News Article | May 8, 2017
Twenty-nine countries from the Paris and the Tokyo Memoranda of Understanding have signed a new Ministerial Declaration on Port State Control (PSC), the Danish Maritime Authority (DMA) informed. The declaration, signed during the Ministerial Conference held in Vancouver, Canada, on May 3-4, 2017, is said to stipulate new goals for PSC and for cooperation on PSC. The DMA said that Danish key issues on, inter alia, enforcement of the sulphur regulations and the Polar Code have been included in the declaration. ”Port State Control is an important part of ensuring compliance with international regulation. That’s why it is gratifying to see that Danish key issues on enforcement of the sulphur regulations and the Polar Code have been included in the declaration. It is important to Denmark that environmental considerations are taken worldwide,” Andreas Nordseth, Director General of the Danish Maritime Authority, commented. In addition to the sulphur regulations and the Polar Code, the declaration focuses on other areas as well, such as the acceptance of electronic certificates, more transparency and reductions of the burdens imposed on the industry in connection with PSC inspections. Furthermore, the inspection regime should continuously be developed in order to optimise the use of the resources available, according to the DMA. The DMA further said that PSC inspections have proven to be an effective instrument for ensuring ships’ compliance with international regulations and, thus, a level playing field for the benefit of safety, the environment and seafarers. PSC inspections have also resulted in reduced number of defects and non-conformities. Additionally, the number of detentions has stabilised at around 3.5 per cent annually, just as more countries are now in compliance with the conditions for being included on the White List, the DMA explained. In addition to the twenty-nine countries, the International Maritime Organisation (IMO) Secretary General, a representative of the International Labour Organisation (ILO) as well as the International Shipping Federation (ISF), the International Transport Workers’ Federation (ITF) and the International Association of Classification Societies (IACS) attended the conference.
News Article | October 26, 2016
The University of Texas MD Anderson Cancer Center's Institute for Applied Cancer Science (IACS) has initiated the first clinical study of a novel drug designed to starve cancer cells, IACS-10759. The study will enroll patients with acute myeloid leukemia (AML) and is supported by a $3.5 million investment from The Leukemia & Lymphoma Society (LLS) Therapy Acceleration Program®. Recent approval from the U.S. Food and Drug Administration to begin clinical studies was based on compelling activity upon IACS-10759 treatment in multiple preclinical models of AML. "We're delighted that this milestone clinical trial, bringing forth an entirely new approach for this difficult disease, has earned the support of The Leukemia & Lymphoma Society," said Giulio Draetta, M.D., Ph.D., head of Therapeutics Development at MD Anderson. "We are hopeful that we will soon see in patients the promising response to IACS-10759 that we observed in preclinical models." All cells rely on two processes to generate the energy they need to survive: oxidative phosphorylation (OXPHOS) and glycolysis. IACS-10759 interferes with one of the molecular machines within mitochondria to inhibit OXPHOS. Normal cells can get around OXPHOS inhibition by turning up glycolysis; however, the IACS team led by Emilia di Francesco, Ph.D., associate director of Medicinal Chemistry, and Joe Marszalek, Ph.D., head of Translational Biology, identified a highly potent and specific OXPHOS inhibitor to target cancer cells that are unable to compensate in that way, and survive. "The IACS model emphasizes the need for us to deeply understand the biological effects of drugs," Draetta said. "We want to increase the precision with which we identify and develop new molecules, to ask critical questions about the effects of any new drug within the most relevant contexts." To accomplish this, Marszalek and Di Francesco, forged collaboration with Marina Konopleva, M.D., Ph.D., professor of Leukemia, who could offer clinical expertise and powerful models for studying AML. The team has since identified subgroups in other hematological malignancies and a variety of solid cancers that could also be vulnerable to OXPHOS inhibition. "We're already working closely with several MD Anderson Cancer Moon Shots Program teams to develop IACS-10759 treatment for patients whose tumors