Soysal H.,Adiyaman University |
Unur E.,Erciyes University |
Duzler A.,Erciyes University |
Karaca O.,Nevehir University |
Ekinci N.,Nonu University
Seizure | Year: 2011
This study was conducted on determining the effects of phenytoin on the skeletal system of the fetuses of 13 Wistar Albino rats. The female rats were divided into two groups after the vaginal smear test: the group 1 (control group) included 6 individuals, whereas the group 2 (phenytoin group) comprised 7 animals. A dose of 25 mg/kg/day phenytoin was administered intraperitoneally to pregnant rats on the 8th-10th days of pregnancy and fetuses were obtained by C-section on the 20th day. A number of 82 fetuses were observed by double staining technique. Their lengths and weights were measured, revealing the statistically significant differences between the two groups (p < 0.001). The lengths of the fetuses in the group 2 were determined as to be 14% shorter and the weights 13% lower compared to those in the group 1. Similarly, number of the fetuses obtained in one gestation decreased 9% in the group 2. Ossification of the skull bones in the fetuses of the group 2 was observed eminently to be deteriorated through using dissection microscope and inspection. Costal separation anomaly was observed in the 10 fetuses of the group 2. The separated-laterally located costal components were not attached to the costal arch. Shape malformations in the last two ribs and wide angularity, particularly in the last six ribs, were also determined. This study has documented that intraperitoneal usage of the pheytoin during pregnancy may cause to different skeletal malformations, even with lower doses, in rat fetuses. © 2010 British Epilepsy Association.
Aydin S.,Firat University |
Erenler S.,Nonu University |
Kendir Y.,Firat University
Journal of Medical Biochemistry | Year: 2011
Acylated ghrelin is a 28-amino acid peptide hormone bearing a fatty acid group based on octanoic acid (caprylic acid) at the serine which is located at position 3 and at the N-terminus. If this fatty acid is cleaved from acylated ghrelin, the remaining peptide is referred to as desacylated ghrelin. Free fatty acids (FFAs) can kill or inhibit the growth of bacteria. The purpose of this study was to test this ability using acylated ghrelin, desacylated ghrelin, and sodium octanoate (caprylic acid) as carbon sources for the genetically engineered Escherichia coli strains MK79 and MK57. For this experimental work, minimal medium was modified by replacing glucose with equal concentrations of acylated ghrelin, desacylated ghrelin, or sodium octanoate. Bacterial optical density, viability, alpha-amylase production, plasmid stability and pH of the growth medium were measured during these experiments. The media that allowed most growth, based on viable cell counts and the OD 600 of MK79, was minimal medium, followed by the medium containing desacylated ghrelin or acylated ghrelin, and finally the medium containing sodium octanoate. The same order was observed for MK57. Neither of the strains lost plasmids during the entire course of each experiment. There was also little change in the pH of any of the media used for both strains. These results suggest that sodium octanoate, acylated ghrelin, and desacylated ghrelin, when compared with minimal medium, inhibit Escherichia coli growth. Proliferation was lowest when sodium octanoate was used as the carbon source, followed by acylated ghrelin and desacylated ghrelin. Therefore, the acylated ghrelin found previously in human saliva might help to inhibit pathogenic microorganisms, and acylated ghrelin levels below a critical concentration in saliva could result in an increased risk of oral infection.
Birinci M.,Nonu University |
Miller J.D.,University of Utah |
Sarikaya M.,Nonu University |
Wang X.,University of Utah
Minerals Engineering | Year: 2010
In this study, the effect of an external magnetic field on cationic flotation of quartz from magnetite was investigated by using a magnetic micro-flotation column. For this purpose, a micro-flotation column jacketed with three coils was fabricated to create a funnel-shaped magnetic field. Both the theoretical magnetic field strengths and the magnetic forces were calculated. The results from flotation experiments with 6 × 10-5 M dodecylamine as collector using a binary mixture of quartz and magnetite as a feed material show that the separation efficiency increased from 0% without the magnetic field to 88% in the presence of the magnetic field. The significant enhancement in separation efficiency is evident. © 2010 Elsevier Ltd. All rights reserved.
