News Article | March 16, 2016
A diverse team of global experts has been selected to lead ACS Omega, the American Chemical Society’s newest open access journal publishing peer-reviewed articles. Based in the Americas, Europe, India, and China, the editors not only represent key geographic regions of active R&D, they also bring expertise from four distinct scientific areas of interest. The new editors are Cornelia Bohne, a professor of chemistry at the University of Victoria in Canada; Krishna Ganesh, director of the Indian Institute of Science Education & Research in India; Luis Liz-Marzán, Ikerbasque research professor and scientific director at CIC biomaGUNE in Spain; and Deqing Zhang, director of the Institute of Chemistry, Chinese Academy of Sciences, in China. Bohne’s research focuses on developing the fundamental understanding of the dynamics of supramolecular systems and on the application of this knowledge to functional supramolecular materials. Ganesh is an expert in modified DNA and peptide-nucleic acids as novel cell-penetrating agents. As the first (founding and serving) director of IISER, Ganesh has built a unique, interdisciplinary infrastructure in which teaching and education are wholly integrated into state-of-the-art research. Liz-Marzán’s research focuses on nanoparticle synthesis and assembly, nanoplasmonics, and the development of nanoparticle-based sensing and diagnostic tools. He most recently served as a senior editor of the ACS journal Langmuir. Zhang’s research focuses on organic functional materials involving synthesis of organic functional molecules, spectroscopic studies, characterizations of self-assembly structures and optoelectronic properties, as well as applications for chemo/biosensing and imaging. “The ACS Omega editors have themselves authored in aggregate more than 850 peer-reviewed research articles, book chapters, and patents,” says Penelope Lewis, director of editorial and new product development in ACS Publications. “Their prolific publishing records and academic and professional achievements set the foundation for a team that will define and lead the editorial vision for the journal, drawing on a geographically diverse editorial board they will soon enlist—to be composed of active researchers with wide-ranging expertise and scientific backgrounds across chemistry, chemical engineering, and allied interdisciplinary scientific fields.” ACS Omega will begin accepting research submissions in April 2016 and will publish its first articles online early this summer.
News Article | December 27, 2016
The Biophysical Society has announced the winners of its international travel grants to attend the Biophysical Society's 61st Annual Meeting in New Orleans, February 11-15, 2017. The purpose of these awards is to foster and initiate further interaction between American biophysicists and scientists working in countries experiencing financial difficulties. Recipients of this competitive award are chosen based on scientific merit and their proposed presentation at the meeting. They will be honored at a reception on Sunday, February 12 at the Ernest N. Morial Convention Center. The 2017 recipients of the International Travel Award, along with their institutional affiliation and abstract title, are listed below. Ana F. Guedes, Institute of Molecular Medicine, Portugal, ATOMIC FORCE MICROSCOPY AS A TOOL TO EVALUATE THE RISK OF CARDIOVASCULAR DISEASES IN PATIENTS. Karishma Bhasne Mohali, Indian Institute of Science Education and Research (IISER), A TALE OF TWO AMYLOIDOGENIC INTRINSICALLY DISORDERED PROTEINS: INTERPLAY OF TAU AND