News Article | May 1, 2017
A new study out of Hyogo, Japan suggests that mesothelioma patients who relapse after extrapleural pneumonectomy (EPP) surgery may extend their survival with additional rounds of chemotherapy. Surviving Mesothelioma has just posted news of the report on its website. Click here to read the details. The Hyogo College of Medicine study focused on 39 patients with malignant mesothelioma whose cancer started growing again in the months after they had lung-removing EPP surgery. The median time to relapse was just under a year. According to the study in the International Journal of Clinical Oncology, mesothelioma patients who underwent additional chemotherapy after relapse experienced better outcomes. “The median survival time after EPP was significantly longer in 21 patients who received additional chemotherapy than in 18 patients who did not,” says Dr. Teruhisa Takuwa with Department of Thoracic Surgery at Hyogo College of Medicine. “The treatment path is not always clear for mesothelioma patients after first-line therapy fails, since there is no universally-accepted second-line treatment” says Alex Strauss, Managing Editor for Surviving Mesothelioma. “With median mesothelioma survival times more than three years after surgery, this study suggests that there is reason to hope, even after relapse.” To read the details of the new study including a comparison of survival times between patients who did and did not have additional chemotherapy, see Additional Chemotherapy Extends Survival in Relapsed Mesothelioma Patients, now available on the Surviving Mesothelioma website. Takuwa, T, et al, Post-recurrence chemotherapy for mesothelioma patients undergoing extrapleural pneumonectomy”, April 24, 2017, International Journal of Clinical Oncology, Epub ahead of print, https://link.springer.com/article/10.1007/s10147-017-1126-x For more than a decade, Surviving Mesothelioma has brought readers the most important and ground-breaking news on the causes, diagnosis and treatment of mesothelioma. All Surviving Mesothelioma news is gathered and reported directly from the peer-reviewed medical literature. Written for patients and their loved ones, Surviving Mesothelioma news helps families make more informed decisions.
News Article | May 5, 2017
-- Researchers have shown that following a stroke-induced ischemic injury to the human brain, stem cells are produced that have the potential to differentiate and mature to form neurons that can help repair the damage to the brain. The new clinical study that provides direct evidence of ischemia-induced stem cells (iSCs) in brain tissue removed during treatment of post-stroke patients is published in, a peer-reviewed journal from. The article is available open access on thewebsite.In the article entitled "Identification of Multipotent Stem Cells in Human Brain Tissue Following Stroke (http://online.liebertpub.com/doi/full/10.1089/scd.2016.0334),", and coauthors from Hyogo College of Medicine, Nishinomiya, Japan, present this first clinical report describing the isolation of iSCs from the post-stroke human brain. The stem cells were situated near blood vessels in areas of the brain containing neurons that had died as a result of stroke-related lack of oxygen. The iSCs expressed multiple stem cell markers, demonstrated high proliferative potential, and were shown to be multipotent in culture with the ability to differentiate into various cell types including neurons."This excellently performed demonstration in the human brain confirms previous work in the mouse that showed cerebral ischemia induced multipotent stem cells that were restricted to areas of the brain damaged by stroke," says Editor-in-Chief, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI. http://www.liebertpub.com/ scd ) is an authoritative peer-reviewed journal published 24 times per year in print and online. The Journal is dedicated to communication and objective analysis of developments in the biology, characteristics, and therapeutic utility of stem cells, especially those of the hematopoietic system. A complete table of contents and free sample issue may be viewed on thewebsite. http://www.liebertpub.com/ ) is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, includingandIts biotechnology trade magazine, GEN (), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on thewebsite.
Hyogo College of Medicine, Eusense Medical Co., Food Care Co. and J Craft Co. | Date: 2016-07-06
[Summary] [Object] Provided are a swallowing estimation device that can maintain high swallowing estimation accuracy even when information for swallowing estimation is collected in a living environment, and an information terminal device and a program that are to be used therefor. [Solution] A swallowing estimation device includes: a sound detection part configured to detect sound of a larynx portion; a respiration detection part configured to detect respiration; and a swallowing estimation part configured to estimate swallowing based on sound information outputted from the sound detection part and based on respiration information outputted from the respiration detection part. The swallowing estimation part obtains a value of a parameter for swallowing estimation with respect to a biological sound generation interval that corresponds to an apneic interval longer than or equal to 400 msec, and estimates whether swallowing has occurred in the biological sound generation interval based on whether the obtained value of the parameter satisfies a swallowing determination condition.
National Cerebral And Cardiovascular Center, Foundation For Biomedical Research And Innovation, Hyogo College of Medicine, Hokkaido University and Kaneka Corporation | Date: 2016-06-29
An object of the present invention is to provide a method for producing a mesenchymal stromal cell composition, comprising conveniently and aseptically separating high-purity amnion-derived MSCs by performing enzyme treatment only once. According to the present invention, the following are provided: a method for producing a mesenchymal stromal cell composition, comprising: performing enzyme treatment of an amnion with collagenase and thermolysin and/or dispase; and filtering the enzyme-treated amnion through a mesh; a method for producing a cryopreserved mesenchymal stromal cell composition; and a therapeutic agent comprising as an active ingredient the mesenchymal stromal cell composition for a disease selected from graft-versus-host disease, inflammatory bowel disease, systemic lupus erythematosus, liver cirrhosis, or radiation enteritis.
