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News Article | May 22, 2017
Site: www.decanter.com

Every wine region needs its star properties.  Not, of course, to dominate, but to draw attention to what can be done, to open up distant markets, and to inspire and encourage smaller and newer competitors. It’s most useful if the stars strive for different forms of excellence rather than apeing or cloning each other.  Languedoc is lucky in this respect.  Mas de Daumas Gassac and Grange des Pères explore varietal non-conformism in different ways, the former with a fresh-edged classicism and the latter in a richer, more indigenous style.  Mas Jullien’s modulations have drawn it ever nearer to the finesse and ability to age which is the hallmark of most fine European reds; the baroque Peyre Rose tests the limits of the possible on many fronts; La Pèira’s sensuality, sumptuousness and purity would be remarkable in any region; Didier Barral holds the torch for a ‘natural’ approach with inconsistent but sometimes magnificent results.  There are many others, of course, and newer entrants (including Gérard Bertrand’s Clos d’Ora) are adding to the region’s interest. There is, though, a dark horse in this increasingly crowded field: Puech-Haut.  It’s celebrated and successful, but I’ve often struggled to understand its wine.  I had the chance to take a closer look when new co-owners Marc and Olga Escassut recently suggested a visit. The holdings are significant: 200 ha all told, split between the historical zones of St Drézéry and St Christol, and the newer appellation of Pic St Loup (La Closerie du Pic).  Visitors are welcomed. There’s the world largest barrique, to start with; you can’t miss it as you drive down the olive-lined drive, not least because it’s painted red.  Its theoretical contents of 300,000 litres make it larger than Mercier’s giant barrel in Reims (at 160,000 litres) and the historical Heidelberg tun (at 219,000 litres).  Walk on in: the giant barrique contains a shop where the world’s most expensive bag-in-box wines are sold. These take the form of miniature limited-edition ‘barriques’ (or ‘Bib’art’) which commemorate and reproduce the collection of artist-painted barriques which Puech-Haut’s founder and now co-owner, Gérard Bru, has commissioned down the years ; the bag-in-box blend inside them, called Le Benjamin, is an IGP Oc based on the young vines of the three domaines plus some bought fruit.  They’re hugely popular with collectors; Puech-Haut sells 100,000 of them every year. There’s also a museum of olive presses and a château – which, like the barrel, isn’t exactly what it seems.  It is, in fact, the old annexe to Montpellier’s prefecture.  Gérard Bru had it moved out to Puech-Haut stone by stone, and extended with some other bits and pieces (including some fine pillars from the former railway station in Grenoble). As you’re probably guessing by now, M.Bru is a character. He has winegrowing roots, and remembers his grandfather swopping wine for potatoes with ‘the people from the mountains’, and putting stones into his wine tanks as he sold their contents in order to keep them topped up.  Gérard Bru began by founding an electical business which he eventually sold to Alstom, buying Puech-Haut in his middle years. He also bought a Camargue ranch where he raises 360 wagyu cattle for kobe-style beef production. When lunch time beckoned, out came steaks the size of small cushions which he whacked down onto the open grill flames in his kitchen. It was ‘the art of living’ and ‘the work of pleasure’, he explained, that had been the leitmotiv of his second career — hence the beef and the wine. “I know nothing, other than how to surround myself with competent people,” he claims, though that may be an exaggeration.  The estate was celebrated for being one advised for a decade (until 2008) by Michel Rolland and (after a brief period with Claude Gros and Jean Natoli) now by Philippe Cambie; its wines have been enthusiastically reviewed by Robert Parker and his collaborators David Schildknecht and Jeb Dunnuck, and are sold in large quantities in the UK by Farr Vintners, not least thanks to a unique points-to-price ratio. The Puech-Haut wines as they’ve been made so far seem to me to be the epitome of that ‘New World Languedoc’ style which appealed so strongly to outsiders in the 1990s, with deep, fleshy profiles, prominent acidity and lavish oak (some of the special cuvée wines have 24 months in new oak), but with discreet tannin profiles and hence smooth textures. The range includes a large number of occasional parcellaires.  