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Chaturvedi N.P.,IIT BHU | Solanki H.,IIT BHU
International Journal of Applied Pharmaceutics | Year: 2013

Growing attention has been given to the potential of pulmonary route as an alternative for non-invasive systemic delivery of therapeutic agents.Pulmonary drug delivery can be used as an alternative to oral delivery. These systems can be best utilized for both local and systemic actions.Pulmonary drug delivery is an importantresearch area which impacts the treatment of illnesses including asthma, chronic obstructive pulmonary disease and various other diseases. Inhalation gives the most direct access to drug target. This route can be used to deposit the drug to the target site at high concentration, reducing the amount of drug given to the patient and also help in reducing the systemic side effect and first pass metabolism. In the treatment of obstructive respiratory diseases, pulmonary delivery can minimize systemic side effects, provide rapid response and minimize the required dose since the drug is delivered directly to the conducting zone of the lungs. Generally half of all pharmaceuticals are not soluble in water, but are soluble in lipid. As the lung is able to absorb both water and oil into the tissue, this is not a restriction of pulmonary delivery. Carriers like micro particles, nanoparticles, liposomes can be used in lung targeting.This article focuses on the technologies, mechanism of drug deposition, devices, carriers and recent advances used in pulmonary drug delivery system.


Chakraborty S.,Truba College of Engineering and Technology | Hora M.S.,MANIT | Pathak K.K.,IIT BHU
ARPN Journal of Engineering and Applied Sciences | Year: 2017

The present work focuses on the study of buckling behaviour of square steel column by varying the position of single intermediate support along the height of column. The analysis of long steel column of size 200 mm × 200 mm and height 10 m is carried out using finite element software (ANSYS) to obtain the position of intermediate support which provides maximum buckling load and lateral deflection of the column for different boundary conditions. The position of single intermediate support is varied by 1 m along the height of column measured from the bottom end of the column and buckling load and lateral deflection is evaluated for each position to determine the maximum value of buckling load and lateral deflection for different boundary conditions. The results of analysis are compared with Euler's theory for general end support conditions. © 2006-2017 Asian Research Publishing Network (ARPN).


Akeel M.,IIT BHU | Mishra R.,IIT BHU
International Arab Journal of Information Technology | Year: 2014

Machine translation is the process by which computer software is used to translate a text from one natural language into another language with or without minimal human intervention. This definition involves accounting for the grammatical structure of each language and using rules and grammars to transfer the grammatical structure of the source language into the target language. This paper presents an English into Arabic Machine Translation (MT) system for translating simple well-structured English sentences into well-structured Arabic sentences using a rule-based approach and feed-forward back-propagation Artificial Neural Network (ANN). Our system is able to translate sentences having gerunds, infinitives, prepositions and prepositional objects, direct objects, indirect objects, etc. Neural network works as bilingual dictionary, which does not only store the meaning of English word in Arabic but it also stores linguistic features attached to the word. The performance is evaluated by different MT evaluation methods. The n-gram blue score achieved by the system is 0.6029, METEOR score achieved is 0.8221 and 0.8386 on F-measure.


Garg M.,IIT BHU | Singh R.K.,IIT BHU
Proceedings of the IEEE International Conference on Industrial Technology | Year: 2015

A coupled inductor boost converter with the enhanced equivalent series resistance (ESR) of the filter capacitor for DC microgrid applications is presented in this paper. The converter uses only four state variables and shows a fourth order minimum phase behavior, i.e., right half plane (RHP) zero gets completely eliminated. The display of minimum phase behavior of the proposed converter makes it linear and thereby enabling a simpler control design. A complete closed loop operation of the DC microgrid using proposed converter with the maximum power point tracking (MPPT) using photovoltaic (PV) has been carried out to verify the applicability of the converter in DC microgrid. The steady state and dynamic modeling of the proposed converter is done to exhibit the advantages of the proposed converter. Simulation and experimental results are presented to verify the behavior of the proposed converter and its operation in the DC microgrid. © 2015 IEEE.


Singh M.,IIT BHU | Gangwar M.,Banaras Hindu University | Nath G.,Banaras Hindu University | Singh S.K.,IIT BHU
Indian Journal of Experimental Biology | Year: 2014

Antimicrobial screening of several novel 4-thiazolidinones with benzothiazole moiety has been performed. These compounds were evaluated for antimicrobial activity against a panel of bacterial and fungal strains. The strains were treated with these benzothiazole derivatives at varying concentrations, and MIC’s were calculated. Structures of these compounds have been determined by spectroscopic studies viz., FT-IR,1H NMR,13C NMR and elemental analysis. Significant antimicrobial activity was observed for some members of the series, and compounds viz. 3-(4-(benzo[d]thiazol-2-yl) phenyl)-2-(4-methoxyphenyl)thiazolidin-4-one and 3-(4-(benzo[d]thiazol-2-yl)phenyl)-2-(4-hydroxy phenyl)thiazolidin-4-one were found to be the most active against E.coli and C.albicans with MIC values in the range of 15.6-125 μg/ml. Preliminary study of the structure-activity relationship revealed that electron donating groups associated with thiazolidine bearing benzothiazole rings had a great effect on the antimicrobial activity of these compounds and contributes positively for the action. DNA cleavage experiments gave valuable hints with supporting evidence for describing the mechanism of action and hence showed a good correlation between their calculated MIC’s and its lethality. ©, National Institute of Science Communication. All rights reserved.