Miwa H.,Hyogo College of Medicine
Journal of Gastroenterology | Year: 2012
Functional dyspepsia (FD), one of the most common conditions in medicine, is a gastrointestinal disorder in which the patient suffers from chronic dyspeptic symptoms such as epigastralgia and a heavy feeling in the stomach despite the absence of organic disease. Elucidating the pathogenesis of FD means answering the question, "Why do symptoms occur?" The factors contributing to symptom manifestation in FD probably should be divided into 3 categories: (1) physiological abnormalities that directly induce symptoms, (2) factors that modify those physiological abnormalities, and (3) factors that govern abnormal responses to stress. The symptoms of FD are directly caused by two major physiological abnormalities - abnormal gastric motility and visceral hypersensitivity - occurring in patients who have acquired excessive responsiveness to stress as a result of the environment during early life, genetic abnormalities, residual inflammation after gastrointestinal infections, or other causes, with the process modified by factors including psychophysiological abnormalities, abnormal secretion of gastric acid, Helicobacter pylori infection, diet, and lifestyle. If the basis of this model of FD pathogenesis is excessive responsiveness of gastrointestinal function to stress and external stimuli, psychosomatic approaches to alter stress perception could be important treatment options. However, in the primary care setting, the treatment of FD has focused on local gastric factors, including abnormal gastric acid secretion, abnormal gastric motility, and H. pylori infection. Acid secretion inhibitors and prokinetics have been commonly used, and H. pylori eradication therapy has been carried out, but the effectiveness of drug therapy has been limited. © Springer 2012.
Matsubara N.,Hyogo College of Medicine
Diseases of the Colon and Rectum | Year: 2012
Epigenetic silencing of genes is now recognized to be an important mechanism for inactivation of tumor suppressor genes in carcinogenesis. Because the role of genetic alterations in colorectal carcinogenesis has been well studied, colorectal cancer also offers an excellent model for elucidation of epigenetic mechanisms involved in carcinogenesis. DNA methylation and histone modification are involved in a complex network to maintain gene silencing and cause carcinogenesis. DNA methylation of cancer-related gene promoters generally begins early in the process of tumorigenesis, affecting various types of colorectal cancer to differing degrees. These advances in the understanding of the biology of tumorigenesis can be expected to provide distinct biomarkers that will aid future diagnosis, risk assessment, and treatment methods for patients with colorectal cancer. ©The ASCRS 2012.
Miwa H.,Hyogo College of Medicine
Neurogastroenterology and Motility | Year: 2012
Background Care of patients with functional gastrointestinal disorders (FGIDs) commonly includes offering guidance on diet, exercise, and other lifestyle factors, but there is little information available on the actual lifestyles of FGID sufferers. Methods An internet questionnaire survey of 15000 adult members of the general public in Japan who were screened for functional dyspepsia (FD) and irritable bowel syndrome (IBS) using the Rome III adult FGID questionnaire was conducted. Key Results The prevalence of FD and IBS was 6.5% and 14.0%, respectively, and 3.0% of the subjects met the criteria for both FD and IBS. The prevalence of both FD and IBS was higher in women than in men. The lifestyles of 2547 subjects who met the Rome III criteria for FD, IBS, or both were compared with the lifestyles of 1000 control subjects who did not meet the criteria for FD or the criteria for IBS. Compared to the control subjects, a significantly lower percentage of subjects with FD, IBS, or both exercised frequently, and a significantly higher percentage thought that their sleep was insufficient, ate meals irregularly, did not have an appetite, did not like meat, thought that their vegetable consumption was insufficient, felt stress in their daily lives, and regarded themselves as being highly susceptible to stress. Conclusions & Inferences Persons with FGIDs are affected by impairment of sleep, eating habits, diet, exercise and other lifestyle factors, and feel excessive stress. This suggests that offering lifestyle guidance to FGID patients may be useful. © 2012 Blackwell Publishing Ltd.
Hyogo College of Medicine | Date: 2015-02-24
A swallowing assist device for assisting swallowing includes a respiration detection part, an application unit, and a control part. The respiration detection part detects respiration. The application unit is attached to a target section to apply a stimulus for facilitation of swallowing. The control part controls the application unit. The control part controls the application unit to start application of the stimulus to the target section during an expiration period detected according to a detection signal from the respiration detection part, and terminate the application of the stimulus to the target section during the expiration period.
Hyogo College of Medicine and Mie University | Date: 2014-04-30
The present invention provides a transgenic non-human mammal retaining, in a specifically expressible state, a DNA encoding IL-33 in the skin, and having one or more features selected from the group consisting of
Hyogo College of Medicine and EuSense Medical Co. | Date: 2016-02-01
A swallowing estimation device includes: a sound detection part configured to detect sound of a larynx portion; a respiration detection part configured to detect respiration; and a swallowing estimation part configured to estimate swallowing based on sound information outputted from the sound detection part and based on respiration information outputted from the respiration detection part. The swallowing estimation part obtains a value of a parameter for swallowing estimation with respect to a biological sound generation interval that corresponds to a respiratory cessation interval longer than or equal to 400 msec, and estimates whether swallowing has occurred in the biological sound generation interval based on whether the obtained value of the parameter satisfies a swallowing determination condition.