There are some successful whites, and a recent addition to the Puech-Haut offer is some of Languedoc’s best (and most attractively packaged) rosés. Will there be a change of direction now that the Escassuts are involved?  They’re both winemakers, Marc having formerly owned and run a wine-sourcing enterprise called Vignobles du Soleil.  When Vignobles du Soleil became part of the Invivo agricultural co-operative group (which also owns Cordier and Mestrezat), Marc Escassut decided to invest in Puech-Haut. I asked Marc Escassut whether he might ease back on the lavish oaking profiles.  He pointed out that these had always been a key element of the Puech-Haut style, and the aim was not to make a sudden change of direction.  The giant barrique and the ‘Bib’art’ bag-in-box series, of course, all underlines the estate’s historical affection for wood.  A more delicate approach to elevage might help the wines of the fine, high-potential Pic St Loup vineyards, for example, differentiate themselves more clearly from those produced in St Drézéry.  More structure and density in the red wines (and a less prominent acid balance) would be welcome, too, at least by me – but we’ll see what the future brings.  The point about locomotives, after all, is that they should never stand still. This steel-fermented blend of 60% Roussanne with 40% Marsanne has fresh, sweet floral aromas with some creamy lemon; the palate is lively and bright, sappy, with more lemon and nougatine richness in deftly judged balance.  90 A barrel-fermented blend of Viognier with Marsanne and Roussanne, this is both aromatically and texturally lush and extravagant, with generous summer fruits, attractive vanilla and a mellow, marrowy vegetal backdrop to it.  Drink soon before its weight begins to obtrude.  91 This is a barrel-fermented blend (in new barriques) of 60 per cent old-vine Grenache Blanc with the balance from Viognier.  The scents are soft, haunting and attractive, a blend of green malt, plant sap and a little crushed aniseed, while the palate is bright and tangy with yellow-plum sweetness and a forceful acid balance, too.  90 Bottled with a glass stopper and blended from 90 per cent Mourvèdre with just 10 per cent Grenache, this is a characterful though still pale rosé with scents of soft summer fruit and ripe peach, apricot and quince flavours with some sappiness.  91 This Grenache/Syrah blend is a pale salmon-peach in colour with enticing scents combining creaminess with almondy freshness.  It’s vinous, firm and elegant on the palate, every inch a meal-time rosé, but with enough softness and charm for a glassful to seduce first, too.  An outstanding effort for Languedoc.  93 This is Puech-Haut’s entry-level red (and you wouldn’t know it was a Puech-Haut wine from the label).  It’s an exuberantly fruity blend of Syrah and Grenache with a soft, fleshy, voluptuous, burnt-blackberry character – and no oak at all.  Lots of guzzling pleasure here.  89 Made from 70 per cent Syrah with the balance from Grenache and principally aged in large wood rather than small, this is ripe, mushroomy and almost pruney in aroma and flavour, soft in texture, with firm acidity playing more of a balancing role than tannin.  87 From a blend of 50% Syrah with 35% Grenache and a little Mourvèdre and Carignan, this has fig, prune, mushroom and menthol aromatic notes with mature ripe-fruit notes which mingle the dried fruits of the nose with a little dark raspberry.  The oak dries the palate a little and makes it hard to see the skin tannins, though the overall style is generous and exuberant.  89 The 2014 cuvée of Tête de Belier has soft red fruits in a plummy style with a touch of tobacco-leaf savouriness.  It has a smooth, oaky-acid palate without great depth or structure, though the black pastille-style fruit is enjoyable.  87 This is one of no fewer than seven occasional ‘parcellaires’ produced using the Puech-Haut label, even though this particular wine comes from the Pic St Loup vineyards (which are otherwise differently labelled)  It’s a wine of tangy, gentle red-fruit style, but there is more breed to the Pic St Loup fruit than to the St Drezery fruit and a little more herbal allusion, too; some supporting tannins are palable, even though it is oak and acidity which creates the fundamental balance in this smooth-textured wine.  89 A 60/40 blend of Grenache and Syrah in new wood, this is certainly oaky but you can also pick out notes of thyme and scrub, and there is more of a fresh creaminess to the fruit compared to the St Drézery fruit.  There are herb and spice notes to the fruit on the palate behind the oak.  88

