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Sao Paulo, Brazil

Vale F.A.,Ibirapuera University | Moreira M.S.,Ibirapuera University | Almeida F.C.S.D.,University of Sao Paulo | Ramalho K.M.,Ibirapuera University
Scientific World Journal | Year: 2015

Recurrent aphthous ulcers (RAUs) are the most common lesion found in the oral cavity. There is no definitive cure for RAUs and current treatments are aimed at minimizing symptoms. Since low-level laser therapy (LLLT) modulates inflammatory responses, and promotes pain reduction and cellular biostimulation, LLLT can be suggested as an alternative treatment for RAUs. The literature concerning the potential of LLLT in the treatment of RAUs was evaluated. A systematic literature review identified 22 publications, of which only 2 studies were adopted. The eligibility criteria consisted of randomized controlled trials (RCTs). Both RCTs achieved significant results concerning LLLT and pain-level reductions and reduced healing times. Despite the variance in irradiation conditions applied in both studies, very similar wavelengths were adopted. There is accordingly strong evidence that wavelength plays an important role in RAU treatment. Taking into account the different parameters applied by selected RCTs, it is not possible to suggest that a specific protocol should be used. However, in light of the significant results found in both studies, LLLT can be suggested as an alternative for RAU treatment. Additional RCTs should be performed in order to reach a clinical protocol and better understand the application of LLLT in RAU treatment. © 2015 Fernando Alves Vale et al.

Moura-Netto C.,Southern Cross University of Brazil | Mello-Moura A.C.V.,Ibirapuera University | Palo R.M.,Sao Paulo State University | Prokopowitsch I.,Southern Cross University of Brazil | And 2 more authors.
Journal of Biomedical Optics | Year: 2015

This research analyzed the quality of resin-based sealer adaptation after intracanal laser irradiation. Extracted teeth (n = 168) were root canal treated and divided into four groups, according to dentin surface treatment: no laser; Nd:YAG laser (1.5 W, 100 mJ, 15 Hz); diode laser (2.5Win CW), and Er:YAG laser (1 W, 100 mJ, 10 Hz). The teeth were divided into four subgroups according to the sealer used: AH Plus, EndoREZ, Epiphany, and EpiphanySE. For testing the sealing after root canal obturation, the penetration of silver nitrate solution was measured, whereas to evaluate the adaptation and penetration of the sealer into the dentin, environmental scanning electron microscopy (ESEM) was used. The ESEM images were analyzed using a four-grade criteria score by three evaluators. The inter-examiner agreement was confirmed by Kappa test and the scores statistically compared by the Kruskal-Wallis' test (p < 0.05). Both adaptation and sealer penetration in root canals were not affected by the laser irradiation. Nd:YAG and diode laser decreased the tracer penetration for AH Plus, whereas EndoREZ and EpiphanySE performances were affected by Nd:YAG irradiation (p < 0.05). It can be concluded that intracanal laser irradiation can be used as an adjunct in endodontic treatment; however, the use of hydrophilic resin sealers should be avoided when root canals were irradiated with Nd: YAG laser. © 2015 The Authors.

Cini L.,Ibirapuera University | Flores A.G.,Ibirapuera University | Pannuti C.M.,University of Sao Paulo
Pesquisa Brasileira em Odontopediatria e Clinica Integrada | Year: 2012

Objective: Smoking has been associated with several oral and systemic diseases. Despite their knowledge of the harms associated with smoking, many patients keep on smoking, which may be related to the nicotine dependence. Thus, the aim of this study was to assess nicotine dependence among smoking patients at the Ibirapuera University Dental Clinic. Methods: A cross-sectional study involving 77 adult smoking patients undergoing dental treatment was conducted. A structured questionnaire was applied, where subjects were asked about smoking habits and demographic information. Then the Fagerström Test of Nicotine Dependence was applied to assess nicotine dependence. Exhaled carbon monoxide levels were measured to validate the cigarette consumption reported by the participants. Results: The subjects reported smoking a mean of 13.7 cigarettes per day. Mean smoking exposure time was 26.7 years. Twenty-six subjects (33.7%) exhaled carbon monoxide levels above 21 ppm and thus were classified as heavy smokers. According to the Fagerström Test of Nicotine Dependence, 44 subjects (57.2%) were classified as nicotine dependent, 64 (83.1%) reported interest to stop smoking in the next 6 months, and 80.5% would accept help from a dentist to quit smoking. A significant correlation was observed between the reported amount of cigarettes consumed per day and the number of points obtained in the Fagerström Test of Nicotine Dependence. Conclusion: The majority of dental patients was considered as nicotine dependent, but they reported interest on stop smoking and would accept the help from a dentist in order to achieve this goal.

