iangsu University

Zhenjiang, China

iangsu University

Zhenjiang, China
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Ouyang Z.,Iangsu University | Zhao M.,Iangsu University | Tang J.,Iangsu University | Pan L.,Iangsu University
Pharmacognosy Magazine | Year: 2012

Background: Nao-De-Sheng decoction (NDS), a traditional Chinese medicine (TCM) prescription containing Radix puerariae lobatae, Floscarthami, Radix et Rhizoma Notoginseng, Rhizoma chuanxiong and Fructus crataegi, is effective in the treatment of cerebral arteriosclerosis, ischemic cerebral stroke and apoplexy linger effect. Ferulic acid and puerarin are the main absorbed effective ingredients of NDS. Objective: To assess the affection of other components in medical material and compound recipe compatibility on the pharmacokinetics of ferulaic acid and puerarin, of ferulic acid from the monomer Rhizoma chuanxiong aqueous extract and NDS were studied. And pharmacokinetics comparisons of puerarin from the monomer Radix puerariae extract and NDS decoction were investigated simultaneously. Materials and Methods: At respective different time points after oral administration of the monomer, medicinal substance aqueous extract and NDS at the same dose in rats, plasma concentrations of ferulic acid and puerarin in rats were determined by RP-HPLC, and the main pharmacokinetic parameters were estimated with 3P97 software. Results: The plasma concentration-time curves of ferulaic acid and puerarin were both best fitted with a two-compartment model. AUC 0-t, AUC 0→∞ , Tmax , and Cmax of ferulic acid in the monomer and NDS decoction were increased significantly (P < 0.05) compared with that in Rhizoma chuanxiong aqueous extract. And statistically signicant increase (P < 0.05) in pharmacokinetic parameters of puerarin including AUC 0-t, AUC 0→∞ , CL, Tmax and Cmax were obtained after oral administration of puerarin monomer compared with Radix puerariae extract. Although the changes of AUC 0-t, AUC 0→ ∞ and CL had no statistically significant, Cmax of puerarin in NDS was increased remarkably (P < 0.05) compared with that in single puerarin. Conclusions: Some ingredients of Rhizoma chuanxiong and Radix puerariae may be suggested to remarkably influence plasma concentrations of ferulaic acid and puerarin. Some ingredients in NDS may increase dissolution and absorption of ferulaic acid and puerarin, delay elimination, and subsequently enhance bioavailability of ferulaic acid and puerarin in rats after compatibility.


He M.-Q.,iangsu University | Wen C.-Z.,iangsu University | Jin T.-H.,iangsu University | Bao L.-L.,iangsu University | And 2 more authors.
Lizi Jiaohuan Yu Xifu/Ion Exchange and Adsorption | Year: 2013

Molecularly imprinted polymers for aminotriazole (AMI) were synthesized with aminotriazole as template molecule, methacrylic acids as functional monomer, and EDMA as crosslinker in isobutanol solution by molecular imprinting technique. The binding affinity and recognition of the imprinted polymers to aminotriazole were evaluated by equilibrium adsorption experiments. Moreover, the adsorption selectivity experiments and the adsorption kinetics were observed, respectively. The results showed that two classes of binding sites were formed in AMI-MIP, and AMI-MIP exhibited higher affinity and recognition to aminotriazole. Pseudo-second order equation was fitted for adsorption of AMI on AMI-MIP.

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