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Kumar P.V.,UCSI University | Ramu P.,IITMadras | Kumar A.S.,Vellore Institute of Technology
Archives of Pharmacal Research | Year: 2011

A number of compounds have been prepared in order to improve pharmacological roles of antihyperglycemic activity. In the present paper, a series of 3-benzyl-2-(4′-substituted phenyl)-4(5H)-(4″-nitrophenyl amino)-1,3-oxazolidines (6a-e) were tested against hyperglycemia. Their antihyperglycemic activity was evaluated by streptozotocin (STZ) and sucrose-loaded (SLM) models. Compounds 6a, b, c, d, and e displayed significant reductions in blood glucose in the streptozotocin and sucrose loaded rat models. The purity of the synthesized compounds was characterized by means of IR, 1H-NMR, mass spectral and elemental analysis. © 2011 The Pharmaceutical Society of Korea and Springer Netherlands.

Kolla B.P.,Sathyabama University | Dorairangaswamy M.A.,Engineering Colleges | Rajaraman A.,IITMadras
2010 International Conference on Computer and Communication Technology, ICCCT-2010 | Year: 2010

A two input neuron model for multi-lingual web pages for education Indian subcontinent is an area of multi-lingual and multi-cultural diversity. Introducing web-enabled education is a challenge as one needs content-based approaches for web pages with english and regional language texts. Translational tools many times get hampered due to time and context-based interpretations. So a generic tool to identify the content of web pages is needed and this will form the basis for later elaborations on the text. The aim of the paper is to present a 2-input neural model which captures salient features of a subject to identify the content in a regular web page containing both English and Telugu-one of the regional languages of India- and test it with computer generated, printed and handwritten formats. Typical words having common content are chosen and neural network is used to arrive at a normalised output. The example of a physics text discussing magnetism is used as an illustration. ©2010 IEEE.

Gharpure S.J.,IITMadras | Nanda L.N.,IITMadras | Shukla M.K.,IITMadras
European Journal of Organic Chemistry | Year: 2011

Enantioselective synthesis of Hagen's gland lactone is described. The enantiomerically enriched diol was prepared by organocatalytic α-oxidation of the aldehyde. The other key reactions involved a highly diastereoselective intramolecular cyclopropanation of vinylogous carbonates to furnish donor-acceptor-substituted cyclopropanes and their ring opening and iodolactonization followed by reduction. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Sharma A.K.,Indian Institute of Technology Roorkee | Krishnamurthy R.,IITMadras
Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology | Year: 2010

The main objective of the present study is to present the wear characteristics of postprocessed plasma deposits of alumina-titania (AT-13) ceramic composites under high-speed sliding. Spray deposits were post-processed (microwave glazed) by way of exposing them to microwave radiation at a frequency of 2.45GHz in a multi-mode cavity by using the microwave hybrid heating principle. During 'microwave glazing', densification of the coating's structure takes place as a consequence of microwave-heating-induced phase transformation, leading to significant enhancement in hardness and reduction in porosity. Responses of the as-sprayed and microwave-glazed composites were monitored while they were subjected to sliding type of tribocontact at a speed of 5 m/s. Subsequent analyses are presented in terms of wear rate, pressure-velocity-time (p-v-t) characteristics, fractography, elemental count, and acoustic emission (AE) emanated during the trials. The results show a steady sliding wear response after an initial higher rate. The p-v-t factor analysis confirms a better operating condition with glazed composites. Glazed composites exhibit higher stability towards elemental transfer between the wear surface and the counter surface. AEs emanating during trials indicate deformation and brittle fracture as the dominating wear mechanisms of the as-sprayed and microwave-glazed ceramic composites. © Authors 2010.

Kannapan D.,IITMadras | Mahindrakar A.D.,IITMadras | Bandyopadhyay S.,IITMadras
Advances in the Astronautical Sciences | Year: 2013

A new strategy for the design of tracking control laws is presented for line-of-sight (LoS) pointing control of satellites that use only magnetorquers. This strategy makes use of the backstepping approach, and applies to satellites that require the LoS of a single instrument, such as a transmission antenna or camera, to be pointed at a given time, but not both simultaneously. Asymptotic stability of the desired trajectory is proved, provided the target pointing-direction lies outside some critical range. A control law so developed is numerically simulated for a nanosatellite mission scenario to demonstrate feasibility. © 2013 2013 California Institute of Technology.

Bhuvaneshwari S.,IITMadras | Robinson R.G.,IITMadras | Gandhi S.R.,IITMadras
Unsaturated Soils: Theoretical and Numerical Advances in Unsaturated Soil Mechanics - Proceedings of the 4th Asia Pacific Conference on Unsaturated Soils | Year: 2010

The cyclic swell shrink behaviour of expansive soils due to alterations in moisture content causes extensive distress to structures found on them. The volume change behaviour of the lime column stabilized expansive soil, under repeated wetting and drying is studied in the present investigation. The tests are carried out in modified oedometer cells at controlled temperature of 40 ± 5°C for faster drying. Diameter ratio of soil to lime column was varied and different techniques were adopted to improve the rate of diffusion. Microstructure observations were made through Scanning Electron Microscope studies. The equilibrium magnitude of swell-shrink is reached after about six to seven cycles. The lime column takes at least two cycles to get diffused into the surrounding soil to curtail the swelling. The subsequent shrinkage induced cracks enabled faster diffusion into the soil. © 2010 Taylor & Francis Group, London.

Soundara B.,IITMadras | Robinson R.G.,IITMadras
Unsaturated Soils: Theoretical and Numerical Advances in Unsaturated Soil Mechanics - Proceedings of the 4th Asia Pacific Conference on Unsaturated Soils | Year: 2010

Yield stress is one of the most important properties of soils. This paper addresses the yield stress of a desiccated expansive soil that was subjected to repeated cycles of wetting and drying under controlled laboratory conditions. Identical samples were subjected to different surcharge pressures such as 6.25, 12.5, 25, 50, 100 and 200 kPa so as to simulate the depth in the field. The samples were dried up to equilibrium at a temperature of 40 ± 5°C, in a thermostat controlled oedometer. Wetting was done by submerging the samples under water. The movements during wetting and drying were recorded and it was found that equilibrium is reached in about five cycles. After reaching equilibrium, samples were unloaded to a seating pressure of 6.25 kPa and conventional one-dimensional consolidation testwas conducted. The experimental results showthat the yield stress of desiccated expansive soil depends on the surcharge pressure. The overconsolidation margin, which is the difference between the yield stress and the effective vertical stress, of desiccated expansive soil is almost constant of about 100 kPa. This suggest that desiccation induced yield stress is similar to overburden pressure in the geological past. © 2010 Taylor & Francis Group, London.

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