α-SYNUCLEIN. Chan Cao, East China University of Science and Technology, DIRECT IDENTIFICATION OF ADENINE, THYMINE, CYTOSINE AND GUANINE USING AEROLYSIN NANOPORE. Venkata Reddy Chirasani, Indian Institute of Technology Madras, LIPID TRANSFER MECHANISM OF CETP BETWEEN HDL AND LDL: A COARSEGRAINED SIMULATION STUDY. Assaf Elazar, Weizmann Institute of Science, Israel, DECIPHERING MEMBRANE PROTEIN ENERGETICS USING DEEP SEQUENCING; TOWARDS ROBUST DESIGN AND STRUCTURE PREDICTION OF MEMBRANE PROTEINS. Manuela Gabriel, University of Buenos Aires, Argentina, 3D ORBITAL TRACKING OF SINGLE GOLD NANOPARTICLES: A NEW APPROACH TO STUDY VESICLE TRAFFICKING IN CHROMAFFIN CELLS. Farah Haque National Centre for Biological Sciences, India, A NEW HUMANIZED MOUSE MODEL FOR STUDYING INHERITED CARDIOMYOPATHIC MUTATIONS IN THE MYH7 GENE. Stephanie Heusser, Stockholm University, Switzerland, STRUCTURAL AND FUNCTIONAL EVIDENCE FOR MULTI-SITE ALLOSTERY MEDIATED BY GENERAL ANESTHETICS IN A MODEL LIGAND-GATED ION CHANNEL. Amir Irani, Massey University, New Zealand, HOMOGALACTURONANS ILLUMINATE THE ROLE OF COUNTERION CONDENSATION IN POLYELECTROLYTE TRANSPORT. Olfat Malak, University of Nantes, France, HIV-TAT INDUCES A DECREASE IN IKR AND IKS VIA REDUCTION IN PHOSPHATIDYLINOSITOL-(4,5)-BISPHOSPHATE AVAILABILITY. CONFORMATIONAL TRANSITION AND ASSEMBLY OF E.COLI CYTOLYSIN A PORE FORMING TOXIN BY SINGLE MOLECULE FLUORESCENCE. Sabrina Sharmin, Shizuoka University, Japan, EFFECTS OF LIPID COMPOSITIONS ON THE ENTRY OF CELL PENETRATING PEPTIDE OLIGOARGININE INTO SINGLE VESICLES. Xin Shi, East China University of Science and Technology, DIRECT OBSERVATION OF SINGLE BIOPOLYMER FOLDING AND UNFOLDING PROCESS BY SOLIDSTATE NANOPORE. Omar Alijevic, University of Lausanne, Switzerland, ANALYSIS OF GATING OF ACID-SENSING ION CHANNELS (ASICS) UNDER RAPID AND SLOW PH CHANGES. Swapna Bera, Bose Institute, India, BIOPHYSICAL INSIGHTS INTO THE MEMBRANE INTERACTION OF THE CORE AMYLOID-FORMING Aβ40 FRAGMENT K16-K28 AND ITS ROLE IN THE PATHOGENESIS OF ALZHEIMER'S DISEASE. Anais Cassaignau, University College London, United Kingdom, STRUCTURAL INVESTIGATION OF AN IMMUNOGLOBULIN DOMAIN ON THE RIBOSOME USING NMR SPECTROSCOPY. Bappaditya Chandra, Tata Institute of Fundamental Research, India, SECONDARY STRUCTURE FLIPPING CONNECTED TO SALT-BRIDGE FORMATION CONVERTS TOXIC AMYLOID-β40 OLIGOMERS TO FIBRILS. Gayathri Narasimhan, Cinvestav, Mexico, ANTIHYPERTROPHIC EFFECTS OF DIAZOXIDE INVOLVES CHANGES IN MIR-132 EXPRESSION IN ADULT RAT CARDIOMYCYTES. Giulia Paci, European Molecular Biology Laboratory, Germany, FOLLOWING A GIANT'S FOOTSTEPS: SINGLE-PARTICLE AND SUPER-RESOLUTION APPROACHES TO DECIPHER THE NUCLEAR TRANSPORT OF HEPATITIS B VIRUS CAPSIDS. Bizhan Sharopov, Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine, DISSECTING LOCAL AND SYSTEMIC EFFECTS OF TRPV1 ON BLADDER CONTRACTILITY IN DIABETES. Chao Sun, East China Normal University, FUNCTION OF BACTERIORUBERIN IN ARCHAERHODOPSIN 4, FROM EXPRESSION TO CHARACTERIZATION. Matthew Batchelor, University of Leeds, United Kingdom STRUCTURAL DYNAMICS IN THE MYOSIN 7A SINGLE α-HELIX DOMAIN. Daniel Havelka, Czech Academy of Sciences, MICROVOLUME DIELECTRIC SPECTROSCOPY AND MOLECULAR DYNAMICS OF AMINO ACIDS. Ivan Kadurin, University College London, United Kingdom, INVESTIGATION OF THE PROTEOLYTIC CLEAVAGE OF α2δ SUBUNITS: A MECHANISTIC SWITCH FROM NHIBITION TO ACTIVATION OF VOLTAGE-GATED CALCIUM CHANNELS? Linlin Ma, University of Queensland, Australia, NOVEL HUMAN EAG CHANNEL ANTAGONISTS FROM SPIDER VENOMS. Ivana Malvacio, University of Cagliari, Italy, MOLECULAR