News Article | May 5, 2017
A review of drug delivery systems based on nanotechnology and green chemistry This review discusses the impact of green and environmentally safe chemistry on the field of nanotechnology-driven drug delivery in a new field termed "green nanomedicine." Studies have shown that among many examples of green nanotechnology-driven drug delivery systems, those receiving the greatest amount of attention include nanometal particles, polymers, and biological materials. Furthermore, green nanodrug delivery systems based on environmentally safe chemical reactions or using natural biomaterials (such as plant extracts and microorganisms) are now producing innovative materials revolutionizing the field. In this review, the use of green chemistry design, synthesis, and application principles and eco-friendly synthesis techniques with low side effects are discussed. The review ends with a description of key future efforts that must ensue for this field to continue to grow. 1Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2Department of Chemistry, Faculty of Science, Ilam University, Ilam, Iran; 3School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Selangor, 4Department of Electrical Engineering, Faculty of Engineering, University of Malaysia, Kuala Lumpur, Malaysia
Dehghani M.,Ilam University
New Astronomy | Year: 2017
The possible corrections to the thermodynamic quantities of higher dimensional Schwa-rzschild black hole have been investigated by considering the generalized uncertainty principle (GUP) and the modified dispersion relation (MDR) separately. The quantum gravitational corrections to the Hawking temperature, energy and entropy of the black hole have been calculated based on both the GUP and the MDR analysis. The explicit form of the corrections are worked out up to the sixth power of the Planck length. The impacts of GUP and MDR have been used separately to obtain the quantum gravitational corrections to the Cardy-Verlinde (C-V) formula. It has been shown that the usual C-V entropy formula receives some new corrections. Also the renormalized form of the C-V formula has been introduced by redefining Virasoro operator and central charge within both the GUP and the MDR. Through comparison of the corrections obtained from GUP and MDR approaches it has been found that the results of these two alternative approaches should be identical if one uses the suitable expansion coefficients. © 2016 Elsevier B.V.
Haghani K.,Ilam University
Molecular and cellular biochemistry | Year: 2012
Bone marrow multipotent stromal cells (BMSCs) have the ability to transdifferentiate into various cell types, including: osteoblasts, chondrocytes, adipocytes, neurons, and cardiomyocytes. This study aimed to differentiate the BMSCs into cardiomyocyte. BMSCs were exposed to 5-azacytidine for 24 h. Seven days after the induction of cell differentiation by 5-azacytidine, the cardiomyogenic cells were stained by fushin and binucleated cells were counted and compared with the neonate cardiomyocyte as positive control. In addition, immunofluorescence analysis and western blot were performed using the antibodies against α-actinin, desmin, troponin T, and β-myosin heavy chain. Our results showed that there was no significant difference between the number of binucleated cells within the cardiomyogenic cell group and positive control group; however, a statistically significant difference was observed between both of these groups and undifferentiated cell group (P < 0.005). In addition, after 5-azacytidine treatment, BMSCs had a higher expression of cardiac-specific markers such as desmin, α-actinin, troponin T and β-myosin heavy chain compared with the untreated groups (P < 0.005). We concluded that 5-azacytidine is an effective inducer for the differentiation of BMSCs into cardiomyocytes and could produce a population of binucleated cells, which express α-actinin, desmin, troponin T, and β-myosin heavy chain, four markers of cardiomyocytes.
Dehghani M.,Ilam University
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2015
Although the tunneling approach is fully established for black hole radiation, much work has been done to support the extension of this approach to more general settings. In this paper the Parikh-Kraus-Wilczeck tunneling proposal of black hole tunneling radiation is considered. The thermodynamics of the higher dimensional Schwarzschild black hole is studied based on the generalized uncertainty principle (GUP) and the modified dispersion relation (MDR) analysis, separately. It is shown that entropy and the rate of the higher dimensional Schwarzschild black hole tunneling radiation receive some corrections. The leading-order corrections does not contain the logarithmic term of the entropy, if the dimensions of the space-time is an odd number. Through the comparison, it is found that the results of these two alternative approaches are identical if one uses the suitable expansion coefficients. © 2015 The Author.
