Osteocentrum II. Interni Klinika FN Plzen

Czech Republic

Osteocentrum II. Interni Klinika FN Plzen

Czech Republic
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Suchy D.,Oddeleni Klinicke Farmakologie FN Plzen | Grundmann M.,Ustavy Klinicke Farmakologie FN Ostrava A Lekarske Fakulty | Vyskocil V.,Osteocentrum II. Interni Klinika FN Plzen | Loudova S.,Oddeleni Klinicke Farmakologie FN Plzen | Mayer O.,Oddeleni Klinicke Farmakologie FN Plzen
Klinicka Farmakologie a Farmacie | Year: 2011

Objective: The objective of this research was 1) to evaluate the effect of CSA therapy in rheumatoid arthritis patients using disease activity indexes: DAS 28 (CRP) 28 (CRP) and CDAI, 2) assess the relationship of the previously obtained and measured pharmacokinetic variables (AUCCSA0-12′ C max) and the disease activity in RA. Methods: The investigated group comprised 19 patients with rheumatoid arthritis who were treated for three months with CSA. The authors evaluated the influence of CSA treatment (dose 1,34 ± 0,32 mg/kg/day) on predefined core set of variables in RA patients, activity of disease was assessed using tworecent indices of activity. For evaluating the relationship between pharmacokinetic and disease activity C max and area under the plasma concentration curve between 0 h and 12 h (AUCCSA 0-12h) was chosen. It was estimated by linear trapezoidal rule using 8 samplings in times of 0,5 h, 1 h, 1,5 h, 2 h, 4 h, 6 h, 8 h 12 h after a first drug administration. Results: 1) In RA patients, there was found a significant drop in the number of painful and swollen joints. Changes in selected indexes of disease activity were statistically significant, (DAS 28 (CRP) p < 0,005, CDAI < 0,003), howewer the changes in DAS 28 (CRP) index were clinicaly only moderate. There was demonstrated sufficient correlation between used activity indexes. Pharmacokinetic (AUC and Cmax) variables do not correlate with changes in an index of activity.

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