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Marines is certified by the American Board of Surgery and completed his fellowship training in this specialty at Rutgers University. He uses laparoscopic and robotic techniques for the treatment of colorectal diseases that result in decreased complications, less pain, better oncological outcomes, and faster return to work. "Now we have an option for ABL patients who haven't been candidates for other treatments or have not been satisfied with the results of other treatments," said Dr. Marines. "Current treatment options are very limited with many patients ultimately requiring a colostomy." The disease Accidental Bowel Leakage (ABL) affects an estimated 30 million people in the U.S. and Europe alone. ABL results from damage or weakening of the anal sphincter muscle. The impact of ABL on patients' quality of life is debilitating, causing absence from work, constant risk of embarrassment, and the inability to engage in routine activities. To schedule an appointment with Dr. Marines or to find a physician at Houston Methodist Willowbrook Hospital, call 281.737.2500. Houston Methodist Willowbrook Hospital is a 312 bed, not-for-profit, faith-based hospital, which is part of Houston Methodist. The hospital has expanded in Northwest Houston to serve the comprehensive health care needs of the growing community. Houston Methodist Willowbrook Hospital has been named a Magnet recognized health care facility by the American Nurses Credentialing Center's (ANCC) Magnet Recognition Program®. Houston Methodist Willowbrook is ranked No. 8 in the Houston metro area and No. 19 in Texas by U.S. News & World Report as a "Best Hospital" in 2016. Houston Methodist Willowbrook Hospital specializes in cardiology and cardiovascular services, neurology, neurosurgery, orthopedics and sports medicine, and comprehensive cancer services. Houston Methodist Willowbrook Hospital has a Breast Care Center, Cancer Center, Imaging Center, Infusion Center Sleep Center, Surgical Weight Loss Center and operates the largest Childbirth Center in the Greater Northwest Houston area. For more information on the comprehensive services available on the Houston Methodist Willowbrook campus and to learn about upcoming events, please visit houstonmethodist.org/willowbrook. To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/first-surgical-implant-of-fenix-continence-restoration-system-at-houston-methodist-willowbrook-hospital-300457010.html


Howard University Cancer Center has received a grant from the Avon Breast Cancer Crusade at AVON 39 The Walk to End Breast Cancer to add bilingual patient navigation to ensure that patients get the care they need in their preferred language. The grant will also help enhance the electronic health record system to better identify their patients’ needs and connect them to essential follow-up services. The new bilingual patient navigator will assist women at the point they receive abnormal mammograms and continue to offer support in the event of diagnosis and treatment. The funds will also be used to help the Howard University Cancer Center gather and use data about patients' satisfaction with care and data on quality-of-life issues. Howard University Hospital's Women's Imaging Center provides diagnostic services to Cancer Center patients. “We are very thankful to the Avon Breast Cancer Crusade - Avon 39 for the new project funding,” Carla Williams, Ph.D., Interim Director, Howard University Cancer Center. “The support will help us greatly expand our reach to this population. Hispanic women, like African-American women, often experience more delays in follow-up care after an abnormal mammogram. Patient navigation is particularly important for these groups. ” AVON 39 Washington DC drew more than 1,700 participants from 43 states and Washington, DC, including 284 breast cancer survivors who walked a total of 39.3 miles over two days. Since AVON 39’s launch in 2003, more than 235,000 participants have raised nearly $620,000,000. Funds raised are distributed to local, regional and national breast cancer organizations. The Washington event was the second of seven events across the country united by the theme #FierceIsForever. "As the company for women, we are proud of our strong purpose-driven mission to improve the lives of women — and this includes our long-term commitment to the fight against breast cancer. I've had the great privilege of participating in the AVON 39 Walk and being a part of the powerful community of walkers. I'm inspired by the individuals whose lives have been touched by breast cancer, and who have their own personal reason for wanting to take part and make a difference," says Scott White, Chief Executive Officer, New Avon LLC. The Howard University Cancer Center has had a long history of serving minorities and underserved populations and addressing disparities. Thus, the mission of HUCC is to reduce the burden of cancer through research, education, and service, with emphasis on the unique ethnic and cultural aspects of minority and underserved populations. The Cancer Center has provided specialized, culturally competent breast cancer screening and treatment for over 25 years. For more information about the Howard University Cancer Center, visit Facebook.com/huccenter1. About AVON 39 The Walk to End Breast Cancer AVON 39 The Walk to End Breast Cancer is the largest fundraising event for the Avon Breast Cancer Crusade. Since its launch by the Avon Foundation for Women in 2003, more than 235,000 participants have raised nearly $620,000,000 in the fight to end breast cancer. Funds raised at each event provide direct impact in the area where the event takes place, and also help make sure that care and research programs nationwide have adequate resources to make the most progress possible. For more information about AVON 39 The Walk to End Breast Cancer, visit www.avon39.org or join the #FierceIsForever conversation on Facebook, Twitter, YouTube and Instagram. About New Avon LLC  New Avon LLC (“Avon”) is the leading social selling beauty company in North America, with independent sales Representatives throughout the United States, Puerto Rico and Canada. Avon's product portfolio includes award-winning skincare, color cosmetics, fragrance and personal care products, featuring iconic brands such as ANEW, Avon Color, mark., and Skin So Soft, as well as fashion and accessories. Avon has a 130-year history of empowering women through economic opportunity, and supporting the causes that matter most to women. Together, Avon and the Avon Foundation for Women have contributed over $1 billion globally toward eradicating breast cancer and domestic violence. Learn more about Avon and its products at www.avon.com.


