Belgrade, Serbia
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Drakulic B.J.,ICTM | Milenkovic M.,University of Belgrade
Journal of the Serbian Chemical Society | Year: 2012

Five new dioxomolybdenum(VI) complexes of the general formula [MoO2(Rdtc)2], 1-5, where Rdtc- refer to piperidine (Pipdtc), 4-morpholine (Morphdtc), 4-thiomorpholine (Timdtc), piperazine (Pzdtc) or N-methylpiperazine (N-Mepzdtc) dithiocarbamates, respectively, have been prepared. The complexes were characterized by elemental analysis, conductometric measurements, electronic, IR and NMR spectroscopy. The complexes 1-5 contain a cis-MoO2 group and have an octahedral geometry. Two dithiocarbamato ions join as bidentates with both the sulfur atoms to the molybdenum atom. The presence of different heteroatoms in the piperidin? moiety influences the ?(C N) and ?(C S) vibrations, which wavelengths decrease in the order: Pipdtc > N- -Mepzdtc > Morphdtc > Pzdtc > Timdtc ligands. Based on their spectral data, the molecular structures of complexes 1-5 were optimized at the semi-empirical molecular-orbital level, and the geometries, as obtained from calculations, are described. The antimicrobial activities of the complexes were tested against nine different laboratory control strains of bacteria and two strains of the yeast Candida albicans. All the tested strains were sensitive. Complexes bearing heteroatom in position 4 of piperidine moiety were significantly more potent against the tested bacteria compared to the corresponding ligands. Copyright 2012 (CC) SCS.


Sakan S.M.,ICTM | DorDevi D.S.,ICTM | Lazic M.M.,University of Belgrade | Tadic M.M.,University of Belgrade
Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering | Year: 2012

The purpose of this study was to examine the levels of As and Hg and mobility of these contaminants in the sediments of the River Tisa and canal sediments (alluvial formation of the Danube River, Serbia), in order to determine the degree to which the ecosystem is harmed by these pollutants. The sequential extraction procedure (modified Tessier method) was used to extract the metals from the sediments. Arsenic is extracted in the second, third and fifth fraction, with dominant extraction in the second fraction. This distribution indicates that As is significantly present in the form of carbonates, whereas the part of As is present in the form of oxides. The most important extraction of Hg is in the fifth stage (extraction with 6M HCl), with over 80 % of extracted element in both types of sediment, indicating a strong association between Hg and Fe crystalline oxides as well as presence of Hg in the form of sulfides. Based on arsenic and mercury content in sediments and results of sequential extraction it can be concluded that on the studied localities there is no significant As and Hg contamination. © 2012 Copyright Taylor and Francis Group, LLC.


Popovic-Djordjevic J.B.,University of Belgrade | Vitnik V.D.,ICTM | Vitnik Z.J.,ICTM | Ivanovic M.D.,University of Belgrade
Hemijska Industrija | Year: 2015

Glutarimides, 2,6-dioxopiperidines, are compounds that rarely occur in natural sources, but so far isolated ones exert widespread pharmacological activities, which makes them valuable as potential pharmacotherapeutics. Glutarimides act as androgen receptor antagonists, anti-inflammatory, anxiolytics, antibacterials, and tumor suppressing agents. Some synthetic glutarimide derivatives are already in use as immunosuppressive and sedative (e.g., thalidomide) or anxiolytics (buspirone) drugs. The wide applicability of this class of compounds, justify the interest of scientists to explore new pathways for its syntheses. General methods for synthesis of six-membered imide ring are presented in this paper. These methods include: a) reaction of dicarboxylic acids with ammonia or primary amine, b) reactions of cyclization: amido-acids, diamides, dinitriles, nitrilo-acids, amidonitriles, amido-esters, amidoacyl-chlorides or diacyl-chlorides, c) addition of carbon-monoxide on α,β-unsaturated amides, d) oxidation reactions, e) Michael addition of active methylen compounds on methacrylamide or conjugated amides. Some of the described methods are used for closing glutarimide ring in syntheses of pharmacological active compounds sesbanimide and aldose reductase inhibitors (ARI). Analyses of the geometry, as well as, the spectroscopic analyses (NMR and FT-IR) of some glutarimides are presented due to their broad spectrum of pharmacological activity. To elucidate structures of glutarimides, geometrical parameters of newly synthesized tert-pentyl-1-benzyl-4-methyl-glutarimide-3-carboxylate (PBMG) are analyzed and compared with the experimental data from X-ray analysis for glutarimide. Moreover, molecular electrostatic potential (MEP) surface which is plotted over the optimized geometry to elucidate the reactivity of PBMG molecule is analyzed. The electronic properties of glutarimide derivatives are explained on the example of thalidomide. The Frontier Molecular Orbital (FMO) and their energies are presented, as well as the energy gap between them. © 2015, Association of Chemists and Chemical Engineers of Serbia. All rights reserved.