rely on oxidative phosphorylation," said IACS Executive Director Philip Jones, Ph.D. According to Konopleva, who leads the clinical trial, about 40 percent of younger patients with AML survive long term, while survival for patients over age 65 drops to about 10 percent. AML has been treated mainly with chemotherapy combinations for decades, and patient outcomes have not improved for the last 40 years. LLS recently announced its Beat AML Master Trial, a collaborative multi-site, multi-arm clinical trial to develop a precision medicine approach to treating patients with AML. LLS estimates there will be 19,950 new cases of AML diagnosed in 2016, most in adults, and about 10,430 deaths. "LLS is going on the offensive against AML, a disease that has seen little change in the standard of care in more than 40 years," said Lee Greenberger, Ph.D., LLS's chief scientific officer. "Through our Beat AML initiative and other promising projects, such as this very innovative approach being developed by the MD Anderson team, we are hoping to change the paradigm of treatment for this deadly disease." This first trial of IACS-10759 will enroll up to 48 patients with relapsed or resistant AML. The primary objectives aim to determine the safety and tolerability of IACS-10759 and to establish a maximum tolerated dose as well as a recommended dose for a phase 2 trial. Secondary objectives will evaluate pharmacokinetics and pharmacodynamics, as well as progression-free and overall survival. MD Anderson has intellectual property surrounding IACS-10759 that could provide a financial benefit to the institution through activities such as licensing or the technology being sold to a private company for further development. All research at MD Anderson including clinical development will be managed under the institution's policies and procedures to address any such conflicts. Launched in 2011 and developed as part of MD Anderson's Cancer Moon Shots Program, IACS is a drug discovery biopharmaceutical unit embedded within the world's No. 1 cancer hospital. With a Bench-at-Bedside approach, the seamless integration of drug discovery and clinical translation, IACS aims to contribute to MD Anderson's mission of Making Cancer History. In addition to IACS-10759, IACS has a robust drug discovery pipeline of molecules targeting cancer cell metabolism, epigenetics, and other novel targets. MD Anderson's Moon Shots Program is an ambitious effort to reduce cancer deaths by more rapidly developing and implementing advances in prevention, early detection and treatment based on scientific discoveries. Announced in 2012, the program now comprises 13 moon shots focused on a variety of the most challenging cancers backed by 10 platforms that provide deep expertise, cutting-edge technology and infrastructure to support innovative approaches.
News Article | January 20, 2016
Daniel Elton and Marivi Fernandez-Serra used computer simulation models of water developed at Stony Brook’s Institute for Advanced Computational Science to discover its molecular properties are similar to ice. For more than 100 years, scientists have debated what the underlying molecular structure of water is, and the common view has been that H2O molecules are either "water-like" or "ice-like." Now through computer simulation conducted at the Institute for Advanced Computational Science (IACS) at Stony Brook University, researchers can illustrate that the structure and dynamics of hydrogen bonding in liquid water is more similar to ice than previously thought. The finding, published in Nature Communications , changes the common understanding of the molecular nature of water and has relevance to many fields, such as climate science and molecular biophysics, and technologies such as desalinization and water-based energy production. In condensed matter physics, phonons are considered to be a solid-state phenomenon and can be visualized as collective vibrations that propagate through a material. More precisely, a phonon is the fundamental quantum mechanical unit of lattice vibration. Optical phonons are a type of phonon that interact with electromagnetic radiation. These can be visualized as peaks in the infrared absorption spectrum in ice. In the paper, "The hydrogen-bond network of water supports propagating optical phonon-like modes," lead author Daniel C. Elton, a PhD candidate, and Marivi Fernandez-Serra, PhD, Associate Professor, in the Department of Physics and Astronomy and IACS, show that propagating vibrations or phonons can exist in water, just as in ice. "No microscopes can allow us to directly see the behavior of water molecules and