NEW YORK--(BUSINESS WIRE)--Imports of Languedoc AOP wines to the American market have seen astonishing growth over the last seven years. Since 2009 imports of these wines into the U.S. have grown +280% by volume and +403% by value. The 2016 import figures* show +29% volume growth and +43% value growth, 2016 over 2015, outpacing every major French AOP category except Provence. Leading the way, imports of AOP Languedoc Rouge/Rosé wines are up +62% by volume and +86% by value YOY and are a key driver of this growth for the category. “The rise of imports of rosé wines from the South of France is increasingly significant to our producers,” says Christine Molines, Marketing Director for the Conseil Interprofessionnel des Vins du Languedoc. She points to Languedoc wines’ diversity of styles on offer as a key driver, as well as their ability to deliver exceptional quality for approachable pricing. “Our Crus du Languedoc appellations offer the best values for French Crus wines on the market.” The CIVL continues their investment in the U.S. market in 2017 with a full schedule of retail promotion partnerships, trade education initiatives, public relations and digital media support. Benson Marketing Group has been retained for an additional two years as agency of record, building on work begun in the U.S. market by the CIVL and Benson starting in late 2008. Visit languedocadventure.com for updates on activities and enjoy Languedoc wines on May 26 – international #LanguedocDay. The Conseil Interprofessionnel des Vins du Languedoc (CIVL) is the trade council representing the entire AOP wine sector of Languedoc, as well as the IGP sector. It is responsible for organizing the promotion of Languedoc AOPs within France and in all export markets. The CIVL seeks to broaden the exposure of Languedoc wines in the United States to make the public aware of the quality, variety and incredible value they have to offer.

