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Tlalpan, Mexico

Brizhik L.S.,NASU Bogolyubov Institute for Theoretical Physics | Del Giudice E.,IIB | Tedeschi A.,WHITE HB | Voeikov V.L.,IIB | Voeikov V.L.,Moscow State University
Ecological Modelling | Year: 2011

Living organisms and ecosystems have been shown to be sensitive to very weak signals originating very far away. The dynamics governing these phenomena is discussed in the framework of Quantum Field Theory. This phenomenon gives an indication on the dynamics responsible for the exchange of information in ecosystems. The peculiar role of coherent water is stressed. It is shown that energy is able to travel in a coherent medium in form of solitons, without any losses. © 2011 Elsevier B.V. Source

Mutig K.,Charite - Medical University of Berlin | Kahl T.,Charite - Medical University of Berlin | Saritas T.,Charite - Medical University of Berlin | Godes M.,Charite - Medical University of Berlin | And 11 more authors.
Journal of Biological Chemistry | Year: 2011

Active transport of NaCl across thick ascending limb (TAL) epithelium is accomplished by Na+,K+,2Cl- cotransporter (NKCC2). The activity of NKCC2 is determined by vasopressin (AVP) or intracellular chloride concentration and includes its amino-terminal phosphorylation. Co-expressed Tamm-Horsfall protein (THP) has been proposed to interact with NKCC2. We hypothesized that THP modulates NKCC2 activity in TAL. THP-deficient mice (THP-/-) showed an increased abundance of intracellular NKCC2 located in subapical vesicles (+47% compared with wild type (WT) mice), whereas base-line phosphorylation of NKCC2 was significantly decreased (-49% compared with WT mice), suggesting reduced activity of the transporter in the absence of THP. Cultured TAL cells with low endogenous THP levels and low base-line phosphorylation of NKCC2 displayed sharp increases in NKCC2 phosphorylation (+38%) along with a significant change of intracellular chloride concentration upon transfection with THP. In NKCC2-expressing frog oocytes, co-injection with THP cRNA significantly enhanced the activation of NKCC2 under low chloride hypotonic stress (+112% versus +235%). Short term (30 min) stimulation of the vasopressin V2 receptor pathway by V2 receptor agonist (deamino-cis-D-Arg vasopressin) resulted in enhanced NKCC2 phosphorylation in WT mice and cultured TAL cells transfected with THP, whereas in the absence of THP, NKCC2 phosphorylation upon deamino-cis-D-Arg vasopressin was blunted in both systems. Attenuated effects of furosemide along with functional and structural adaptation of the distal convoluted tubule in THP-/- mice supported the notion that NaCl reabsorption was impaired in TAL lacking THP. In summary, these results are compatible with a permissive role for THP in the modulation of NKCC2-dependent TAL salt reabsorptive function. © 2011 by The American Society for Biochemistry and Molecular Biology, Inc. Source

Del Giudice E.,IIB | Stefanini P.,Hadoshiatsu | Tedeschi A.,WHITE HB | Vitiello G.,University of Salerno
Journal of Physics: Conference Series | Year: 2011

It is shown that the main component of living matter, namely liquid water, is not an ensemble of independent molecules but an ensemble of phase correlated molecules kept in tune by an electromagnetic (e.m) field trapped in the ensemble. This field and the correlated potential govern the interaction among biomolecules suspended in water and are in turn affected by the chemical interactions of molecules. In particular, the phase of the coherent fields appears to play an important role in this dynamics. Recent experiments reported by the Montagnier group seem to corroborate this theory. Some features of the dynamics of human organisms, as reported by psychotherapy, holistic medicine and Eastern traditions, are analyzed in this frame and could find a rationale in this context. Source

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