Ibn Sina National College for Medical Studies

Jeddah, Saudi Arabia

Ibn Sina National College for Medical Studies is the First private medical college of higher education under the supervision of the Ministry of higher Education, Kingdom of Saudi Arabia. Ibn Sina National College for Medical Studies is being promoted by Al-Jedani Group of Hospitals, KSA. It is located in the southern part of the historic city Jeddah, on the red sea coast. This college aims to: Establish an appropriate scientific atmosphere for teaching and learning Medicine, Dentistry and Pharmacy. Keep up with international standards of education programs utilizing the most up-to-date curricula for Medicine, Dentistry and Pharmacy. Play a major role in providing society with highly qualified physicians and pharmacists. To avoid the potential risk of studying aboard. Ibn Sina National College for Medical Studies is being promoted by Al-Jedani Group of Hospitals, KSA. It is located in the southern part of the historic city Jeddah, on the red sea coast.. Wikipedia.

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Molvi Khurshid I.,Ibn Sina National College for Medical Studies
International Journal of Pharma and Bio Sciences | Year: 2014

Plants have been used both in the prevention and cure of various diseases of humans and their pets. With the beginning of human culture, different medicinal systems have been developed comprising on plants. It is estimated that there are 250,000 to 500,000 species of plants on Earth. Relatively small percentages (1 to 10%) of these are used as foods by both humans and other animal species. It is possible that even more are used for medicinal purposes. Meyna laxiflora is a plant which having traditional importance for its medical uses, for treatment of Inflammation, Gastrointestinal disorder etc. It is distributed all over the satpuda region in Nandurbar district it is found in Sawarimal, Umarpata, Morkaranja and kondaibari. But lacking in information about an ethnomedicnal uses of this plant from tribes of satpuda region, hence it is necessary to initiate ethnomedicinal survey of this plant in Nandurbar District.

PubMed | Fayoum University, Beni Suef University, Al Jouf University and Ibn Sina National College for Medical Studies
Type: | Journal: Bioorganic chemistry | Year: 2017

Two new series of 4,6-diaryl-3-cyanopyridine 4a-r and 1,3,5-triaryl-2-pyrazolines 6a-f and were prepared. The new compounds were evaluated for their in vitro COX-2 selectivity and in vivo anti-inflammatory activity. Compounds 4o,r and 6d,f had moderate to high selectivity index (S.I.) compared to celecoxib (selectivity indexes of 4.5, 3.14, 4.79 and 3.21, respectively) and also, showed in vivo anti-inflammatory activity approximately equal to or higher than celecoxib (edema inhibition %=60.5, 64.5, 59.3 and 59.3, after 3h, respectively) and the effective anti-inflammatory doses were (ED

Ur Rahaman S.M.,Ibn Sina National College for Medical Studies | Mujib B.R.A.,Bapuji Dental College and Hospital
Journal of Oral and Maxillofacial Pathology | Year: 2014

Background: Oral Squamous Cell Carcinoma (OSCC) is commonly noted in elder men, when occurring in younger individuals, its aggression and prognosis is questioned due to biased data in literature. Traditionally, various histopathological grading systems have been used for assessing aggression and prognosis of OSCC. However, multifactorial grading of Anneroth et al., is considered effective. Materials and Methods: In this retro-prospective study, files of 75 OSCC patients were retrieved from Oral Pathology Department; among this 50 patients were >40 years and 25 patients were ≤40 years of age. Archival formalin fixed paraffin embedded tissue blocks of these patients were used to prepare hematoxylin and eosin (H and E) stained sections for grading OSCC based on Broder's and Anneroth et al., criteria. Further, recurrence of OSCC among study subjects within 5 years of treatment was evaluated. Chi-square test was used to compare the disease in patients who were >40 years with ≤40 years. Results: Comparison according to Broder's classification didn't show any relevant variation. Three of the six parameters and overall grading according to Anneroth et al., criteria showed statistically higher grades of OSCC in the younger age-group; however, there was no significant difference in 5-year recurrence rate. Interpretation and Conclusion: Results of the study are suggestive of aggressive OSCC among young patients when compared to older. Conversely, this aggression didn't affect the recurrence in younger patients. Further studies on genetics, diet and demographics of patients below 40 years of age affected by OSCC will be of greater value.

Ansari S.A.,King Abdulaziz University | Satar R.,Ibn Sina National College for Medical Studies | Alam F.,Aligarh Muslim University | Alqahtani M.H.,King Abdulaziz University | And 4 more authors.
Process Biochemistry | Year: 2012

The present study demonstrates synthesis, characterization and surface functionalization of silver nanoparticles (AgNPs) via glutaraldehyde for high yield immobilization of Aspergillus oryzae β-galactosidase. Soluble β-galactosidase (SβG), enzyme adsorbed on unmodified AgNPs (UβG) and surface modified AgNPs (MβG) showed same pH-optima at pH 4.5. However, it was observed that MβG exhibited enhanced pH stability toward acidic and alkaline sides, and increased temperature resistance as compared to SβG and UβG. Michaelis constant, Km was increased nearly three-folds for MβG while Vmax for soluble and MβG was 0.515 mM/min and 0.495 mM/min, respectively. Furthermore, MβG showed greater resistance to product inhibition mediated by galactose as compared to it soluble counterpart and exhibited excellent catalytic activity even after its fourth successive reuse. The remarkable bioconversion rates of lactose from milk in batch reactors further revealed an attractive catalytic efficiency of β-galactosidase adsorbed on surface functionalized AgNPs thereby promoting its use in the production of lactose free dairy products. Crown Copyright © 2012 Published by Elsevier Ltd. All rights reserved.

