New Albany, IN, United States
New Albany, IN, United States

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Sajja V.S.K.,Auburn University | Hanley T.R.,Auburn University | Gapsis H.,Techshot, Inc. | Guernsey B.,Ikotech Inc. | And 5 more authors.
Biotechnology and Bioengineering | Year: 2011

Magnetic isolation is a promising method for separating and concentrating pancreatic islets of Langerhans for transplantation in Type 1 diabetes patients. We are developing a continuous magnetic islet sorter to overcome the restrictions of current purification methods that result in limited yield and viability. In Quadrupole Magnetic Sorting (QMS) islets are magnetized by infusing superparamagnetic microbeads into islets' vasculature via arteries that serve the pancreas. The performance of the islet sorter depends on the resulting speed of the islets in an applied magnetic field, a property known as magnetophoretic mobility. Essential to the design and successful operation of the QMS is a method to measure the magnetophoretic mobilities of magnetically infused islets. We have adapted a Magnetic Particle Tracking Velocimeter (MPTV) to measure the magnetophoretic mobility of particles up to 1,000μm in diameter. Velocity measurements are performed in a well-characterized uniform magnetic energy gradient using video imaging followed by analysis of the video images with a computer algorithm that produces a histogram of absolute mobilities. MPTV was validated using magnetic agarose beads serving as islet surrogates and subjecting them to QMS. Mobility distributions of labeled porcine islets indicated that magnetized islets have sufficient mobility to be captured by the proposed sorting method, with this result confirmed in test isolations of magnetized islets. © 2011 Wiley Periodicals, Inc.


Ikotech Inc. | Entity website

Regenerative Medicine Market IKOTECH is a biotechnology company that has developed high-speed magnetic cell-sorting systems for use in life science applications, specifically cell therapy in the Regenerative Medicine Market. IKOTECH began research on three cell therapy devices in October 2005 based on the license of nine patents owned jointly by The Ohio State University and the Cleveland Clinic Foundation, Techshot has licensed one patent to IKOTECH to enhance the patent portfolio ...


Ikotech Inc. | Entity website

by Team IKOTECH | May 9, 2014 | AnnouncementsThe Louisville Islet Auto-Transplantation program will be highlighted on Jean West Medical Digest this Sunday May 11th at 10:30 am on WAVE 3 (NBC). This program uses IKOTECH instrumentation in its ...


Ikotech Inc. | Entity website

IKOTECH LLC has received a contract from Techshot, Inc to work on a Grant received from the National Institute of Diabetes and Digestive and Kidney Diseases. The three year agreement engages IKOTECH with the responsibility for the successful commercialization of the QMS technology (Quadrapole magnetic flow sorting) for the isolation of pancreatic islets ...


Ikotech Inc. | Entity website

Contact Information IKOTECH LLC 7200 Highway 150 Greenville, IN 47124 Tel: 812-206-8395 Fax: 812-206-8291


Ikotech Inc. | Entity website

Researchers from the University of Birmingham and hospitals across the West Midlands have revealed how a common symptomless condition can develop into the blood cancer myeloma. [ ...


Ikotech Inc. | Entity website


Ikotech Inc. | Entity website

Paul Todd, PhD. Chief Technology Officer Dr ...


Ikotech Inc. | Entity website

Have yourmagnetic beads characterized using the at Auburn UniversityIKOTECH Hyperflux Velocimeter.Several manufacturers have already taken advantage of this program and have had their products characterized, we are making the process easy for you ...

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