Hyogo Prefectural Amagasaki Hospital

Amagasaki, Japan

Hyogo Prefectural Amagasaki Hospital

Amagasaki, Japan
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Ueta M.,Kyoto Prefectural University of Medicine | Ueta M.,Doshisha University | Matsuoka T.,Hyogo Prefectural Amagasaki Hospital | Yokoi N.,Kyoto Prefectural University of Medicine | Kinoshita S.,Kyoto Prefectural University of Medicine
British Journal of Ophthalmology | Year: 2011

Background: Prostaglandin (PG) E2 is produced during inflammatory responses and suppresses the production of cytokines induced by lipopolysaccharide stimulation in macrophages and dendritic cells. In this study, we examined the expression of PGE2 receptors in human conjunctival epithelial cells and investigated whether PGE2 downregulates polyinosine - polycytidylic acid (polyI:C)-induced cytokine production. Methods: ELISA and quantitative reverse transcription (RT)-PCR were used to examine the effects of PGE2 on the polyI:C-induced cytokine expressions by primary human conjunctival epithelial cells (PHCjEC). Reverse transcription-PCR was performed to examine the mRNA expression of the PGE 2 receptors EP1, -2, -3 and -4. Results: PGE2 significantly attenuated the expressions of chemokine (C-C) motif ligand (CCL) 5, chemokine (C-X-C motif) ligand (CXCL) 10, CXCL11 and interleukin (IL) 6 in PHCjECs. Human conjunctival epithelial cells exhibited expression of EP2, -3 and -4, but not of EP1. EP2 agonist significantly suppressed the polyI:C-induced the expressions of CCL5, CXCL10 and CXCL11 but not of IL-6. EP3 agonist significantly suppressed the expressions of CCL5, CXCL10, CXCL11 and IL-6. On the other hand, EP4 agonist failed to suppress the cytokine production induced by polyI:C stimulation. Conclusion: Our results show that PGE2 attenuated the expression of CCL5, CXCL10 and CXCL11 via both EP2 and EP3, and that the expression of IL-6 was attenuated only by EP3.

Takemura G.,Gifu University | Kanoh M.,Gifu University | Minatoguchi S.,Gifu University | Fujiwara H.,Hyogo Prefectural Amagasaki Hospital
International Journal of Cardiology | Year: 2013

It has been suggested that apoptosis may be responsible for a significant amount of the cardiomyocyte death that contributes to the development and progression of heart failure. However, studies of actual heart disease and in vivo experimental models have provided little or no direct morphological evidence that cardiomyocyte apoptosis occurs at any stage of heart failure, despite the availability of much indirect evidence that includes detection of DNA fragmentation and apoptosis-related factors. The Nomenclature Committee on Cell Death (NCCD), an international organization consulting on cell death, proposed an international standard for the definition and classification of cell death, in which cell death was defined based purely on morphological criteria. This is because there is no clear-cut equivalence between ultrastructural alterations and biochemical cell death characteristics. This review will first introduce the NCCD definition and classification of cell death and, based on this classification, survey the available data from both animals and humans to critically assess the impact of cardiomyocyte apoptosis during the progression of heart failure of various etiologies. Particularly noteworthy is the wide variation in the reported rates of apoptosis - e.g., the difference was > 1000-fold in one heart failure model - but even more importantly, no morphological (ultrastructural) data has ever been shown definitively demonstrating apoptosis of a cardiomyocyte. We conclude from our survey that even the existence of cardiomyocyte apoptosis in heart failure remains controversial. © 2013 Elsevier Ireland Ltd.

