Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: KBBE-2009-3-2-01 | Award Amount: 7.90M | Year: 2010
Biodiversity in the seas is only partly explored, although marine organisms are excellent sources for many industrial products. Through close co-operation between industrial and academic partners, the MAREX project will collect, isolate and classify marine organisms, such as micro- and macroalgae, cyanobacteria, sea anemones, tunicates and fish from the Atlantic, Pacific and Indian Oceans as well as from the Mediterranean, Baltic and Arabian Seas. Extracts and purified compounds of these organisms will be studied for several therapeutically and industrially significant biological activities, including anticancer, anti-inflammatory, antiviral and anticoagulant activities by applying a wide variety of screening tools, as well as for ion channel/receptor modulation and plant growth regulation. Chromatographic isolation of bioactive compounds will be followed by structural determination. Sustainable cultivation methods for promising organisms, and biotechnological processes for selected compounds will be developed, as well as biosensors for monitoring the target compounds. The work will entail sustainable organic synthesis of selected active compounds and new derivatives, and development of selected hits to lead compounds. The project will expand marine compound libraries. MAREX innovations will be targeted for industrial product development in order to improve the growth and productivity of European marine biotechnology. MAREX aims at a better understanding of environmentally conscious sourcing of marine biotechnology products and increased public awareness of marine biodiversity and potential. Finally, MAREX is expected to offer novel marine-based lead compounds for European industries and strengthen their product portfolios related to pharmaceutical, nutraceutical, cosmetic, agrochemical, food processing, material and biosensor applications.
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: NMP-2007-1.1-1 | Award Amount: 4.94M | Year: 2008
The cause of diseases is often unknown, but their origin can frequently be found at the biomolecular and cellular level situated on nm-scale. Early diagnostics combined with early intervention on that nanoscale is one of the holy grail of modern medicine. Inorganic nanoparticles are very promising agents in that respect. One of the promising biomedical applications of these nanoparticles is their use as agents for tumor hyperthermia. Hyperthermia is a form of cancer treatment that uses an elevated temperature to kill the tumor tissue. Compared to the more conventional surgical procedures, it is hailed as a less invasive approach that could be used for small, non-defined tumors. Well-designed instrumentation in combination with engineered inorganic nanoparticles that (a) possess the desired physical properties to generate a local heat and that (b) can specifically target the tumor offer immense potentials for targeted hyperthermia therapy. The overall objective of the present multi-disciplinary project is to develop and to explore various metal/magnetic nanoparticles as agents for targeted tumor therapy. To strive for this overall objective, a successful integration and convergence of different technologies at the nanoscale is indispensable. In this project, we will focus on the synthesis routes of tailor designed biofunctionalized nanoparticles for hyperthermia. This requires a profound physical and chemical characterization of the synthesized nanostructures, but the project is certainly not limited hereto. It will also include a toxicological and biological evaluation of the different nanoparticles. Hereby a detailed exploration and characterization of the interaction mechanism of the biological entities and the nanostructures will be pursued to obtain a better understanding of the phenomena occurring at the nanoscale. In addition, this project also comprises the design of advanced instrumentation that can be used for a controlled hyperthermia treatment.
Agency: European Commission | Branch: FP7 | Program: CP | Phase: SEC-2007-4.2-01 | Award Amount: 14.68M | Year: 2009
The Emergency Support System (ESS) is a suite of real-time data-centric technologies which will provide actionable information to crisis managers during abnormal events. This information will enable improved control and management, resulting in real time synchronization between forces on the ground (police, rescue, firefighters) and out-of-theater command and control centers (C&C). The approach guiding the ESS project is based on the fusion of variable forms of field-derived data within a central system which will then provide information analysis and decision support applications at designated C&C locations. To do this, ESS will achieve the following objectives: i) Improvement of front end data collection technologies (radioactivity, bio-chemical, audio-video, etc.) installed both on portable and fixed platforms, providing a flexible yet comprehensive coverage of the affected area; ii) this data will then be fused and analyzed to provide real-time decision support; iii) ESS will make these resources readily available to commanders through the use of easily accessible web-portals. Thus, ESS will minimize the uncertainty that characterizes crisis events, thereby limiting their scope. The ESS will then be field tested at three different scenarios, including a stadium evacuation, a forest fire and toxic waste dump accidents. The ESS consortium consists of 19 partners that will bring together a wide spectrum of European SMEs, industrial and academic partners from a variety of fields, ranging from sensor design and electronic communications to civil protection. The resulting cooperation will help provide an added measure of security to European citizens. Crisis situations are characterized by partial information according to which commanders need to make life and death decisions. By helping decision makers make decisions based on better and more complete data, ESS will help limit the scope of crises, ultimately saving precious lives.
