Hyogo Science and Technology Association

Himeji, Japan

Hyogo Science and Technology Association

Himeji, Japan
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Chikawa J.-I.,Hyogo Science and Technology Association | Mouri Y.,Himeji Health Center | Shima H.,Shima Institution for Quantum Medicine | Yamada K.,Hyogo Science and Technology Association | And 2 more authors.
Journal of X-Ray Science and Technology | Year: 2014

Time variations of elemental concentrations and their abnormalities due to breast cancer have been observed along single hair strands by X-ray fluorescence excited by synchrotron radiation. The renal-controlled elements Ca, Sr, S, K, Cl, Br and P have upper and lower levels associated with gating and closing of ion channels in the hair-making cells. The Ca lower level is normal. In cases of Ca deficiency, with a decrease from the normal, store-operated Ca channel gating occurs so as to keep the hair Ca at the normal, and paradoxically high Ca levels near or at the upper level are produced by PTH-operated channel gating of the cells. Chronic Ca deficiency shows a temporal pattern along the hair consisting of a long-term duration of the upper [Ca] level, 10-month long decay to the lower level and abrupt increase to the upper level. The observation for hair from breast-cancer patients also shows the upper Ca level for the time period well before detection, and suggests that cancer is always generated at the long-lasting [Ca] upper level and the hair [Ca] decreases gradually toward the lower level with the cancer growth. This decay of [Ca] is accompanied by those of [Sr] and [K]. Their different decay forms can be explained by parathyroid hormone related peptide (PTHrP) in serum secreted from the cancer having 150 times longer dwell time on the PTH receptors than that of PTH. Patient hair has a memory for the entire cancer process from the state before cancer generation, and the pattern can be distinguished from concentration variation due to the chronic Ca deficiency without cancer, leading to a criterion for cancer detection by the ratio of [Sr]/[Ca]. The hair analysis is useful for early detection of cancer. © 2014-IOS Press.


PubMed | Osaka Breast Clinic, Shima Institution for Quantum Medicine, Himeji Health Center, Hyogo Science and Technology Association and Hyogo College of Medicine
Type: Journal Article | Journal: Journal of X-ray science and technology | Year: 2014

Time variations of elemental concentrations and their abnormalities due to breast cancer have been observed along single hair strands by X-ray fluorescence excited by synchrotron radiation. The renal-controlled elements Ca, Sr, S, K, Cl, Br and P have upper and lower levels associated with gating and closing of ion channels in the hair-making cells. The Ca lower level is normal. In cases of Ca deficiency, with a decrease from the normal, store-operated Ca channel gating occurs so as to keep the hair Ca at the normal, and paradoxically high Ca levels near or at the upper level are produced by PTH-operated channel gating of the cells. Chronic Ca deficiency shows a temporal pattern along the hair consisting of a long-term duration of the upper [Ca] level, 10-month long decay to the lower level and abrupt increase to the upper level. The observation for hair from breast-cancer patients also shows the upper Ca level for the time period well before detection, and suggests that cancer is always generated at the long-lasting [Ca] upper level and the hair [Ca] decreases gradually toward the lower level with the cancer growth. This decay of [Ca] is accompanied by those of [Sr] and [K]. Their different decay forms can be explained by parathyroid hormone related peptide (PTHrP) in serum secreted from the cancer having 150 times longer dwell time on the PTH receptors than that of PTH. Patient hair has a memory for the entire cancer process from the state before cancer generation, and the pattern can be distinguished from concentration variation due to the chronic Ca deficiency without cancer, leading to a criterion for cancer detection by the ratio of [Sr]/[Ca]. The hair analysis is useful for early detection of cancer.