Kita M.,Hyogo Prefectural Amagasaki Hospital | Kita M.,Kyoto University | Yoshimura N.,Kyoto University
Retina | Year: 2011

Purpose: To demonstrate the efficacy of endoscope-assisted pars plana vitrectomy in treating patients with retinal detachments with no retinal breaks detected preoperatively. Methods: Medical records of 20 consecutive eyes with pseudophakic and aphakic rhegmatogenous retinal detachments but without retinal breaks detected preoperatively were reviewed. In each case, endoscope-assisted pars plana vitrectomy was performed. Results: In 19 of 20 eyes, breaks were identified with the help of an endoscope during surgery. To treat breaks, transscleral cryopexy or endolaser was performed under the endoscopic vision. The retina was reattached after a single surgery in all cases. No serious complication related to the operation was experienced. Conclusion: Endoscope-assisted vitrectomy is useful in the management of pseudophakic and aphakic retinal detachments with undetected retinal breaks preoperatively. Copyright © by Ophthalmic Communications Society, Inc.

Sato Y.,Hyogo Prefectural Amagasaki Hospital
Journal of Cardiology | Year: 2015

The mortality associated with end-stage heart failure (HF) is high despite the development of new and increasingly effective drugs and non-pharmacological therapies. Repetitive hospitalizations predict fatal outcomes and each hospitalization should prompt individual conversations with the patient, the family, and the caregivers. A multidisciplinary disease management program promotes the education of patients and their families and modifies their behavior, with a view to ultimately improve the prognosis and quality of life. From the early to the late stages of HF, a multidisciplinary disease management program should be implemented. In Western societies this multidisciplinary management has long been debated and endorsed, in contrast to Japan, where it has just begun. In 2012, the Japanese Nursing Association launched a certification in chronic HF nursing. A Japanese version of HF disease management should soon be developed in its own social environment. © 2015 .

Koyama S.,Hyogo Prefectural Amagasaki Hospital | Sato Y.,Hyogo Prefectural Amagasaki Hospital | Tanada Y.,Hyogo Prefectural Amagasaki Hospital | Fujiwara H.,Hyogo Prefectural Amagasaki Hospital | Takatsu Y.,Hyogo Prefectural Amagasaki Hospital
Circulation: Heart Failure | Year: 2013

Background.Urine albumin excretion is an important predictor of adverse cardiovascular events in various populations. Its correlation in patients with acute heart failure has not been described. Methods and Results.This prospective, observational study included 115 patients presenting with acute heart failure. The urine albumin/creatinine ratio (UACR) was measured from spot urine samples collected on days 1 and 7 of hospitalization. Median UACR decreased from 83 to 22 mg/gCr on days 1 and 7, respectively (P<0.0001). The proportion of patients with normoalbuminuria (UACR <30 mg/gCr) increased from 31% on day 1 to 60% on day 7, whereas the proportion with microalbuminuria (UACR between 30 and 299 mg/gCr) and macroalbuminuria (UACR ≥300 mg/gCr) decreased, respectively, from 42% and 27% on day 1 to 30% and 10% on day 7 (P<0.0001). These changes in UACR were correlated with changes in serum bilirubin and N-terminal pro b-type natriuretic peptide concentrations (correlation coefficients 1.087 and 0.384, respectively; 95% confidence interval, 0.394.1.781 and, respectively; and P=0.003 and 0.013, respectively), although they were not correlated with change in estimated glomerular filtration rate. Conclusions.In this sample of patients presenting with acute heart failure, urine albumin excretion was often increased at admission to the hospital and decreased significantly within 7 days of treatment. The decrease was correlated with serum N-terminal pro b-type natriuretic peptide and bilirubin concentrations, although neither with baseline nor with changes in indices of renal function. © 2013 American Heart Association, Inc.

A 65-year-old woman presenting with cardiac sarcoidosis underwent serial measurement of her serum high-sensitivity cardiac troponin I (Hs-cTnI) and N-terminal proB-type natriuretic peptide (NT-proBNP) concentrations. She was treated with 1,000 mg/day methylprednisolone for 2 days, which was subsequently replaced by 30 mg/day prednisolone, and decreased to 20 mg/day at the time of discharge, 2 months later. Her echocardiogram showed improvements in the left ventricular systolic and diastolic function, along with a decrease in the concentration of Hs-cTnI and NT-proBNP. This is the first report suggesting that Hs-cTnI might be a reliable means of assessing the effects of treatment of cardiac sarcoidosis.