News Article | May 17, 2017
Site: www.prweb.com

PMMC, a leading revenue cycle management company, helped JFK Health complete a successful first year in the Comprehensive Care for Joint Replacement (CJR) program by providing bundled episode analytics and a collaboration strategy with its physicians to reduce spend and earn a repayment from CMS. PMMC provided JFK with actionable analytics so the organization could quickly evaluate spend performance among its post-acute care (PAC) providers and pinpoint the cost savings opportunities. By the completion of the first year, JFK Health finished $242,000 under the episode spend target and earned a repayment of $171,000 from CMS after the stop-gain limit was applied. “The data is what provides the insight for the hospitals to make decisions to hit the targets,” explained Steve Miller, Director of Managed Care at JFK. “We quickly realized by drilling the data down to the Service level that Skilled Nursing Facilities (SNF) were a cost strain. The PMMC model allowed us to identify the “sweet spot” between SNF length of stay and exceeding the stop gain”.” JFK Health decreased its length of stay by more than 50 percent -- from 21 to 10 days. The model, which requires hospitals to manage spend across the entire episode of care, is uncharted territory for many providers. An inherent challenge in this model is the need to build collaboration among the hospital and its physicians. To help build this collaboration strategy, PMMC consulted with the physicians at JFK Health. By presenting a transparent, third-party perspective supported by data, JFK’s physicians responded positively. “The relationship with a third-party like PMMC is unquantifiable. It made the process more transparent and really solidified the message of the need for collaboration,” added Steve Miller. Going forward into the second year of the program, JFK Health envisions its physicians being more engaged and taking more of a leadership role. JFK Health is one of approximately 800 hospitals required to participate in the CJR model, a five-year program intended to hold hospitals financially accountable for the quality and cost of a CJR episode of care and incentivizes increased coordination of care among hospitals, physicians, and post-acute care providers. With PMMC’s bundled episode analytics, hospitals can easily compare its own costs for the entire episode to CMS targets – as well as internal benchmarks – on a quarterly basis. PMMC provides high value revenue cycle software and services to improve the financial performance of healthcare organizations. Our software and expertise focuses on payment accuracy and identifying more revenue opportunities across the revenue cycle. PMMC helps hospitals identify underpayments and denials, increase price transparency, and manage bundled payments. Clients see, on average, a 10 to 1 return on investment with software and services. JFK Medical Center, an affiliate of JFK Health, is a 498-bed full-service, acute care hospital, and the adjacent JFK Johnson Rehabilitative Institute. Located in the heart of Edison, NJ, it has remained at the forefront of quality care in the region since its inception in 1967. Today, JFK accommodates more than 20,000 admissions, 3,000 births and 60,000 Emergency Room visits on a yearly basis. The Medical Center features a complete array of services, including general surgery, emergency medicine, mental health, orthopedics, maternity and pediatric care. It is home to two world renowned institutes: the JFK Neuroscience Institute and the JFK Johnson Rehabilitation Institute, as well as JFK Haven Hospice, JFK Imaging Center and the Center for Wound Healing. JFK Medical Center is proud to be rated the #1 stroke program in New Jersey and in the top 5% in the entire country. With a Gold Plus award for stroke care by the American Heart Association and a comprehensive and primary stroke center designation, our neuroscience program is unmatched with both neurological and rehabilitation services.


