Ascone I.,École Nationale Supérieure de Chimie de Paris |
Ascone I.,Synchrotron Soleil |
Savino C.,CNR Institute of Molecular Biology and Pathology |
Kahn R.,IBS |
Fourme R.,Synchrotron Soleil
Acta Crystallographica Section D: Biological Crystallography | Year: 2010
The 2 Å resolution crystal structure of bovine erythrocyte Cu,Zn superoxide dismutase (CuZnSOD) has been determined by X-ray diffraction at high pressure (0.57 GPa) and room temperature. At 0.57 GPa the secondary, tertiary and quaternary structures are similar to other previously determined bovine erythrocyte CuZnSOD structures. Nevertheless, pressure has a localized impact on the atomic coordinates of Cα atoms and on side chains. The compression of the crystal and of the protein backbone is anisotropic. This anisotropy is discussed, taking into account intermolecular contacts and protein conformation. Pressure perturbation highlights the more flexible zones in the protein such as the electrostatic loop. At 0.57 GPa, a global shift of the dimetallic sites in both subunits and changes in the oxidation state of Cu were observed. The flexibility of the electrostatic loop may be useful for the interaction of different metal carriers in the copper-uptake process, whereas the flexibility of the metal sites involved in the activity of the protein could contribute to explaining the ubiquitous character of CuZnSODs, which are found in organisms living in very different conditions, including the deep-sea environment. This work illustrates the potential of combining X-ray crystallography with high pressure to promote and stabilize higher energy conformational substates. © 2010 International Union of Crystallography.
Proceedings of the 9th International Conference on System of Systems Engineering: The Socio-Technical Perspective, SoSE 2014 | Year: 2014
The paper presents an analysis of the ineffectiveness of the information and computer technologies (ICT) used by Russian enterprises. A capability based approach is proposed to improve this situation. The approach is focused on establishing a close and direct link from enterprise capabilities and values to ICT systems. The approach comprises: • A set of 9 universal capabilities, which are mandatory for ICT system. • Practical algorithm to transform/ concretize these capabilities into functional requirements for ICT-systems. Such requirements to be realized make ICT-systems valuable for enterprises and their stakeholders. The approach is illustrated by exemplar projects from the practice of the IBS Company where the author works. © 2014 IEEE.
Proceedings - 2012 7th International Conference on System of Systems Engineering, SoSE 2012 | Year: 2012
The paper is devoted to the safety of complex technical systems of systems (SoS) through the improvement of engineering processes at all system lifecycle stages. The safety of complex technical facilities (such as nuclear and conventional power plants, offshore oil and gas platforms and chemical processing plants) is analyzed based on the systems theory and SoS engineering. The safety concept discussed is the development and implementation of engineering process constraints to identify and prevent engineering inconsistencies which endanger systems safety. The method proposed consists of inconsistency classification as well as practical recommendations on how to formulate and implement safety constraints. The paper is based on the project implementation experience of IBS in 2010-2012 in the capital industry in Russia. © 2012 IEEE.
Mishra V.,IBS |
Singh Bisht S.,IBS
Telecommunications Policy | Year: 2013
India needs inclusive growth to pull millions out of poverty. Despite the best efforts of mainstream financial institutions, financial exclusion is depriving millions of poor any chance to attain adequate standard of living. Telecommunication infrastructure growth especially mobile phone penetration has created an opportunity for providing financial inclusion. The current state of mobile banking is characterized by a top-down approach. This paper presents a bottom-up approach of designing mobile banking service which would be acceptable and accessible to the poor customers. The results point to clear preference of the urban poor for a joint bank-telecom led mobile banking model. Conjoint analysis of the data points to preference for attributes related to security/safety of a bank along with the coverage, accessibility and nimbleness of a telecom service provider with minimal documentation. The paper in its conclusion exhorts the regulators, telecom service providers and financial institutions to involve end-users in order to create a sustainable mobile banking service for financial inclusion. © 2012 Elsevier Ltd. All rights reserved.
International Journal of Manufacturing, Materials, and Mechanical Engineering | Year: 2013
Recent disruptions in global supply chains have led to increased interest in supply chain risk management investigation. On the other hand, increased environmental regulation has urged firms to compulsorily have their routine operations environmental friendly. Last few years, researchers have investigated these two streams as distinct but have mentioned them to be related in the long run. The current study attempts to bridge this gap of allied literature by conceptually arguing that it to arrive at sustainability in supply chain operations, firms must co-integrate their supply chain risk management and green practices in supply chain. While risk management broadly aims to reduce the exposure to a risky situation coupled with minimizing the negative impact of disruption of firm performance; green practices aims to make operational, tactical and strategic operations of the firm environment friendly. Based on sufficient theoretical tenets from related literature, the study attempts to develop a theoretical model linking supply chain risk management, green supply chain practices and sustainable supply chain. In doing so, the study provides an indicative list of various risk classifications and proposed risk mitigating strategies till date. Finally, the study indicates managerial implications and suggests further research opportunities. Copyright © 2013.
