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Firenze, Italy

Russo S.,Azienda Sanitaria Firenze | Masi L.,IFCA | Francescon P.,Ospedale di Vicenza | Frassanito M.C.,Citta di Bari Hospital spa | And 9 more authors.
Physica Medica | Year: 2016

Purpose: The aim of the present work was to evaluate small field size output factors (OFs) using the latest diamond detector commercially available, PTW-60019 microDiamond, over different CyberKnife systems. OFs were measured also by silicon detectors routinely used by each center, considered as reference. Methods: Five Italian CyberKnife centers performed OFs measurements for field sizes ranging from 5 to 60mm, defined by fixed circular collimators (5 centers) and by Iris™ variable aperture collimator (4 centers). Setup conditions were: 80cm source to detector distance, and 1.5cm depth in water. To speed up measurements two diamond detectors were used and their equivalence was evaluated. MonteCarlo (MC) correction factors for silicon detectors were used for comparing the OF measurements. Results: Considering OFs values averaged over all centers, diamond data resulted lower than uncorrected silicon diode ones. The agreement between diamond and MC corrected silicon values was within 0.6% for all fixed circular collimators. Relative differences between microDiamond and MC corrected silicon diodes data for Iris™ collimator were lower than 1.0% for all apertures in the totality of centers. The two microDiamond detectors showed similar characteristics, in agreement with the technical specifications. Conclusions: Excellent agreement between microDiamond and MC corrected silicon diode detectors OFs was obtained for both collimation systems fixed cones and Iris™, demonstrating the microDiamond could be a suitable detector for CyberKnife commissioning and routine checks. These results obtained in five centers suggest that for CyberKnife systems microDiamond can be used without corrections even at the smallest field size. © 2016 Associazione Italiana di Fisica Medica. Source

Zaja F.,Clinica Ematologica | Baldini L.,University of Milan | Ferreri A.J.M.,San Raffaele Scientific Institute | Luminari S.,University of Modena and Reggio Emilia | And 5 more authors.
Annals of Hematology | Year: 2013

Treatment of relapsed/refractory T cell neoplasms represents an unmet medical need. We recorded, retrospectively, data on 20 consecutive adult patients with T cell neoplasms (8 T cell lymphoma not otherwise specified (T-NOS), 4 angioimmunoblastic (AILT), 3 prolymphocytic leukemia (T-PLL), 3 advance-stage mycosis fungoides (MF) or Sézary syndrome (SS), and 2 T cell large granular lymphocytic leukemia (T-LGL)), treated with bendamustine. Partial (PR) and complete response (CR) rates were reached in nine (45 %) and two (10 %) patients, respectively, including three PR in T-NOS, one CR in AILT, three PR in T-PLL, two PR in MF/SS, and one CR and one PR in T-LGL lymphoma. The 6 months estimated progression free and overall survival was 44 and 67 %, respectively. Grade 3-4 neutropenia and thrombocytopenia were registered in 44 and 25 % of cases. Four patients developed major infectious complications. At a median follow-up of 6 months (range 1-18), 13 patients are alive and 7 patients died all because of lymphoma progression. Bendamustine deserves further investigation in patients with T cell neoplasms. © 2013 Springer-Verlag Berlin Heidelberg. Source

Martinez Rivero C.,IFCA
EPJ Web of Conferences | Year: 2013

In this talk, the latest results from CMS and ATLAS on searches for new physics with multiple leptons in the final state are presented using up to 20/fb of data from the 8 TeV LHC run of 2012. Interpretation of results in terms of SUSY searches for production of gauginos and sleptons are shown. For RP conserving models, both neutralinos and gravitinos as lightest supersymmetric particles are considered. © 2013 Owned by the authors, published by EDP Sciences. Source

Cianchi F.,University of Florence | Trallori G.,University of Florence | Mallardi B.,ISPO | Macri G.,University of Florence | And 11 more authors.
BMC Surgery | Year: 2015

Background: Some recent studies have suggested that laparoscopic surgery for colorectal cancer may provide a potential survival advantage when compared with open surgery. This study aimed to compare cancer-related survivals of patients who underwent laparoscopic or open resection of colon cancer in the same, high volume tertiary center. Methods: Patients who had undergone elective open or laparoscopic surgery for colon cancer between January 2002 and December 2010 were analyzed. A clinical database was prospectively compiled. Survival analysis was calculated by using the Kaplan-Meier method. Results: A total of 460 resections were performed. There were no significant differences between the laparoscopic (n∈=∈227) and the open group (n∈=∈233) apart from tumor stage: stage I tumors were more frequent in the laparoscopic group whereas stage II tumors were more frequent in the open group. The mean number of harvested lymph nodes was significantly higher in the laparoscopic than in the open group (20.0∈±∈0.7 vs 14.2∈±∈0.5, P∈<∈0.01). The 5-year cancer-related survival for patients undergoing laparoscopic resection was significantly higher than that following open resections (83.1% vs 68.5%, P∈=∈0.01). By performing a stage-to-stage comparison, we found that the improvement in survival in the laparoscopic group occurred mainly in patients with stage II tumors. Conclusions: Our study shows a survival advantage for patients who had undergone laparoscopic surgery for stage II colon cancer. This may be correlated with a higher number of harvested lymph nodes and thus a better stage stratification of these patients. © 2015 Cianchi et al.; licensee BioMed Central. Source

Sanchez-Portal M.,ESAC INSA | Pintos-Castro I.,IAC | Perez-Martinez R.,ESAC INSA | Cepa J.,IAC | And 5 more authors.
Revista Mexicana de Astronomia y Astrofisica: Serie de Conferencias | Year: 2013

Aimed at understanding the evolution of galaxies in clusters, the GLACE survey is mapping a set of key optical lines in several galaxy clusters at z∼0.40, 0.63 and 0.85, using the Tunable Filters (TF) of the OSIRIS instrument. This study will address key questions about the physical processes acting upon the infalling galaxies during the course of hierarchical growth of clusters. © 2013: Instituto de Astronomía, UNAM - Fourth Science Meeting with the GTC Ed. C. Muñoz-Tuñón & J. M. Rodríguez-Espinosa. Source

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