"My philosophy of care centers around providing personalized and customized care for each patient," said Adeoye, who served as an assistant team physician for the San Francisco 49ers, Golden State Warriors and Stanford football and athletic teams while a clinical fellow in sports medicine and arthroscopy at Stanford University. "By utilizing innovative techniques, I focus on taking a patient from injury and pain, back into an active lifestyle. This is extremely rewarding work and fulfills purpose in my life daily." Adeoye attended LA Sierra University where he graduated summa cum laude and received the Outstanding Senior Award for the highest departmental GPA from the Department of Physics. Additionally, he attended the Wharton School at University of Pennsylvania where he received his MBA and was a volunteer in the Wharton Healthcare International Program in South Africa. Adeoye completed medical school at the University of California in San Francisco where he served as chapter president of the Student National Medical Association. He completed his orthopedic surgery residency at Yale University New Haven Hospital where he was named chief resident. Adeoye is an associate master instructor for the Arthroscopy Association of North America and is board certified by the American Board of Orthopedic Surgery. He is currently in practice at Houston Methodist Willowbrook Hospital. For more information or to schedule an appointment with Dr. Adeoye visit houstonmethodist.org/doctor/olusanjo-adeoye or call 281.737.0999. About Houston Methodist Orthopedics & Sports Medicine at Willowbrook Utilizing the latest research and state-of-the-art technology, Houston Methodist Orthopedics & Sports Medicine has become the leader in orthopedic care in Northwest Houston. Team physicians to high school and collegiate sports teams and sports clubs across Houston, the elite group of orthopedic surgeons - with subspecialties in foot and ankle, hand and wrist, hip and spine and sports medicine - collaborate with primary care sports medicine physicians and rehabilitation therapists to offer patients of all ages the least invasive, advanced treatment options available. About Houston Methodist Willowbrook Hospital Houston Methodist Willowbrook Hospital is a 312 bed, not-for-profit, faith-based hospital, which is part of Houston Methodist. The hospital has expanded in Northwest Houston to serve the comprehensive health care needs of the growing community. Houston Methodist Willowbrook Hospital has been named a Magnet recognized health care facility by the American Nurses Credentialing Center's (ANCC) Magnet Recognition Program®. Houston Methodist Willowbrook is ranked No. 8 in the Houston metro area and No. 19 in Texas by U.S. News & World Report as a "Best Hospital" in 2016. Houston Methodist Willowbrook Hospital specializes in cardiology and cardiovascular services, neurology, neurosurgery, orthopedics and sports medicine, and comprehensive cancer services. Houston Methodist Willowbrook Hospital has a Breast Care Center, Cancer Center, Imaging Center, Infusion Center Sleep Center, Surgical Weight Loss Center and operates the largest Childbirth Center in the Greater Northwest Houston area. For more information on the comprehensive services available on the Houston Methodist Willowbrook campus and to learn about upcoming events, please visit houstonmethodist.org/willowbrook. To find a physician, call 281.737.2500. To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/olusanjo-adeoye-md-mba-joins-houston-methodist-orthopedics--sports-medicine-at-willowbrook-300459710.html


BOSTON--(BUSINESS WIRE)--Sync Project, Inc., a Boston-based company developing music as a personalized treatment across a range of conditions, is accelerating development of its physiologically-responsive music health platform. To date, Sync Project has raised $5 million in financing from investors Reid Hoffman, Greylock Partners (via Discovery Fund), Esther Dyson, David Shaw, Digital Garage, and PureTech Health. The company aims to validate interventions in both large-scale consumer experiments and controlled clinical studies in conditions such as stress, sleep, anxiety, and pain. “Developing music as precision medicine requires the right mix of people and funding that bridge consumer technology, music, and biotech,” said Marko Ahtisaari, CEO and Co-founder. “Our investors, advisors, and team are just such a mix. With the support of our investors, Sync Project is accelerating the development and validation of generative music for health.” “We are excited about the Sync Project team and how they are using artificial intelligence to create a new kind of personalized music that responds to your physiology to improve health,” said Reid Hoffman, partner at Greylock Partners. Sync Project is building a unique data set on the biometric impact (e.g., heart rate, brain activity, and sleep patterns) of certain structural properties of music (e.g., beat, key, and timbre). Datasets generated through Sync Project’s consumer initiatives will be further validated through controlled clinical trials in individuals suffering from sleep disorders, anxiety, and pain, among others. Sync Project aims to commercialize the clinical applications of this platform and deliver a personalized, low-cost, non-invasive therapy, across a range of conditions. Sync Project’s generative music platform is based on scientific research into the health effects of music. Recent research has shown that music can modulate neural systems like the dopamine response, autonomic nervous system, and other key pathways related to stress, movement, learning, and memory. This body of research shows that music affects some of the same neural pathways that are regulated by pharmaceuticals such as psychostimulants and suggests that music may hold significant therapeutic potential. Earlier this year, Sync Project launched unwind.ai, the first global experiment using algorithmically-generated music to potentially improve relaxation