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Paris, France

Wells T.N.C.,ICC Inc
Infectious Disorders - Drug Targets | Year: 2013

A steady increase in the number of antimalarial drug candidates since 2007 follows a call to eradicate malaria from the World Health Organization (WHO), the Bill and Melinda Gates Foundation and others. Four new fixed dose combination medicines have been approved by stringent authorities or the WHO in as many years. OZ439, a synthetic endoperoxide currently in Phase II, could reduce treatment to a single dose. Significant challenges remain: while drugs to treat patients suffering from malaria are essential, drugs focused on breaking the lifecycle between human and mosquito host are needed. Effective medicines that are easy to take in the field are needed, together with treatments for infants and for women in the first trimester of pregnancy. Research has concentrated on Plasmodium falciparum infection but there is a need for medicines that prevent relapses of P. vivax infection. In addition, the evolution of pathogen resistance against established drugs poses a threat to existing medicines. Direct testing of compounds against whole parasites as well as target approaches has accelerated the process of drug discovery, and identified new classes of compounds. The most advanced of these, spiroindolone, already in clinical development, kills the blood stages of both P. falciparum and P. vivax by a mechanism unrelated to any current antimalarial. The collaborative model of drug discovery between the Medicines for Malaria Venture, pharmaceutical companies and academic institutions has resulted in the construction of a promising pipeline of new classes of compounds, focused on the needs of the patient. © 2013 Bentham Science Publishers.

Briefly, the present invention relates to a cigarette lighter adapter (CLA) configured to be received in a CLA socket in a vehicle. The CLA includes a positive contact and a negative contact and housing, for example, a plastic housing. The negative contacts are formed as springs, which extend from the housing and are configured to exert spring force against an interior wall of a socket to assure a solid connection. The positive contact is also formed as a spring and is connected in series with a thermal sensor. In accordance with an important aspect of the invention, the thermal sensor, for example, a bi-metallic strip, is in thermal contact with a tip, which is serially connected to the positive contact and which extends outwardly from the plastic housing, the thermal sensor causes the CLA to be disconnected from the socket when an excessive temperature is sensed. The thermal sensor is selected to disconnect the CLA from the socket at a safe temperature, for example, a temperature below the melting temperature of the plastic housing. In accordance with another important aspect of the invention, the positive contact is formed as a spring which is connected by way of soldering to a printed circuit board, thermal sensor and the tip in order to eliminate high resistance pressure contact connections.

ICC Inc | Date: 2015-05-04

The invention relates to a power management system for supplying backup DC power to peak and/or high current demand battery applications, such as motor starting or an uninterruptible power supply (UPS) used to power a critical load, such as, a data bus or other critical load, after an event, such as loss of primary AC or DC input, during relatively cold ambient temperatures. Two or more heaters may be provided; for example, a low power heater and a high power heater. In a maintenance mode, the low power heater is used to maintain the batteries at a predetermined temperature. In this mode, the battery charger is used to power the low power heater. In a boost mode, after the primary AC or DC input is restored, and the battery temperature is too low to back up the critical load, the battery charger supplies power to one or both of the heaters. Since the capacity of the battery charger is normally insufficient to heat the batteries to an acceptable operating temperature in a relatively short period of time, a portion of the residual power from the batteries is used to boost the power to the heaters in order to speed up the time to get the battery to its rated operating temperature.

A multiple cell battery charger configured with a parallel topography is disclosed. In accordance with an important aspect of the invention, the multiple cell battery charger requires fewer active components than known battery chargers while at the same time protecting multiple battery cells from overcharge and discharge. The multiple cell battery charger in accordance with the present invention is a constant voltage battery charger that includes a regulator for providing a regulated source of direct current (DC) voltage to the battery cells to be charged. In accordance with the present invention, each battery cell is connected in series with a switching device, such as a field effect transistor (FET) and optionally a current sensing device. In a charging mode, the serially connected FET conducts, thus enabling the battery cell to be charged. The battery voltage is sensed by a microprocessor. When the microprocessor senses that the battery cell is fully charged, the FET is turned off, thus disconnecting the battery cell from the circuit. Since the battery cell is disconnected from the circuit, no additional active devices are required to protect the battery cell from discharge. As such, a single active device per cell, such as the FET, provides multiple functions without requiring additional devices. Accordingly, the battery charger in accordance with the present invention utilizes fewer active components than known battery chargers and is thus much less be expensive to manufacture.

