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Lambidis C.,Iaso General Hospital of Athens | Galanopoulos G.,Iaso General Hospital of Athens | Galanopoulos G.,National and Kapodistrian University of Athens
Hemodialysis International | Year: 2013

The superiority of autogenous fistulae in patients with end-stage renal disease, performing hemodialysis, is well established and largely accepted. However, in case that superficial veins in the upper arm are not available for fistula construction, brachial vein transposition may be a viable alternative prior to graft placement. This transposition could be done as a primary or staged procedure, depending on the vein size. We present the case of a 63-year-old male patient with a thrombosed arteriovenous graft in the forearm and a large brachial vein in the ipsilateral upper arm. A one-stage (primary) brachial vein transposition was performed. The fistula, 10 months after its construction, is still patent. No complications have occurred. © 2013 The Authors. Hemodialysis International © 2013 International Society for Hemodialysis.


Galanopoulos G.,National and Kapodistrian University of Athens | Galanopoulos G.,Iaso General Hospital of Athens | Lambidis C.,Iaso General Hospital of Athens
Renal Failure | Year: 2014

Synthetic arteriovenous grafts for hemodialysis constitute the second choice in comparison with native arteriovenous fistulas. Lower patency rates and significantly more frequent infections are the main disadvantages of hemodialysis grafts over fistulas. Infectious complications could vary between a simple local erythema at a puncture site that resolves easily with antibiotics to septicemia and death. As a corollary, this kind of complications continue to be among the most important causes of morbidity and mortality in end-stage renal disease patients receiving long-term hemodialysis. The cornerstone is prevention of infections. It is generally accepted that following simple measures during the intervention of graft insertion and consecutively in every hemodialysis session could consistently reduce the risk of infection. © 2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted.


Galanopoulos G.,Iaso General Hospital of Athens | Galanopoulos G.,National and Kapodistrian University of Athens | Lambidis C.,Iaso General Hospital of Athens
International Journal of Surgery | Year: 2012

Varicose veins are a frequently encountered medical condition. In the era of minimally invasive surgery, several techniques, in the treatment of varicose veins, have been developed in the last few years. One of the most frequently used new techniques is endovenous laser ablation. Fibrotic sealing of the treated vein lumen is the final result. The vein ablation is obtained under local - tumescent anaesthesia and the patients can be treated in an office setting with immediate return to full activity. Safety and effectiveness seem to be the major characteristics and advantages of this technique. © 2012 Surgical Associates Ltd.


Kotsakis A.,University of Crete | Vetsika E.-K.,University of Crete | Christou S.,University of Crete | Hatzidaki D.,University of Crete | And 8 more authors.
Annals of Oncology | Year: 2012

Background: TERT (telomerase reverse transcriptase) plays a critical role in tumor cell growth and survival. In an expanded phase II study, we evaluated the immunological and clinical responses to the TERT-targeting Vx-001 vaccine in patients with advanced solid tumors. Methods: HLA-A*0201-positive patients received two subcutaneous injections of the optimized TERT. 572Y peptide followed by four injections of the native TERT. 572 peptide, every 3 weeks. Peptide-specific immune responses were evaluated by enzyme-linked immunosorbent spot at baseline, and after the second and the sixth vaccinations. Results: Fifty-five patients were enrolled and 34 (62%) completed the six vaccinations. A TERT-specific T-cell immune response was observed in 55% and 70% of patients after the second and the sixth vaccinations, respectively. The disease control rate (DCR) was 36% [95% confidence interval (CI) 24% to 49%], including one complete and one partial response. Immunologically responding patients had a better clinical outcome than non responders [DCR: 44% versus 14% (P = 0.047); progression-free survival (PFS): 5.2 versus 2.2 months (P = 0.0001) and overall survival: 20 versus 10 months (P = 0.041)]. Multivariate analysis revealed that the immunological response was an independent variable associated with increased PFS (hazard ratio = 3.35; 95% CI 1.7-6.7). Conclusion: Vx-001 vaccine was well tolerated and induced a TERT-specific immunological response, which was significantly correlated with improved clinical outcome. © The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.