Yamamoto Y.,Tohoku University | Chikawa J.,Hyogo Science and Technology Association | Uegaki Y.,Yamanashi Prefectural Fuji Industrial Technology Center | Usuda N.,Aichi University | And 2 more authors.
Cancer Science | Year: 2010

Exposure to internally deposited radionuclides is known to induce malignant tumors of various histological types. Thorotrast, a colloidal suspension of radioactive Thorium dioxide (232ThO2) that emits alpha-particles, was used as a radiographic contrast during World War II. Thorotrast is known to induce liver tumors, particularly intrahepatic cholangiocarcinoma (ICC) and angiosarcoma (AS), decades after injection. Therefore, patients injected with Thorotrast comprise a suitable study group to understand biological effects of internal ionizing radiation injury. Autoradiography and X-ray fluorescence spectrometry (XRF) were carried out on non-tumorous liver sections from Thorotrast-induced ICC (T-ICC) and Thorotrast-induced AS (T-AS). Autoradiography revealed that the slope of the regression line of the number of alpha tracks for the amount of deposited Thorium (232Th) was higher in non-tumorous parts of the liver with T-ICC than those with T-AS. XRF showed that the intensity ratio of Radium (Ra) to Thorium (Th) in non-tumorous liver tissue with T-ICC was significantly higher than that with T-AS. Furthermore, the mean 228Ra/232Th radioactivity ratio at the time of death calculated was also significantly higher in T-ICC cases than in T-AS cases. These suggest that the metabolic behavior of radionuclides such as relocation and excretion, as well as the content of deposited radionuclides, is a major factor in determining the histological type of Thorotrast-induced liver tumors. © 2009 Japanese Cancer Association.


PubMed | Pohang Accelerator Laboratory, Catholic University of Daegu, Hyogo Science and Technology Association and Seoul National University
Type: Journal Article | Journal: Microscopy research and technique | Year: 2016

Nanoscopic synchrotron X-ray imaging was performed on scalp hair samples of patients with breast cancer and healthy individuals to investigate any structural differences as diagnostic tool. Hair strands were divided into 2-3 segments along the strands from root to tip, followed by imaging either in projection or in CT scanning with a monochromatic 6.78-keV X-ray using zone-plate optics with a resolving power of 60 nm. All the examined cancer hairs exhibited medulla loss with cancer stage-dependent pattern; complete loss, discontinuous or trace along the strands. In contrast, medullas were well retained without complete loss in the healthy hair. In the CT-scanned axial images, the cortical spindle compartments had no contrast in the healthy hair, but appeared hypointense in contrast to the surrounding hyperintense cortical membrane complex in the cancer hair. In conclusion, observation of medulla loss and cortical membrane enhancements in the hair strands of breast cancer patients demonstrated structural variations in the cancer hair, providing a new platform for further synchrotron X-ray imaging study of screening breast cancer patients.


Mori R.,Fuji Pigment Co. | Ueta T.,Fuji Pigment Co. | Sakai K.,Fuji Pigment Co. | Niida Y.,Kobe University | And 4 more authors.
Journal of Materials Science | Year: 2011

In order to prepare the TiO2 liquid dispersions for the electrodes of dye-sensitized solar cells with industrial mass production level at a reasonable cost, the present study investigates the preparation of TiO 2 liquid dispersions by a general industrial dispersion technique using readily available P25. To determine the TiO2 dispersion offering the best light-electricity energy conversion efficiency, the suitability of various types of solvents and resins for use in TiO2 dispersion are tested. In general, organic solvent based TiO2 dispersions are found to allow the formation of more uniform thin films in comparison with water-based dispersions. A preparation using ethyl cellulose as the resin and the terpineol as the solvent is found to exhibit the best conversion efficiency. We have also found that using two kinds of resins of different molecular weights gave rise to better efficiency. Among 26 metal compounds tested in this study, the best metal dopant was Ag. XRD and XPS measurements confirm that the Ag exists as metal Ag and silver oxide. © Springer Science+Business Media, LLC 2010.


Yamaguchi A.,Hyogo Prefectural Institute of Technology | Mitsutani Y.,Hyogo Science and Technology Association | Gotoh K.,Hyogo Prefectural Institute of Technology | Tomita T.,Hyogo Prefectural Institute of Technology | Fukumoto S.,Osaka University
Nippon Kinzoku Gakkaishi/Journal of the Japan Institute of Metals | Year: 2010

The infiltration process of Cu-Sn alloy into indirect selective laser sintered (SLS) stainless steel preforms was investigated. The heating rate for the infiltration process was 0.17 K/s and the holding temperature was varied from 1293 to 1473 K for 3.6 ks. The process was carried out in an inert gas atmosphere. Although the volume of the preforms without infiltration decreased with increasing sintering temperature, the volume of the infiltrated parts remained constant at approximately -5%. The stainless steel particles were coarsened by the increasing holding temperature during infiltration; however, the area ratio of stainless steel particles remained constant at approximately 60% regardless of the holding temperature. The tensile strength and elongation of the infiltrated parts were approximately 540 MPa and 10%, respectively, regardless of the holding temperature. © 2010 The Japan Institute of Metals.


