San Diego, CA, United States
San Diego, CA, United States
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The present application provides compounds of Formula I or salt forms thereof, wherein R_(a), R_(b), R_(c), R_(d), D, W, R_(1a), R_(1b), R_(1c), Y, R_(3), X, E and G are as defined herein, compositions, methods of treatment and uses thereof.


Patent
Ignyta | Date: 2015-11-30

Disclosed are methods of treating neuroblastoma in a cancer patient by administration of a Trk inhibitor in combination with one more chemotherapeutic agents. Also disclosed are pharmaceutical compositions comprising a Trk inhibitor and one or more chemotherapeutic agents.


Patent
Ignyta | Date: 2017-03-10

The present invention is directed to bendamustine esters and bendamustine amides and their use for the treatment of cancer.


Patent
Ignyta and Nerviano Medical science S.r.l. | Date: 2016-12-28

Substituted indazole derivatives of formula (I) or formula 2.(I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.


Patent
Ignyta and NERVIANO MEDICAL science S.R.L. | Date: 2015-02-19

Substituted indazole derivatives of formula (I) or formula 2.(I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.


Patent
Ignyta and Cancer Research Technology Ltd | Date: 2015-03-25

The present application provides a compound of formula (I) and/or a salt thereof, wherein R^(1), G, and X are as defined herein. A compound of formula (I) and/or its salts have aPKC inhibitory activity, and may be used to treat proliferative disorders. Compositions comprising a compound of Formula (I) and/or a salt thereof are also provided.


This application relates to various salts and solid state forms of Compound (I). This application also relates to pharmaceutical compositions and therapeutic uses of these materials and compositions.


Patent
Ignyta | Date: 2016-06-16

The present invention is directed to bendamustine esters and bendamustine amides and their use for the treatment of cancer.


This application relates to various salts and solid state forms of Compound (I). This application also relates to pharmaceutical compositions and therapeutic uses of these materials and compositions.


Patent
Ignyta | Date: 2015-09-28

The present invention is directed to bendamustine esters and bendamustine amides and their use for the treatment of cancer.

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