News Article | May 24, 2017
Site: www.thedrinksbusiness.com

Coming from the IGP vineyards of Ensérune, which are 80% owned by growers that work with Foncalieu and called ‘Ensédune’ which is the old Roman name for the area, the range covers six wines at present; three reds, a rosé and two whites. The wines include a Malbec, Marselan and Petit Verdot, a Cabernet Franc rosé and a Marsanne and dry Muscat. Each wine is a single variety and comes from the vineyards of a single grower whose photograph forms part of the front label. Speaking to the drinks business, Alexandra Ladeuil, export and marketing director for the co-operative, said it was “important for consumers looking for a story and a history.” The range is being aimed at leading UK supermarkets and while Marie-Annick Consola, UK sales and export director for Foncalieu, added that varieties such as Petit Verdot and Marselan were trickier propositions for retailers to work with and there was a need to raise their profile. That said, the range has already been listed by a leading Dutch supermarket chain. As Consola continued: “The aim was to be different. In the company we try to be forward thinking and innovative by proposing different things.” The company added that it has ‘refreshed’ the packaging for its leading on-trade range, ‘Le Versant’. The changes are subtle, admitted both Consola and Ladeuil (such as adopting a white rather than an off-white label) but it was hoped the slight tweaks made the range “more elegant” and would help drive further listings.

