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Moradabad, India

Verma N.,IFTM University | Verma N.,Bhagwant University | Chattopadhyay P.,Indian Defence Research And Development Laboratory
Tropical Journal of Pharmaceutical Research | Year: 2012

Purpose: To develop mucoadhesive patches for buccal administration of metoprolol succinate and to evaluate their in vitro and in vivo bioadhesion. Methods: The mucoadhesive buccal patches were prepared by solvent casting technique using two different mucoadhesive polymers. The formulations were tested for in vitro drug permeation studies, buccal absorption, in vitro drug release studies, moisture absorption as well as for in vitro and in vivo bioadhesion. Results: The peak detachment force and work of adhesion for MC5 (sodium carboxymethylcellulose, i.e., Na CMC) patch were 0.87 N and 0.451 mJ respectively and the corresponding values for CH5 (chitosan) were 5.15N and 0.987 mJ. Formulation CH5 (prepared with chitosan) showed 67.1 % release, while MC5 (Na CMC) showed drug release of 81.9 % in 6 h. Basic pharmacokinetic parameters such as Cmax, Tmax and AUCtotal varied statistically (p < 0.05) when given by the buccal route compared with that of the solution given by the oral route. Conclusion: The results indicate that formulation of suitable bioadhesive buccal patches with the desired permeability is feasible. The development of bioadhesive buccal formulation for metoprolol succinate with a lower dose and few side effects may be attainable. © Pharmacotherapy Group. All rights reserved. Source


Akhtar N.,IFTM University
Current Diabetes Reviews | Year: 2013

Diabetes Mellitus is a chronic metabolic disease affecting wide range of people across the globe. In India the rate of subjects being suffered from diabetes is continuously increasing. So, the development of drugs for its effective treatment is essential. Thereby, various attempts have been made to discover newer drugs, to reduce the rate of anti diabetic occurrence. Anti-diabetic drugs were found to treat diabetes mellitus by lowering glucose levels in the blood. Both the use antidiabetic drugs as well as the changes in lifestyle and proper diet can significantly affect the severity of diabetes mellitus and also reduces the symptoms and occurrence of the disease. Researches in the past few years on diabetes mellitus showed that this disease is spreading at a very faster rate, thereby; various attempts have been made to treat it efficaciously. Development and approval of antidiabetic drugs is quite necessary. There are different classes of anti-diabetic drugs reported to treat diabetes. The objective of the present review is to explore Invokana as a newly approved antidiabetic drug for the effective treatment of type 2 diabetes. This review focuses mainly on the various aspects of diabetes mellitus and its treatment perspectives. From the various clinical studies done on Invokana, it was concluded that and Invokana was found to be very effective for the efficacious therapy of diabetes mellitus. © 2013 Bentham Science Publishers. Source


Khandai M.,P.A. College | Chakraborty S.,Pharmacy Development | Ghosh A.K.,IFTM University
Powder Technology | Year: 2014

The objective behind this study is to ameliorate the flowability, compressibility and tableting properties of aceclofenac by developing a prolonged release microparticulate system using an algino-carbopol polymeric blend. Prepared microspheres were subjected to various physico-chemical studies along with in vitro drug release studies to optimize the concentration of the polymeric blend required to sustain the drug release for 12. h. Optimize formulation was further subjected to different flowability and compressibility studies to observe the impact of microspheres on improvements of flow properties. All the microsphere formulations exhibited good entrapment efficiency and showed prolonged drug release. SEM study revealed that the microspheres were almost spherical in shape with rough outer surface containing small pores. The findings of micromeritic studies suggested that the flowability and compressibility properties of the pure drug were significantly improved by the microsphere formulation. Heckel analysis also suggested that the microspheres exhibited better plasticity and die filling behavior as compared to pure drug. The tablets containing optimized microspheric formulation showed better handling properties than pure drug and no significant difference in drug release when compared with the marketed product. So the present study concluded that encapsulation of aceclofenac into microparticulate system not only enhanced its flowability, compressibility and tableting properties but also simultaneously helped to improve the patient compliance by sustaining the drug release for a prolonged period of time to manage pain and its symptoms. © 2013 Elsevier B.V. Source


Upadhyay S.,IFTM University | Singh V.,BBS Institute of Pharmaceutical and Allied science
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

Objective: Glycyrrhiza glabra is well known herb in Indian and Chinese traditional medicines. In our previous study it shows hair growth promoting property in female rats so here experiments were performed for evaluating its effects in androgenic alopecia in males. Methods: In present study alopecia is induced in three groups(each contain six animals) of male wistar albino rats by intramuscular dose(0.1mL) of testosterone.One group was rendered devoid of any other treatment while other two groups animals are treated with finasteride and petroleum ether extract of G. glabra root topically once daily. The animals were observed during treatment period of 21 days then one animal from each group was euthanized for histoarchitecture study. Results: The study revealed that petroleum ether and finasteride treated animals do not developed alopecia while alopecia was observed in only testosterone treated animals. Conclusion: Thus it is concluded from this study that petroleum ether extract of G. glabra posses anti androgenic alopecia activity which is comparable to that of standard drug recommended for androgenic alopecia finasteride. Source


Nayak A.K.,Seemanta Institute of Pharmaceutical science | Pal D.,IFTM University
International Journal of Biological Macromolecules | Year: 2012

This work investigates the development, optimization and in vitro evaluation of liquid paraffin-entrapped multiple-unit alginate-based floating system containing cloxacillin by emulsion-gelation method for gastro retentive delivery. The effect of process variables like drug to polymer ratio by weight, and liquid paraffin to water ratio by volume on various physicochemical properties in case of liquid paraffin-entrapped calcium alginate beads containing cloxacillin applicable to drug entrapment efficiency, density and drug release was optimized using 3 2 factorial design and analyzed using response surface methodology. The observed (actual values) responses were coincided well with the predicted values, given by the optimization technique. The optimized beads showed drug entrapment efficiency of 64.63±0.78%, density of 0.90±0.05g/cm 3, and drug release of 56.72±0.85% in simulated gastric fluid (pH 1.2) after 8h with floating lag time of 8.45min and floated well over 12h in simulated gastric fluid (pH 1.2). The average size of all dried beads ranged from 1.73±0.04 to 1.97±0.08mm. The beads were characterized by SEM and FTIR for surface morphology and excipients-drug interaction analysis, respectively. All these beads showed prolonged sustained release of cloxacillin over 8h in simulated gastric fluid (pH 1.2). The cloxacillin release profile from liquid paraffin beads followed Korsmeyer-Peppas model over a period of 8h with anomalous (non-Fickian) diffusion mechanism for drug release. © 2011 Elsevier B.V. Source

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