Rich R.L.,University of Utah |
Quinn J.G.,ICx Technologies |
Morton T.,Biologic Software Pty Ltd. |
Stepp J.D.,Genzyme |
Myszka D.G.,University of Utah
Analytical Biochemistry | Year: 2010
We have developed a novel analyte injection method for the SensíQ Pioneer surface plasmon resonance-based biosensor referred to as " FastStep." By merging buffer and sample streams immediately prior to the reaction flow cells, the instrument is capable of automatically generating a two- or threefold dilution series (of seven or five concentrations, respectively) from a single analyte sample. Using sucrose injections, we demonstrate that the production of each concentration within the step gradient is highly reproducible. For kinetic studies, we developed analysis software that utilizes the sucrose responses to automatically define the concentration of analyte at any point during the association phase. To validate this new approach, we compared the results of standard and FastStep injections for ADP binding to a target kinase and a panel of compounds binding to carbonic anhydrase II. Finally, we illustrate how FastStep can be used in a primary screening mode to obtain a full concentration series of each compound in a fragment library. © 2010 Elsevier Inc. Source
Flir Detection Inc. and ICx Technologies | Date: 2011-05-31
electronic sensing instruments for detecting trace chemicals, hydrogen peroxide, explosives, liquid explosives, liquids used in making explosives, and explosive components.
ICx Technologies | Date: 2010-06-23
A method for linearizing a radiation detector is provided, the method including measuring a pulse height spectrum of a predetermined radiation source, identifying at least one spectrum template for the predetermined radiation source, and determining a linearization function by comparing the measured pulse height spectrum with the at least one identified spectrum template. The at least one spectrum template is a predefined synthesized energy spectrum for the predetermined radiation source and for the corresponding radiation detector. Further, a detector for measuring one or more types of radiation is provided, the detector being adapted for transforming the measured pulse height spectrum in an energy-calibrated spectrum, the transformation including a linearization step, where a linearization function used with the linearization step is determined according to the inventive method.
ICx Technologies | Date: 2010-08-03
Laser detectors for security identification of unknown chemical compounds, namely, explosives, narcotics and other hazardous materials in the field of monitoring of commercial, military and industrial sites; lasers for industrial and commercial use, namely, lasers not for medical use; lasers and laser detectors for the detection of chemicals, compounds, gases and biological materials, not for medical purposes; electric or electronic sensors, namely, motion sensors, temperature sensors, acoustic sensors, infrared sensors, passive millimeter wave imaging sensors, electromagnetic radiation sensors, magnetic gradient measurement sensors; radar; range finders; computer software for the collection, editing, organizing, modifying, book marking, transmission, storage and sharing of data and information; facilities management software, namely, software to control building environmental, access, and security system; closed circuit television monitors; electric and electronic video surveillance installations; electric or electronic emitters not for medical purposes, namely, light emitters in the nature of disorienting non-lethal deterrents, infrared and ultraviolet emitters in the nature of friend or foe devices in the fields of military industrial and commercial use. Business management and consultation; business management and consultation in the fields of security, detection and surveillance.
ICx Technologies | Date: 2011-05-24
testing instruments used in analyzing and detecting pathogens, toxins, nucleic acids and proteins for scientific and medical research and facility security; detection devices, namely, instruments using rapid polymerase chain reaction and rapid immonoassay used in analyzing and detecting pathogens, toxins, nucleic acids and proteins for scientific and medical research and facility security.