News Article | May 8, 2017
Site: www.decanter.com

Those who love the breadth, perfume and generosity of the wines of the Southern Rhône are intimately familiar with the Rhône’s left bank.  This is Provençale Rhône, if you like: the great honey-white bowl of stonefields, terraces and garden villages which arcs out to the east, corralled by the jagged Dentelles de Montmirail, by austere Mont Ventoux, by the western end of the Vaucluse Massif, and finally by the prettier Montagne de Luberon and the Alpilles to the south.  You’ll find most of the Southern Rhône’s villages here, and most of its crus, too. What, though, of the right bank?  There are just four named villages here, plus a couple of crus and some ancilliary appellations: a much less familiar wine landscape.  I spent time at this year’s Découvertes en Vallée du Rhône trying to get to know them a bit better, and taste my way to understanding. The right bank’s problem, if you like, is that it has no bowl.  There are terraces but, relatively swiftly, they clamber up into the first foothills of the Cévennes, followed by the pasture and forest associated with altitude.  There are certainly points of interest, but no uniformity.  Let’s take the zones one by one. We’re in the southeast of the Ardèche, here – a plumb line dropped down from St Joseph.  The limestone and marl soils are good-looking, and there’s no shortage of slopes – but altitudes are high (between 150m and 500m) and nights are cool.  The whites and rosé wines in this appellation are much more successful than the rather thin and strained reds.  There are, in point of fact, some very fine white wines hereabouts – but most are IGP.  (For more on this unique white-wine story, see here).  Grower Raphaël Pommier of the leading organic domain Notre Dame de Cousignac confirmed that most growers preferred to make IGP than AOC wine here – because sales are buoyant, and permitted yields are higher.  This may be one of those rare parts of wine-growing France where IGP will always have the upper hand over AOC – unless the appellation regulations are modified to permit varietal Chardonnay and Viognier.  That looks unlikely. A blend of equal portions of Grenache Blanc, Clairette and Marsanne, and grown at 150m.  Pretty scents of white almond, honeysuckle and pink grapefruit, with a fresh, pithy, cleanly defined palate.  Acid structured, but with some vinous warmth, too.  87 These ‘named village’ wines both come from the relatively confined valley of the Cèze, but there was little wine on show which seemed to be using the names, and none of it impressive.  I have, though, had tasty light reds from Chusclan in the past, and the terraces open out into the main Rhône valley at this point, so there is potential.  Chusclan is for red and rosé only, whereas St Gervais includes white too. This is a ‘named village’ on the move, and a name worth looking out for, especially for white wines: in the Southern Rhône, only Châteauneuf produces more white wine than Laudun (7,282 hl in 2016 compared to Laudun’s 3,766 hl – but Châteauneuf is more than six times larger than Laudun).  It was the whites of Laudun which the celebrated Ardechois writer and agricultural thinker Olivier de Serres picked out for praise in the early C17, and there’s lots more room for expansion here, considering that 81% of Laudun’s production is still red.  Its slopes, benches and terraces open up on to the main Rhône valley from the little river Tave. The blend here is 70 per cent Grenache Blanc with the balance from Clairette, Viognier and Roussanne.  Nettle-cream scents with a little exotic fruit, with ripe summer fruits on the palate and a pithy, sappy, lemony finish.  90 I had a chance to taste both this vintage and its predecessor, and both are excellent.  It’s very southern: a Clairette Blanc/Grenache Blanc blend, but all the better for that: apple, cucumber and fennel scents, with mouthfilling, creamy, aniseed-rich flavours with just enough ‘stony’ edge and ripe acidity to keep it fresh and vibrant; the creamy anis steals back into the finish.  91 I can’t resist mentioning this wine since it is pure Clairette: one of the traditional glories of the South of France, yet hard to find on its own.  It smells of fields of grain with a wild-herb drift behind, while the palate is clean, fresh and citrusy.  At just 12.5% I suspect it’s been picked a little too early, before the switch is flipped on Clairette’s full resonance.  Good all the same.   89 A complex blend (Clairette, Grenache, Marsanne, Roussanne, Viognier and Bourboulenc): perfume grass scents and a bright, focussed, fresh palate with plenty of drive and thrust to it.  There’s nothing evident about the flavours, though – a fruit and meadowflower mix in which no variety has the upper hand.  89 These two crus are best considered together.  The zones don’t overlap (Tavel lies south of Lirac), but since Tavel is for rosé alone, many producers have land in both areas and use Lirac for their reds and white, and Tavel for rosé.  I will look at the ‘gastronomic rosé’ of Tavel (and the challenge posed to it by the success of Provence’s ultra-pale rosés) on another occasion. Lirac is unquestionably the finest site on the Southern Rhône’s right bank for red wines, and in many ways it’s a great red in hiding, lurking in the shadows of Châteauneuf just across the river.  Lirac can’t quite match Châteauneuf’s finest sites for power, thrust and thunder – but you might not want that, preferring the softer and more velvety charms of Lirac, both concentrated and utterly beguiling on occasion.  There is a little limestone plateau land, but most Lirac vineyards are planted on the familiar rolled pebble soils and sands which you’ll also find over to the east, though they tend to lie a little lower here. Pure perfumed finesse: thyme, fennel, lavender, pine and cistus play through the wine, which is both soft and tender yet sustained and resonant.  92 Translucent in colour, with soft, ripe, savoury aromas and a deep-dropping flavour which combines plummy fruits and the complexities of laurel, thyme and lavender; softly and gracefully structured, too.  92 By the time I got to the Mordorée stand, samples of its outstanding Reine des Bois cuvée, an appellation benchmark, had been exhausted, but the ‘classique’ is impressive in the fine 2015 vintage, too: softly spiced mulberry and blackberry scents, with a palate of teased, nuanced ripeness, with tar, stone and resin behind those softly spicy fruits.   91 Regular readers may recall my recent blog about ‘the other Châteauneuf’ – Châteauneuf de Gadagne (http://www.decanter.com/wine-news/opinion/jefford-on-monday/gadagne-the-other-chateauneuf-354772/).  If there is a right-bank echo of Gadagne, it is probably Signargues, which is yet another set of rolled-pebble vineyards and sands linking four villages just a few kilometres west of Avignon.  The name (which is a plateau, not a village as such), I fear, will be a handicap; the easier-to-pronounce Saze or Rochefort might have been a better bet.  The quality potential for reds here looks good for those prepared to invest in quality. Ripeness seemed to be an issue for some of the Signargues reds, but not this wine, which has ample cherry-plum fruit in juicy, lip-smacking style.  There’s fresh acidity and relatively brisk tannins, so after Lirac you’d guess that the site has a little more elevation.  Plenty of classic Rhône spiciness to finsh.  90 My hunt around the right-bank appellations concluded with a look at this intriguing appellation, awarded after many years’ efforts in 2012.  Is it Rhône?  Is it Languedoc?  We’ve retreated well back from the river here, up into the Cévennes – and having tasted the wines, it seems to me that the Cévenol foothill identity might well be the most appropriate.  The words chosen, after all, by the growers themselves to describe their wines are ‘ciselés, aériens’ (chiselled and aerial).  Whites can work very well here (Mathilde Chapoutier has selected one such for her range), but only the most ambitious reds seem to get beyond a faintly green pepperiness at present. Blended principally from Roussanne and Viognier and given barrel-fermentation, this white deftly combined freshness and richness, while the perfumed summer-fruit notes were achieved with great subtlety.  89 Blended principally from Syrah (which looks happy here) and just 20% Grenache, both grown at over 300m, this has real mountain-fresh qualities with cola, coal and peppery notes.  Nonetheless there are some firm, structuring tannins, and the fruit has a mouth-coating quality.  88

