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Jeddah, Saudi Arabia

Ibn Sina National College for Medical Studies is the First private medical college of higher education under the supervision of the Ministry of higher Education, Kingdom of Saudi Arabia. Ibn Sina National College for Medical Studies is being promoted by Al-Jedani Group of Hospitals, KSA. It is located in the southern part of the historic city Jeddah, on the red sea coast. This college aims to: Establish an appropriate scientific atmosphere for teaching and learning Medicine, Dentistry and Pharmacy. Keep up with international standards of education programs utilizing the most up-to-date curricula for Medicine, Dentistry and Pharmacy. Play a major role in providing society with highly qualified physicians and pharmacists. To avoid the potential risk of studying aboard. Ibn Sina National College for Medical Studies is being promoted by Al-Jedani Group of Hospitals, KSA. It is located in the southern part of the historic city Jeddah, on the red sea coast.. Wikipedia.

Ansari S.A.,King Abdulaziz University | Satar R.,Ibn Sina National College for Medical Studies
Journal of Molecular Catalysis B: Enzymatic | Year: 2012

The present review deals with current developments of novel β-galactosidases derived from recombinant vectors and by protein engineering approaches together with the use of efficient recombinant microbial production systems in order to present the applications of recombinant enzymes as a relevant synthetic tool in biotechnology. The union of specific physical and chemical properties of recombinant proteins with specific recognition of catalytic properties of biomolecules has led to their appearance in myriad novel biotechnological applications. The interest in exploiting recombinant enzymes as biocatalysts is constantly increasing nowadays. The plausible advantages involved with their use include their (1) rigidity and permeability, (2) hydrophobic/hydrophilic character, (3) ease of purification and large-scale production, (4) immediate separation from the reaction mixture after completion of reaction without using any chemicals or heating, (5) regenerability as they impart stability to enzymes by protecting their active sites from deactivation, and (6) recombinant enzymes can be conveniently tailored within utility limits. β-Galactosidase is one of the relatively few enzymes that have been used in large-scale processes to perform lactose hydrolysis and galacto-oligosaccharide production. Thus, the present article gives brief outline of recombinant β-galactosidases obtained from various mesophilic, psychrophilic and thermophilic sources and their potential applications in biotechnology industry. © 2012 Elsevier B.V. All rights reserved. Source

Hofni A.,Minia University | El-Moselhy M.A.,Minia University | El-Moselhy M.A.,Ibn Sina National College for Medical Studies | Taye A.,Minia University | Khalifa M.M.,Minia University
European Journal of Pharmacology | Year: 2014

Diabetic nephropathy is one of the most common causes of end-stage kidney disease. Aldosterone and angiotensin II appear to play a crucial role in the pathogenesis of this disease. The present study aimed to investigate effects of the combination therapy with spironolactone and candesartan on diabetic nephropathy and elucidate the underlying mechanism(s) involved. Diabetes was induced in rats by a single intraperitoneal injection of streptozotocin (STZ) (55 mg/kg). The diabetic rats were orally treated with spironolactone (50 mg/kg/day) and/or candesartan (1 mg/kg/day) for 8 weeks. Administration of STZ caused a marked elevation in the serum level of creatinine, urea and urinary albumin-creatinine ratio (ACR). This was associated with upregulated renal protein levels of nuclear factor-kappa B (NF-κB), transforming growth factor (TGF)-β, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) alongside increasing the renal superoxide anion (O2 -) production, malondialdehyde (MDA) level and the systolic blood pressure. There was a marked decrease in nitric oxide (NO) bioavailability and antioxidant enzyme capacity. The combined therapy of spironolactone and candesartan significantly normalized the oxidative stress and fibrotic/inflammatory alterations. Additionally, the elevated blood pressure was attenuated by administration of candesartan alone or in combination. This was associated with improving the renal function parameters. The combined therapy exhibited more profound response compared to the monotherapy. In conclusion, our results demonstrate that the combined therapy of spironolactone and candesartan can confer an additive benefit over the use of either drug alone against STZ-induced diabetic nephropathy, presumably via attenuating the inflammatory responses and oxidative status markers. © 2014 Elsevier B.V. Source

Ur Rahaman S.M.,Ibn Sina National College for Medical Studies | Mujib B.R.A.,Bapuji Dental College and Hospital
Journal of Oral and Maxillofacial Pathology | Year: 2014