prior to sleep. Anyone with a smartphone can participate free of charge and contribute to a global data set on how music affects stress. Designed in collaboration with critically-acclaimed musicians, Sync Project’s generative music is personalized to an individual’s unique physiology. About Sync Project Sync Project is developing music as precision medicine. Sync Project’s generative music platform builds on scientific research into the health effects of music with a unique data set and machine learning that analyses musical attributes (like tempo and timbre) and their impacts on biometrics (like heart rate, brain activity, and sleep patterns.) Insights from Sync Project’s consumer initiatives will be further validated through controlled clinical trials in individuals suffering from sleep disorders, anxiety, and pain, among others. Sync Project aims to commercialize the clinical applications of their platform and deliver a personalized, low-cost, non-invasive therapy, across a range of conditions. Sync Project was co-founded by Marko Ahtisaari, Yadid Ayzenberg, Ketki Karanam, and PureTech Health (LSE: PRTC; www.puretechhealth.com). Sync Project’s advisors and Board comprise a distinguished and diverse team of science, music, health and technology experts committed to uncovering the untapped potential of music’s ability to improve health: Robert Zatorre, Ph.D., Professor of Neurology and Neurosurgery at the Montreal Neurological Institute at McGill University; Adam Gazzaley, M.D., Ph.D., Director of the Neuroscience Imaging Center and Professor of Physiology, Psychology and Psychiatry at the University of California, San Francisco; Tristan Jehan, Ph.D., Founding Chief Technology Officer of The Echo Nest (Spotify); Peter Gabriel, six-time Grammy Award-winning British singer-songwriter; Annie Clark (St. Vincent), award-winning American singer-songwriter and multi-instrumentalist; Jon Hopkins, classically trained British pianist, critically acclaimed recording artist, Ivor Novello nominated composer of film scores, and prominent producer/collaborator; Esa-Pekka Salonen, Principal Conductor and Artistic Advisor of the Philharmonia Orchestra in London and Conductor Laureate for the Los Angeles Philharmonic; and Board Members Joi Ito, Director of the Massachusetts Institute of Technology Media Lab, Marjorie Scardino, DBE, FRSA, Chairman of the MacArthur Foundation, Board member of Twitter and former CEO of Pearson, Steven Holtzman, CEO of Decibel Therapeutics, and Daphne Zohar, Co-Founder and the Chief Executive Officer of PureTech Health. For more information visit syncproject.co or connect with us on Twitter @syncprojectco. Forward Looking Statement This press release contains statements that are or may be forward-looking statements, including statements that relate to the company's future prospects, developments and strategies. The forward-looking statements are based on current expectations and are subject to known and unknown risks and uncertainties that could cause actual results, performance and achievements to differ materially from current expectations, including, but not limited to, those risks and uncertainties described in the risk factors included in the regulatory filings for PureTech Health plc. These forward-looking statements are based on assumptions regarding the present and future business strategies of the company and the environment in which it will operate in the future. Each forward-looking statement speaks only as at the date of this press release. Except as required by law and regulatory requirements, neither the company nor any other party intends to update or revise these forward-looking statements, whether as a result of new information, future events or otherwise.


My Friends House LA and LoveLife Foundation Join Forces to Host a Makeover for Displaced Moms in Honor of Mother’s Day On April 30th, My Friends House LA in conjunction with the LoveLife Foundation will host a special Mother’s Day event to salute seven moms in need. Their special “Mommy Makeover” day will start at 11am at the My Friend’s House Community Outreach and Imaging Center in Downtown Los Angeles (Skid Row community) located at 1244 E. 7th Street, Los Angeles, CA 90021. The center will be transformed into a spa-like setting which will set the tone for the day. The women will have time to rejuvenate and connect with other moms enduring similar situations. The selected women will have their hair groomed; receive manicures, pedicures, massages, make-up tips and consultations as well as have an opportunity to select a very special outfit to have and wear for this occasion. The day will continue with an empowerment message and a photo shoot allowing them to have a photo keepsake for lasting memories. Founder of the LoveLife Foundation, Raheem DeVaughn will serenade the mother’s with his melodic voice adding an extra special touch to this spectacular event. DeVaughn who will also be performing Saturday at the KJLH Women’s Expo proves to be a man of compassion. He along with his foundation has taken time out of their busy schedules to ensure these women have an unforgettable good time. To end this phenomenal day, the mothers will be escorted, by way of limousine provided by Norman Lewis to a local restaurant and will experience an evening of fine dining – all of which will be at no charge to them! “We are super excited about empowering these ladies and building their self-worth and esteem, making them feel beautiful inside and out!” stated Tiffany A. Rose, founder of My Friends House LA. This Mother’s Day celebration at the My Friend’s House Center follows the opening of their newly built Community Outreach and Imaging Centers, located at 1244 E. 7th Street, Los Angeles, Ca 90021, directly in the heart of Skid Row. With the financial support of sponsors, corporations and individuals, the two departments can restore souls with the impact of providing opportunities for relief. It is a place for those struggling to get back on their