Iaso Hospital

Athens, Greece

Iaso Hospital

Athens, Greece
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Yakoumakis E.,National and Kapodistrian University of Athens | Dimitriadis A.,National and Kapodistrian University of Athens | Gialousis G.,National and Kapodistrian University of Athens | Gialousis G.,IASO Hospital | And 4 more authors.
Radiation Protection Dosimetry | Year: 2014

Radiation protection and estimation of the radiological risk in paediatric radiology is essential due to children's significant radiosensitivity and their greater overall health risk. The purpose of this study was to estimate the organ and effective doses of paediatric patients undergoing barium meal (BM) examinations and also to evaluate the assessment of radiation Risk of Exposure Induced cancer Death (REID) to paediatric patients undergoing BM examinations. During the BM studies, fluoroscopy and multiple radiographs are involved. Since direct measurements of the dose in each organ are very difficult if possible at all, clinical measurements of dose-area products (DAPs) and the PCXMC 2.0 Monte Carlo code were involved. In clinical measurements, DAPs were assessed during examination of 51 patients undergoing BM examinations, separated almost equally in three age categories, neonatal, 1- and 5-y old. Organs receiving the highest amounts of radiation during BM examinations were as follows: the stomach (10.4, 10.2 and 11.1 mGy), the gall bladder (7.1, 5.8 and 5.2 mGy) and the spleen (7.5, 8.2 and 4.3 mGy). The three values in the brackets correspond to neonatal, 1- and 5-y-old patients, respectively. For all ages, the main contributors to the total organ and effective doses are the fluoroscopy projections. The average DAP values and absorbed doses to patient were higher for the left lateral projections. The REID was calculated for boys (4.8 × 10-2, 3.0 × 10-2 and 2.0 × 10-2 %) for neonatal, 1- and 5-y old patients, respectively. The corresponding values for girl patients were calculated (12.1 × 10-2, 5.5 × 10-2 and 3.4 × 10-2 %). © The Author 2014.


Pavlakis K.,National and Kapodistrian University of Athens | Messini I.,IASO Hospital | Yiannou P.,IASO Hospital | Chrissanthakis D.,IASO Hospital | And 3 more authors.
Gynecologic Oncology | Year: 2010

Aims: To investigate the immunohistochemical profile of cervical mesonephric remnants. Methods and results: Cases of mesonephric remnants, microglandular hyperplasia, tunnel clusters, tuboendometrioid metaplasia and cervical adenocarcinomas were immunohistochemically stained with Ki-67, CD10, bcl2 and p16. All 26 cases of mesonephric remnants were strongly positive for bcl2 and weakly to moderately positive for p16. CD10 was positive in 19 cases. Seven cases were negative and 19 weakly positive for Ki-67. All 10 cases of tuboendometrioid metaplasia showed high positivity for bcl2. Two cases were negative for p16; seven cases presented low and one case moderate positivity. Five cases were negative for CD10, while in five the staining was low. Six cases of tuboendometrioid metaplasia were negative for Ki-67, while four showed low staining. Tunnel clusters were negative for all antibodies, except one, which showed focal positivity for Ki-67 and p16. All cases of microglandular hyperplasia were negative for bcl2, p16 and CD10 and only 5/12 showed focal positivity for Ki-67. All adenocarcinomas were negative for bcl2 and CD10, and highly positive for p16 and Ki-67. Conclusions: bcl2 is more constantly and strongly expressed in mesonephric remnants than CD10. p16 is weakly to moderately positive, while Ki-67 is negative to weakly positive. © 2009 Elsevier Inc. All rights reserved.