Background: Oral Squamous Cell Carcinoma (OSCC) is commonly noted in elder men, when occurring in younger individuals, its aggression and prognosis is questioned due to biased data in literature. Traditionally, various histopathological grading systems have been used for assessing aggression and prognosis of OSCC. However, multifactorial grading of Anneroth et al., is considered effective. Materials and Methods: In this retro-prospective study, files of 75 OSCC patients were retrieved from Oral Pathology Department; among this 50 patients were >40 years and 25 patients were ≤40 years of age. Archival formalin fixed paraffin embedded tissue blocks of these patients were used to prepare hematoxylin and eosin (H and E) stained sections for grading OSCC based on Broder's and Anneroth et al., criteria. Further, recurrence of OSCC among study subjects within 5 years of treatment was evaluated. Chi-square test was used to compare the disease in patients who were >40 years with ≤40 years. Results: Comparison according to Broder's classification didn't show any relevant variation. Three of the six parameters and overall grading according to Anneroth et al., criteria showed statistically higher grades of OSCC in the younger age-group; however, there was no significant difference in 5-year recurrence rate. Interpretation and Conclusion: Results of the study are suggestive of aggressive OSCC among young patients when compared to older. Conversely, this aggression didn't affect the recurrence in younger patients. Further studies on genetics, diet and demographics of patients below 40 years of age affected by OSCC will be of greater value. Source

Radwan H.,Zagazig University | Radwan H.,King Faisal Specialist Hospital And Research Center | Selem A.,Zagazig University | Selem A.,Ibn Sina National College for Medical Studies | Ghazal K.,Zagazig University
Journal of the Saudi Heart Association | Year: 2014

Background: Measurement of N-terminal pro brain natriuretic peptide (NT-proBNP) in the evaluation of patients with acute coronary syndrome has appeared to be a useful prognostic marker of cardiovascular risk. Aim of the work: To assess the in-hospital prognostic value of NT-proBNP in patients with acute coronary syndrome (ACS) and its relation to the severity of coronary artery disease. Patients and methods: This study included 132 consecutive patients with ACS, 64 patients with unstable angina (UA), 46 patients with non-ST segment elevation myocardial infarction (NSTEMI), and 22 patients with ST segment elevation myocardial infarction (STEMI). ECG, echocardiography and pre and post coronary angiography measurement of troponin I, creatine kinase (Ck), C-reactive protein (CRP) and NT-proBNP were done. Patients were divided into two groups: Group A with NT-proBNP less than 474. pg/ml and Group B with NT-proBNP equal or more than 474. pg/ml. Results: There was a significant negative correlation between NT-proBNP and ejection fraction. Incidence of heart failure and duration of hospital stay were significantly higher in Group B (with NT-proBNP equal or more than 474. pg/ml) than Group A (with NT-proBNP less than 474. pg/ml). Moreover, there was a trend to an increased incidence of cardiogenic shock and mortality in Group B compared to Group A. The number of coronary vessels affected, severity of stenosis and proximal left anterior descending artery (LAD) disease were higher in Group B than in Group A. TIMI flow grade was significantly higher in Group A than in Group B. Conclusion: NT-proBNP is a valuable marker for predicting prognosis and severity of coronary artery disease in patients with acute coronary syndrome. © 2014 King Saud University. Source

Ansari S.A.,King Abdulaziz University | Satar R.,Ibn Sina National College for Medical Studies | Alam F.,Aligarh Muslim University | Alqahtani M.H.,King Abdulaziz University | And 4 more authors.
Process Biochemistry | Year: 2012

The present study demonstrates synthesis, characterization and surface functionalization of silver nanoparticles (AgNPs) via glutaraldehyde for high yield immobilization of Aspergillus oryzae β-galactosidase. Soluble β-galactosidase (SβG), enzyme adsorbed on unmodified AgNPs (UβG) and surface modified AgNPs (MβG) showed same pH-optima at pH 4.5. However, it was observed that MβG exhibited enhanced pH stability toward acidic and alkaline sides, and increased temperature resistance as compared to SβG and UβG. Michaelis constant, Km was increased nearly three-folds for MβG while Vmax for soluble and MβG was 0.515 mM/min and 0.495 mM/min, respectively. Furthermore, MβG showed greater resistance to product inhibition mediated by galactose as compared to it soluble counterpart and exhibited excellent catalytic activity even after its fourth successive reuse. The remarkable bioconversion rates of lactose from milk in batch reactors further revealed an attractive catalytic efficiency of β-galactosidase adsorbed on surface functionalized AgNPs thereby promoting its use in the production of lactose free dairy products. Crown Copyright © 2012 Published by Elsevier Ltd. All rights reserved. Source

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