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Pytliak M.,I. Interna Klinika LF UPJS a FNLP | Vargova V.,III. Interna Klinika LF UPJS a FNLP | Mechirova V.,I. Interna Klinika LF UPJS a FNLP | Felsoci M.,I. Interna Klinika LF UPJS a FNLP
Diabetologie Metabolismus Endokrinologie Vyziva | Year: 2010

Manifested hypoglycemia is relatively frequent cause of out-patient office visit at general practitioner, diabetologist and in severe cases represents emergent situation requiring transport to hospital and hospitalization. Severe and untreated hypoglycemia can even lead to death. The most frequent cause of hypoglycemia is use of hypoglycemic therapy by diabetes mellitus, insulin and its analogs or oral antidiabetic drugs (OAD). However, episodes of hypoglycemia may occur also in patients without diabetes mellitus, insulin or OAD therapy. In these patients, hypoglycemia absents often among diagnostic concerns what might worsen subsequently their prognosis. It is necessary to consider the possibility of drug induced hypoglycemia after excluding its organic etiology (endocrinopathies, malnutrition, cancer etc.). There are various groups of drugs with provable hypoglycemic effects that may potentiate diabetes mellitus treatment or lead to hypoglycemia in nondiabetic patients as well. In this article, we present a review of the most frequent drug induced hypoglycemias. Source


Vargova V.,III. Interna Klinika LF UPJS a FNLP | Pytliak M.,I. Interna Klinika LF UPJS a FNLP | Mechirova V.,I. Interna Klinika LF UPJS a FNLP | Felsoci M.,I. Interna Klinika LF UPJS a FNLP
Diabetologie Metabolismus Endokrinologie Vyziva | Year: 2010

A lot of drugs may interfere in glucose metabolism and cause hyperglycemia in nondiabetic patients or even drug induced diabetes mellitus with its prolongated use. Hyperglycemic and prodiabetic effects of certain drugs are well-known and they are administered carefully in patients with impaired glucose tolerance or overt diabetes mellitus. However, the others are not known for such effects and their influence on glucose metabolism remains out of diagnostic concerns. Therefore it is necessary to consider the possibility of drug induced impairment of glucose metabolism in every acute state of hyperglycemia. In this article, the authors present a review of the most frequent drugs with hyperglycemic or prodiabetic effects. However, there are still remaining many others that are linked with hyperglycemia, although extremely rare with only few reports in literature. Source

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