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Ymittos Athens, Greece

Dimitriadi D.,In Vitro Labs | Charitidou C.,Private Microbiological Laboratory | Charvalos E.,Iaso Hospital
International Arabic Journal of Antimicrobial Agents | Year: 2014

Staphylococcus warneri, similarly to other coagulase-negatine Staphylococcus (CoNS), is a commensal of the skin, mucous membranes, nasal cavities and mouth of humans, found in 50% of the population. This species usually represents less than 1% of the total staphylococcal skin population. S. warneri can potentially cause severe infections usually in immunocompromised individuals, even more in combination with the presence of indwelling devices and/or implants. The key treatment for such infections is the removal of the device. Sometimes, even in the absence of a foreign body, Staphylococcus warneri may be implicated as the causative agent of an infection in immunocompetent patients. We report here a case of chronic urinary tract infection in adult healthy patient caused by S.warneri, its clinical significance and resistant to commonly used beta-lactams. © Under License of Creative Commons Attribution 3.0 License. Source

Lavdas E.,Institute of Technologists | Vlychou M.,University of Thessaly | Zaloni E.,Institute of Technologists | Vassiou K.,University of Thessaly | And 3 more authors.
Skeletal Radiology | Year: 2015

Objectives: To evaluate the ability of proton-density with fat-suppression BLADE (proprietary name for periodically rotated overlapping parallel lines with enhanced reconstruction in MR systems from Siemens Healthcare, PDFS BLADE) and turbo inversion recovery magnitude-BLADE (TIRM BLADE) sequences to reduce motion and pulsation artifacts in shoulder magnetic resonance examinations. Materials and methods: Forty-one consecutive patients who had been routinely scanned for shoulder examination participated in the study. The following pairs of sequences with and without BLADE were compared: (a) Oblique coronal proton-density sequence with fat saturation of 25 patients and (b) oblique sagittal T2 TIRM-weighed sequence of 20 patients. Qualitative analysis was performed by two experienced radiologists. Image motion and pulsation artifacts were also evaluated. Results: In oblique coronal PDFS BLADE sequences, motion artifacts have been significantly eliminated, even in five cases of non-diagnostic value with conventional imaging. Similarly, in oblique sagittal T2 TIRM BLADE sequences, image quality has been improved, even in six cases of non-diagnostic value with conventional imaging. Furthermore, flow artifacts have been improved in more than 80% of all the cases. Conclusions: The use of BLADE sequences is recommended in shoulder imaging, especially in uncooperative patients because it effectively eliminates motion and pulsation artifacts. © 2015, ISS. Source

Zygogianni A.,Iaso Hospital | Zygogianni A.,Larissa University Hospital | Zygogianni A.,National and Kapodistrian University of Athens | Kyrgias G.,Larissa University Hospital | And 8 more authors.
Head and Neck Oncology | Year: 2012

Aim The aim of this study was to investigate the treatment efficacy, acute and late toxicity using a hypofractionated irradiation schedule combined with oral administration of glutamine (GLN) in elderly patients with advanced squamous cell carcinoma of head and neck (SCCHN). Methods In a retrospective manner, we studied 31 patients with advanced SCCHN treated with hypofractionated radiotherapy and administration of GLN. The irradiation schedules consisted of three hypofractionated schedules. The first schedule consisted of 21 irradiation fractions (56.7 Gy) within 29 days by using intensive modulated radiation therapy technique or 3D conformal radiotherapy. The second and the third schedules were performed with 3D conformal techniques by 49.5 Gy in 18 daily fractions and 59.8 Gy in 26 daily fractions. All patients received 30 g powdered GLN daily as soon as oral mucositis was presented. The median follow-up was 18 months (range: 9-24). The severity of skin toxicity and oral mucositis was graded according to the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer (RTOG/EORTC) criteria. Results Overall complete response was seen in 12 patients (38.7%), while 5 patients (16.1%) had partial response, 7 patients (22.6%) had stable disease and 7 patients (22.6%) had progressive disease. The median relapse-free survival was 14 months. Three patients (9.7%) experienced grade III acute skin toxicity. Twenty-one (67.7%) and seven (22.6%) patients experienced grade II and grade I acute skin toxicity, respectively. A significant decrease was noted in the incidence of toxicity after the administration of GLN (P < 0.01, chi-square test). The mean score of dysphagia-related pain and oral mucositis regressed significantly (P < 0.01, Wilcoxon test) in the last week of irradiation after GLN administration. Conclusion In elderly patients suffering from SCCHN with co-morbitities and unsuitable for daily irradiation and chemotherapy, an alternative schedule of hypofractionation is possible when combined with GLN administration. Source

Pavlakis K.,National and Kapodistrian University of Athens | Messini I.,Iaso Hospital | Yiannou P.,Iaso Hospital | Chrissanthakis D.,Iaso Hospital | And 3 more authors.
Gynecologic Oncology | Year: 2010

Aims: To investigate the immunohistochemical profile of cervical mesonephric remnants. Methods and results: Cases of mesonephric remnants, microglandular hyperplasia, tunnel clusters, tuboendometrioid metaplasia and cervical adenocarcinomas were immunohistochemically stained with Ki-67, CD10, bcl2 and p16. All 26 cases of mesonephric remnants were strongly positive for bcl2 and weakly to moderately positive for p16. CD10 was positive in 19 cases. Seven cases were negative and 19 weakly positive for Ki-67. All 10 cases of tuboendometrioid metaplasia showed high positivity for bcl2. Two cases were negative for p16; seven cases presented low and one case moderate positivity. Five cases were negative for CD10, while in five the staining was low. Six cases of tuboendometrioid metaplasia were negative for Ki-67, while four showed low staining. Tunnel clusters were negative for all antibodies, except one, which showed focal positivity for Ki-67 and p16. All cases of microglandular hyperplasia were negative for bcl2, p16 and CD10 and only 5/12 showed focal positivity for Ki-67. All adenocarcinomas were negative for bcl2 and CD10, and highly positive for p16 and Ki-67. Conclusions: bcl2 is more constantly and strongly expressed in mesonephric remnants than CD10. p16 is weakly to moderately positive, while Ki-67 is negative to weakly positive. © 2009 Elsevier Inc. All rights reserved. Source

Georgakopoulos J.,University Hospital | Zygogianni A.,Iaso Hospital | Zygogianni A.,Radiation Oncology Unit | Papadopoulos G.,Genimatas Hospital | And 5 more authors.
Reviews on Recent Clinical Trials | Year: 2012

Brachytherapy nowadays has become a widely accepted treatment modality in the management of localized prostate cancer. With recent improvements in ultra-sound technology, imaging, treatment planning and post-implant dosimetry, permanent implantation has become minimally invasive, well tolerated, and safe and most importantly has progressed to a treatment modality comparable to external beam radiation therapy (EBRT) and radical prostatectomy. Multiple studies have proven the efficacy of brachytherapy analyzing also its superiority in health related quality of life; especially in potency preservation after treatment. © 2012 Bentham Science Publishers. Source

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