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Bucharest, Romania

Background: The metabolic syndrome is associated with an increased risk for cardiovascular disease, including coronary heart disease and ischemic stroke. The aim of the study was to describe the association between intima media thickness (IMT), left ventricular diastolic dysfunction and hepatic steatosis to the women with metabolic syndrome. Materials and Methods: This was a prospective study of 123 female patients with metabolic syndrome hospitalized in the Internal Department of Ilfov Emergency Hospital between 1st of January 2010 and 31st of July 2010, aged between 48 and 67 (mean age 58). All the patients had physical examination, blood tests, including fasting glycaemia, lipid profile, C-reactive protein, ECG, chest radiography and carotid, cardiac and abdominal ultrasound. Results: Among our 123 women IMT increased with each component of the metabolic syndrome, and the degree of hepatic steatosis vary from mild to severe according to the same fact. IMT varied from 8.24 to 1.28 mm (mean IMT 1.06) and the plaque prevalence was 73%. All the patients had left ventricular diastolic dysfunction, with pattern of delayed relaxation 85%, pseudonormal 9.7% and restrictive 5.3%. Conclusions: The effect of metabolic syndrome on early atherosclerosis in women is very pronounced. Screening for IMT might be beneficial for assessment of future atherosclerotic complications of metabolic syndrome. Copyright © 2011 CELSIUS. Source

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