INSIGHTS ON THE RECOGNITION OF SUBSTRATES BY THE PROMISCUOUS EFFLUX PUMP ACRB. Cristina Moreno Vadillo, Cardiovascular Research Institute Maastricht, Netherlands, RESTORING DEFECTIVE CAMP-DEPENDENT UPREGULATION IN LONG-QT SYNDROME TYPE-1 THROUGH INTERVENTIONS THAT PROMOTE IKS CHANNEL OPENING. Melanie Paillard, Claude Bernard University Lyon 1, France, TISSUE-SPECIFIC MITOCHONDRIAL DECODING OF CYTOPLASMIC CA2+ SIGNALS IS CONTROLLED BY THE STOICHIOMETRY OF MICU1/2 AND MCU. Mohammed Mostafizur Rahman, Institute for Stem Cell Biology and Regenerative Medicine, India, STRESS-INDUCED DIFFERENTIAL REGULATION LEADS TO DECOUPLING OF THE ACTIVITY BETWEEN MPFC AND AMYGDALA. Marcin Wolny, University of Leeds, United Kingdom, DESIGN AND CHARACTERIZATION OF LONG AND STABLE DE NOVO SINGLE α-HELIX DOMAINS. Elvis Pandzic, University of New South Wales, Australia, VELOCITY LANDSCAPES RESOLVE MULTIPLE DYNAMICAL POPULATIONS FROM FLUORESCENCE IMAGE TIME SERIES. The Biophysical Society, founded in 1958, is a professional, scientific Society established to encourage development and dissemination of knowledge in biophysics. The Society promotes growth in this expanding field through its annual meeting, monthly journal, and committee and outreach activities. Its 9000 members are located throughout the U.S. and the world, where they teach and conduct research in colleges, universities, laboratories, government agencies, and industry. For more information on these awards, the Society, or the 2017 Annual Meeting, visit http://www.
Srinivasan V.,IISER |
Srinivasan V.,Princeton University |
Sebastiani D.,Free University of Berlin |
Sebastiani D.,Max Planck Institute for Polymer Research
Journal of Physical Chemistry C | Year: 2011
We investigate the quantum-mechanical localization of 1H and 2H isotopes in the symmetric low-barrier hydrogen-bonds of potassium dihydrogen phosphate (KDP) crystals in the paraelectric phase. The spatial density distributions of these hydrogen atoms are suspected to be responsible for the surprisingly large isotope effect observed for the ferroelectric phase transition in KDP. We employ ab initio path integral molecular dynamics simulations to obtain the nuclear real-space and momentum-space densities n(R) and n(k) of 1H and 2H, of which the latter densitites are compared to experimental neutron compton scattering data. Our results suggest a qualitative difference in the nature of the paraelectric phase in KDP between the two isotopes. Whereas both paraelectric states result from quantum delocalization, the essential difference is the change from a probably coherent to incoherent tunneling behavior of the hydrogen atoms across the hydrogen-bonds. © 2011 American Chemical Society.
Arora B.,IISER |
Safronova M.S.,University of Delaware |
Clark C.W.,U.S. National Institute of Standards and Technology
Physical Review A - Atomic, Molecular, and Optical Physics | Year: 2011
Using first-principles calculations, we identify "tune-out" optical wavelengths, λzero, for which the ground-state frequency-dependent polarizabilities of alkali-metal atoms vanish. Our approach uses high-precision, relativistic all-order method in which all single, double, and partial triple excitations of the Dirac-Fock wave functions are included to all orders of perturbation theory. We discuss the use of tune-out wavelengths for sympathetic cooling in two-species mixtures of alkali metals with group II and other elements of interest. Special cases in which these wavelengths coincide with strong resonance transitions in a target system are identified. © 2011 American Physical Society.