Plessa E.,Zante Medical Care ZanteMed | Plessa E.,Alfa Institute of Biomedical science AIBS | Tansarli G.S.,Alfa Institute of Biomedical science AIBS | Xanthopoulos D.,Zante Medical Care ZanteMed | And 3 more authors.
PLoS ONE | Year: 2014

Background: Although there is satisfactory recording of diseases affecting travelers visiting developing countries, little is known regarding morbidity of travelers when visiting developed countries. We sought to evaluate the morbidity of foreign travelers in Zakynthos, a popular Greek island attracting large number of foreign tourists every summer. Methods: Data from foreign travelers that accommodated in Zakynthos and sought medical services from the private offices of Zante Medical Care from May 1 to October 30 2012 were retrospectively analyzed. Results: Two thousand six hundred and eighty-eight patients were included in the study. The mean age (±SD) of the patients whom the age was recorded was 29.6 (±18.3) and 51.5% of them were from 18 to 40 years old. Disorders of the respiratory tract (32.7%), dermatologic conditions (21.1%), musculoskeletal injuries (16.4%), and gastrointestinal disorders (16.3%) were the four most prevalent clinical categories among patients. Ear disorder was the most common syndromic description (14.5%) among which 81.2% were ear infections; otitis externa and otitis media were diagnosed in 8.5% and 3.3% patients in total. The most common specific diagnosis was gastroenteritis (14.3%). Insect bite and sunburn were the most common diagnosis (6.5% and 3.8%, respectively) among patients with a dermatologic condition. Ear infection was the most common diagnosis in pediatric patients. Conclusion: Disorders mainly of the upper respiratory tract were the predominant causes of illness among foreign travelers in Zakynthos. Traveler's diarrhea was the most common specific diagnosis but the prevalence within the total population was not very high. © 2014 Plessa et al.


PubMed | St Savas Cancer Hospital, National and Kapodistrian University of Athens and IASO Hospital
Type: | Journal: BioMed research international | Year: 2015

Endometrial cancer is the most common malignancy of the female genital tract while aberrant DNA methylation seems to play a critical role in endometrial carcinogenesis. Galanins expression has been involved in many cancers. We developed a new pyrosequencing assay that quantifies DNA methylation of galanins receptor-1 (GALR1). In this study, the preliminary results indicate that pyrosequencing methylation analysis of GALR1 promoter can be a useful ancillary marker to cytology as the histological status can successfully predict. This marker has the potential to lead towards better management of women with endometrial lesions and eventually reduce unnecessary interventions. In addition it can provide early warning for women with negative cytological result.


Dimitriadis A.,National and Kapodistrian University of Athens | Gialousis G.,National and Kapodistrian University of Athens | Gialousis G.,IASO Hospital | Makri T.,Ag Sofia Hospital | And 5 more authors.
Physics in Medicine and Biology | Year: 2011

Organ doses are important quantities in assessing the radiation risk. In the case of children, estimation of this risk is of particular concern due to their significant radiosensitivity and the greater health detriment. The purpose of this study is to estimate the organ doses to paediatric patients undergoing barium meal and micturating cystourethrography examinations by clinical measurements and Monte Carlo simulation. In clinical measurements, dose-area products (DAPs) were assessed during examination of 50 patients undergoing barium meal and 90 patients undergoing cystourethrography examinations, separated equally within three age categories: namely newborn, 1 year and 5 years old. Monte Carlo simulation of photon transport in male and female mathematical phantoms was applied using the MCNP5 code in order to estimate the equivalent organ doses. Regarding the micturating cystourethrography examinations, the organs receiving considerable amounts of radiation doses were the urinary bladder (1.87,2.43 and 4.7 mSv, the first, second and third value in the parentheses corresponds to neonatal, 1 year old and 5 year old patients, respectively), the large intestines (1.54,1.8, 3.1 mSv), the small intestines (1.34,1.56,2.78 mSv), the stomach (1.46,1.02,2.01 mSv) and the gall bladder (1.46,1.66,2.18 mSv), depending upon the age of the child. Organs receiving considerable amounts of radiation during barium meal examinations were the stomach (9.81, 9.92, 11.5 mSv), the gall bladder (3.05, 5.74, 7.15 mSv), the rib bones (9.82, 10.1, 11.1 mSv) and the pancreas (5.8, 5.93, 6.65 mSv), depending upon the age of the child. DAPs to organ/effective doses conversion factors were derived for each age and examination in order to be compared with other studies. © 2011 Institute of Physics and Engineering in Medicine Printed in the UK.


