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Sauri J.,University of Barcelona | Millan D.,Laboratory Kern Pharma | Sune-Negre J.M.,University of Barcelona | Sune-Negre J.M.,IDIBELL UB Research Group Pharmacotherapy | And 11 more authors.
International Journal of Pharmaceutics | Year: 2014

The SeDeM diagram expert system has been used to study excipients, Captopril and designed formulations for their galenic characterization and to ascertain the critical points of the formula affecting product quality to obtain suitable formulations of Captopril direct compression SR matrix tablets. The application of the SeDeM diagram expert system enables selecting excipients with in order to optimize the formula in the preformulation and formulation studies. The methodology is based on the implementation of ICH Q8, establishing the design space of the formula with the use of experiment design, using the parameters of the SeDeM diagram expert system as system responses. © 2013 Elsevier Ltd. All rights reserved.

Sarrate R.,University of Barcelona | Tico J.R.,University of Barcelona | Tico J.R.,IDIBELL UB Research Group Pharmacotherapy | Minarro M.,University of Barcelona | And 9 more authors.
Powder Technology | Year: 2015

This study investigates the effect of pneumatic spray drying using a two fluid nozzle on pharmaceutical excipients used in compression analyzing, modifications in the morphology, particle size and particle size distribution. The pharmaceutical excipients selected were classified into three groups according to their solubility in water: excipients that are soluble in water, partially soluble in water, and practically insoluble in water. Both spray drying conditions and properties of the liquid to be atomized were established for each of the excipients studied. The results obtained, in terms of the characterization of particles, were different depending on the excipient and the group to which they belonged. Properties such as flowability and compressibility that pertain to bulk level of solid state are strongly influenced by changes in characteristics at the particle level, such as size, size distribution and morphology of particles, which is the subject of study in this investigation. © 2014 Elsevier B.V.

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