Ranjan R.K.,Jawaharlal Nehru University |
Routh J.,IISER |
Ramanathan A.L.,Jawaharlal Nehru University
Applied Geochemistry | Year: 2010
The Pichavaram mangrove ecosystem is located between the Vellar and Coleroon Estuaries in south-eastern India. To document the spatial-depth-based variabilities in organic matter (OM) input and cycling, five sediment cores were collected. A comparative study was carried out of grain-size composition, pore water salinity, dissolved organic C (DOC), loss-on-ignition (LOI), elemental ratios (C/N and H/C), pigments (Chl a, Chl b, and total carotenoids), and humification indices. Sand is the major fraction in these cores ranging from 60% to 99% followed by silt and clay; cores from the estuarine margin have high sand content. In mangrove forests, pore-water DOC concentrations are high (32±14mgL-1), whereas salinity levels are low (50±5.5‰). Likewise, LOI, organic C and N, and pigment concentrations are high in mangroves. OM is mainly derived from upstream terrestrial matter and/or mangrove litter, and marine OM. The humification indices do not vary significantly with depth because of rapid OM turnover. The bulk parameters indicate that the Vellar and Coleroon Estuaries are more affected by anthropogenic processes than mangrove forests. Finally, greater variability and sometimes lack of specific trends in bulk parameters implies that the 2004 tsunami caused extensive mixing in sediments. © 2010 Elsevier Ltd.
News Article | February 2, 2016
"The telescope is dedicated to amateur radio astronomers ranging from high school students to college graduates," Devansh Agarwal, one of the co-authors of the paper, told Phys.org. While large radio telescopes are needed to detect radio waves from astronomical sources, the students have shown that a small one could also make great discoveries in the field of radio astronomy. A small radio telescope designed by the team was able to measure the brightness temperature of the sun. The scientists also demonstrated the usefulness of their telescope by detecting point sources such as Saturn and extended sources such as the galactic arm of our home galaxy Milky Way. The team revealed that by performing drift scans, the brightness temperature of the sun was calculated to near 10,000 K with a maximum error of 3.23 percent. Sources like Saturn and the galactic arm were confirmed by correlating the time of arrival of the source signal in the field of view of the telescope with the predicted times via free, open-source planetarium software called Stellarium, based on the team's pointing. The flux received from the sources was calibrated against the standardized data from various geostationary satellites. Agarwal notes that their radio telescope reached expectations when studying the sun and also works very well when detecting other astronomical sources. The radio telescope designed by IISER students consists of a satellite antenna, a satellite signal meter called 'satellite finder' and a microcontroller board named Arduino Uno. The antenna has a 68 cm parabolic dish reflector and a low noise block (LNB). According to the paper, LNB receives the radio signal from the satellite reflected by the dish and amplifies it. There is also a set-top box that powers the satellite finder and the LNB. Satellite finder is used for orienting satellite dishes towards geostationary satellites. "We have used a commercially available analog satellite finder (GC SF-02). Such a device acts as a square law detector and is used to read directly the intensity," the team wrote in the paper. Arduino Uno is a microcontroller board with a 10 bit analog to digital converter. It enables digitizing the intensity from the satellite finder at 10Hz sampling rate. The tool is connected to a personal computer. The students emphasize that their radio telescope, assembled from commonplace items, is an affordable and a versatile instrument to demonstrate the working of a radio telescope and to provide crucial hands-on experience with radio astronomy tools. It goes without saying that one of the main advantages of their instrument is its low cost. "In India, this telescope cost was less than $75. However, it is highly dependent on rates of components available at your place," Agarwal said. The project also leaves a lot of space for future improvements. For instance, an increase in sensitivity would offer the opportunity to look at many other sources than just the sun. "All-sky visibility maps can be generated at a rudimentary level that would make one familiar with a bigger part of the radio sky," the team concluded. Explore further: Looking at Jupiter's radio frequencies Abstract We have developed an affordable, portable college level radio telescope for amateur radio astronomy which can be used to provide hands-on experience with the fundamentals of a radio telescope and an insight into the realm of radio astronomy. With our set-up one can measure brightness temperature and flux of the Sun at 11.2 GHz and calculate the beam width of the antenna. The set-up uses commercially available satellite television receiving system and parabolic dish antenna. We report the detection of point sources like Saturn and extended sources like the galactic arm of the Milky way. We have also developed python pipeline, which are available for free download, for data acquisition and visualization.