their pattern of hydrogen bonding. Therefore by simulating liquid water using the fundamental laws of physics, the structure and motion of molecules in water can be analyzed in great detail beyond what microscopes can reveal of liquid water," said Elton. "Our method involved both experimental data and extensive molecular dynamics simulations, and we found that the optical phonon coupling leads to similar absorption peaks also found in ice." The authors used a new high-powered computer cluster at Stony Brook's IACS to create the water dynamics simulations. By centering on water's unique hydrogen bond network, they routinely demonstrated that optical phonon-like modes can propagate the hydrogen bond network, just as in ice. Unlike in ice, however, hydrogen bonds in water are constantly being broken and reformed, so the phonons only last for about one trillionth of a second yet can travel over long distances up to two nanometers. "Our findings challenge older ideas about water dynamics, which characterized peaks in the absorption spectrum as being due to the vibrational motions of at most a few molecules, as in ice," said Professor Fernandez-Serra. "We found water peaks in spectra correspond to two different types of phonons, called longitudinal and transverse. The shifting of the position of the longitudinal and transverse peaks with temperature can be related to important structural changes in the hydrogen bond network, which provides a new window into how water's structure changes with temperature." Additionally, by comparing several different simulation techniques, the authors also found that the current non-polarizable water models used in biophysics fail to capture the higher frequency optical phonons. This work builds on their previous work , which showed that polarizable models are more accurate than the more often used non-polarizable models. More information: Daniel C. Elton et al. The hydrogen-bond network of water supports propagating optical phonon-like modes, Nature Communications (2016). DOI: 10.1038/ncomms10193 D. C. Elton et al. Polar nanoregions in water: A study of the dielectric properties of TIP4P/2005, TIP4P/2005f and TTM3F, The Journal of Chemical Physics (2014). DOI: 10.1063/1.4869110
Mukhopadhyay K.,University of Burdwan |
Sutradhar S.,University of Burdwan |
Modak S.,University of Burdwan |
Roy S.K.,IACS |
Chakrabarti P.K.,University of Burdwan
Journal of Physical Chemistry C | Year: 2012
Nanoparticles of GaFeO 3 (GFO) and Ni 0.4Zn 0.4Cu 0.2 Fe 2O 4 (NZCF) and their nanocomposite [(GaFeO 3) 0.50 (Ni 0.4Zn 0.4Cu 0.2Fe 2O 4) 0.50, GFONZCF] were prepared by chemical route. Nanoparticles of GFO were synthesized by sol-gel route, and those of NZCF were prepared by chemical coprecipitation method. The nanoparticles of GFO were incorporated in the matrix of NZCF by coprecipitating the salts required for NZCF in the presence of GFO particles, followed by subsequent washing and heat treatment at 500 °C. X-ray diffractograms (XRDs) were recorded to confirm the formation of the desired crystallographic phases of the samples. The sizes of the nanoparticles were estimated from the broadening of the well-defined peaks using the Debye-Scherrer equation. The nanoparticle size and its distribution, crystallographic phase, nanocrystallinity, and so on were studied by a high-resolution transmission electron microscope (HRTEM), and the extracted results were in good agreement with those obtained from the XRD patterns. The static and dynamic magnetic measurements were carried out. The observations of field-cooled (FC), zero-field-cooled (ZFC) magnetizations, and hysteresis loops (M-H loop) in the temperature range of 300 to 2 K were carried out in the static measurements. The static magnetic data were analyzed to evaluate the particle size, nanocrystalline anisotropy, and so on, and the agreement of these evaluated data are quite satisfactory, so far as the extracted results obtained from XRD and HRTEM are concerned. The maximum magnetization of the GFO sample has been drastically enhanced by incorporating them in the matrix of NZCF. Also, the nature of variation of the magnetization in all cases of FC, ZFC, and M-H curves of the nanoparticles of GFO has been drastically modulated by the NZCF. The dynamic magnetic measurements include the measurements of ac magnetization versus excitation curves, hysteresis loops at different frequencies at room temperatures, and so on. The remarkable enhancement of magnetization of the multiferroic system of GFO by the encapsulation of NZCF would be quite interesting for various applications. © 2012 American Chemical Society.