feet by meeting some of their needs that get overlooked such as, literacy on finances, appearances and styling for going on interviews, free counseling and access to computers for seeking employment and housing. Classes for health and nutrition is also offered. My Friend’s House Foundation is a 501 (c) (3) non-profit human organization who inspired by Matthew 25:35-40 has a mission to provide life sustaining staples that includes food, clothing, toiletries and spiritual motivation to the economically disadvantaged, regardless of race, color, creed, or religious belief. To date the foundation has served over 100,000 (an average of 250 per week) during their weekly outreach program held on Skid Row. The LoveLife Foundation is a 501 (c) (3) non-profit founded by three-time Grammy-nominated singer/songwriter Raheem DeVaughn. Out of his genuine concern for the community and youth, Raheem established The Love Life Foundation to embrace several causes closest to his heart, with an emphasis on HIV/AIDS, domestic violence, mental illness, autism, cancer, education, music and the arts. Their mission is to improve lives through social development, education, and health and wellness by collaborating with community organizations and foundations to raise awareness and tackle issues that affect our communities. Los Angeles, CA, April 26, 2017 --( PR.com )-- My Friends House LA in conjunction with the LoveLife Foundation will host a special Mother’s Day event to salute seven moms in need. Their special “Mommy Makeover” day will start at 11am at the My Friend’s House Community Outreach and Imaging Center in Downtown Los Angeles (Skid Row community) located at 1244 E. 7th Street, Los Angeles, CA 90021.The center will be transformed into a spa-like setting which will set the tone for the day. The women will have time to rejuvenate and connect with other moms enduring similar situations. The selected women will have their hair groomed; receive manicures, pedicures, massages, make-up tips and consultations as well as have an opportunity to select a very special outfit to have and wear for this occasion. The day will continue with an empowerment message and a photo shoot allowing them to have a photo keepsake for lasting memories.Founder of the LoveLife Foundation, Raheem DeVaughn will serenade the mother’s with his melodic voice adding an extra special touch to this spectacular event.DeVaughn who will also be performing Saturday at the KJLH Women’s Expo proves to be a man of compassion. He along with his foundation has taken time out of their busy schedules to ensure these women have an unforgettable good time.To end this phenomenal day, the mothers will be escorted, by way of limousine provided by Norman Lewis to a local restaurant and will experience an evening of fine dining – all of which will be at no charge to them!“We are super excited about empowering these ladies and building their self-worth and esteem, making them feel beautiful inside and out!” stated Tiffany A. Rose, founder of My Friends House LA.This Mother’s Day celebration at the My Friend’s House Center follows the opening of their newly built Community Outreach and Imaging Centers, located at 1244 E. 7th Street, Los Angeles, Ca 90021, directly in the heart of Skid Row. With the financial support of sponsors, corporations and individuals, the two departments can restore souls with the impact of providing opportunities for relief. It is a place for those struggling to get back on their feet by meeting some of their needs that get overlooked such as, literacy on finances, appearances and styling for going on interviews, free counseling and access to computers for seeking employment and housing. Classes for health and nutrition is also offered.My Friend’s House Foundation is a 501 (c) (3) non-profit human organization who inspired by Matthew 25:35-40 has a mission to provide life sustaining staples that includes food, clothing, toiletries and spiritual motivation to the economically disadvantaged, regardless of race, color, creed, or religious belief. To date the foundation has served over 100,000 (an average of 250 per week) during their weekly outreach program held on Skid Row.The LoveLife Foundation is a 501 (c) (3) non-profit founded by three-time Grammy-nominated singer/songwriter Raheem DeVaughn. Out of his genuine concern for the community and youth, Raheem established The Love Life Foundation to embrace several causes closest to his heart, with an emphasis on HIV/AIDS, domestic violence, mental illness, autism, cancer, education, music and the arts. Their mission is to improve lives through social development, education, and health and wellness by collaborating with community organizations and foundations to raise awareness and tackle issues that affect our communities.


News Article | February 16, 2017
Site: www.eurekalert.org

BLOOMINGTON, Ind. -- A study reported Feb. 17 in the journal Science led by researchers at Indiana University and Harvard University is the first to reveal in extreme detail the operation of the biochemical clockwork that drives cellular division in bacteria. The discovery, made possible through a revolutionary method used to color bacterial cell walls developed at IU, is an important step forward in research on bacterial growth and could inform efforts to develop drugs that combat antibiotic-resistant bacteria. Globally, antibiotic-resistant bacteria, or "superbugs," pose a major risk to human health. The World Health Organization estimates about 480,000 people develop multi-drug resistant tuberculosis each year. In the U.S., the Centers for Disease Control estimates 1 in 4 hospital-acquired infections in long-term patients are caused by six major strains of the bugs. "This is the first study to 'connect the dots' between each part of the cell involved in bacterial cellular division," said Yves Brun, the Clyde Culbertson Professor of Biology in the IU Bloomington College of Arts and Sciences' Department of Biology, who is an author on