News Article | June 18, 2015
Site: www.vanguardngr.com

Senator Rabiu Kwankwaso immediate past governor of Kano State in this interview with newsmen in Abuja gives his views on the crisis arising from the National Assembly leadership contest. Excerpts: You were one of the senators at the ICC when the leadership contest started in the National Assembly? Honestly speaking, it was on the morning of that day that I saw a text message that we should go to the ICC, unfortunately for me I had so many people who came from Kano, so I was trying to receive them when I got a call that members and senators were waiting at the ICC. As I was moving out of Hilton Hotel, somebody called again that they were at the National Assembly and were just about to start election. So I diverted the driver, instead of going to the ICC I thought now that election was taking place, I said instead of going to ICC, it was more important for me to go the National Assembly and in any case I was sure that those who were at the ICC will not want to stay there when election was taking place. So I drove straight to the National Assembly, moved straight to the chamber.   It was when I entered that I saw Bukola being sworn in as Senate President.   So I wasn’t at the ICC, I was at the National Assembly but I arrived after the election and I was there calling them to come unfortunately they didn’t come so I had to follow them to ICC and other places. That was what happened that day. Did the president summon that meeting? Nobody told me but I saw a text message that we were going to be addressed by the President but the message did not come from the President himself but from the officials of the party. Did you suspect mischief by the party leaders? You see I told you the party missed some vital steps and gave ample opportunity to the Bukola group and they used it effectively using all the advantages that had to do with the mistakes of our leaders. One, I am aware that the G-7 group and their supporters were interested in seeing one of them being relevant, I am aware of that group within the APC. I am also aware that there are some people within the party who also believe that my brother, Senator Bola Tinubu has taken so many things and they thought it was time for them to put a brake so that he does not have to go with that election because they have the perception that Tinubu was supporting another candidate. There are other groups of senators who believe that Bukola had given them so many things, they believe he supported them in the party, maybe he had taken advantage of some supporters of the party who channelled a lot of support through him and many senators believe they were supported by him and therefore went all out to support him. I think all these things were not taken into consideration by the party leaders. There were many other senators and members that very much believe that the consultation between them and the party was not good enough, that the party could have done more in terms of the relationship in terms of closeness and even in terms of letting them know precisely the direction of the party. Some of these things are correctable like making consultations with members of the National Assembly etc. I’m sure you know that I’m in the group of Ahmad Lawan and Akume, but before then I was one of the supporters of Akume because under normal circumstances he should get the seat, he is the natural owner of the seat for many obvious reasons. One he is probably the most senior among all of them, he was the minority leader and I have not heard anybody pass a vote of no confidence on him and now that the party is the majority party, under normal circumstances he should have been Senate President and his state did very well for the party and all these put together qualify him to be the Senate president. I supported him from the beginning but when the decision was made by some other people that two of them should come together, in fact he called me 4 a.m. one day, I was in Kano, he said this was what was happening in Abuja; what is my opinion because he doesn’t want to do anything that will go against our collective interest. It is sad that they didn’t get it because under normal circumstances all members of our party should toe the party line that is how it should. But here we are with the situation where party is on one side and some members of the party are on the other side. So are you saying the party is divided? Well I think the party unfortunately is divided but it is not too late to correct many things but the party should take certain steps to ensure such things do not happen again. I am one of those who advised Bukola that he shouldn’t go too far with that ambition under the circumstances. At his level   people should be more careful and cautious in what they do and what they don’t do especially as the situation is even worse than the case of Tambuwal because during the 2011 elections, the Tambuwal case was a case of going out of the zoning but all the positions went to the members of the party but this time because of the ambition of these members of our party, they went and connived with people who are not only opponents nut enemies of the party to fight the party after the people of this country have discarded these people. Now because of ambition, these people were made relevant. I don’t think that is the best way to go. Members of the party should have limitations, they should know where to start and stop, I think this is going too far romancing members of the PDP, as far as we are concerned PDP was dead, until recently when ambition brought certain people to do what they should not do in a democracy and party politics and now we are about to create another line for them to the extent that some of them are surfacing again and making all sorts of statements. saying they have reasons to speak again and I think this has to do with the mistake of our own members. I believe at the end of the day the party members must get a way of coming together and behave well. I think that is the only way we can make progress. Some have justified Ekweremadu’s emergence as compensation for the South-East? There are ways the APC can carry the South-east by way of appointment. I’m sure our party had it in mind to carry the South-east but not with the position of the Senate president. That position doesn’t belong to the PDP and that is the mistake Ekweremadu is making, he said he was elected deputy senate president yet he reduced himself to a zone and to a tribe which is not good enough.

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