Foustanos A.,Iaso Hospital | Messinis L.,University of Patras | Panagiotopoulos K.,Iaso Hospital
Acta Chirurgiae Plasticae | Year: 2012

Background: Prominent ears are a common congenital deformity. Numerous techniques have been developed for the treatment of protruding ears, indicating that there is no single widely-accepted procedure. Modern otoplasty techniques fall into of two main surgical categories, (1) cartilage sparing (Mustardé & Furnas), and (2) cartilage cutting (Chongchet & Stenström). This study compares an antihelixmastoid suture technique with the normal Mustardé & Furnas technique. Methods: Within a 5-year period (between 2005 and 2009), 78 patients (mean age 27 years; range 7 to 46) underwent otoplasty performed by the senior author (in a private plastic surgery center), employing the posterior suturing technique (Mustardé & Furnas). Of these 78 patients, 44 underwent otoplasty which combined the usual posterior suturing technique with modification we have developed (antihelixmastoid sutures). Depending on the suture technique used, the patients were divided into two groups: Group 1 (Mustardé & Furnas sutures), Group 2 (Mustardé & Furnas sutures with extra modification). Patients were invited for follow-up examinations 1 month and 1 year after surgery, and all of them attended both these follow-up checks, where recurrence and suture extrusion were evaluated. Results: Group 1: the clinical recurrence rate was 4.55% (3 ears). The suture extrusion rate was 7.6% (5 ears). Group 2: the clinical recurrence rate was 1.25% (1 ear). The suture extrusion rate was 7.5% (6 ears). Patients were generally satisfied with the results in terms of shape and symmetry. There were no complications such as haematoma, ear deformity and skin necrosis. Conclusions: Posterior suturing with conchomastoid and modification of Mustardé sutures is a simple operation which can be performed quickly. It appears to be effective in terms of recurrence rate (especially in the upper segment) and patient satisfaction.


PubMed | Institute of Technologists, University of Thessaly and IASO Hospital
Type: Journal Article | Journal: Skeletal radiology | Year: 2015

To evaluate the ability of proton-density with fat-suppression BLADE (proprietary name for periodically rotated overlapping parallel lines with enhanced reconstruction in MR systems from Siemens Healthcare, PDFS BLADE) and turbo inversion recovery magnitude-BLADE (TIRM BLADE) sequences to reduce motion and pulsation artifacts in shoulder magnetic resonance examinations.Forty-one consecutive patients who had been routinely scanned for shoulder examination participated in the study. The following pairs of sequences with and without BLADE were compared: (a) Oblique coronal proton-density sequence with fat saturation of 25 patients and (b) oblique sagittal T2 TIRM-weighed sequence of 20 patients. Qualitative analysis was performed by two experienced radiologists. Image motion and pulsation artifacts were also evaluated.In oblique coronal PDFS BLADE sequences, motion artifacts have been significantly eliminated, even in five cases of non-diagnostic value with conventional imaging. Similarly, in oblique sagittal T2 TIRM BLADE sequences, image quality has been improved, even in six cases of non-diagnostic value with conventional imaging. Furthermore, flow artifacts have been improved in more than 80% of all the cases.The use of BLADE sequences is recommended in shoulder imaging, especially in uncooperative patients because it effectively eliminates motion and pulsation artifacts.


Foustanos A.,IASO Hospital | Drimouras G.,IASO Hospital | Panagiotopoulos K.,IASO Hospital
Archives of Plastic Surgery | Year: 2015