Halawa M.R.,Ain Shams University | Halawa M.R.,Dr Erfan and Bagedo General Hospital | Karawagh A.,King Khalid National Guard Hospital | Zeidan A.,Alexandria University | And 3 more authors.
Current Medical Research and Opinion | Year: 2010

Objective: To determine the prevalence of painful diabetic peripheral neuropathy in adult patients with diabetes mellitus (type 1 and 2) attending outpatient clinics in Saudi Arabia and to determine the demographic profile and pharmaceutical management of these patients. Research design and methods: Eligible patients from 100 outpatient clinics treating patients with diabetes mellitus across Saudi Arabia completed an epidemiologic questionnaire to obtain demographic information and medication history. Following this, the validated DN4 pain questionnaire was used to identify the presence of painful diabetic peripheral neuropathy (score of ≥4). Results: A total of 1039 patients were enrolled. Following the DN4 pain questionnaire, an overall prevalence of painful diabetic peripheral neuropathy of 65.3 (n=678) was found. The age of patients, their sex, and the duration of underlying diabetes were found to be statistically significant factors in the development of painful diabetic peripheral neuropathy. No statistically significant difference was found between smoking history, body mass index, or racial origin and presence of painful diabetic peripheral neuropathy. On initial evaluation, 42.3 (n=440) stated they were receiving treatment for pain. Following evaluation using the DN4 pain questionnaire, the number prescribed therapeutic pain management increased to more than two thirds (68.7, n=714) of which 62.3 (n=579) were prescribed pregabalin. Conclusions: In patients with reduced pain intensity DN4 has not been directly compared with other tools to measure neuropathic pain; however, using the DN4 in this study 65.3 of adult outpatients with type 1 and 2 diabetes in Saudi Arabia were found to have painful diabetic peripheral neuropathy; far higher than anticipated. © 2010 Informa UK Ltd All rights reserved.

Hofni A.,Minia University | El-Moselhy M.A.,Minia University | El-Moselhy M.A.,Ibn Sina National College for Medical Studies | Taye A.,Minia University | Khalifa M.M.,Minia University
European Journal of Pharmacology | Year: 2014

Diabetic nephropathy is one of the most common causes of end-stage kidney disease. Aldosterone and angiotensin II appear to play a crucial role in the pathogenesis of this disease. The present study aimed to investigate effects of the combination therapy with spironolactone and candesartan on diabetic nephropathy and elucidate the underlying mechanism(s) involved. Diabetes was induced in rats by a single intraperitoneal injection of streptozotocin (STZ) (55 mg/kg). The diabetic rats were orally treated with spironolactone (50 mg/kg/day) and/or candesartan (1 mg/kg/day) for 8 weeks. Administration of STZ caused a marked elevation in the serum level of creatinine, urea and urinary albumin-creatinine ratio (ACR). This was associated with upregulated renal protein levels of nuclear factor-kappa B (NF-κB), transforming growth factor (TGF)-β, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) alongside increasing the renal superoxide anion (O2 -) production, malondialdehyde (MDA) level and the systolic blood pressure. There was a marked decrease in nitric oxide (NO) bioavailability and antioxidant enzyme capacity. The combined therapy of spironolactone and candesartan significantly normalized the oxidative stress and fibrotic/inflammatory alterations. Additionally, the elevated blood pressure was attenuated by administration of candesartan alone or in combination. This was associated with improving the renal function parameters. The combined therapy exhibited more profound response compared to the monotherapy. In conclusion, our results demonstrate that the combined therapy of spironolactone and candesartan can confer an additive benefit over the use of either drug alone against STZ-induced diabetic nephropathy, presumably via attenuating the inflammatory responses and oxidative status markers. © 2014 Elsevier B.V.