Nishino T.,Kobe University | Kotera M.,Kobe University | Suetsugu M.,Kobe University | Murakami H.,Kobe University | Urushihara Y.,Hyogo Science and Technology Association
Polymer | Year: 2011

Natural cellulosic ramie fiber was acetylated using supercritical carbon dioxide (sc-CO2) as a reaction medium. The structure and properties of the acetylated fibers were investigated using infrared spectroscopy, scanning electron microscopy, X-ray diffraction (including synchrotron microbeam X-ray diffraction), nano-Raman scattering, and a tensile test. The acetylation reaction proceeded without using an organic solvent, and it reached to the core part of the fiber within a short period while maintaining the fiber morphology. The crystallites of cellulose triacetate II and cellulose coexist in the fiber. The acetylated fiber with an average degree of substitution of 1.9 showed high modulus (34.5 GPa) and high strength (763 MPa), which are the highest values for cellulose diacetate so far reported to date. © 2010 Elsevier Ltd. All rights reserved.


Hongo C.,Kobe University | Kotera M.,Kobe University | Urushihara Y.,Hyogo Science and Technology Association | Izumo D.,Kobe University | Nishino T.,Kobe University
16th European Conference on Composite Materials, ECCM 2014 | Year: 2014

Polymer laminate interfaces were analyzed with high spatial resolutions using scanning thermal microscopy, synchrotron micro-beam X-ray diffraction, and confocal laser nano-Raman spectroscopy. For poly-α-olefin laminates, such as linear low density polyethylene (LLDPE)/deuterated polyethylene (D-PE) and, LLDPE/isotactic polypropylene (it.PP) combinations, the interfacial thickness was evaluated as several micrometer, which changed by annealing. The adhesive strength was found to be correlated with the interfacial thickness.


Kotera M.,Kobe University | Urushihara Y.,Hyogo Science and Technology Association | Izumo D.,Kobe University | Nishino T.,Kobe University
Thermochimica Acta | Year: 2012

The interfacial structure of laminated poly-α-olefin, polyethylene (PE)/polypropylene (PP), film was investigated by scanning thermal microscope (SThM). Spatial resolution of this technique was estimated as 1.5 μm. Notwithstanding the flatness of the sample as observed in the height image of an atomic force micrograph, micro-thermomechanical analysis could distinguish each polymer. By scanning the thermal probe at isothermal temperature over a cross-section of the laminate film, a high-contrast image of apparent thermal conductivity at the interfacial region was obtained. The interfacial thickness was estimated to be in the micrometer order depending on the thermal treatment of the laminate film. This result coincides with the results of synchrotron X-ray microbeam diffraction. Moreover, the peel strength of the PE/PP laminate was considered to be influenced by the interfacial thickness. It is concluded that this proposed thermal-probe method is as a powerful tool for investigating the interfacial region of the polymer composites. © 2012 Elsevier B.V. All rights reserved.


Kotera M.,Kobe University | Urushihara Y.,Hyogo Science and Technology Association | Izumo D.,Kobe University | Nishino T.,Kobe University
Polymer | Year: 2012

The interfacial structure of all-polyethylene laminate (linear low density polyethylene (LLDPE)/deuterated polyethylene (D-PE)) was investigated using different microprobe methods, scanning thermal microscopy (SThM), and confocal laser nano-Raman spectroscopy. By scanning the thermal probe under isothermal conditions over a cross section of the laminate film, a high-contrast image of apparent thermal conductivity at the interfacial region was obtained even for the flat height region observed using an atomic force micrograph. The apparent thermal conductivity and the Raman intensity gradually change across the tapered interfacial region between the two PEs. The interfacial thickness was estimated to be in the micrometer-order depending on the thermal treatment of the laminate film. Additionally, the peel strength of the LLDPE/D-PE laminate increased as the interfacial thickness increased. This suggests that both the LLDPE and D-PE molecular chains were entangled with each other, and/or both crystalline lamellae were in an interlocking state during thermal treatment. © 2012 Elsevier Ltd. All rights reserved.

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