Sato Y.,Hyogo Prefectural Amagasaki Hospital | Fujiwara H.,Hyogo Prefectural Amagasaki Hospital | Takatsu Y.,Hyogo Prefectural Amagasaki Hospital
Journal of Cardiology | Year: 2012

In industrialized countries, chronic heart failure (HF) is a major illness and cause of death. However, because of the paucity of specific clinical manifestations of HF, its early diagnosis and management might be challenging. Therefore, biochemical markers of HF are now being closely scrutinized. An ideal biochemical marker should be a prognostic indicator, should assist in the early diagnosis, reflect the therapeutic response, and help grading the risk associated with each stage of HF. This review summarizes our current understanding of biochemical markers of HF. © 2011 Japanese College of Cardiology.

Oh H.,Hyogo Prefectural Amagasaki Hospital
Developments in Ophthalmology | Year: 2014

Idiopathic macular hole is a disease that arises from adhesion in the vitreomacular interface and can theoretically be treated by vitrectomy surgery. Surgical techniques include removal of the vitreous with or without simultaneous peeling of the internal limiting membrane (ILM), fluid-air exchange, and gas tamponade. Since the advent of microincision vitrectomy surgery, macular hole surgery has been performed with minimal invasiveness, and significant visual improvement is a common outcome. This chapter describes the pathology of this disease, including presurgical evaluation using optical coherence tomography (OCT), and then shows the fundamental techniques required for the surgery. Also important is the understanding of the postsurgical 'healing' process of the disease, which may confirm the fact that the subjective improvement is closely related to the retinal imaging obtained by OCT. More recent advances are the inverted ILM peeling technique for larger macular holes and 27-gauge vitrectomy that can potentially minimize the surgical invasiveness mainly by smaller wound construction and the reduced volume of irrigation during surgery. © 2014 S. Karger AG, Basel.

Matsuoka T.,Hyogo Prefectural Amagasaki Hospital
Kyobu geka. The Japanese journal of thoracic surgery | Year: 2012

A 75-year-old woman was followed up at the urology department of our hospital after left nephrectomy for renal cell carcinoma. Chest computed tomography (CT) showed ground-glass opacity in the right lower lobe( S6), 6 mm in size, in December 2010. 3 months later, the tumor was enlarged and she was introduced to our department. Wedge resection was performed to establish giagnosis. Pathological diagnosis was atypical adenomatous hyperplasia( AAH) and many small spindle-shaped cell nests were found at the same tissue. Immunohistochemically, this nest was shown to be minute pulmonary meningothelial-like nodules(MPMNs). MPMNs are asymptomatic small pulmonary nodules incidentally found during pathologic evaluation of pulmonary specimens. Combinations of MPMNs with adenocarcinoma or AAH have been reported, and the genetic relation of MPMNs and AAH is suggested.

Kobayashi T.,Hyogo Prefectural Amagasaki Hospital | Ohno H.,Hyogo Prefectural Amagasaki Hospital
Internal Medicine | Year: 2011

We report a 59-year-old man with intravascular large B-cell lymphoma (IVLBCL) associated with hemophagocytic syndrome, disseminated intravascular coagulopathy, and lung involvement. G-banding analysis of the metaphase spreads obtained from the bone marrow showed that the lymphoma cells were near-tetraploid and included two homologues of the 14q+ chromosome. Spectral karyotyping revealed that complex translocations occurred among chromosomes 3, 12, 14, and 19, and additional materials of 14q+ were from chromosome 19 with the breakpoint at 14q32 and 19q13. To the best of our knowledge, this is the first report describing t(14;19)(q32;q13) in IVLBCL. © 2011 The Japanese Society of Internal Medicine.

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