the study. "We've finally closed the circle on this mechanism and opened the door to more precise methods in the fight against antibiotic-resistant bacteria. "If you understand how an engine works, you can shut it down by removing a single part," Brun said. "You no longer need to throw a hammer into the works to destroy it." Early antibiotics like penicillin function like a hammer: a blunt instrument that destroys the bacterial cell in the midst of division by tricking cell wall-making enzymes called penicillin-binding proteins, or PBPs, into binding to the drug rather than the building blocks of the cell walls, causing the walls to breach and the cells to explode. Other parts of the cell that drive bacterial division include cytoskeletal proteins, called FtsA and FtsZ, which form skeleton-like fibers inside cells to direct construction of the cell wall. All three elements must coordinate to build a cell wall in the middle of the cell to ensure the material inside doesn't escape after it splits in half. The fact that these three parts of the cell play a role in cellular division is known, but the new study is the first to show exactly how they coordinate. Essentially, Brun said, FtsZ acts as a "foreman" that directs the movement of PBP "workers" as they construct a cell wall. The researchers were able to detect the action with high-tech, multi-colored dyes called fluorescent D-amino acids, or FDAAs, discovered five years ago in the lab of Michael VanNieuwenhze, professor in the IU Bloomington College of Arts and Sciences' Department of Chemistry, who is a co-author on the study. "The application of different colors of these dyes during the cell wall construction process revealed a 'bull's-eye pattern,' indicating the circular wall is built from the outer edge of the cell inward to the center," VanNieuwenhze said. The study also solves another mystery: How do FtsZ molecules build the wall? The researchers found that FtsZ -- which is arrayed in a biochemical chain called a filament -- constantly loses a molecule at one end and gains a molecule at the other end, resulting in a circular motion around the cell's edge described as "treadmilling." IU researchers chemically labeled the cells for analysis. Harvard scientists performed the experiments that showed the motion of the FtsZ and PBP proteins inside the cell. The subject of a U.S. patent filed by the IU Research and Technology Corp., FDAA dyes have played an important part in dozens of other scientific papers on bacteria since 2012. VanNieuwenhze's lab also has about 50 material transfer agreements with researchers across the globe to provide access to the tool. The creation of the dyes at IU was led by Erkin Kuru, a former Ph.D. student in the labs of VanNieuwenhze and Brun who is currently a research fellow at Harvard. Kuru and Yen-Pang Hsu, a IU Ph.D. student also in the labs of VanNieuwenhze and Brun, are co-authors on the study. "This is the first time we've been able to observe cell division as a dynamic process -- that is, a process occurring over time," Kuru said. "This wasn't possible before since we lacked the tools to see it." Hsu added that "the visualization of these cell structures is no small task when you consider the organism that contains them is less than a micrometer -- or one-thousand of a millimeter -- wide. We wouldn't have been able to measure the fluorescent patterns in these cells without the technology at the IU Light Microscopy Imaging Center." Harvard authors on the paper were Ethan C. Garner, Alexandre W. Bisson Filho, Georgia R. Squyres and Yingjie Sun. Additional authors were Cees Dekker of Delft University of Technology, The Netherlands; Seamus Holden of Newcastle University, England; and Fabai Wu of the California Institute of Technology. This research was funded in part by the National Institutes of Health.


New Onsite MRI and Expanded Physical Therapy Provide One-Stop Orthopedic Care to Gwinnett Area ​​​OrthoAtlanta orthopedic and sports medicine specialists has recently remodeled and expanded its Gwinnett office with additional exam rooms, convenient onsite magnetic resonance imaging (MRI), C-Arm imaging, and an expanded physical therapy facility. The OrthoAtlanta Gwinnett office serves the orthopedic and sports medicine needs of patients in the greater Duluth, Lawrenceville, and Suwanee areas. Located in the Terrace Park Medical Center, at the intersection of Lawrenceville-Suwanee and Old Norcross Roads, the office is just minutes from Gwinnett Medical Center in Lawrenceville. “OrthoAtlanta has served the Gwinnett area in this location since 2010,” stated Dr. Brian E. Morgan, OrthoAtlanta orthopedic surgeon and an OrthoAtlanta physician owner who serves patients at this location and in Johns Creek. As described by Dr. Morgan, “the OrthoAtlanta Gwinnett office expansion was designed with patient convenience, comfort and access in mind. The new facility provides our patients with a single destination for all their orthopedic and sports medicine needs, including additional examination rooms, new MRI Imaging capabilities on premise, and expanded onsite physical therapy. OrthoAtlanta Gwinnett provides the convenience of one-stop for expert musculoskeletal care valued by patients today, from initial examination, to onsite X-ray, MRI, diagnosis, treatment and rehabilitation services including physical therapy.” Front desk reception, check-in and an expanded waiting room welcome patients on the third floor, Suite 390. Twenty exam rooms, onsite X-ray, a triage room, and checkout are also located on this level. The new MRI and remodeled Physical Therapy facilities are situated in a separate first floor suite of the building. The Imaging Center features a new Siemens MAGNETOM Espree imaging unit. This state-of-the art open bore MRI system provides added comfort and convenience to patients during imaging, and is particularly appreciated by claustrophobic patients. A C-Arm imaging unit offers flexibility and easy maneuverability for select