Das B.K.,Indian Institute of Technology Kharagpur |
Chakraborty M.,Indian Institute of Technology Kharagpur |
Proceedings - IEEE International Symposium on Circuits and Systems | Year: 2011
In the context of system identification, it is shown that sometimes the level of sparseness in the system impulse response can vary greatly depending on the time-varying nature of the system. When the response is strongly sparse, convergence of the conventional approach such as least mean square (LMS) is poor. The recently proposed, compressive sensing based sparsity-aware ZA-LMS algorithm performs satisfactorily in strongly sparse environments, but is shown to perform worse than the conventional LMS when sparseness of the impulse response reduces. We propose an algorithm which works well both in sparse and non-sparse circumstances and adapts dynamically to the level of sparseness, using a convex combination based approach. The proposed algorithm is supported by simulation results that show its robustness against variable sparsity. © 2011 IEEE.
Mishra R.,IISER |
Journal of Mathematical Biology | Year: 2012
This paper aims to enthuse mathematicians, especially topologists, knot theorists and geometers to examine problems in the study of proteins. We have highlighted those advances and breakthroughs in knot theory that directly and indirectly help in understanding proteins. We have discussed the phenomena of knotting of protein backbone. This paper also provides a few open questions for knot theorists, the answers to which will help in further understanding of proteins. © 2011 Springer-Verlag.
Roy B.,IISER |
Pal S.B.,IISER |
Haldar A.,IISER |
Gupta R.K.,IISER |
And 2 more authors.
Optics Express | Year: 2012
The dynamics of an optically trapped particle are often determined by measuring intensity shifts of the back-scattered light from the particle using position sensitive detectors.We present a technique which measures the phase of the back-scattered light using balanced detection in an external Mach-Zehnder interferometer scheme where we separate out and beat the scattered light from the particle and that from the top surface of our trapping chamber. The technique has improved axial motion resolution over intensity-based detection, and can also be used to measure lateral motion of the trapped particle. In addition, we are able to track the Brownian motion of trapped 1.1 and 3 μm diameter particles from the phase jitter and show that, similar to intensity-based measurements, phase measurements can also be used to simultaneously determine displacements of the trapped particle as well as the spring constant of the trap. For lateral displacements, we have matched our experimental results with a simulation of the overall phase contour of the back-scattered light by using plane wave decomposition in conjunction with Mie scattering theory. The position resolution is limited by path drifts of the interferometer which we have presently reduced to demonstrate the capability of sub-nm displacement resolution in the axial direction for 1.1 μm diameter particles by locking the interferometer to a frequency stabilized diode laser. © 2012 Optical Society of America.
Kumar A.,IISER |
Yadav K.L.,Indian Institute of Technology Roorkee
Journal of Applied Physics | Year: 2014
One of the induced multiferroic materials, CuO has the magnetic as well as ferroelectric phase transition at same temperature (TN1 ∼213K, TC and TN2 ∼230K). These type of materials can show two types of entropy; magnetic field induced entropy (Magnetocaloric Effect) as well as electeric field induced entropy (Electrocaloric Effect). The presence of both type of entropy may be called "Multicaloric Entropy" (M. Vopson, Solid State Commun. 152, 2067 (2012) and Meng et al., Phys. Lett. A 377, 567 (2013)). We observed that "Multicaloric Entropy" in the induced multiferroic materials also depends on the magnetoelectric interaction (γ). Therofore, this numerical attempt to calculate the entropy of CuO may be useful for the future "electro-magnetic" based refrigerator technology. © 2014 AIP Publishing LLC.