Proceedings - 29th International Symposium on Ballistics, BALLISTICS 2016 | Year: 2016
A concise computer code for in-bore balloting of APFSDS is formulated. The basics of the model is that long rod was taken as a Bernoulli-Euler beam with freefree ends. Forces are distributed in accordance with the natural mode of vibration. This allow us to neglect ambiguous contact between sabot and rod. Tube is simulated as a cantilever of Bernoulli-Euler beam having gravity droop, regional warp of the centerline. Vibrations of gun tube are excited by Recoil Load, "Bourdon" pressure, Projectile collision, and Bearing support. This analytical model is formulated and operated on a personal computer. Time to calculate one shot is about 10 to 20 minutes and it is useful to evaluate system constituents.
International Journal of Disaster Resilience in the Built Environment | Year: 2014
Purpose – The purpose of this paper is to report a comprehensive review of supply chain resilience and identify several research issues.Design/methodology/approach – The articles which have been published in international journals in the period 1980-2012 were collected by using databases like ISI Web of Knowledge, ScienceDirect and EBSCO. The articles were scrutinized based on relevance to context and value addition. The articles contributing significantly in the domain of supply chain resilience were selected for final review and various issues were identified.Findings – The paper argues that though several conceptual to few empirical works been done on supply chain resilience in recent years, there is large scope for research to address the issues in risk management, supply chain design, sourcing strategies, green practices, sustainable competitive advantage, supply chain security, supply chain performance and supply chain resilience.Research limitations/implications – The insights deduced in the paper are primarily based on 45 articles selected for critical review and analysis in the domain of supply chain resilience and hence should be interpreted only as key concerns in the area.Originality/value – The paper reports an evaluation of 45 key articles reported in the domain of supply chain resilience and indicates the research opportunities in the area. © 2014, Emerald Group Publishing Ltd. All rights reserved.
CEUR Workshop Proceedings | Year: 2013
The paper is devoted to one of the practical approaches to manage complex projects. A case study of complex project management is described. This concerns transforming a Russian IT-company into an enterprise system and system of systems (ES/SoS) at the same time. Main elements of the transformation - the goal, solution, structure, and relations among constituents of ES/SoS, ES/SoS engineering process, and results - are represented. The analysis of the project -environment, constraints, risks, opportunities, and uncertainty - is considered. It is found that it is exactly uncertainty that causes grave problems in complex project management and that is responsible for the main challenges facing the governing body. An "agile stylized approach" to complex project management which was successfully used in the case study is described. The applicability of this approach to manage other complex projects and further research prospects are discussed.
Proceedings of 2013 8th International Conference on System of Systems Engineering: SoSE in Cloud Computing and Emerging Information Technology Applications, SoSE 2013 | Year: 2013
The paper is about the drastic transformation of the strategy and business model of the Russian information technological enterprise which incorporates autonomous but interrelated business units: in 2001 top management of the IBS Company made the decision to switch to the information technology services and consulting area. The creation of new capabilities was the transformation objective. Capability based approach was successfully applied to achieve the transformation goals. An "ES/SoS nuclear model" has been introduced to describe the transformation. The model represents the enterprise as the "hard business nucleus" or kernel (major business-agents, who really make the business), a "soft business shell" (non-material environment: governing media, competences, knowledge, etc. - intangible assets), and the "cloud of extended enterprise" (clients, partners, etc., interlinked by common "across"-business processes). The great majority of transformation activities and outcomes lie in the ES/SoS's "soft shell" which includes new capabilities, governing relations, competences, etc. © 2013 IEEE.
International Journal of Applied Engineering Research | Year: 2016
Supply chain analytics has received scant attention in supply chain management. Studies have not been exploring the development of supply chain analytics as an essential supply chain capability to meet the growing challenges of the ever changing world around us. Supply chain analytics refers to the usage of different application packages in the efficient functioning of the four basic processes of planning, sourcing, making and delivering the final product. We argue that supply chain relationships are going to have a dominant influence on the development of supply chain analytics as such relationships spans across the supply chains and affects the operation across each level. The current study proposes a conceptual framework of supply chain analytics, based on extant literature, that can guide academicians and practitioners for further empirical exploration of supply chain analytics as a capability. © Research India Publications.