News Article | May 5, 2017
Site: www.thedrinksbusiness.com

The Concept: Founded in 2004 Obica is a cheese-laden chain of casual Italian eateries, which counts sites across Italy, the US, UK and Japan, and claims to have been the first to offer a mozzarella bar concept. Chef Nancy Silverton recently credited the chain with providing the inspiration behind her LA restaurant Osteria Mozza in the latest Chef’s Table series on Netflix. Most recently, the chain has brought Italian chef Alessandro Borghese on board as its creative chef, developing a new menu, which has coincided with the opening of its latest London outpost in Poland Street, joining sites in Charlotte Street, South Kensington, St Pauls and Canary Wharf. The décor: Located in the heart of Soho, Obica Poland Street is divided into a front bar area with stools facing the street, giving the option of a more casual setting, leading to a smaller, more intimate dining room at the back. Clean lines, wooden tables and candlelight combine to create a sophisticated, yet fast-casual vibe. Below decks, the restaurant boasts an even larger second dining room. The food: The foundation of the chain’s cheesy menu is based on eight varieties of mozzarella di bufala campana DOP, which are infused throughout a wider menu of small plates, pizzas, pastas and salads. Dishes include Crochette di Patate e Cime di Rapa, croquettes stuffed with turnip greens, anchovies and smoked mozzarella, and zucchine alla scapece, a pretty plate of courgettes and mozzarella di bufala scattered with pine nuts. We started our evening with a selection of small plates. A wooden board of bresaola della Valtellina IGP (£6) – aged air-dried beef – was a triumph, arriving piled high with thin slices packed with flavour. Likewise the burrata al tartufo (£10.50), the pinnacle of its mozzarella cheese selection at £10.50 a pop, was a truffle-lovers dream, generously garnished and suitably smelling of the prized fungi, oozy and gooey at its centre. The baccala mantecato (£6.50) amounted to two mounds of whipped salt cod on corn chips with smoked mozzarella. They were devoured, a bit too quickly, with a hunk of oregano and sea salt focaccina (£5). Sadly the suppli al telefono (£4.50) – croquettes of breadcrumbed rice with mozzarella di bufala, tomato, pecorino romano and basil – failed to live up to expectations. The two croquettes that arrived to our table were disappointingly dry and lacked any real flavour. Five small plates between two, including bread, proved sufficient and didn’t seem excessive. Our mains proved to be more solid, with a nduja burrata pizza (£14), slathered with the spicy sausage and strewn with dollops of stracciatella di burrata, tomato and basil, was pizza perfection. Deeply favoured with a sweet spice, it had a memorable kick, without being overpowering, set off by a perfectly crisped base. A portion of fresh taglioni (£15.50), a reassuringly eggy-yellow in colour, arrived in a neatly piled twist, topped with a generous helping of tiger prawns, courgettes, tomatoes and fresh thyme. We capped off the meal with a “piccola” sbrisolona (£3) – a traditional crunchy almond ‘cake’ (in fact more like a biscuit) with passito and lemon mascarpone. A larger “grande” portion was available for £5.50. The dessert trophy however was handed to the “grande” tirimisu (£5) – a comforting bowl of creamy, gooey indulgence to cap off an Italian feast. Signature dishes: Mozzarella is the star of the show at Obica, with its mozzarella bar its signature act. Obica’s mozzarella Bar experience (£30), intended for 2-4 people to share, offers two portions of mozzarella (with its burrata with black truffle options an extra £4) with a platter consisting of cured meats, tomato and basil pesto, caponata, sundried tomatoes and a helping of focaccini. The drinks: Obica’s exclusively Italian wine list is compact but well formed, offering a reasonable but rather generic selection. Bottles start from £24 for a bottle of Piemonte Barbera DOC, with the majority of wines on its list available by the glass. We quaffed a glass of the Sicilia Insolia Terre Siciliane IGT at £7 a glass, and a glass of the Sicilia Nero d’Avola IGT, also £7. La Collezione Obica is reserved for its better offerings, and comprises two whites, including a £74 IGT white blend from Jermann in Friuli, and three reds, topped by a £105 bottle of Barbaresco DOCG from Sottimano in Piedmonte. The cocktail menu is packed with reliable favourites, including the classically Italian Aperol/Campari Spritz (£8) and the Promesa (£9) –  a twist on the whisky sour – a refreshingly light blend of whisky, Drambuie and lemon juice, walnut bitters and agave syrup. Who to know: The man of the moment, Alessandro Borghese, recently brought on board as the chain’s creative chef. Born in San Francisco, the Neapolitan chef is the son of Italian actress Barbara Bouchet and entrepreneur Luigi Borghese. A familiar face in Italy, Borghese is playfully referred to as the “rock’n social chef”. He judged the first Italian edition of Junior Masterchef on Sky TV, has hosted a number of his own TV shows; Alessandro Borghese 4 Ristoranti and Alessandro Borghese Kitchen Sound for Sky Italia, and published a number of cookery books. Last word: To call Obica an upmarket Pizza Express seems unfair – it’s more of a high-end Strada – far more polished and imaginative in its menu choices, which Borghese should be given full credit for, and offering a genuine point of difference in its mozzarella bar concept that will appeal and deliver to cheese purists. But those that enjoy the casual conviviality that comes with a Pollo Ad Astra or Sloppy Giuseppe will likely be first to be wooed through the door of Obica, and so the comparison is relevant. Obica is sophisticated, charming and approachable, and offers far more pizazz than its ubiquitous Italian pizza chain brethren. If you are looking for a generous, welcoming slice of Italian comfort food in the heart of Soho, then Obica fits the bill. Service by staff was impeccable, the location convenient and the menu creative, just don’t expect pizza chain prices. Three courses with wine costs around £50 per person.

News Article | December 8, 2016
Site: www.eurekalert.org

Antibody-based immunotherapy is a new promising method to treat cancer. Unfortunately, today's treatments can result in adverse side effects. New findings from Uppsala University show an alternative way to administer the therapy, which has the same effect on the tumour but less impact other parts of the body. In antibody-based immunotherapy drugs are used to stimulate the body's own immune cells to attack and destroy the tumour cells. This method is presently used to treat certain types of metastasised cancer, such as melanoma and bladder cancer. However, a disadvantage of the therapy is that the drug is injected in the blood, which will lead to an exposure of the whole body and thereby possible adverse events. An alternative strategy would be to administer the drug directly in or close to the tumour, provided that this still leads to the desired immune cell stimulation. In the present study a group of researchers, led by Sara Mangsbo at Department of Immunology, Genetics and Pathology, IGP, has demonstrated that a local immune activation in the tumour area had the same tumour inhibiting capacity as when the drug was delivered in the blood. 'We found that the therapy that we tested in a model system of bladder cancer could stimulate the immune cells to find and attack the cancer cells, even if it was administered locally. These results are very promising since they indicate that it's not necessary to activate the body's whole immune system, but only the one that is relevant in the tumour. This way adverse events caused by the drug can be reduced,' says Sara Mangsbo. In the study immune activation was achieved by administering blocking antibodies close to the tumour. The results complement the researcher's previous findings where they found that a direct immune stimulatory antibody had superior anti-tumour capacity when used locally at the tumour, as compared to after injection into the blood. The hope is also that the immune cells, not the drug itself, can find potential metastases and eliminate them. To understand if and how this is happening, further research is required. The present results are based on studies in mice and to determine if drug administration to the tumour results in fewer adverse events in patients, as compared to injections into the blood stream, clinical studies are also needed. The study is a collaboration with researchers in Lund and in Canada and was recently published in European Journal of Immunology. Luuk van Hooren et al, Local checkpoint inhibition of CTLA-4 as a monotherapy or in combination with anti-PD1 prevents the growth of murine bladder cancer, European Journal of Immunology november 2016, http://onlinelibrary. Sara Mangsbo, associated Professor and researcher at Department of Immunology, Genetics and Pathology (IGP), Uppsala university, sara.mangsbo@igp.uu.se, tel 070-425 08 78

