Krems an der Donau, Austria

IMC University of Applied Sciences in Krems
Krems an der Donau, Austria
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Vogl J.,University of Vienna | Heine A.M.,IMC University of Applied Sciences in Krems | Steinhoff N.,OptimaMed Neurological Rehabilitation | Steinhoff N.,Regional Hospital Hochegg | And 2 more authors.
Frontiers in Neuroscience | Year: 2015

A growing understanding of music therapy with patients with disorders of consciousness has developed from observing behavioral changes and using these to gain new ways of experiencing this research environment and setting. Neuroscience provides further insight into the effects of music therapy; however, various studies with similar protocols show different results. The neuroanthropological approach is informed by anthropological and philosophical frameworks. It puts emphasis on a research with and not just on human beings concerning the subject/object question within a research process. It examines relational aspects and outcomes in the context of working in an interdisciplinary team. This allows a broader view of music therapy in a reflective process and leads to a careful interpretation of behavioral reactions and imaging results. This article discusses the importance of the neuroanthropological perspective on our way of obtaining knowledge and its influence on therapeutic practice. It is important to consider how knowledge is generated as it influences the results. Data from two cases will be presented to illustrate the neuroanthropological approach by comparing quantitative PET data with qualitative results of video analyses. © 2015 Vogl, Heine, Steinhoff, Weiss and Tucek.

Steinhoff N.,OptimaMed Neurological Rehabilitation | Heine A.M.,IMC University of Applied Sciences in Krems | Vogl J.,University of Vienna | Weiss K.,Regional Hospital Wiener Neustadt | And 4 more authors.
Frontiers in Neuroscience | Year: 2015

The global cerebral network allows music " to do to us what it does." While the same music can cause different emotions, the basic emotion of happy and sad songs can, nevertheless, be understood by most people. Consequently, the individual experience of music and its common effect on the human brain is a challenging subject for research. Various activities such as hearing, processing, and performing music provide us with different pictures of cerebral centers in PET. In comparison to these simple acts of experiencing music, the interaction and the therapeutic relationship between the patient and the therapist in Music Therapy (MT) provide us with an additional element in need of investigation. In the course of a pilot study, these problems were approached and reduced to the simple observation of pattern alteration in the brains of four individuals with Unresponsive Wakefulness Syndrome (UWS) during MT. Each patient had three PET investigations: (i) during a resting state, (ii) during the first exposure to MT, and (iii) during the last exposure to MT. Two patients in the MT group received MT for 5 weeks between the 2nd and the 3rd PET (three times a week), while two other patients in the control group had no MT in between. Tracer uptake was measured in the frontal, hippocampal, and cerebellar region of the brain. With certain differences in these three observed brain areas, the tracer uptake in the MT group was higher (34%) than in the control group after 5 weeks. The preliminary results suggest that MT activates the three brain regions described above. In this article, we present our approach to the neuroscience of MT and discuss the impact of our hypothesis on music therapy practice, neurological rehabilitation of individuals in UWS and additional neuroscientific research. © 2015 Steinhoff, Heine, Vogl, Weiss, Aschraf, Hajek, Schnider and Tucek.

Imhof M.,Life Technologies | Karas I.,Cell Pro Danube | Gomez I.,Life Technologies | Eger A.,IMC University of Applied Sciences in Krems | Imhof M.,General Teaching Hospital Korneuburg
Drug Discovery Today | Year: 2013

There is a continuous demand for preclinical modeling of the interaction of dendritic cells with the immune system and cancer cells. Recent progress in gene expression profiling with nucleic acid microarrays, in silico modeling and in vivo cell and animal approaches for non-clinical proof of safety and efficacy of these immunotherapies is summarized. Immunoinformatic approaches look promising to unfold this potential, although still unstable and difficult to interpret. Animal models have progressed a great deal in recent years, finally narrowing the gap from bench to bedside. However, translation to the clinic should be done with precaution. The most significant results concerning clinical benefit might come from detailed immunologic investigations made during well designed clinical trials of dendritic-cell-based therapies, which in general prove safe. © 2012 Elsevier Ltd.

