Entity

Time filter

Source Type


Noda H.,Osaka University | Noda H.,Harvard Center for Population and Development Studies | Iso H.,Osaka University | Irie F.,Ibaraki Prefectural Office | And 3 more authors.
Journal of Atherosclerosis and Thrombosis | Year: 2010

Aim: The aim of this study was to examine whether non-high-density lipoprotein cholesterol (non-HDL-cholesterol) raises the risk of coronary heart disease in a dose-response fashion in a non-obese population with low total cholesterol levels and high HDL-cholesterol levels, such as Japanese. Methods: A total of 30,802 men and 60,417 women, aged 40 to 79 years with no history of stroke or coronary heart disease, completed a baseline risk factor survey in 1993 under the auspices of the Ibaraki Prefectural Health Study. Systematic mortality surveillance through 2003 identified 539 coronary heart disease deaths. Results: The mean values for non-HDL-cholesterol were 140 mg/dL for men and 151 mg/dL for women. The corresponding mean values were 193 mg/dL and 208 mg/dL total cholesterol and 52 mg/dL and 57 mg/dL HDL-cholesterol, respectively. Men with non-HDL-cholesterol ≥ 180 mg/dL had a two-fold higher age-adjusted risk of mortality from coronary heart disease than did those with non-HDL-cholesterol <100 mg/dL, whereas no such association was found for women. The multi-variable hazard ratio for ≥ 180 mg/dL versus <100 mg/dL of non-HDL-cholesterol was 2.22 (95% confidence interval: 1.37 to 3.62) for men and 0.71 (0.37 to 1.34) for women. Conclusion: Higher concentrations of non-HDL-cholesterol were associated with an increased risk of mortality from coronary heart disease for men, but not for women. Source


Noda H.,Osaka University | Noda H.,Harvard Center for Population and Development Studies | Iso H.,Osaka University | Irie F.,Ibaraki Prefectural Office | And 3 more authors.
Journal of Internal Medicine | Year: 2010

Objective. The aim of this study was to examine whether LDL cholesterol raises the risk of coronary heart disease in a dose-response fashion in a population with low LDL-cholesterol levels. Design. Population-based prospective cohort study in Japan. Subjects and main outcome measures. A total of 30 802 men and 60 417 women, aged 40 to 79 years with no history of stroke or coronary heart disease, completed a baseline risk factor survey in 1993. Systematic mortality surveillance was performed through 2003 and 539 coronary heart disease deaths were identified. Results. The mean values for LDL-cholesterol were 110.5 mg dL-1 (2.86 mmol L-1) for men and 123.9 mg dL -1 (3.20 mmol L-1) for women. Men with LDL-cholesterol ≥140 mg dL-1 (≥3.62 mmol L-1) had two-fold higher age-adjusted risk of mortality from coronary heart disease than did those with LDL-cholesterol <80 mg dL-1 (<2.06 mmol L-1), whereas no such association for women was found. The multivariable hazard ratio for the highest versus lowest categories of LDL-cholesterol was 2.06 (95 percent confidence interval: 1.34 to 3.17) for men and 1.16 (0.64 to 2.12) for women. Conclusion. Higher concentrations of LDL-cholesterol were associated with an increased risk of mortality from coronary heart disease for men, but not for women, in a low cholesterol population. © 2010 Blackwell Publishing Ltd. Source

Discover hidden collaborations