Acharya S.,University of Burdwan |
Mondal J.,University of Burdwan |
Ghosh S.,IACS |
Roy S.K.,IACS |
Chakrabarti P.K.,University of Burdwan
Materials Letters | Year: 2010
LaFeO3 was prepared by solid state reaction method using Fe2O3 and La2O3 as starting materials. The crystallographic phase of the LaFeO3 has been confirmed by X-ray diffractograms. Magnetic mass susceptibilities (χm) of the sample at different magnetic fields have been measured in the temperature range of 300-14 K. Thermal variations of χm and the observed ac magnetic hysteresis loop indicate the presence of magnetic ordering in LaFeO3. Ferroelectric hysteresis loop observed at room temperature indicates the presence of ferroelectric ordering in LaFeO3. Measured values of dielectric constant in the presence and absence of magnetic field confirmed that LaFeO3 is multiferroic. © 2009 Elsevier B.V. All rights reserved.
Islam S.M.,Kalyani University |
Roy A.S.,Kalyani University |
Mondal P.,Kalyani University |
Tuhina K.,Bs College |
And 2 more authors.
Tetrahedron Letters | Year: 2012
A new polymer-anchored Cu(II) complex has been synthesized and characterized. The catalytic performance of the complex has been tested for the oxidation of sulfides and in oxidative bromination reaction with hydrogen peroxide as the oxidant. Sulfides have been selectively oxidized to the corresponding sulfoxides in excellent yields and in the presence of KBr as the bromine source, organic substrates have been selectively converted to mono bromo substituted compounds using polymer-anchored Cu(II) catalyst. This catalyst showed excellent catalytic activity, high selectivity, and recyclability. The polymer-anchored Cu(II) catalyst could be easily recovered by filtration and reused more than five times without appreciable loss of its initial activity. © 2011 Published by Elsevier Ltd.
Mandal S.,IACS |
Shankar R.,Chennai Mathematical Institute |
Baskaran G.,Chennai Mathematical Institute |
Baskaran G.,Perimeter Institute for Theoretical Physics
Journal of Physics A: Mathematical and Theoretical | Year: 2012
We relate the Z 2 gauge theory formalism of the Kitaev model to the SU(2) gauge theory of the resonating valence bond physics. Furthermore, we reformulate a known (Feng et al (2007 Phys. Rev. Lett. 98 087204), Chen and Hu (2007 Phys. Rev. B 76 193101), Chen and Nussinov (2008 J. Phys. A: Math. Theor. 41 075001) and Mandal et al (2006 Int. Conf. on Physics Near the Mott Transition)) Jordan-Wigner transformation of the Kitaev model on a torus in a general way that shows that it can be thought of as a Z 2 gauge-fixing procedure. We give an explicit construction of the generators of large gauge transformations on a torus in terms of the spin operators. Using these and the non-trivial loop operators, weconstruct four mutually anti-commuting operators which commute with the Hamiltonian enabling us to prove that all eigenstates of this model, for the time-reversal symmetric case, are fourfold degenerate in the thermodynamic limit. © 2012 IOP Publishing Ltd.
Ward B.F.L.,Baylor University |
Majhi S.K.,IACS |
Mukhopadhyay A.,Baylor University |
Yost S.A.,The Citadel
Nuclear and Particle Physics Proceedings | Year: 2015
We present the current status of the comparisons with the respective data of the predictions of our approach of exact amplitude-based resummation in quantum field theory as applied to precision QCD calculations as needed for LHC physics, using the MC Herwiri1.031. The agreement between the theoretical predictions and the data exhibited continues to be encouraging. © 2015 Elsevier B.V.
Saha Roy A.,R K Mission Residential College |
Saha P.,R K Mission Residential College |
Mitra P.,IACS |
Sundar Maity S.,Presidency College at Chennai |
And 2 more authors.
