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Delgado-Gomez D.,Charles III University of Madrid | Blasco-Fontecilla H.,IIS Inc | Sukno F.,Dublin City University | Socorro Ramos-Plasencia M.,I.E.S Gran Tarajal | Baca-Garcia E.,Columbia University
Neurocomputing | Year: 2012

Suicide is a major public health issue with considerable human and economic cost. Previous attempts to delineate techniques capable of accurately predicting suicidal behavior proved unsuccessful. This paper aims at classifying suicide attempters (SA) as a first step toward the development of predictive models of suicidal behavior. A sample of 883 adults (347 SA and 536 non-SA) admitted to two university hospitals in Madrid, Spain, between 1999 and 2003 was used. Five multivariate techniques (linear regression, stepwise linear regression, decision trees, Lars-en and support vector machines) were compared with regard to their capacity to accurately classify SA. These techniques were applied to the Holmes-Rahe social readjustment rating scale and the international personal disorder examination screening questionnaire. Combining both scales, the Lars-en and stepwise linear regression techniques achieved 83.6% and 82.3% classification accuracy, respectively. In addition, these classification results were obtained using less than half of the available items. Multivariate techniques demonstrated to be useful in classifying SA using a combination of life events and personality criteria with reasonable accuracy, sensitivity and specificity. © 2012 Elsevier B.V.. Source

Fukuba T.,University of Tokyo | Aoki Y.,University of Tokyo | Fukuzawa N.,University of Tokyo | Yamamoto T.,Tokyo Institute of Technology | And 3 more authors.
Lab on a Chip - Miniaturisation for Chemistry and Biology | Year: 2011

We have developed and tested a functionally integrated in situ analyzer, the IISA-ATP system, for microbial activity assays based on a quantitative determination of the total (particulate and dissolved) ATP in ocean environments. The IISA-ATP utilizes a PDMS-glass hybrid microfluidic device as its core functional element, which can perform cell lysis and total ATP quantification by a luciferin-luciferase bioluminescence assay in situ. Transparent heaters and a temperature sensor fabricated on a glass substrate provide temperature control. As a result of the evaluation using the microfluidic device with ATP standard solutions, the bioluminescence intensity was linearly correlated with 2 × 10-12 to 2 × 10 -8 M of ATP. A detection limit of 1.1 × 10-11 M was determined using the completed IISA-ATP system, which includes a miniature pumping module and a control module. As a result of the evaluation using the environmental seawater sample collected from Tokyo Bay, Japan, 2.7 × 10-10 M of total ATP was successfully determined in the laboratory by the IISA-ATP. The system was operated at a shallow submarine hot spring area in Okinawa, Japan for an in situ trial. The result shows the system was successfully operated in situ and the total ATP was determined to be 3.4 × 10-10 M. This journal is © The Royal Society of Chemistry. Source

The tentative arguments mentioned by Paul De Bievre are discussed and alternatives are given that may lead to different insights. © 2016 Springer-Verlag Berlin Heidelberg Source

Valle-Caballero M.J.,University of Seville | Fernandez-Jimenez R.,Hospital Universitario Clinico San Carlos | Mateos A.,Francisco de Vitoria University | Rodriguez-Alvarez M.,Complejo Hospitalario Universitario Of Vigo Meixoeiro | And 4 more authors.
International Journal of Cardiology | Year: 2016

Background: QRS distortion is an electrocardiographic (ECG) sign of severe ongoing ischemia in the setting of ST-segment elevation acute myocardial infarction (STEMI). We sought to evaluate the association between the degree of QRS distortion and myocardium at risk and final infarct size, measured by cardiac magnetic resonance (CMR). Methods: A total of 174 patients with a first anterior STEMI reperfused by primary angioplasty were prospectively recruited. Pre-reperfusion ECG was used to divide the study population into three groups according to the absence of QRS distortion (D0) or its presence in a single lead (D1) or in 2 or more contiguous leads (D2 +). Myocardium at risk and infarct size were determined by CMR one week after STEMI. Multiple regression analysis was used to study the association of QRS distortion with myocardium at risk and infarct size, with adjustment for relevant clinical and ECG variables. Results: 101 patients (58%) were in group D0, 30 (17%) in group D1, and 43 (25%) in group D2 +. Compared with group D0, presence of QRS distortion (groups D2 + and D1) was associated with a significantly adjusted larger extent of myocardium at risk (group D2 +: absolute increase 10.4%, 95% CI 6.1-14.8%, p < 0.001; group D1: absolute increase 3.3%, 95% CI 1.3-7.9%, p = 0.157) and larger infarct size (group D2 +: absolute increase 10.1%, 95% CI 5.5-14.7%, p < 0.001; group D1: absolute increase 4.9%, 95% CI 0.08-9.8%, p = 0.046). Conclusions: Distortion in the terminal portion of the QRS complex on pre-reperfusion ECG in two or more leads is independently associated with larger myocardium at risk and infarct size in the setting of primary angioplasty-reperfused anterior STEMI. QRS distortion in only one lead is independently associated with larger infarct size in this setting. Our findings suggest that QRS distortion analysis could be included in risk-stratification of patients presenting with anterior STEMI. © 2015 Elsevier Ireland Ltd. All rights reserved. Source

Makino H.,NILIM | Kamijo S.,IIS Inc
IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences | Year: 2015

ITS R&D includes wide variety of research area such as mechanical engineering, road engineering, traffic engineering, information and communication engineering, and electrical engineering. In spite of initiatives across the variety of engineering is essential to solve the problems of practical social systems, it is difficult to collaborate among engineering. Based on the joint research of the Japan Society of Civil Engineers and the Institute of Electrical Engineers held at the Great East Japan Earthquake, this paper discusses about necessity of collaboration among academies on ITS R&D. International collaboration is also important for ITS R&D. Asian countries could share the same problems and solutions, since many of mega cities exist in Asia region and they suffers from heavy traffics. Therefore, we need to discuss the common solution to our problems. Copyright © 2015 The Institute of Electronics, Information and Communication Engineers. Source

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