Bajrektarevic A.,IMC University of Applied Sciences in Krems
E-Learning and Digital Media | Year: 2013

From Rio to Rio with Kyoto, Copenhagen and Durban in between, the conclusion remains the same: we fundamentally disagree on realities of this planet and the ways we can address them. A decisive breakthrough would necessitate both wider contexts and a larger participatory base so as to identify problems, formulate policies, and broaden and synchronise our actions. Luminaries from the world of science, philosophy, religion, culture and sports are invited too. But, they - as usual - will stuff side-events panels, while only politics will make decisions. Who in politics is sincerely motivated for the long-range policies? This does not pay off politically as such policies are often too complex and too time-consuming to survive the frequency and span of national elections as well as the taste or comprehension of the median voter. Our crisis is not environmental, financial or politico-economic. Deep and structural, this is a crisis of thought, of courage, of our ideas, all which runs us into a deep moral recession. Therefore, very little headway will be made at the Rio Summit.

Bakiri L.,National Cancer Research Center | MacHo-Maschler S.,University of Veterinary Medicine Vienna | Custic I.,Research Institute of Molecular Pathology | Custic I.,Hamburg Unit | And 9 more authors.
Cell Death and Differentiation | Year: 2015

Epithelial-to-mesenchymal transition (EMT) is essential for embryonic morphogenesis and wound healing and critical for tumour cell invasion and dissemination. The AP-1 transcription factor Fra-1 has been implicated in tumorigenesis and in tumour-associated EMT in human breast cancer. We observed a significant inverse correlation between Fra-1 mRNA expression and distant-metastasis-free survival in a large cohort of breast cancer patients derived from multiple array data sets. This unique correlation among Fos genes prompted us to assess the evolutionary conservation between Fra-1 functions in EMT of human and mouse cells. Ectopic expression of Fra-1 in fully polarized, non-tumourigenic, mouse mammary epithelial EpH4 cells induced a mesenchymal phenotype, characterized by a loss of epithelial and gain of mesenchymal markers. Proliferation, motility and invasiveness were also increased in the resulting EpFra1 cells, and the cells were tumourigenic and efficiently colonized the lung upon transplantation. Molecular analyses revealed increased expression of Tgfβ1 and the EMT-inducing transcription factors Zeb1, Zeb2 and Slug. Mechanistically, Fra-1 binds to the tgfb1 and zeb2 promoters and to an evolutionarily conserved region in the first intron of zeb1. Furthermore, increased activity of a zeb2 promoter reporter was detected in EpFra1 cells and shown to depend on AP-1-binding sites. Inhibiting TGFβ signalling in EpFra1 cells moderately increased the expression of epithelial markers, whereas silencing of zeb1 or zeb2 restored the epithelial phenotype and decreased migration in vitro and tumorigenesis in vivo. Thus Fra-1 induces changes in the expression of genes encoding EMT-related transcription factors leading to the acquisition of mesenchymal, invasive and tumorigenic capacities by epithelial cells. This study defines a novel function of Fra-1/AP-1 in modulating tgfb1, zeb1 and zeb2 expression through direct binding to genomic regulatory regions, which establishes a basis for future in vivo genetic manipulations and preclinical studies using mouse models. © 2015 Macmillan Publishers Limited.

Fernandez-Muinos T.,Tissue Engineering Laboratory | Suarez-Munoz M.,Tissue Engineering Laboratory | Suarez-Munoz M.,IMC University of Applied Sciences in Krems | Sanmarti-Espinal M.,Tissue Engineering Laboratory | Semino C.E.,Tissue Engineering Laboratory
Tissue Engineering - Part A | Year: 2014