News Article | November 21, 2016
Site: www.wired.com

Perú Sabancaya has been restless for the last two years, with periods of heightened activity and a return to quiet. However, it looks like the Peruvian volcano has entered a new phase of activity since early November. The volcano has produced dozens of explosive eruptions since November 6, when the renewed activity began. This first explosion generated an M3.6 earthquake as well. Ash has reached 1.5-3.5 kilometers (4,900-11,400 feet) over the volcano and spread ash over 40 kilometers (25 miles) from the volcano on the people living across the area. The ash plumes (see below) have been some of the highest ever recorded at Sabancaya and video from the explosions show a vigorous plume of dark grey ash from the volcano. Interestingly, the number of earthquakes is down some from late September and early October, possibly betraying the time for the magma to rise from depth into the volcano to cause these explosions. Deformation of the volcano continues, which supports the idea that magma is still rising into the edifice and sulfur dioxide emissions remain high (almost 3,000 tonnes/day), so all signs still point to continued likelihood of explosive eruptions. This continued threat means that a state of emergency has been declared across 23 districts around Sabancaya due to this ash hazard for the next 60 days. This area is a tourist destination, so any prolonged unrest at Sabancaya could impact that industry. The volcano remains on Yellow alert status. You can see the changing activity at Sabancaya on the webcam pointed at the crater. Sabancaya isn’t the only restless volcano in Peru right now, either. Ticsani has been experiencing earthquakes over the past few months that all suggest magma is moving into the volcano. The number of earthquakes has dropped some at Ticsani since earlier in the year, but harmonic tremor, a sure sign of magma movement, has increased over the past few weeks. However, deformation and degassing is low, so an eruption isn’t likely happening in the immediate future. The only known eruption of Ticsani was in ~1800 A.D. Ubinás has also had an eventful 2016, with numerous explosions from Peru’s most active volcano. Over the past few months, the volcano has had a couple bouts of seismicity that quieted during much of October. However, since the start of November, there have been numerous earthquakes, tremor and some explosions that sent ash ~1.5 km (4,900 feet) over the volcano. Those explosions coincided with a spike in sulfur dioxide emissions, all supporting the conclusions that new magma is rising into the volcano. You can check out the IGP webcam or INGEMMET webcam to see what’s going on at the restless Andean volcano. Further south, an explosive eruption on November 17 occurred at Nevados de Chillán that sent ash 1.2 kilometers (3,900 feet) over the volcano. This is one of a number of “ash puffs” that the volcano has produced over the last year, most of which were noticed thanks to the webcam pointed at the volcano. Nevados de Chillán remains at Yellow alert status. Meanwhile, M3.6 earthquake shook Hudson in southern Chile. The SERNAGEOMIN thinks the earthquake was related to fluid movement within the volcano, although it could be from hydrothermal activity rather than magma. The last eruption from Hudson was in 2011 and the 1991 eruption was a VEI 5, one of the largest of the 20th century.