Naghdi M.,Ilam University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2013
With use of a 6-form field strength of ten-dimensional type IIA supergravity over AdS4×CP3, when S7/Zk is considered as a S1 Hopf fibration on CP3, we earn a fully localized solution in the bulk of Euclideanized AdS4. Indeed, this object appears in the external space because of wrapping a D4(M5)-brane over some parts of the respective internal spaces. Interestingly, this supersymmetry breaking SU(4)×U(1)- singlet mode exists in already known spectra when one uses the 8c gravitino representation of SO(8). To adjust the boundary theory, we should swap the original 8s and 8c representations for supercharges and fermions in the Aharony-Bergman-Jafferis-Maldacena model. The procedure could later be interpreted as adding an anti-D4(M5)-brane to the prime N=6 membrane theory, resulting in a N=0 antimembrane theory while other symmetries are preserved. Then, according to the well-known state-operator correspondence rules, we find a proper dual operator with the conformal dimension of Δ+=3 that matches to the bulk massless pseudoscalar state. After that, by making use of some fitting Ansätze for the used matter fields, we arrive at an exact boundary solution and comment on the other related issues as well. © 2013 American Physical Society.
Jalilian R.,Ilam University
Computer Physics Communications | Year: 2010
Smooth approximate solutions of the one-dimensional Bratu's problem are developed by using non-polynomial spline function. The inverse of some tridiagonal matrices are obtained which are required in proving the convergence analysis of the presented method. By considering the maximum absolute errors in the solution at grid points and tabulated in tables for different choices of step size we conclude that our presented method produces more accurate results in comparison with those obtained by B-spline, Laplace and decomposition methods. © 2010 Elsevier B.V. All rights reserved.
Kouchakzadeh A.,Ilam University
American Journal of Food Technology | Year: 2011
The moisture diffusion coefficients of five major varieties of Iranian pistachios (Ahmad_aghayee, Akbari, Badami, Fandoghi and Kaleh_ghoochi) were successfully interpreted and modeled by using Fick's law. The moisture content of the dried nut was increased to 5-7% (d.b.) and drying temperatures (50-90°C) were varied, but the drying air was kept at constant velocity and humidity. The analysis of the data shows no statistically significant difference between the five varieties at the 95.0% confidence level. The diffusivity was estimated from drying rate curves and expressed by exponential relations. © 2011 Academic Journals Inc.
Khodakarami J.,Ilam University |
Nasrollahi N.,Ilam University
Renewable and Sustainable Energy Reviews | Year: 2012
In general, there is a wide range of literature covering the area of thermal comfort, but not a focused literature review of thermal comfort in hospitals has published yet. However, there has been no study on the direct effect of thermal comfort on health. The authors have found a reasonable amount of literature in thermal comfort in hospitals. This paper presents a literature review on thermal comfort in hospitals. From the review, the paper concludes that it is important to undertake original studies in the relationship between thermal comfort conditions and productivity for hospital staff. The study finally concluded that it is important to find some solutions to reconcile the different thermal comfort conditions required by different occupants in hospitals. These solutions could be used whenever patients and the attending caregivers have to stay in one room for a long time compulsorily. © 2012 Elsevier Ltd. All right reserved.
Kouchakzadeh A.,Ilam University
Energy Conversion and Management | Year: 2013
A new approach of ultrasound-assisted sun drying was tested in this study using a flat bed as product support and two extensional piezoelectric Bolt-clamped 20 kHz transducer elements. The mono layer of moist unshelled pistachios was dried under open sun by applying 500 and 1000 W power ultrasound. The results showed that the Page model was found to be the most suitable for describing drying curve of pistachios. But, the Logarithmic model was described to satisfactorily drying curve of pistachios for open sun method when the ultrasound power was turned off. By applying the ultrasound about 17 W/kg moist pistachios in thin layer, the drying period could be reduced to 4 h. © 2012 Elsevier Ltd. All rights reserved.
Tabaraki R.,Ilam University |
Nateghi A.,Ilam University
Ultrasonics Sonochemistry | Year: 2011
Ultrasonic technology was applied for extraction of polyphenols and antioxidants from the rice bran using ethanol as a food grade solvent. Response surface methodology (RSM) was used to optimize experimental conditions for extraction of polyphenols and antioxidants. Three independent variables such as solvent percentage (%), temperature (°C) and time (min) were studied. Effect of ethanol concentration was found to be significant on all responses. Total phenolic content (TPC) varied from 2.37 to 6.35 mg gallic acid equivalent/g of dry sample. Antioxidant activity of the extracts was determined by the ferric reducing antioxidant power (FRAP) assay and scavenging activity of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. FRAP and DPPH values varied from 31.74 to 57.23 μmol Fe 2+/g of dry sample and 16.88% to 55.61% inhibition, respectively. Extraction yields ranged from 11 to 20.2%. Optimal ultrasonic-assisted extraction (UAE) conditions were identified as 65-67% ethanol, 51-54°C, 40-45 min. The experimental values agreed with those predicted by SRM models, thus indicating suitability of the model employed and the success of RSM in optimizing the extraction conditions. © 2011 Elsevier B.V. All rights reserved.