Jo C.,Changwon National University | Gupta O.,IIT BHU
Proceedings of the 2013 6th International Congress on Image and Signal Processing, CISP 2013 | Year: 2013

This paper presents a basic research results to visualize the micro-movement of formant tracks for the purpose of using it to analyze speech signal on the research of speech analysis and synthesis etc. Current analysis method on formant is mainly focusing on analysis of static statistical characteristics. But dynamic information about changing vowels is hard to acquire using conventional statistical results such as mean, variance etc. In this experiment we propose a new visualization method to display the dynamic behavior of vowel changes according to the micro movement of formant on vowel space. © 2013 IEEE.


Singh S.V.,Jaypee Institute of Information Technology | Tomar R.S.,Anand Engineering College | Chauhan D.S.,IIT BHU
2014 International Conference on Signal Processing and Integrated Networks, SPIN 2014 | Year: 2014

In this topic, a new trans-impedance-mode filter structure realizing low pass (LP), band pass (BP), band reject (BR), high pass (HP) and all pass (AP) filtering functions using three Z- copy current follower trans-conductance amplifiers (ZC-CFTAs) and two grounded capacitors is proposed. The proposed structure realizes all the five standard filtering functions, but one at a time without requiring any inverting type current input signal(s) and component matching conditions. Since ZC-CFTAs are implemented using CMOS topology, thus filter circuit provides temperature insensitive performance parameters. Moreover, the proposed circuit enjoys the features of low active/passive sensitivities, independent electronic tunability of pole frequency and quality factor. The workability of the proposed trans-impedance-mode filter is verified using PSPICE circuit simulation software. © 2014 IEEE.


Singh S.V.,Jaypee Institute of Information Technology | Tomar R.S.,Anand Engineering College | Chauhan D.S.,IIT BHU
2014 International Conference on Signal Processing and Integrated Networks, SPIN 2014 | Year: 2014

This paper introduces a new current tunable current-mode biquad filter topology which is based on the active elements namely, modified current follower transconductance amplifiers (MCFTAs) and two grounded capacitors. It can realize all the five standard filtering responses such as band pass (BP), low pass (LP), high pass (HP), band reject (BR), and all pass (AP) at single high impedance current output through appropriate selection of three applied current inputs. So this circuit is three input single output (TISO) current-mode filter topology. The circuit offers an advantage of wide range of orthogonal electronic tunability of pole-frequency and quality factor and capable of realizing various filtering responses without using inverted and double current input signal. Moreover, the circuit also provides low active and passive sensitivities. Performance of the circuit is verified through P-SPICE simulation on ORCAD tool. © 2014 IEEE.


Agarwal A.,Samsung | Singh R.K.,IIT BHU
7th IET International Conference on Power Electronics, Machines and Drives, PEMD 2014 | Year: 2014

The objective of this paper is to implement and control a modified magnetically coupled 'Cuk converter for the optimal charging of a battery. The paper shows how simple modifications in the bidirectional magnetically coupled 'Cuk converter results in a converter that exhibits a fifth order minimum phase behaviour for both buck and boost operation. With the use of a novel feedback clamped controller, the converter is tested for the optimal bidirectional battery charging applications. Steady-state and dynamic analysis of the derived converter is also described. Experimental and simulation results are presented to verify the proposed algorithm.


Chitransh V.,IIT BHU | Singh A.,IIT BHU | Singh R.K.,IIT BHU
Proceedings of the International Conference on Power Electronics and Drive Systems | Year: 2015

Due to the increasing awareness and adoption of eco-friendly vehicle technologies, hybrid electric vehicle (HEV) and plug-in hybrid electric vehicle (PHEV) technologies have become one of the most interesting areas of research because of the reduced use of fuel and green house emission. Battery chargers are one of the most important parts in developing the HEV's and PHEV's. The various existing optimal battery charging techniques are constant current (CC)-constant voltage (CV) charging, pulse charging and reflex charging. The major problem with these conventional optimal battery charging techniques are that different circuits are needed for adopting different optimal charging techniques. This paper presents design and implementation of a field programmable gate array (FPGA) based versatile optimal bidirectional digital battery charger for HEV/PHEV. The proposed digital optimal charger is capable of adapting all the existing optimal battery charging techniques i.e., constant current-constant voltage (CC-CV) charging, Pulse charging and Reflex charging in a single circuit. The proposed system uses a bidirectional magnetically coupled inductor topology with a damping network. When the proposed system adapts CC-CV charging technique, it shows automatic and smooth transition from CC to CV mode without using any extra switching circuit and when the proposed system adapts pulse and reflex charging techniques it gives regulated charging and discharging currents. Modeling, analysis, and simulation have been carried out on a 250W prototype to validate the proposed algorithm. © 2015 IEEE.

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