News Article | December 6, 2016
Site: www.marketwired.com

ATLANTA, GA--(Marketwired - December 06, 2016) - Jacada Ltd. ( : JCDAF), a leading global provider of customer experience technology designed to simplify the interaction between businesses and their customers, announces that Israel Growth Partners (IGP), a Private Equity investment firm founded by two of Israel's most experienced global tech leaders, has invested in Jacada Ltd., becoming a major shareholder of the company. Known for seeking companies with valuable intellectual properties, IGP recognized Jacada's unique technology and valued its positioning for Visual IVR market leadership and other digital transformation solutions aiming to reduce the cost to serve customers while driving a seamless customer journey. "Enterprises around the world are looking to optimize their customer interactions across different channels to reduce costs and improve customers' satisfaction," said Haim Shani, Co-Founder and General Partner at IGP. "Jacada's innovative Visual IVR technology was chosen by leading tier-1 customers across several industries. Jacada possesses a dynamic interaction platform and many years of experience in complex multi-system environments. This is very relevant to address the market need for digital transformation." Haim Shani is the former Director General of the Israeli Ministry of Finance and former CEO of NICE Systems, which he led for 9 years as the company became a major global technology company. Following the investment, Haim Shani and Assaf Harel, a partner at IGP, joined Jacada's Board of Directors. "The recognition from IGP demonstrates Jacada's potential to become an industry leader in its field," says Guy Yair, Chief Executive Officer of Jacada. "We look forward to working with the leadership team at IGP to further accelerate Jacada's growth. Jacada Ltd. enables organizations to deliver effortless customer self-service and agent assisted interactions by implementing cutting-edge mobile, smart device, and web based visual IVR solutions, as well as optimized agent desktops, and business process optimization tools. Customers can benefit from an improved customer experience at every touch point with the organization, whether at the contact center, on the mobile device, the website, or at the retail store. Most Jacada deployments provide complete return on investment within the first three to seven months after deployment. Founded in 1990, Jacada operates globally with offices in Atlanta, USA; London, England; Munich, Germany; and Herzliya, Israel. More information is available at www.Jacada.com. Founded in 2014, Israel Growth Partners (IGP) is a Private Equity investment firm founded by Moshe Lichtman and Haim Shani and backed by leading financial institutions including banks, insurance companies and pension funds. IGP's mission is to provide growth capital, strategic guidance, and active involvement in Israeli-related technology companies benefiting from its founders' vast operational experience.

News Article | February 21, 2017
Site: cleantechnica.com

UK solar developer Island Green Power has teamed up with local Australian renewable energy developer Overland Sun Farming to construct three large-scale solar projects in Victoria’s north, which together will total 320 megawatts. Located in the north of Victoria, in the southeast of Australia, Island Green Power (IGP) and Overland Sun Farming (Overland) will construct three separate large-scale solar projects near the towns of Wemen, Yatpool, and Iraak. The three projects will total 320 megawatts (MW) together, and are expected to deliver enough clean electricity to power more than 600,000 homes. The projects are currently listed as “Shovel ready” by IGP, and have been granted council approval, as well as agreements signed with Powercor Australia to connect each of the projects to the state electrical grid upon completion. Construction is expected to start soon, and will be completed within 12 months. ‘‘As the input prices fall and future energy and Large-scale Generation Certificates (LGC’s) prices continue to remain high, the conditions are in place for investment,” said Island Green Power managing director Ian Lawrie. “The Overland/IGP team has the experience in delivering utility-scale renewable energy projects from start to finish, which will finally realise Victoria’s potential.” ‘‘Solar is Australia’s next great energy opportunity,” added Brett Thomas, Overland’s managing director. “We could see that Victoria’s north-west region was a fantastic opportunity for solar farming — it has the best solar radiation in the state and there is plenty of clear flat land. Construction is set to get underway later this year.” This is one of the first renewable energy development announcements to land in Australia this year, a year which the country’s Clean Energy Council is expecting to be a “huge year” for large-scale renewable energy development. Earlier this month the Council suggested that there is up to 2,250 MW worth of large-scale renewable energy under development, generating up to $5 billion in investments and almost 3,000 construction jobs this year alone. Reports are also floating around that London-based solar developer Eco Energy World has plans to build a 280 MW solar farm in the north of the country, near Bouldercombe, Queensland. Construction is expected to start as early as the third quarter, and EEW chairman Svante Kumlin expects energy storage to be added to the project in its second phase, entirely replacing the need for fossil fuel energy generation. Buy a cool T-shirt or mug in the CleanTechnica store!   Keep up to date with all the hottest cleantech news by subscribing to our (free) cleantech daily newsletter or weekly newsletter, or keep an eye on sector-specific news by getting our (also free) solar energy newsletter, electric vehicle newsletter, or wind energy newsletter.

News Article | December 23, 2016
Site: www.prlog.org

IGP.com, the largest online gift store of India offers a wide range of gifts to celebrate New Year. It is now possible to send exciting to your dear ones online no matter where they live in the world with excellent services of IGP.com.

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