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BERLIN, Germany

Imagenes Gmbh | Date: 2006-04-04

Chemicals for use in industry and science; amino acid, cells and nucleic acid for laboratory use; cultures of microorganisms for use in industry and science. Compilation and systemization of data in computer data bases; database management; business investigations for third parties in databases and on the Internet. Scientific research and development; industrial analysis and research; providing data bases in the fields of scientific research and development and industrial analysis and research; and rental of data base servers to third parties.

Imagenes Gmbh | Date: 2005-02-07

Chemical products for industrial and scientific purposes. Services in the area of science and technology as well as research and development services in these areas.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2011.2.2.1-4 | Award Amount: 3.97M | Year: 2011

The DEM-CHILD project focusses on the main cause for childhood dementia in Europe, the neuronal ceroid lipofuscinoses (NCLs). The NCLs are neurodegenerative diseases characterized by dementia, blindness, epilepsy and physical decline leading to an early death of the patients. Since no cure is currently available, these disorders represent a serious social, medical, and economic challenge. To date, eight NCL genes have been characterised. There is evidence suggesting that further gene loci remain to be identified. NCLs are under-diagnosed in many countries around the world as there is an overall lack of research, early diagnosis, treatment and expert availability. Furthermore, due to their broad genetic heterogeneity it is difficult to collect large numbers of genetically similar patients. As such, large therapeutic studies required for advances in treatment are difficult to initiate. The DEM-CHILD project will combine the expertise of (i) recognized European research teams with (ii) high-technology SMEs, and will (iii) collaborate with Indian experts on the following objectives: (1) High-technology SMEs will develop innovative cost- and time-effective testing and screening methods for all NCLs in order to ensure early diagnosis and thereby prevention. (2) DEM-CHILD will collect the worlds largest, clinically and genetically best characterised set of NCL patients in order to study disease prevalence and precisely describe the natural history of the NCLs leading to the development of an evaluation tool for experimental therapy studies. (3) Novel biomarkers and modifiers of NCL will be identified to support the development of innovative therapies. (4) Focussing on the development of therapies for NCLs caused by mutations in intracellular transmembrane proteins, two complementary therapeutic strategies will be used and compared in eye and brain of mouse models: a) viral-mediated gene transfer and b) neural stem cell-mediated delivery of neuroprotective factors.

Agency: Cordis | Branch: FP7 | Program: CP-FP-SICA | Phase: HEALTH.2011.2.4.3-4 | Award Amount: 3.85M | Year: 2012

Migration from Sub-Saharan Africa (SSA) to Europe is increasing. The limited evidence suggests that the risk of type 2 diabetes (T2D) and obesity among SSA migrants is higher than among their SSA peers living in Africa and European host populations. The reasons for these observations are only poorly understood, but may involve migration-related changes in lifestyle, genetic predisposition as well as peculiarities in perceptions and practises. Contrasting the increasing number of African migrants in Europe, the health status and needs of these populations remain largely unexamined, and have only insufficiently been integrated into national plans, policies and strategies. Implementation of tailored intervention programmes among migrants implicitly requires the identification and the disentanglement of environmental, lifestyle and genetic factors modifying T2D and obesity risk. The RODAM project addresses these fundamental health issues among a homogeneous, and one of the largest SSA migrant groups in Europe (i.e. Ghanaians). RODAM thus aims to contribute to the understanding of the complex interplay between environment, lifestyle, (epi)genetic as well as social factors in T2D and obesity among SSA immigrants, and to identify specific risk factors to guide intervention and prevention and to provide a basis for improving diagnosis and treatment. In a multi-centre study, 6,250 Ghanaians aged >25 years will be recruited in rural and urban Ghana, Germany, the Netherlands, and the UK. The differences in prevalence rates within Ghana on the one hand, and three European countries on the other, will allow us to unravel environmental, lifestyle and (epi)genetic as well as social factors in relation to T2D and obesity. The proposed study will generate relevant results that will ultimately guide intervention programmes and will provide a basis for improving diagnosis and treatment among SSA migrants in Europe as well as in their counterparts in Africa and beyond.

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