Galanopoulos G.,Iaso General Hospital of Athens
Il Giornale di chirurgia | Year: 2011

Sudden sensorineural hearing loss following non-otologic surgery, under general anesthesia, is an extremely rare complication. Furthermore, postoperative deafness has more commonly been associated with cardiac surgery. This acute dysfunction of the inner ear consists a controversial subject in terms of etiopathogenic mechanisms and treatment modalities. We present the case of a 60-year-old male patient who underwent varicose vein surgery under general anesthesia and presented immediately after the operation bilateral and profound impairment of his hearing acuity. A high index of suspicion is required to early diagnosis of this complication, although prompt treatment does not guarantee a good outcome.


Panagiotou I.,Iaso General Hospital of Athens | Patris K.,Iaso General Hospital of Athens | Kotileas P.,401 General Military Hospital of Athens | Kotoulas C.,Iaso General Hospital of Athens
Hellenic Journal of Cardiology | Year: 2010

We report a case of aortic root dissection in a middle-aged male without history of recent trauma, presenting as a critical aortic regurgitation due to right cusp dislodgement. The intraoperative transesophageal echocardiogram revealed the "double aortic valve" sign suggestive of low dissection, which proved to extend to both coronary arteries.


Vetsika E.-K.,University of Crete | Konsolakis G.,University of Crete | Aggouraki D.,University of Crete | Kotsakis A.,University of Crete | And 7 more authors.
Cancer Immunology, Immunotherapy | Year: 2012

Vx-001, an HLA-A*0201 restricted telomerase (TERT)-specific anti-tumor vaccine, is composed of the 9-mer cryptic TERT 572 peptide and its optimized variant TERT 572Y. We have previously shown that Vx-001 is non-toxic, highly immunogenic and in vaccinated NSCLC patients early specific immune response is associated with prolonged survival. The aim of the present study was to investigate the specific T-cell immune response against Vx-001. Fifty-five patients with chemo-resistant advanced solid tumors were vaccinated with TERT 572Y (2 subcutaneous injections) followed by TERT 572 peptide (4 subcutaneous injections) every 3 weeks. Specific immune response was evaluated by IFN-γ and perforin ELISpot and intracellular cytokine staining assays. TERT-reactive T cells were detected in 27 (51%) out of 53 evaluable patients after the 2nd vaccination and in 22 (69%) out of 32 evaluable patients after the completion of 6 vaccinations. Immune responses developed irrespective of the stage of disease and disease status before vaccination. Patients with disease progression at study entry who developed a post-vaccination-induced immunological response had a significant overall survival benefit compared to the post-vaccination non-responders. The Vx-001 vaccine is a promising candidate for cancer immunotherapy since it can induce a TERT-specific T-cell immune response that is associated with prolonged survival. © 2011 Springer-Verlag.


Kotoulas C.,IASO General Hospital of Athens
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo | Year: 2011

Post-coarctation surgical repair aneurysm formation is observed rarely with end-to-end anastomosis technique. The redo surgery is associated with high mortality and morbidity rate. Although the minimal invasive method with stented grafts has been reported in only small number of patients, this could represent a valid alternative treatment. We present a case of successful endovascular treatment of a patient with a late post-coarctation repair saccular aneurysm.


PubMed | Iaso General Hospital of Athens
Type: Case Reports | Journal: Hemodialysis international. International Symposium on Home Hemodialysis | Year: 2013

The superiority of autogenous fistulae in patients with end-stage renal disease, performing hemodialysis, is well established and largely accepted. However, in case that superficial veins in the upper arm are not available for fistula construction, brachial vein transposition may be a viable alternative prior to graft placement. This transposition could be done as a primary or staged procedure, depending on the vein size. We present the case of a 63-year-old male patient with a thrombosed arteriovenous graft in the forearm and a large brachial vein in the ipsilateral upper arm. A one-stage (primary) brachial vein transposition was performed. The fistula, 10 months after its construction, is still patent. No complications have occurred.


PubMed | Iaso General Hospital of Athens
Type: Journal Article | Journal: International journal of surgery (London, England) | Year: 2012

Varicose veins are a frequently encountered medical condition. In the era of minimally invasive surgery, several techniques, in the treatment of varicose veins, have been developed in the last few years. One of the most frequently used new techniques is endovenous laser ablation. Fibrotic sealing of the treated vein lumen is the final result. The vein ablation is obtained under local - tumescent anaesthesia and the patients can be treated in an office setting with immediate return to full activity. Safety and effectiveness seem to be the major characteristics and advantages of this technique.

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