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Sobstyl M.,Katedra i Klinika Ginekologii i Endokrynologii Ginekologicznej | Bednarek W.,Katedra i Klinika Ginekologii Onkologicznej i Ginekologii | Tkaczuk-Wlach J.,Katedra i Klinika Ginekologii i Endokrynologii Ginekologicznej | Sobstyl J.,Katedra i Klinika Chorob Wewnetrznych | Jakiel G.,Klinika Poloznictwa i Ginekologii
Przeglad Menopauzalny | Year: 2011

Hot flashes and night sweats are common menopausal symptoms, which influence greatly the quality of women's lives, often by eliminating them from professional or everyday lives. Etiopathogenesis of symptoms has not been fully explained. A great role is attributed to sudden decrease of estrogens, disorders of neurotransmitters and neuromodulators activity such as noradrenalin, dopamine, serotonin and thermoregulation disorders. Estrogen and estrogen-progestogen therapy is recommended as the most effective treatment for vasomotor symptoms. Yet, more and more consideration should be given to selective inhibitors of serotonin and noradrenalin, gabapentin. Source


Sobstyl M.,Medical University of Lublin | Tkaczuk-Wlach J.,Medical University of Lublin | Tarkowski R.,Katedra i Klinika Ginekologii Onkologicznej i Ginekologii | Jakiel G.,Klinika Poloznictwa i Ginekologii
Przeglad Menopauzalny | Year: 2013

Symptoms of vulval disease are not characteristic. Women with this disease complain of pruritus, pain, changes of the color and structure of vulva's skin. Diagnosis can be difficult to determine because changes may be affected by immunological reactions and lack of estrogens in post menopausal women. A comprehensive differential diagnosis should include: vulvitis, lichen sclerosus, lichen planus, vulval intraepithelial neoplasia (VIN) and rare diseases: Behçet's disease, Zoon vulvitis and extramammary Paget's disease. Source


Kulak K.,Katedra i Klinika Ginekologii Onkologicznej i Ginekologii | Bobinski M.,Katedra i Klinika Ginekologii Onkologicznej i Ginekologii | Polak G.,Katedra i Klinika Ginekologii Onkologicznej i Ginekologii | Jedrych B.J.,Katedra i Zaklad Histologii i Embriologii | And 2 more authors.
Ginekologia Polska | Year: 2014

Uterine sarcomas are heterogeneous malignancies, both clinically and histologically. The process of oncogenesis depends on gene mutations and uncontrolled mitotic cell division that is promoted by blocking pathways of apoptosis. Caspase 9 and p53 protein play an important role in the process of cell apoptosis. Objectives: The aim of the study was to assess the expression of selected apoptosis proteins (caspase 9 and p53) using immunohistochemistry. Material and methods: A total of 28 tissue samples diagnosed in postoperative histopathological examination as leiomyosarcoma were tested. Twenty eight samples of leiomyomas were used as the control group. Colorful reactions with appropriate antibodies were performed to assess the expression of caspase 9 and p53. From every section 5 fields on view were chosen, in each one 100 cells were assessed using 400x magnification. TStudent parametric test and U Mann-Whitney test were used for statistical analysis. Results: Expression of caspase 9 was significantly lower (p<0.05) in leiomyosarcoma tissues (33.2%) as compared to leiomyomas (60.4%). Expression of p53 protein was significantly lower in leiomyosarcoma tissues than in leiomyomas (30.1% vs. 51.3%, p<0.001). Conclusions: Significantly lower expression of caspase 9 and p53 in leiomyosarcoma tissue samples suggests that impaired deregulation of apoptosis mechanisms plays a role in the development of these tumors. © Polskie Towarzystwo Ginekologiczne. Source


Grzegorz P.,Katedra i Klinika Ginekologii Onkologicznej i Ginekologii | Iwona W.,Katedra i Klinika Ginekologii Onkologicznej i Ginekologii | Rafal T.,Katedra i Klinika Ginekologii Onkologicznej i Ginekologii | Jan K.,Katedra i Klinika Ginekologii Onkologicznej i Ginekologii
Ginekologia Polska | Year: 2010

Aim: Endometriosis is characterized by a cyclic hemorrhage within the peritoneal cavity. Accumulating data suggests that iron homeostasis in the peritoneal cavity may be disrupted by endometriosis. The aim of our study was to evaluate iron levels in peritoneal fluid (PF) of women with and without endometriosis. Material and Methods: Seventy-five women were studied: 50 women with endometriosis and, as a reference group, 25 patients with functional follicle ovarian cysts. Iron concentrations in the PF were measured using a commercially available colorimetric assay kit. Results: Iron concentrations were significantly higher in PF from women with endometriosis as compared to the reference group. Patients with stages III/IV endometriosis had significantly higher PF iron concentrations than women with stages I/II of the disease. Conclusions: Disrupted iron homeostasis in the peritoneal cavity of women with endometriosis plays a role in the pathogenesis of the disease. © Polskie Towarzystwo Ginekologiczne. Source


Wertel I.,Katedra i Klinika Ginekologii Onkologicznej i Ginekologii | Bednarek W.,Katedra i Klinika Ginekologii Onkologicznej i Ginekologii | Polak G.,Katedra i Klinika Ginekologii Onkologicznej i Ginekologii | Surowka J.,Katedra i Klinika Ginekologii Onkologicznej i Ginekologii | And 2 more authors.
Ginekologia i Poloznictwo | Year: 2014

Ovarian cancer is the fifth most common cancer and the fourth leading cause of cancer death among women in Poland. Despite improvements in surgical techniques and advances in chemotherapy, the overall survival rates still remain unacceptably low. Cancer cells develop many mechanisms to avoid detection and killing by activated effector cells of the host immune system, reducing effectiveness of standard anticancer treatment. One of the most promising approaches to modify immunological status of ovarian cancer patients and induce a tumor specific immune response is dendritic cell-based immunotherapy. In this paper we review the published literature on this subject and present perspectives of dendritic cells use in ovarian cancer immunotherapy. © GinPolMedProject. Source

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