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Ainane T.,Hassan II University | Abourriche A.,Hassan II University | Oukkache N.,Pasteur Institute of Morocco | Lamdini H.,Ibn Rochd Hospital University Center | And 2 more authors.
Der Pharma Chemica | Year: 2015

Four extracts of tunicate Cynthia squamulata from the atlantic coast were subject of DNA affinity screening, to identify potential antitumor activity. The assay uses a HPLC method for detecting the presence or absence of interactions between molecules of low molecular weight DNA. Also, this method based on the ability of antitumor agents to reduce DNA peak size. The results obtained in this work show that tow extracts from tunicate Cynthia squamulata (ether and methanol) were positive activities, contrariwise, the petroleum ether and chloroform extract showed negative peak reduction.

Tahiri M.,Ibn Rochd Hospital University Center | Sodqi M.,Ibn Rochd Hospital University Center | Lahdami F.E.Z.,Ibn Rochd Hospital University Center | Marih L.,Ibn Rochd Hospital University Center | And 9 more authors.
World Journal of Hepatology | Year: 2013

AIM: To study the prevalence and risk factors of significant hepatic fibrosis in Moroccan human immunodeficiency virus (HIV) monoinfected patients. METHODS: We conducted a cross-sectional study among HIV monoinfected patients (negative for hepatitis B surface antigen and hepatitis C antibody). Clinical and laboratory data were collected from the data base of the Infectious Diseases Unit in Ibn Rochd Hospital Center [age, gender, duration of HIV infection, CD4 T lymphocyte count, HIV viral load, glycemia and current or prior use of antiretroviral and antiretroviral therapy (ART) duration]. The primary outcome was a FIB4 score > 1.45. Multivariable logistic regression identified independent risk factors for FIB4 > 1.45. RESULTS: A FIB4 score > 1.45 was identified in 96 among 619 (15.5%). HIV monoinfected patients followed up between September 1990 and September 2012. Multivariate analysis showed that only a viral load > 75 (OR = 2.23, 95%CI: 1.36-3.67), CD4 > 200 cells/mm3 (OR = 0.39, 95%CI: 0.21-0.72) and age at FIB4 index calculation (OR = 1.10, 95%CI: 1.07-1.13) were independently associated with the occurrence of FIB4 index (> 1.45). Gender, duration of HIV infection, glycemia, use of antiretroviral therapy and ART duration were not associated with significant fibrosis by FIB4. CONCLUSION: FIB4 score > 1.45 was found in 15.5% of Moroccan HIV monoinfected patients. Age, HIV viremia > 75 copies/mL and CD4 count > 200 cells/mm3 are associated with liver fibrosis. Further studies are needed to explore mechanisms for fibrosis in HIV monoinfected patients. © 2013 Baishideng.

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