Rosso L.G.,French Institute of Health and Medical Research |
Rosso L.G.,University of Buenos Aires |
Lhomme M.,French Institute of Health and Medical Research |
Lhomme M.,University Pierre and Marie Curie |
And 19 more authors.
Objective: High-density lipoprotein (HDL) particles exert potent antiatherogenic activities, including antioxidative actions, which are relevant to attenuation of atherosclerosis progression Such activities are enriched in small, dense HDL and can be compromised under conditions of chronic inflammation like rheumatoid arthritis (RA) However, structure-function relationships of HDL largely remain indeterminate Methods: The relationships between HDL structure and function were evaluated in normolipidemic patients with active RA (DAS28>3.2; n=12) and in normolipidemic age-matched controls (n=10) Small, dense HDL3b and 3c particles were isolated from plasma or serum by density gradient ultracentrifugation and their physicochemical characteristics, lipidome (by LC/MS/MS) and antioxidative function (as protection of normolipidemic LDL from free radical-induced oxidation) were evaluated Results: As expected, active RA patients featured significantly elevated plasma levels of high-sensitivity C-reactive protein (hsCRP; p < 0.001) and serum amyloid A (SAA; p < 0.01) relative to controls Antioxidative activity and weight % chemical composition of small, dense HDL did not differ between RA patients and controls (p>0.05), whereas HDL phosphosphingolipidome was significantly altered in RA Subgroup analyses revealed that RA patients featuring high levels of inflammation (hsCRP>10mg/l) possessed small, dense HDL with reduced antioxidative activities (p<0.01) Furthermore, antioxidative activity of HDL was inversely correlated with plasma hsCRP (p<0.01) Conclusions: These data revealed that (i) despite normolipidemic state, the lipidome of small, dense HDL was altered in RA and (ii) high levels of inflammation can be responsible for the functional deficiency of small, dense HDL in RA. 2014 Elsevier Ireland Ltd. Source
Chandon P.,Ican Inc |
Wansink B.,Cornell University
Food marketing is often singled out as the leading cause of the obesity epidemic. The present review examines current food marketing practices to determine how exactly they may be influencing food intake, and how food marketers could meet their business objectives while helping people eat healthier. Particular attention is paid to the insights provided by recently published studies in the areas of marketing and consumer research, and those insights are integrated with findings from studies in nutrition and related disciplines. The review begins with an examination of the multiple ways in which 1) food pricing strategies and 2) marketing communication (including branding and food claims) bias food consumption. It then describes the effects of newer and less conspicuous marketing actions, focusing on 3) packaging (including the effects of package design and package-based claims) and 4) the eating environment (including the availability, salience, and convenience of food). Throughout, this review underscores the promising opportunities that food manufacturers and retailers have to make profitable "win-win" adjustments to help consumers eat better. © 2012 International Life Sciences Institute. Source
Filou S.,University of Patras |
Lhomme M.,Ican Inc |
Karavia E.A.,University of Patras |
Kalogeropoulou C.,University of Patras |
And 7 more authors.
In addition to high-density lipoprotein cholesterol (HDL-C) levels, HDL quality also appears to be very important for atheroprotection. Analysis of various clinical paradigms suggests that the lipid and apolipoprotein composition of HDL defines its size, shape, and functions and may determine its beneficial effects on human health. Previously, we reported that like apolipoprotein A-I (Apoa1), apolipoprotein E (Apoe) is also capable of promoting the de novo biogenesis of HDL with the participation of ATP binding cassette A lipid transporter member 1 (Abca1) and plasma enzyme lecithin:cholesterol acyltransferase (Lcat), in a manner independent of a functional Apoa1. Here, we performed a comparative analysis of the functions of these HDL subpopulations. Specifically, Apoe and Apoa1 double-deficient (Apoe-/- × Apoa1-/-) mice were infected with APOA1- or APOE3-expressing adenoviruses, and APOA1-containing HDL (APOA1-HDL) and APOE3-containing HDL (APOE3-HDL), respectively, were isolated and analyzed by biochemical and physicochemical methods. Western blot and lipidomic analyses indicated significant differences in the apolipoprotein and lipid composition of the two HDL species. Moreover APOE3-HDL presented a markedly reduced antioxidant potential and Abcg1-mediated cholesterol efflux capacity. Surprisingly, APOE3-HDL but not APOA1-HDL attenuated LPS-induced production of TNFα in RAW264.7 cells, suggesting that the anti-inflammatory effects of APOA1 are dependent on APOE expression. Taken together, our data indicate that APOA1 and APOE3 recruit different apolipoproteins and lipids on the HDL particle, leading to structurally and functionally distinct HDL subpopulations. The distinct role of these two apolipoproteins in the modulation of HDL functionality may pave the way toward the development of novel pharmaceuticals that aim to improve HDL functionality. © 2016 American Chemical Society. Source
Ican Inc | Date: 2008-06-03
A series of books, written articles, handouts and worksheets in the field of nursing and healthcare for the purpose of aiding students and teachers.
Ican Inc | Date: 2010-02-03
Geothermal energy generation systems comprising heat exchangers, pumps, heat pumps, piping, and electrical and electronic apparatus and equipment all for use in generating energy obtained from alternative energy sources and replacement parts therefor; Solar energy generation systems comprising solar-powered electricity generators and motors, gears, drives for orientating solar panels, and electrical and electronic apparatus and equipment all for use in generating energy obtained from alternative energy sources and replacement parts therefor; Wind energy generation systems comprising wind-powered electricity generators, wind turbines, generators for wind turbines, propellers for wind-powered electricity generators, and electrical and electronic apparatus and equipment all for use in generating energy obtained from alternative energy sources and replacement parts therefor; structural components and replacement parts for each of the foregoing, namely, wind power turbines. Consulting services in the fields of energy usage management and conservation; Management and operations assistance for energy generation and co-generation systems, including geothermal energy systems, solar energy systems and wind energy systems. Consulting in the areas of energy distribution. Consulting services in the areas of energy production, generation, co-generation, and treatment of electrical energy for others. Inspection of facilities and plants for energy production, generation, co-generation, distribution, transportation, transmission, storage and treatment of electrical energy; Remote monitoring of facilities and plants for energy production, generation, co-generation, distribution, transportation, transmission, storage and treatment of electrical energy for others; Architectural and engineering services in the area of energy generation and co-generation systems, including geothermal energy systems, solar energy systems, wind energy systems, and components therefor.