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Calderon E.J.,CIBER ISCIII | Dei-Cas E.,Ifr 142 Institute Pasteur Of Lille
Expert Review of Anti-Infective Therapy | Year: 2010

A Commemorative Conference of Pneumocystis Discovery First Centenary was held in Brussels, Belgium, on 5-6 November 2009. A total of 16 keynote speakers from different countries attended the meeting. This conference has allowed the principal European and non-European groups who are working on Pneumocystis infection to gather together, in order to expose the most recent advances accomplished in the basic and translational scientific knowledge of Pneumocystis infection, and to discuss the trends of future research in this area. © 2010 Expert Reviews Ltd.

Dei-Cas E.,Parasitology Mycology Service | Dei-Cas E.,Ifr 142 Institute Pasteur Of Lille | Dei-Cas E.,Institute Pasteur Of Lille | Aliouat C.-M.,University of Lille Nord de France | And 4 more authors.
NATO Science for Peace and Security Series A: Chemistry and Biology | Year: 2010

Foodborne parasites have usually environmental infectious stages. In developing countries, high concentrations of parasite infectious forms contaminate the environment entailing high prevalence of foodborne parasitic diseases with significant impact on health and economy. Complex interactions among exposure to contaminated food and water, disease, poverty and malnutrition take place. In developed countries, food- or waterborne parasitic infections keep also a considerable importance, as shown by the persistence of infectious water- or foodborne outbreaks and the occurrence of infections due to emergent or reemergent eukaryotic pathogens. Since parasite infections are usually rare in developed areas, a breakdown in prevention measures and specific health staff training often occur. Most emerging or reemerging parasite species are agents of foodborne infections. Considering only parasite "protists", most emerging or reemerging species can be foodborne, waterborne or contagious as Giardia, Cryptosporidium species or, likely, Microsporidia. These pathogens belong to taxonomically unrelated Eukaryotic groups but they share common features: (a) mostly monoxenous; (b) ubiquitous; (c) challenging taxonomy; (d) unclear notions on transmission, infection source or reservoir; (e) highly resistant infectious life stages; (f) lack of efficient experimental models; (g) uncertain pathogenic power to immunocompetent hosts. Regarding emerging or reemerging helminthes, those transmitted by foodborne route are: Anisakis simplex, Echinococcus granulosus, Diphyllobothrium species, Metorchis conjunctus, Taenia solium and Trichinella spiralis. To consume exotic meals could increase foodborne parasitic risk in Europe. Although common representations of human daily life show a humanity that has in some way "escaped" from ecosystems, men take on their role of top level consumers, and are therefore exposed to the associated highly diversified parasitological risk. © Springer Science+Business Media B.V. 2010.

Creusy C.,Groupe Hospitalier Of Luniversite Catholique Of Lille | Certad G.,Ifr 142 Institute Pasteur Of Lille | Certad G.,Central University of Venezuela | Guyot K.,Ifr 142 Institute Pasteur Of Lille | Dei-Cas E.,Ifr 142 Institute Pasteur Of Lille
NATO Science for Peace and Security Series A: Chemistry and Biology | Year: 2010

In the last years a large number of infectious agents including virus, bacteria and parasites have been identified as direct causes or as risk factors to specific cancers around the world. Among the parasites linked to oncogenesis in humans there are strong associations. Particularly, Schistosoma haematobium is usually recognized as a cause of urinary bladder carcinoma. Some hepatic and colorectal cancers have been linked to infection by S. japonicum or S. mansoni. Moreover, a high proportion of cholangiocarcinoma in Far-East countries was imputable to Opisthorchiidae liver flukes. Among the parasitic Protists, the Apicomplexan Theileria annulata and T. parva, which are the agents of theileriosis in cows, induce often lethal lymphoproliferative process in these animals. The association between Cryptosporidium and digestive carcinomas has also been reported in a clinic study in Poland. More recently, the ability of C. parvum to induce neoplastic changes was established experimentally. This model revealed that C. parvum strains are able to induce gastrointestinal intraepithelial neoplasia in dexamethasone-treated SCID mice. Neoplastic lesions spread often to more than one digestive organ, and severity correlated with the inoculum size and the duration of the infection. Further studies are needed in order to characterize this process in mice, and to explore its occurrence in human cryptosporidiosis. © Springer Science+Business Media B.V. 2010.

Dumas D.,University of Lorraine | Hupont S.,University of Lorraine | Huselstein C.,University of Lorraine | De Isla N.,University of Lorraine | And 5 more authors.
Bio-Medical Materials and Engineering | Year: 2012

For this study, we have considered a new large field of view imaging dedicated to matrix collagen (no stained samples). To integrate a multidimensional scale (non-sliced samples), a femtosecond oscillator (two photon excitation laser) has been coupled with a large field optical setup to collect SHG signal. We introduced an index (F-SHG) based on decay time response measured by TCSPC for, respectively, Fluorescence (F) and Second Harmonic Generation (SHG) values. For samples where protein collagen is the major component of extracellular matrix (skin) or not (nacre), we compared the index distribution (from 2 to 12) obtained with large field optical setup. In this work, we showed for the first time that multiscale large field imaging combined to multimodality approaches (SHG-TCSPC) could be an innovative and non invasive technique to detect and identify some biological interest molecules (collagen) in biomedical topics. © 2012-IOS Press and the authors. All rights reserved.

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