Ilsong Memorial Institute of Head and Neck Cancer

Seoul, South Korea

Ilsong Memorial Institute of Head and Neck Cancer

Seoul, South Korea

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Kim H.C.,Kangwon National University | Kim H.C.,Hallym University | Yoon D.Y.,Hallym University | Chang S.K.,Hallym University | And 8 more authors.
Journal of Ultrasound in Medicine | Year: 2010

Objective. The purpose of this study was to assess the probability of metastasis of small atypical cervical lymph nodes detected on sonography in patients with squamous cell carcinoma (SCC) of the head and neck. Methods. We reviewed, retrospectively and blindly, sonographic findings of 148 patients (118 men and 30 women; mean age, 58.2 years) who underwent curative neck dissection. Each lymph node was classified by using a 4-point scale: 1, definitely benign; 2, indeterminate (small [short-axis diameter <10 mm for levels I and II and <7 mm for levels III-VI] atypical node); 3, definitely metastatic; and 4, large (>3-cm) metastatic. Lymph nodes were considered atypical if they met at least 1 of the following criteria: a long- to short-axis diameter ratio of less than 2.0, absence of a normal echogenic hilum, and heterogeneous echogenicity of the cortex. These results were verified, on a level-by-level basis, with histopathologic findings. Results. Small atypical nodes were found on sonography in 63 cervical levels of 48 patients, of which 18 (28.6%) were proved to have metastatic nodes. The probability of metastasis was significantly higher with than without a large (>3-cm) ipsilateral metastatic node (0.50 versus 0.20; P = .038) and marginally higher with than without an ipsilateral metastatic node (0.41 versus 0.16; P = .061) but not significantly associated with the T stage of the primary tumor (P = .238) or the presence of an ipsilateral tumor (P = .904). Conclusions. Metastasis was encountered in about 30% of small atypical cervical nodes on sonography in patients with SCC of the head and neck. Our results indicate that small atypical nodes must be interpreted with consideration of metastatic nodes in the ipsilateral neck. © 2010 by the American Institute of Ultrasound in Medicine.


Choi K.Y.,Ilsong Memorial Institute of Head and Neck Cancer | Rho Y.S.,Ilsong Memorial Institute of Head and Neck Cancer | Kwon K.H.,Ilsong Memorial Institute of Head and Neck Cancer | Chung E.J.,Ilsong Memorial Institute of Head and Neck Cancer | And 3 more authors.
Cancer Biomarkers | Year: 2012

Background And Objectives: The Aim of this study was to examine the pattern of SNPs in ECRG1 and FGFR4 gene of oral squamous cell carcinoma, and to evaluate the association between SNPs and prognostic parameters. Materials And Methods: Total 24 cases of oral squamous cell carcinoma patients were enrolled in this study. We analyzed the pattern of SNPs in ECRG1 and FGFR4 gene using PCR and direct sequence. Also we evaluated the association between SNPs pattern and clinicopathologic parameters of oral squamous cell carcinoma. Results: The allele type Arg/Arg in ECRG1 gene was found in 13 (54.2%) patients, Arg/Gln in 11 (45.8%) patients and Gln/Gln in no patient. No clinical or pathological factor was associated with the SNP pattern in ECRG1. The allele types of FGFR4 amino acid 388 in 24 OSCC patients were Arg/Arg (8.3%), Arg/Gly (54.2%) and Gly/Gly (37.5%). No clinical or pathological factor was significantly associated with the SNP pattern except the nodal stage. The patients carrying FGFR4 allele Arg/Arg or Arg/Gly at amino acid 388 were associated with advanced N stage (pathologic N2+N3), compared to Gly/Gly allele carrying group (p=0.009). Conclusion: This study is the first to describe a SNP pattern of both FGFR4 and ECRG1 gene with OSCC in Asian patients. In this study, FGFR4 Arg allele carrier was associated with higher N stage compared with Gly allele. If the important biological role of FGFR4 and ECRG1 in OSCC can be confirmed in further studies, this might be a rational to consider the evaluation of these genes as a therapeutic target in OSCC. © 2013-IOS Press and the authors. All rights reserved.

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