News Article | December 9, 2015
Site: www.materialstoday.com

The Fraunhofer Institutes for Production Technology IPT and Laser Technology ILT, and RWTH Aachen University’s Laboratory for Machine Tools and Production Engineering (WZL) have launched the International Center for Turbomachinery Manufacturing (ICTM) in Aachen together with 19 renowned industrial partners. The center will focus on research relating to the repair and manufacturing of turbomachines, and, according to one partner, will be used in part to research 3D printing for turbine manufacture. The industrial partners in the new network include turbine manufacturers as well as corporations and medium-sized companies. Another company is interested in improving the surface quality of aerospace components made of titanium. This story is reprinted from material from Fraunhofer Institute, with editorial changes made by Materials Today. The views expressed in this article do not necessarily represent those of Elsevier.


Ilic S.B.,University of Niš | Konstantinovic S.S.,University of Niš | Savic D.S.,University of Niš | Veljkovic V.B.,University of Niš | Gojgic-Cvijovic G.,ICTM
Medicinal Chemistry Research | Year: 2010

A media consisting of isatin-Schiff bases (isatin-3-thiosemicarbazone, isatin-3-semicarbazone, and isatin-3-phenylhydrazone) was developed to maximize the production of antibiotics Hexaene H-85 and Azalomycine B by Streptomyces hygroscopicus. The media isatin-3-thiosemicarbazone resulted in the maximum antibiotics concentration of 372 μg cm-3 for Hexaene H-85 and 118 μg cm-3 for Azalomycine B. The impact of modified media on soil morphology also was investigated. © The Author(s) 2009.


Krstic J.,ICTM
Environmental Earth Sciences | Year: 2011

Technological development brought a number of advantages and conveniences to the modern life, but also brought many problems, environment pollution above all. Although a number of methods for water refining are already developed, there is still a demand to find a more efficient, cheaper and ecologically more acceptable sorbents. Possibility of using bentonite as naturally occurring material for methylene blue (MB) removal from its aqueous solutions was investigated in this paper. Characterization of starting material has been conducted by chemical analysis, XRD, particle size analysis, and N2 physisorption at -196C. The influence of the acidity of the initial MB solution on bentonite sorption characteristic was examined. Equilibrium sorption isotherms were determined. It was shown that with increase of pH and temperature the amount of sorbed MB increases. © Springer-Verlag Berlin Heidelberg 2011.


PubMed | ICTM
Type: Journal Article | Journal: Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering | Year: 2012

The purpose of this study was to examine the levels of As and Hg and mobility of these contaminants in the sediments of the River Tisa and canal sediments (alluvial formation of the Danube River, Serbia), in order to determine the degree to which the ecosystem is harmed by these pollutants. The sequential extraction procedure (modified Tessier method) was used to extract the metals from the sediments. Arsenic is extracted in the second, third and fifth fraction, with dominant extraction in the second fraction. This distribution indicates that As is significantly present in the form of carbonates, whereas the part of As is present in the form of oxides. The most important extraction of Hg is in the fifth stage (extraction with 6M HCl), with over 80 % of extracted element in both types of sediment, indicating a strong association between Hg and Fe crystalline oxides as well as presence of Hg in the form of sulfides. Based on arsenic and mercury content in sediments and results of sequential extraction it can be concluded that on the studied localities there is no significant As and Hg contamination.

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