganic nanoparticles that (a) possess the desired physical properties to generate a local heat and that (b) can specifically target the tumor offer immense potentials for targeted hyperthermia therapy. The overall objective of the present multi-disciplinary project is to develop and to explore various metal/magnetic nanoparticles as agents for targeted tumor therapy. To strive for this overall objective, a successful integration and convergence of different technologies at the nanoscale is indispensable. In this project, we will focus on the synthesis routes of tailor designed biofunctionalized nanoparticles for hyperthermia. This requires a profound physical and chemical characterization of the synthesized nanostructures, but the project is certainly not limited hereto. It will also include a toxicological and biological evaluation of the different nanoparticles. Hereby a detailed exploration and characterization of the interaction mechanism of the biological entities and the nanostructures will be pursued to obtain a better understanding of the phenomena occurring at the nanoscale. In addition, this project also comprises the design of advanced instrumentation that can be used for a controlled hyperthermia treatment.
Agency: Cordis | Branch: FP7 | Program: CP | Phase: SEC-2009-2.2-02 | Award Amount: 14.97M | Year: 2010
TASS is a multi-segment, multi-level intelligence and surveillance system, aimed at creating an entire airport security monitoring solution providing real-time accurate situational awareness to airport authorities.The TASS concept is based on integrating different types of selected real time sensors & sub-systems for data collection in a variety of modes, including fixed and mobile, all suitable for operation under any environmental conditions. TASS divides the airport security into six security control segments (environmental, cargo, people, airplanes, vehicle-fleet & facilities) each of them being monitored by various technologies that are fused together, creating a multisource labyrinth fusion logic enabling situational and security awareness of the airport anytime and anywhere. These fused control segments will be accessed through the TASS WEB-based portal by running a suite of applications making the airport security control centralized to all airport authorities. Information will be shared and synchronized between all of them in order to generate a comprehensive, real time, security overview for the airport C2, providing all the necessary features to assure a total no breach security environment. The integration will include the use of in-place technologies that will result in a cost-effective solution.The TASS consortium consists of 3 main end users representing 16 airports and 16 technological partners, which bring together European SMEs, industrial and academic partners, ranging from sensor design and electronic communications through to civil airport protection. The technologies will be tested at 3 airports including the hub airport Heathrow, an Israeli domestic airport and Athens airport, in order to cover a wide range of needs at different levels of airport protection. The main test at Heathrow airport will involve scenarios including 2 connected to the upcoming 2012 Olympic Games in London ultimately resulting in a high & smooth passengers flow.
Halas M.,Slovak University of Technology in Bratislava |
Anguelova M.,Imego AB
Automatica | Year: 2013
The paper shows that nonlinear retarded time-delay systems can admit an input-output representation of neutral type. This behaviour represents a strictly nonlinear phenomenon, for it cannot happen in the linear time-delay case where retarded systems always admit an input-output representation of retarded type. A necessary and sufficient condition for a nonlinear system to exhibit this behaviour is given, and a strategy for finding an input-output representation of retarded type is outlined. Some open problems that arise consequently are discussed as well. All the systems considered in this work are time-invariant and have commensurable delays. © 2012 Elsevier Ltd. All rights reserved.
Imego AB | Date: 2011-10-28
A detecting unit is provided, including a transmitter arranged to emit electromagnetic radiation, having a frequency in the range of 0.1 to 10 THz, towards a paper web moving in a printing unit; a receiver arranged to receive electromagnetic radiation being transmitted through or reflected by the paper web and to create a signal representing the received radiation; and a controller having an input channel for receiving the signal and a calculating unit for determining a measure relating to the properties of the paper web from the signal.
Imego AB | Date: 2010-02-10
A method of manufacturing at least one customized MIP unit including: (a) providing at least one MIP unit having a surface including at least one target binding site configured to resemble a target molecule and surface-bound chargeable groups; (b) contacting the MIP unit(s) from the step (a) with at least one template molecule in a first solvent allowing the template molecule(s) to bind to the MIP unit(s); (c) passivating the surface-bound chargeable groups on the MIP unit(s) by adding a passivating agent; and (d) removing the template molecule(s) by washing in a second solvent, wherein the passivating agent binds to the surface of the unit(s) through bonds which remain stable upon washing in the second solvent.