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 3.40M | Year: 2011
Decompression sickness (DCS) is caused by circulating inert gas bubble formation in blood vessels and tissues resulting from supersaturation during inadequate decompression. It is an acknowledged risk of situations involving variations in ambient pressure, such as space flight and extravehicular activity, exposure to altitude, hyperbaric tunnelling intervention, as well as recreational and commercial underwater diving. Because new industrial challenges (human space flight programs, deeper planed tunnelling interventions and offshore oil excavation) and emerging recreational demands, the range of both environmental conditions and population characteristics involved in such activities regularly widen. Thus, new interdisciplinary approaches of decompression are needed to reduce risk for DCS. To foster knowledge of decompression phenomena, the PHYPODE ITN proposes to : - Develop an educational and research framework for cross-fertilization of currently fragmented research activities on physiopathology of decompression; - Give young researchers opportunities to share research techniques and resources, benefit from the best international scientists knowledge in this field, have the advantages of strong interactions between industry, medical centres and academia; - Widen career prospectives of young researchers by embracing the whole chain of research : from fundamental research for pathophysiological understanding of decompression to applied research in the industry for management of decompression. To achieve this training programme, academic partners, non profit association with worldwide activities, hyperbaric medical centres and industrial partners, with complementary expertises will build up the common agreed program concerning education and research.
Agency: European Commission | Branch: FP7 | Program: CP | Phase: SEC-2009-2.2-02 | Award Amount: 14.97M | Year: 2010
TASS is a multi-segment, multi-level intelligence and surveillance system, aimed at creating an entire airport security monitoring solution providing real-time accurate situational awareness to airport authorities.The TASS concept is based on integrating different types of selected real time sensors & sub-systems for data collection in a variety of modes, including fixed and mobile, all suitable for operation under any environmental conditions. TASS divides the airport security into six security control segments (environmental, cargo, people, airplanes, vehicle-fleet & facilities) each of them being monitored by various technologies that are fused together, creating a multisource labyrinth fusion logic enabling situational and security awareness of the airport anytime and anywhere. These fused control segments will be accessed through the TASS WEB-based portal by running a suite of applications making the airport security control centralized to all airport authorities. Information will be shared and synchronized between all of them in order to generate a comprehensive, real time, security overview for the airport C2, providing all the necessary features to assure a total no breach security environment. The integration will include the use of in-place technologies that will result in a cost-effective solution.The TASS consortium consists of 3 main end users representing 16 airports and 16 technological partners, which bring together European SMEs, industrial and academic partners, ranging from sensor design and electronic communications through to civil airport protection. The technologies will be tested at 3 airports including the hub airport Heathrow, an Israeli domestic airport and Athens airport, in order to cover a wide range of needs at different levels of airport protection. The main test at Heathrow airport will involve scenarios including 2 connected to the upcoming 2012 Olympic Games in London ultimately resulting in a high & smooth passengers flow.
Halas M.,Slovak University of Technology in Bratislava |
Anguelova M.,Imego AB
Automatica | Year: 2013
The paper shows that nonlinear retarded time-delay systems can admit an input-output representation of neutral type. This behaviour represents a strictly nonlinear phenomenon, for it cannot happen in the linear time-delay case where retarded systems always admit an input-output representation of retarded type. A necessary and sufficient condition for a nonlinear system to exhibit this behaviour is given, and a strategy for finding an input-output representation of retarded type is outlined. Some open problems that arise consequently are discussed as well. All the systems considered in this work are time-invariant and have commensurable delays. © 2012 Elsevier Ltd. All rights reserved.