Dalton Transactions | Year: 2011
Three types of atropisomeric unsymmetrical diimine complexes, tetrahedral (LR)MX2 (M = Zn, Cd; X = Cl, Br; R = Me, CMe3, OH, OMe, Cl; 1a-k, type-I), tetrahedral (LMe2)ZnBr2 (2, type-II) and square planar (LOH)PdCl2 (3, type-III) with different photoluminescence properties, have been reported (LR = (E)-4-R-N-(pyridine-2-ylmethylene)aniline; = dihedral angle between the diimine unit including the pyridine ring and the phenyl ring planes). In crystals, = 0°for type-I, 90°for type-II and 63°for type-III atropisomers have been confirmed by single crystal X-ray structure determinations of 1c, 1e, 2 and 3H2O isomers. Optimizations of geometries in methanol have established = 28-32°for type-I, 90.83°for type-II and 43.44°for type-III isomers. In solids, type-I atropisomers with = 0, behave as conjugated 14πe systems facilitating π-π stacking and are brightly luminescent at room temperature while type-II and type-III isomers in solid and type-I isomers in solutions are more like non-conjugated 8πe + 6πe systems and non-emissive. Frozen glasses of acetonitrile, methanol and dichloromethane- toluene mixture at 77 K of type-I isomers are emissive and display structured excitation and emission spectra for R = Me, CMe3, OMe species. Excitation and emission maxima of frozen glasses (λex = 320-380 nm; λem = 440-485 nm) are red shifted in the solid (λex = 390-455 nm; λem = 470-550 nm). TD-DFT calculations on 1b, 1d, 1f and stacked (1b)2 isomers and luminescence lifetime measurements have elucidated that an excited 1ILCT state has been the origin of emission of the type-I isomers and delocalizations of the photoactive πdiimine and πdiimine * orbitals of the LR over the stacked layers shift the λext and λem of solids to lower energies than those in frozen glasses. The trends of diimine ligand based electron transfer events of the complexes in DMF have been investigated by cyclic voltammetry at 298 K. © 2011 The Royal Society of Chemistry.
News Article | November 30, 2016
The Hiller Companies is proud to be the exclusive distributor of Teekay Couplings in the United States. Teekay Couplings provide space, weight, time and cost savings with each and every installation. “Teekay Systems have a superior design that is uniform whether they are working with a Navy combatant ship or on an offshore supply vessel.” Hiller Marine Products Manager Jorda Elliot said. “These couplings offer a simple and cost effective solution for pipe joining without the need for flanging, grooving, threading or welding. Our customers around the country have been very happy with the Teekay Coupling Systems.” Hiller carries the two configurations of couplings offered by Teekay, Axilock and Axiflex. The Axilock version is for axially restrained piping and has two metallic anchor rings that dig into the pipe wall when the coupling is installed. This prevents the two pipes from pushing apart under pressure or pulling away under end-load. The Axilock Fire Proof Coupling is a new offering which features a patented, internal fire sleeve that cannot be lost damaged or removed. It exceeds expected changes to IACS P2 regulations with room to spare for the future. The Axiflex is for non-axially restrained pipes. This configuration joins pipes already anchored. The pipeline forces do not have to be contained by the coupling, and therefore, diameters up to 180” are possible using Axiflex. Each coupling configuration consists of a casing, a gasket and locking parts. The purpose of the casing is to house the gasket and to press it onto the pipe surface when the locking parts are closed. The lock parts are designed to pull the two ends of the casing together circumferentially around the pipe. In order to achieve this, the coupling is labeled clearly with a torque figure, which ensures that the gasket is compressed sufficiently against the pipe surface. A common phrase used by shipyard installation technicians to describe the easy Teekay Couplings installation is “two pipes, two screws, two minutes!” Teekay Couplings have been sold for more than three decades in over 85 countries worldwide for civil, water, oil & gas, marine, building service, process, automotive and countless other industrial projects for pipes between ¾” and 180” in diameter.