Barbosa F.T.,Federal University of Alagoas | Barbosa L.T.,Clinico do Hospital Geral do Estado Professor Osvaldo Brandao Vilela | Juca M.J.,Federal University of Alagoas | Juca M.J.,University of Texas at Dallas | And 2 more authors.
Revista Brasileira de Anestesiologia | Year: 2010

BACKGROUND AND OBJECTIVES: Magnesium is predominantly an intracellular ion. Its blocking effects on NMDA receptors are responsible for the analgesic and sedative characteristics of this ion. The objective of this study was to review the physiology, pharmacology, and decreased plasma levels of magnesium, as well as its applications in obstetrics and anesthesia. CONTENTS: Magnesium is an intracellular cation with multiple functions: it is a cofactor for enzymes of the glucose metabolism and those that participate in the degradation of nucleic acids, proteins, and fatty acids; it regulates the movements of transmembrane ions; and it intervenes in the activity of several enzymes. Critical patients have a tendency to develop hypomagnesemia, and the treatment consists in correcting the cause, whenever possible, and replacement of magnesium. A reduction in the minimum alveolar concentration (MAC) of inhalational agents in animals and the use of opioids in humans under anesthesia has been demonstrated. CONCLUSIONS: Magnesium sulfate has been used in obstetrics with good results, inhibiting premature labor and in the treatment of eclampsia-associated seizures. It is potentially analgesic and sedative, and could be used as adjuvant during general anesthesia, attenuating the blood pressure response to tracheal intubation and decreasing the need of anesthetics.

Moreira M.S.,University of Sao Paulo | Moreira M.S.,Ibirapuera University | Velasco I.T.,University of Sao Paulo | Ferreira L.S.,University of Sao Paulo | And 4 more authors.
Journal of Photochemistry and Photobiology B: Biology | Year: 2011

Laser phototherapy emerges as an alternative or auxiliary therapy for acute ischemic stroke, traumatic brain injury, degenerative brain disease, spinal cord injury, and peripheral nerve regeneration, but its effects are still controversial. We have previously found that laser phototherapy immunomodulates the response to focal brain damage. Following direct cortical cryogenic injury the effects of laser phototherapy on inflammation and repair was assessed after cryogenic injury (CI) to the central nervous system (CNS) of rats. The laser phototherapy was carried out with a 780 nm AlGaAs diode laser. The irradiation parameters were: power of 40 mW, beam area of 0.04 cm2, energy density of 3 J/cm2 (3 s) in two points (0.12 J per point). Two irradiations were performed at 3 h-intervals, in contact mode. Rats (20 non-irradiated - controls and 20 irradiated) were used. The wound healing in the CNS was followed in 6 h, 1, 7 and 14 days after the last irradiation. The size of the lesions, the neuron cell viability percentages and the amount of positive GFAP labeling were statistically compared by ANOVA complemented by Tukey's test (p < 0.05). The distribution of lymphocytes, leukocytes and macrophages were also analyzed. CI created focal lesions in the cortex represented by necrosis, edema, hemorrhage and inflammatory infiltrate. The most striking findings were: lased lesions showed smaller tissue loss than control lesions in 6 h. During the first 24 h the amount of viable neurons was significantly higher in the lased group. There was a remarkable increase in the amount of GFAP in the control group by 14 days. Moreover, the lesions of irradiated animals had fewer leukocytes and lymphocytes in the first 24 h than controls. Considering the experimental conditions of this study it was concluded that laser phototherapy exerts its effect in wound healing following CI by controlling the brain damage, preventing neuron death and severe astrogliosis that could indicate the possibility of a better clinical outcome. © 2011 Elsevier B.V. All rights reserved.

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