types of orthopedic imaging procedures. The new physical therapy area features a spacious, open-design, the latest equipment, and two private treatment rooms. The OrthoAtlanta Gwinnett office in Lawrenceville is staffed by OrthoAtlanta physicians Tuan Bui, MD, spine; Snehal Dalal, MD, hand and upper extremity; Timothy Gajewski, MD, adult total joint reconstruction; Douglas Kasow, DO, spine and spinal trauma; William Lichtenfeld, MD, physical medicine and rehabilitation; Brian Morgan, MD, sports medicine; Jeffrey Smith, MD, foot and ankle; and David Stokes, MD, sports medicine. The office is supported by a professional staff including seven physician assistants, plus physical therapists, technicians and administrative personnel. OrthoAtlanta Gwinnett is located at 771 Old Norcross Road, Suite 390, in Lawrenceville, Georgia, and serves existing patients and accept new patients with orthopedic and sports medicine needs ranging from sprains, strains and fractures, workers’ compensation injuries, to the most complex total joint preservation, reconstruction or replacement and both non-surgical and surgical spine needs. Appointments may be requested by calling 678-957-0757, or connecting via the Patient Portal on the OrthoAtlanta web site. For more information about OrthoAtlanta and the expanded Gwinnett office, please visit www.orthoatlanta.com. About OrthoAtlanta OrthoAtlanta is one of the largest orthopedic and sports medicine practices in the greater Atlanta, Georgia area. With 39 physicians serving in 12 offices, the physician-owned practice is dedicated to providing the highest level of patient care for injury or deformity of muscles, joints, bones and spine. OrthoAtlanta offers convenient accessibility to a full range of musculoskeletal surgeons, specialists and patient services including on-site physical therapy, pain management care, six MRI imaging centers and workers’ compensation coordination. OrthoAtlanta Surgery Centers in Austell and Fayetteville provide cost-effective, same-day surgical procedures in an accredited outpatient center. Comprehensive operative and non-operative musculoskeletal care and expertise includes sports medicine, arthroscopic surgery, hip replacement, knee replacement, neck and spine surgery, elbow and shoulder surgery, foot and ankle surgery, pain management, arthritis treatment, general orthopedics, work related injuries and acute orthopaedic urgent care.  Learn more at www.OrthoAtlanta.com. For additional information, please contact Pat Prosser, Public Relations Manager, at OrthoAtlanta, 678-996-7254, or via email pprosser@OrthoAtlanta.com.


News Article | February 16, 2017
Site: phys.org

The discovery, made possible through a revolutionary method used to color bacterial cell walls developed at IU, is an important step forward in research on bacterial growth and could inform efforts to develop drugs that combat antibiotic-resistant bacteria. Globally, antibiotic-resistant bacteria, or "superbugs," pose a major risk to human health. The World Health Organization estimates about 480,000 people develop multi-drug resistant tuberculosis each year. In the U.S., the Centers for Disease Control estimates 1 in 4 hospital-acquired infections in long-term patients are caused by six major strains of the bugs. "This is the first study to 'connect the dots' between each part of the cell involved in bacterial cellular division," said Yves Brun, the Clyde Culbertson Professor of Biology in the IU Bloomington College of Arts and Sciences' Department of Biology, who is an author on the study. "We've finally closed the circle on this mechanism and opened the door to more precise methods in the fight against antibiotic-resistant bacteria. "If you understand how an engine works, you can shut it down by removing a single part," Brun said. "You no longer need to throw a hammer into the works to destroy it." Early antibiotics like penicillin function like a hammer: a blunt instrument that destroys the bacterial cell in the midst of division by tricking cell wall-making enzymes called penicillin-binding proteins, or PBPs, into binding to the drug rather than the building blocks of the cell walls, causing the walls to breach and the cells to explode. Other parts of the cell that drive bacterial division include cytoskeletal proteins, called FtsA and FtsZ, which form skeleton-like fibers inside cells to direct construction of the cell wall. All three elements must coordinate to build a cell wall in the middle of the cell to ensure the material inside doesn't escape after it splits in half. The fact that these three parts of the cell play a role in cellular division is known, but the new study is the first to show exactly how they coordinate. Essentially, Brun said, FtsZ acts as a "foreman" that directs the movement of PBP "workers" as they construct a cell wall. The researchers were able to detect the action with high-tech, multi-colored dyes called fluorescent D-amino acids, or FDAAs, discovered five years ago in the lab of Michael VanNieuwenhze, professor in the IU Bloomington College of Arts and Sciences' Department of Chemistry, who is a co-author on the study. "The application of different colors of these dyes during the cell wall construction process revealed a 'bull's-eye pattern,' indicating the circular wall is built from the outer edge of the cell inward to the center," VanNieuwenhze said. The study also solves another mystery: How do FtsZ molecules build the wall? The researchers found that FtsZ—which is arrayed in a biochemical chain called a filament—constantly loses a molecule at one end and gains a molecule at the other end, resulting in a circular motion around the cell's edge described as "treadmilling." IU researchers chemically labeled the cells for analysis. Harvard scientists performed the experiments that showed the motion of the FtsZ and PBP proteins inside the cell. The subject of a U.S. patent filed by the IU Research and Technology Corp., FDAA dyes have played an important part in