Elshazly S.M.,Zagazig University | El-Moselhy M.A.,Minia University | El-Moselhy M.A.,Ibn Sina National College for Medical Studies | Barakat W.,Zagazig University
European Journal of Pharmacology | Year: 2014

Acetaminophen (APAP) is one of the most widely used analgesic antipyretic drugs and is a major cause of acute liver failure at overdose. The aim of this study is to investigate the possible protective effect of α-lipoic acid (α-LA, 20 or 100 mg/kg administered simultaneously or after 1.5 h) against APAP-induced hepatotoxicity in rats. Administration of APAP (1.5 g/kg i.p.) resulted in elevation of serum ALT and hepatic malondialdehyde (MDA) content, as well as decrease in hepatic glutathione (GSH) content. In addition, elevation in hepatic hemeoxygenase-1 (HO-1) and NADPH oxidase expression was observed accompanied with a significant reduction in glutathione synthase and cystathionine-beta-synthase (CβS) expression. Furthermore, nuclear factor kappa-B (NF-κB) activity was enhanced in APAP-treated rats. Administration of the standard APAP antidote; N-acetylcysteine (NAC, 1200 mg/kg) or α-LA (20 mg/kg), simultaneously or 1.5 h after APAP, ameliorated APAP-induced alterations in liver function, oxidant and inflammatory markers. Importantly, simultaneous administration of NAC or α-LA (20 mg/kg) was more protective than their later administration. However, the beneficial effect of α-LA was lost at higher dose level (100 mg/kg). Taken together, the beneficial effects of α-lipoic acid (20 mg/kg) were comparable to those of NAC which provides a new possible treatment for APAP-induced hepatotoxicity in patients who cannot tolerate NAC. However, careful dose selection is warranted since the beneficial effects of α-LA were lost at higher doses. © 2014 Elsevier B.V.

Baby Sudha N.,St Peters Institute Of Pharmaceutical Science | Raju A.B.,Ibn Sina National College for Medical Studies | Ashok A.,Indian Institute of Toxicology Research
Indian Journal of Pharmaceutical Education and Research | Year: 2016

Background: Glutamate mediated excitotoxicity is proved to be involved in neurodegenerative diseases like ischemia, trauma, diabetic retinopathy, glaucoma, seizures. Development of specific glutamate antagonists favors a better treatment opportunity of these neurodegenerative diseases. Hesperidin, a proven antioxidant and memantine a known NMDA antagonist were selected and evaluated for their neuroprotective property against monosodium glutamate induced excitotoxicity model both in vitro and in vivo. Materials and methods: Monosodium glutamate commonly known as Ajinomoto which is used as flavoring agent was exposed to chick retina (In vitro model) and subcutaneously administered to rats (In vivo model). Various biochemical parameters including oxidative stress related parameters and histopathology studies were conducted. Results: A significant cell death through a process mediated by excitotoxicity was reported. Memantine and hespiridin have produced protective effects in our studies. As hespiridin is a natural antioxidant and it elicited its protective effect by decreasing lipid peroxidation and elevation of superoxide dismutase, catalase activity. Conclusion: Both memantine and hespiridin have shown protective effect against monosodium induced excitotoxicity in both in vitro and in vivo experiments. Food intake and body weight increased due to glutamate was antagonized by memantine and hespiridin. Biochemical parameters and histopathological studies also supported the above claim. However, further investigations are necessary to find mechanisms involved. © 2016, Association of Pharmaceutical Teachers of India. All rights reserved.

Sayeed S.A.,Ibn Sina National College for Medical Studies | Prakash A.,Ibn Sina National College for Medical Studies
Indian Journal of Psychiatry | Year: 2013

Religion and its practices have been duly implicated in treating not only problems related to medical health, rather, intervening and preventing such problems as well. In the present article, the authors have reviewed significance of the Islamic prayers (Salah/Namaaz) in healthcare in general and mental health in particular. The nature, procedures, practices and the benefits of Salah have been comprehensively described and discussed. In addition, an attempt to combine yoga and its practices with Salah has been made for intervening and preventing the problems of mental health as an expeditious tool. In upshot, the clinicians in the field of mental health care have been suggested to incorporate these two viewpoints in their intervention program, at least, for the Muslim patients for a more desirable outcome.

Ansari S.A.,King Abdulaziz University | Satar R.,Ibn Sina National College for Medical Studies
Journal of Molecular Catalysis B: Enzymatic | Year: 2012

The present review deals with current developments of novel β-galactosidases derived from recombinant vectors and by protein engineering approaches together with the use of efficient recombinant microbial production systems in order to present the applications of recombinant enzymes as a relevant synthetic tool in biotechnology. The union of specific physical and chemical properties of recombinant proteins with specific recognition of catalytic properties of biomolecules has led to their appearance in myriad novel biotechnological applications. The interest in exploiting recombinant enzymes as biocatalysts is constantly increasing nowadays. The plausible advantages involved with their use include their (1) rigidity and permeability, (2) hydrophobic/hydrophilic character, (3) ease of purification and large-scale production, (4) immediate separation from the reaction mixture after completion of reaction without using any chemicals or heating, (5) regenerability as they impart stability to enzymes by protecting their active sites from deactivation, and (6) recombinant enzymes can be conveniently tailored within utility limits. β-Galactosidase is one of the relatively few enzymes that have been used in large-scale processes to perform lactose hydrolysis and galacto-oligosaccharide production. Thus, the present article gives brief outline of recombinant β-galactosidases obtained from various mesophilic, psychrophilic and thermophilic sources and their potential applications in biotechnology industry. © 2012 Elsevier B.V. All rights reserved.

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