Idibell Institute Dinvestigacio Biomedica Of Bellvitge

Spain

Idibell Institute Dinvestigacio Biomedica Of Bellvitge

Spain
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Zamora N.P.,Hospital Of Bellvitge | Sugranes D.C.,Hospital Of Bellvitge | Cabaleiro N.M.,Hospital Of Bellvitge | Suriol A.F.,Idibell Institute Dinvestigacio Biomedica Of Bellvitge | Masanes R.J.,Hospital Of Bellvitge
Farmacia Hospitalaria | Year: 2013

Objective: To assess the efficacy and safety profile of omalizumab treatment. The conditions under which omalizumab was prescribed agreed with those in Xolair® drug information: age > 12 years old, severe uncontrolled asthma, FEV1 < 80%, IgE 30-700 UI/ml and positive test results for perennial allergens. Methods: Asthmatic patients treated with omalizumab between January 2010 and July 2011 were evaluated retrospectively. Age, sex, weight, IgE level, concomitant asthma medications, change in FEV 1, emergency department visits, hospitalizations, asthma exacerbations and corticosteroids bursts were recorded before and after omalizumab initiation. A 1.5- year period was chosen. Results: A total of 22 patients were included. The mean weight of subjects was 73 Kg (range, 51-102). Mean IgE was 203 UI/ml (range, 30-992) and mean FEV1 60% (range, 30-93%) at baseline. Adverse events were observed in 4 patients. There were no significant changes in FEV1 values after omalizumab treatment but omalizumab was associated with a reduction in concomitant asthma medications use in 14 patients and improvements in global asthma control in 12. Conclusion: In these patients add-on therapy with omalizumab reduced asthma exacerbations and emergency visits or hospitalizations. Only 55% of patients significantly improved global asthma control and no significant changes in FEV1 were observed.mejoría global según criterios clínicos y no se observaron cambios estadísticamente significativos en la FEV 1.

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