dozens of other scientific papers on bacteria since 2012. VanNieuwenhze's lab also has about 50 material transfer agreements with researchers across the globe to provide access to the tool. The creation of the dyes at IU was led by Erkin Kuru, a former Ph.D. student in the labs of VanNieuwenhze and Brun who is currently a research fellow at Harvard. Kuru and Yen-Pang Hsu, a IU Ph.D. student also in the labs of VanNieuwenhze and Brun, are co-authors on the study. "This is the first time we've been able to observe cell division as a dynamic process—that is, a process occurring over time," Kuru said. "This wasn't possible before since we lacked the tools to see it." Hsu added that "the visualization of these cell structures is no small task when you consider the organism that contains them is less than a micrometer—or one-thousand of a millimeter—wide. We wouldn't have been able to measure the fluorescent patterns in these cells without the technology at the IU Light Microscopy Imaging Center." Explore further: Filming bacterial life in multicolor as a new diagnostic and antibiotic discovery tool More information: "Treadmilling by FtsZ filaments drives peptidoglycan synthesis and bacterial cell division" Science, science.sciencemag.org/cgi/doi/10.1126/science.aak9973


News Article | February 17, 2017
Site: www.biosciencetechnology.com

A study reported Feb. 17 in the journal Science led by researchers at Indiana University and Harvard University is the first to reveal in extreme detail the operation of the biochemical clockwork that drives cellular division in bacteria. The discovery, made possible through a revolutionary method used to color bacterial cell walls developed at IU, is an important step forward in research on bacterial growth and could inform efforts to develop drugs that combat antibiotic-resistant bacteria. Globally, antibiotic-resistant bacteria, or "superbugs," pose a major risk to human health. The World Health Organization estimates about 480,000 people develop multi-drug resistant tuberculosis each year. In the U.S., the Centers for Disease Control estimates 1 in 4 hospital-acquired infections in long-term patients are caused by six major strains of the bugs. "This is the first study to 'connect the dots' between each part of the cell involved in bacterial cellular division," said Yves Brun, the Clyde Culbertson Professor of Biology in the IU Bloomington College of Arts and Sciences' Department of Biology, who is an author on the study. "We've finally closed the circle on this mechanism and opened the door to more precise methods in the fight against antibiotic-resistant bacteria. "If you understand how an engine works, you can shut it down by removing a single part," Brun said. "You no longer need to throw a hammer into the works to destroy it." Early antibiotics like penicillin function like a hammer: a blunt instrument that destroys the bacterial cell in the midst of division by tricking cell wall-making enzymes called penicillin-binding proteins, or PBPs, into binding to the drug rather than the building blocks of the cell walls, causing the walls to breach and the cells to explode. Other parts of the cell that drive bacterial division include cytoskeletal proteins, called FtsA and FtsZ, which form skeleton-like fibers inside cells to direct construction of the cell wall. All three elements must coordinate to build a cell wall in the middle of the cell to ensure the material inside doesn't escape after it splits in half. The fact that these three parts of the cell play a role in cellular division is known, but the new study is the first to show exactly how they coordinate. Essentially, Brun said, FtsZ acts as a "foreman" that directs the movement of PBP "workers" as they construct a cell wall. The researchers were able to detect the action with high-tech, multi-colored dyes called fluorescent D-amino acids, or FDAAs, discovered five years ago in the lab of Michael VanNieuwenhze, professor in the IU Bloomington College of Arts and Sciences' Department of Chemistry, who is a co-author on the study. "The application of different colors of these dyes during the cell wall construction process revealed a 'bull's-eye pattern,' indicating the circular wall is built from the outer edge of the cell inward to the center," VanNieuwenhze said. The study also solves another mystery: How do FtsZ molecules build the wall? The researchers found that FtsZ -- which is arrayed in a biochemical chain called a filament -- constantly loses a molecule at one end and gains a molecule at the other end, resulting in a circular motion around the cell's edge described as "treadmilling." IU researchers chemically labeled the cells for analysis. Harvard scientists performed the experiments that showed the motion of the FtsZ and PBP proteins inside the cell. The subject of a U.S. patent filed by the IU Research and Technology Corp., FDAA dyes have played an important part in dozens of other scientific papers on bacteria since 2012. VanNieuwenhze's lab also has about 50 material transfer agreements with researchers across the globe to provide access to the tool. The creation of the dyes at IU was led by Erkin Kuru, a former Ph.D. student in the labs of VanNieuwenhze and Brun who is currently a research fellow at Harvard. Kuru and Yen-Pang Hsu, a IU Ph.D. student also in the labs of VanNieuwenhze and Brun, are co-authors on the study. "This is the first time we've been able to observe cell division as a dynamic process -- that is, a process occurring over time," Kuru said. "This wasn't possible before since we lacked the tools to see it." Hsu added that "the visualization of these cell structures is no small task when you consider the organism that contains them is less than a micrometer -- or one-thousand of a millimeter -- wide. We wouldn't have been able to measure the fluorescent patterns in these cells without the technology at the IU Light Microscopy Imaging Center."

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