Mir F.,Jamia Hamdard University |
Shafi S.,Jamia Hamdard University |
Zaman M.S.,Jamia Hamdard University |
Kalia N.P.,IIIM Jammu |
And 5 more authors.
European Journal of Medicinal Chemistry | Year: 2014
A series of benzfused heterocyclic derivatives such as amide conjugates of 2-(benzo[d]thiazol-2-ylthio)acetic acid with aromatic/aliphatic/cyclic secondary amines (5a-5o & 8a-8m); 1,2,3-triazole conjugates of 2- mercaptobenzothiazoles and amide conjugates of indole-3-glyoxalic acid with cyclic secondary amines (14a-14g) have been synthesized and were screened for their antitubercular activity against Mycobacterium tuberculosis H37Rv strain by broth microdilution assay method. Compounds 8b, 8f, 8g and 8l inhibited the growth of the H37Rv strain at concentrations of 8 μg/mL. These compounds (8b, 8f, 8g and 8l) have been further identified as bactericidal and are completely killing the microbes at 32-64 μg/mL concentrations. Molecular docking studies of the active compounds reveal that these compounds are targeting DprE1 and may act as DprE1 inhibitors. © 2014 Elsevier Masson SAS. All rights reserved.
Ahmed Z.,IIIM Jammu |
Bhushan S.,IIIM Jammu
Journal of Chemical and Pharmaceutical Sciences | Year: 2013
Ougeinia oojeinensis (Fabaceae) commonly known as Tinsa, mostly found sub-tropical regions of India. Whole parts of the plant are rich in secondary metabolites, which impart mariculous medicinal uses to the plant. The bioactive constituents isolated from Ougeinia oojeinensis are genistein, ougenin, dalbergioidin, kaempferol, lupeol, Ferreirin, neophellamuretin, orobol, wedelolactone, homoferririn isoflavanone and betulin etc. The plant has found applications in pharmaceuticals. The bark used as astringent, acrid, cooling, stimulant, anti-inflammatory, constipating, urinary astringent, anthelmintic, sudorific, depurative, styptic, febrifuge and rejuvenating. The extract of the whole plant showed anti-inflammatory, hypotensive action, antioxidant activity, hepatoprotective, anthelmintic, hypoglycemic and wound healing activities. This review attempts to encompass the available literature of Ougeinia oojeinensis with respect to its ethanomedical information and summary of its pharmacognostical and pharmacological activities for further investigations and forms an important aspect of drug studies.