Experimental models for cartilage and bone development have been studied in order to understand the biomechanical and biological parameters that regulate skeletal tissue formation. We have previously described that when mouse embryonic fibroblasts (MEFs) were cultured in a three-dimensional (3D)-soft self-assembling peptide nanofiber, the system engaged in a spontaneous process of cartilage-like formation evidenced by the expression of Sox9, Collagen type II, and proteoglycans. In the present work, we studied the influence that matrix mechanical properties have in modulating lineage commitment in an in vitro model of chondrogenesis. This effect was observed only when MEFs were cultured at low elastic modulus values (∼0.1kPa). Interestingly, under these conditions, the system expressed the chondrogenic inductor BMP4 and its antagonist Noggin. On the other hand, at higher elastic modulus values (∼5kPa), the system expressed Noggin but not BMP4, and did not engage in chondrogenesis, which suggest that the balance between bone morphogenetic protein/Noggin could be implicated in the chondrogenic process. Finally, no evidence of hypertrophy was detected under the conditions tested (by assessing expression of Collagen type X and Runx2) unless we challenged the system by co-culturing it with endothelial cells. Importantly, under these new conditions, the system underwent spontaneous matrix calcium mineralization. These results suggest that the 3D-system described here is sensitive to respond to environmental changes such as biomechanical and biological cues. © 2014, Mary Ann Liebert, Inc. 2014.

Reiner M.,IMC University of Applied Sciences in Krems
IADIS International Conference on Cognition and Exploratory Learning in Digital Age, CELDA 2011 | Year: 2011

Out of the needs of industry the idea of a Europe wide certification schema for different job professions was generated. The ECQA now acts as a Europe wide success story for industry certificates in management level. The trainings are provided by certified trainers online (e-learning or blended learning) or in house trainings at several companies. The certification is done at a certification centre online via multiple choice tests.

Bajrektarevic A.,IMC University of Applied Sciences in Krems
Geopolitics of Energy | Year: 2012

The MENA theatre is situated in one of the most dramatic locations of the world. It is the only existing land corridor that connects three continents. With some 6% of the total world population, it is roughly the same demographic weight as the US and Russia combined. The US withdrawal from Iraq, announced military reductions in Afghanistan, limited influence in Pakistan, and overall overextension on the southwestern flank of the Euro-Asian continent - all of these outcomes have raised concern and feelings of insecurity within the GCC. The US has a lasting geo-economic interest in the Gulf, which is inevitably coupled with its overarching global security concerns. Oil is the most traded commodity in the world-roughly 12% of overall world trade. As long as oil remains priced in US dollar, it will represent the prime foreign reserve currency, as the functional tie between the major currencies' exchange rates and fossil-fuel energy cannot be derailed or delinked.

Fanninger J.,IMC University of Applied Sciences in Krems
Eco.mont | Year: 2012

In March 2004 the Regionalverbund (regional association) of the Lungau region (Salzburg Province) initiated a meeting with representatives from agriculture, tourism, business as well as with mayors, chaired by the Gemeindeentwicklung Salzburg (municipal development service), where the idea of establishing a biosphere reserve (BR) was quite well received. Geographer Birgit Reutz-Hornsteiner reported on Großes Walsertal BR (Vorarlberg), at that time the only BR in Austria to fulfill the criteria of the new Seville Strategy. As the meeting ended, all chamber representatives expressed their support for continuing work on the BR proposal apace. In a next step, a working group was established. It contacted the Austrian National MAB Committee and also sought the view of conservation authorities. Anita Moser (municipal development service) prepared the presentation to the MAB Committee. © SLK, W. Bedek.

Maurer C.,IMC University of Applied Sciences in Krems
Springer Proceedings in Mathematics | Year: 2015

Tourists need information about destinations for travel decision making. Thus the importance of information in the tourism industry is apparent. Tourists inform themselves before and during travelling, gather information about prices, hotels, sights, activities, alternatives, weather conditions, local traditions, food, drinks and religious views of the destination. After the visit they share information with others. Therefore, a reasonable diffusion with information and communication technologies (ICTs) can benefit both the tourists as well as the businesses. However, disparities still exist in access, skills, use of and attitudes towards ICTs. Although, the phenomenon of digital divide has been addressed in several studies, especially with regard to small and medium sized tourism enterprises, research on the adoption and implementation of ICTs in cultural and heritage tourism is still scant. This paper aims at raising awareness for the influence and effect of the digital divide on the tourism industry in general and cultural and heritage institutions in particular. © Springer International Publishing Switzerland 2015.

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