Background Descent of the lateral aspect of the brow is one of the earliest signs of aging. The purpose of this study was to describe an open surgical technique for lateral brow lifts, with the goal of achieving reliable, predictable, and long-lasting results. Methods An incision was made behind and parallel to the temporal hairline, and then extended deeper through the temporoparietal fascia to the level of the deep temporal fascia. Dissection was continued anteriorly on the surface of the deep temporal fascia and subperiosteally beyond the temporal crest, to the level of the superolateral orbital rim. Fixation of the lateral brow and tightening of the orbicularis oculi muscle was achieved with the placement of sutures that secured the tissue directly to the galea aponeurotica on the lateral aspect of the incision. An additional fixation was made between the temporoparietal fascia and the deep temporal fascia, as well as between the temporoparietal fascia and the galea aponeurotica. The excess skin in the temporal area was excised and the incision was closed. Results A total of 519 patients were included in the study. Satisfactory lateral brow elevation was obtained in most of the patients (94.41%). The following complications were observed: total relapse (n=8), partial relapse (n=21), neurapraxia of the frontal branch of the facial nerve (n=5), and limited alopecia in the temporal incision (n=9). Conclusions We consider this approach to be a safe and effective procedure, with long-lasting results. © 2015 The Korean Society of Plastic and Reconstructive Surgeons.


Foustanos A.,Iaso Hospital | Panagiotopoulos K.,Iaso Hospital | Skouras G.,Iaso Hospital
Aesthetic Plastic Surgery | Year: 2011

Background: The Pitanguy method of reduction mammaplasty has been shown to be an anatomically safe technique in the management of the ptotic breast. However, the technique, as first described, cannot be applied in gigantomastia or severe breast ptosis cases or cases of dense parenchyma of the breast. The senior surgeon suggested an intraoperative modification of the Pitanguy method of reduction mammaplasty to make it applicable for such cases. Methods: A retrospective study of 122 patients with severe breast ptosis (70), gigantomastia (45), or dense breast parenchyma (7) who underwent a modification of the Pitanguy method was performed. The current procedure involves all the operating steps of the superior pedicle technique as described by Pitanguy, from the marking technique to the keel resection of the breast. If the nipple-areola complex is elevated inadequately, the surgeon can use the senior surgeon's modification to elevate the complex to the desired height. This modification consists of dissecting the upper pole of the breast vertically to the fascia of the pectoralis major muscle and laterally to the nipple-areola complex. The medial flap is then advanced superiorly, rotated 90°, and sutured to point A, while the lateral flap is placed below the medial one. This maneuver maximizes elevation of the nipple-areola complex to the desired height. Results: The mean change in nipple position was 14 cm (range = 10-16 cm). The mean weight reduction of each breast was 900 g (range = 700-1300 g). The follow-up included 119 patients and the follow-up period ranged from 1 to 3 years (mean follow-up = 2 years). Three patients were operated on less than 3 months ago and were not involved in this study. All patients gained natural shaped breasts and they were pleased with the results. Serious complications, including flap necrosis, were avoided since caution was used to preserve the internal mammary perforators while performing this method. Conclusion: This technique provides a versatile, well-vascularized pedicle that allows elevation of the nipple-areola complex at the desired height in cases of severe breast ptosis, gigantomastia, or dense breast parenchyma. © 2010 Springer Science+Business Media, LLC and International Society of Aesthetic Plastic Surgery.


PubMed | IASO Hospital
Type: Journal Article | Journal: Archives of plastic surgery | Year: 2015

Descent of the lateral aspect of the brow is one of the earliest signs of aging. The purpose of this study was to describe an open surgical technique for lateral brow lifts, with the goal of achieving reliable, predictable, and long-lasting results.An incision was made behind and parallel to the temporal hairline, and then extended deeper through the temporoparietal fascia to the level of the deep temporal fascia. Dissection was continued anteriorly on the surface of the deep temporal fascia and subperiosteally beyond the temporal crest, to the level of the superolateral orbital rim. Fixation of the lateral brow and tightening of the orbicularis oculi muscle was achieved with the placement of sutures that secured the tissue directly to the galea aponeurotica on the lateral aspect of the incision. An additional fixation was made between the temporoparietal fascia and the deep temporal fascia, as well as between the temporoparietal fascia and the galea aponeurotica. The excess skin in the temporal area was excised and the incision was closed.A total of 519 patients were included in the study. Satisfactory lateral brow elevation was obtained in most of the patients (94.41%). The following complications were observed: total relapse (n=8), partial relapse (n=21), neurapraxia of the frontal branch of the facial nerve (n=5), and limited alopecia in the temporal incision (n=9).We consider this approach to be a safe and effective procedure, with long-lasting results.

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