Karakoc M.B.,Nonu University |
Demirboa R.,University Putra Malaysia |
Turkmen I.,Nonu University |
Can I.,Ataturk University
Construction and Building Materials | Year: 2011
The objective of this work is to calculate the compressive strength, ultrasound pulse velocity (UPV), relative dynamic modulus of elasticity (RDME) and porosity induced into concrete during freezing and thawing. Freeze-thaw durability of concrete is of great importance to hydraulic structures in cold areas. In this paper, freezing of pore solution in concrete exposed to a freeze-thaw cycle is studied by following the change of concrete some mechanical and physical properties with freezing temperatures. The effects of pumice aggregate (PA) ratios on the high strength concrete (HSC) properties were studied at 28 days. PA replacements of fine aggregate (0-2 mm) were used: 10%, 20%, and 30%. The properties examined included compressive strength, UPV and RDME properties of HSC. Results showed that compressive strength, UPV and RDME of samples were decreased with increase in PA ratios. Test results revealed that HSC was still durable after 100, 200 and 300 cycles of freezing and thawing in accordance with ASTM C666. After 300 cycles, HSC showed a reduction in compressive strength between 6% and 21%, and reduction in RDME up to 16%. For 300 cycles, the porosity was increased up to 12% for HSC with PA. In this paper, feed-forward artificial neural networks (ANNs) techniques are used to model the relative change in compressive strength and relative change in UPV in cyclic thermal loading. Then genetic algorithms are applied in order to determine optimum mix proportions subjected to 300 thermal cycling. © 2011 Elsevier Ltd. All rights reserved.
Gullu M.,Nonu University |
Menevoe A.,Nonu University |
Arslan C.,Nonu University
World Journal of Medical Sciences | Year: 2012
The aim of this study was to define and compare the occupational diseases that frequently relapse in physical education teachers and teachers in other branches. 64 physical education teachers from Malatya Province, 30 physical education teachers and 30 teachers in other branches from Amasya Province and 16 physical education teachers and 83 other branch teachers from • •rnak province took part in the study. Statistical data of the diseases of 113 other branch teachers and 110 physical education teachers - 223 in total - [in physical education branch, 42 females (38.2%)and 68 males (61.8%) and in other branches, 52 females (46.0%) and 61 males (54.0%)] in 2010 were analyzed. The level of statistical significance was considered to be 0.05. In the evaluation by branches; musculoskeletal system diseases (24.5%), brain and neurological diseases (29.1%), dermatological diseases (30.9%), hematological diseases (11.8%) and gastrological diseases (23.6%) were seen in physical education teachers (p<0.05). In other branch teachers, general surgery diseases (17.7%) were found to be very often (p<0.05). Otorhinolaryngology diseases (54.5-41.6%), neurological diseases (10.0-8.0%), cardiovascular diseases (10.0-9.7%) and urological diseases (10.0-8.0%) were frequently seen in both physical education teachers and teachers in other branches. In an evaluation by gender; general surgery diseases (20.2%), urological diseases (13.8%) and hematological diseases (12.8%) were seen in females (p<0.05) whereas neurological diseases (14.0%) were seen in males (p<0.05). Musculoskeletal system diseases (12.8 - 21.7%), otorhinolaryngology diseases (40.4-53.5%), brain and neurological diseases (18.1-14.7%), dermatological diseases (23.4-14.0%), cardiovascular diseases (11.7-8.5%) and gastrological diseases (20.2-12.4%) were reported in males and females, respectively. As a conclusion, physical education teachers had a high tempo in both mental and physical terms. Statistical findings supported that musculoskeletal diseases, brain and neurological diseases, hematological and gastrological diseases are seen in physical education teachers more frequently. © IDOSI Publications, 2012.