HVIVO Services Ltd

London, United Kingdom

HVIVO Services Ltd

London, United Kingdom

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Fullen D.J.,HVIVO Services Ltd | Noulin N.,HVIVO Services Ltd | Catchpole A.,HVIVO Services Ltd | Fathi H.,HVIVO Services Ltd | And 7 more authors.
PLoS ONE | Year: 2016

Background Influenza and its associated diseases are a major cause of morbidity and mortality. The United States Advisory Committee on Immunization Practices recommends influenza vaccination for everyone over 6 months of age. The failure of the flu vaccine in 2014-2015 demonstrates the need for a model that allows the rapid development of novel antivirals, universal/intra-seasonal vaccines, immunomodulators, monoclonal antibodies and other novel treatments. To this end we manufactured a new H3N2 influenza virus in compliance with Good Manufacturing Practice for use in the Human Viral Challenge Model. Methods and Strain Selection We chose an H3N2 influenza subtype, rather than H1N1, given that this strain has the most substantial impact in terms of morbidity or mortality annually as described by the Centre for Disease Control. We first subjected the virus batch to rigorous adventitious agent testing, confirmed the virus to be wild-type by Sanger sequencing and determined the virus titres appropriate for human use via the established ferret model. We built on our previous experience with other H3N2 and H1N1 viruses to develop this unique model. Human Challenge and Conclusions We conducted an initial safety and characterisation study in healthy adult volunteers, utilising our unique clinical quarantine facility in London, UK. In this study we demonstrated this new influenza (H3N2) challenge virus to be both safe and pathogenic with an appropriate level of disease in volunteers. Furthermore, by inoculating volunteers with a range of different inoculum titres, we established the minimum infectious titre required to achieve reproducible disease whilst ensuring a sensitive model that can be translated to design of subsequent field based studies. © 2016 Fullen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Trademark
HVIVO SERVICES Ltd | Date: 2014-06-12

Pharmaceutical and medical compositions for human and/or veterinary use; vaccines for human beings and/or animals; adjuvants for use with vaccines; biological laboratory preparations for medical and/or veterinary purposes; chemical preparations and reagents for medical, pharmaceutical and veterinary purposes; viruses for the treatment of humans and/or animals; diagnostic preparations for medical purposes; in-vitro diagnostics for medical purposes; in-vivo diagnostics for medical purposes. Business investigation and research services relating to cost and business efficiency, all relating to pharmaceuticals, medicine, medicines, vaccines, science, bacteriology, toxicology, chemistry, clinicology, oncology, biochemistry and biotechnology; systemisation and compilation of medical information into computer databases; statistical information all relating to pharmaceuticals, medicine, medicines, vaccines, science, bacteriology, toxicology, chemistry, clinicology, oncology, biochemistry and biotechnology; registration services for diagnostic testing; product demonstration services in the field of diagnostic testing; computer database management services, including information storage and retrieval services in the fields of diagnostic testing and preparations for the treatment, monitoring or diagnosis of disease; trade information services in the fields of medical, health, or clinical care; database management of diagnostic testing and results, database management of medical, hospital, insurance or billing records; collation and provision of business information for the purpose of providing referral services in the fields of medical, health or clinical care; collation and provision of business information for the purpose of providing information services providing results from diagnostic testing in relation to medicine and pharmacy; collation and provision of business information regarding medical and pharmaceutical testing procedures; collation and provision of business information for the regarding disease conditions and disease prevention; collation and provision of business information regarding medical, hospital, insurance or billing records. Medical research services; conducting clinical trials; medical research laboratory services; medical research laboratory services for the analysis of samples taken from patients; scientific analysis and research services; product development relating to pharmaceuticals, medicines, medicaments and veterinary products; medical and health care testing research services, namely, clinical testing services, physician testing services for assisting pharmacists, pharmacy testing services, medical laboratory and testing services; medical research into the causes and treatment of influenza and the common cold.


Trademark
HVIVO SERVICES Ltd | Date: 2015-12-24

Pharmaceutical and medical compositions for human and / or veterinary use; vaccines for human beings and / or animals; adjuvants for use with vaccines; biological laboratory preparations for medical and / or veterinary purposes; chemical preparations and reagents for medical, pharmaceutical and veterinary purposes; viruses for the treatment of humans and / or animals; diagnostic preparations and substances; diagnostic preparations for medical purposes; in-vitro diagnostics for medical purposes; in-vivo diagnostics for medical purposes. Business investigation and research services relating to cost and business efficiency, all relating to pharmaceuticals, medicine, medicines, vaccines, science, bacteriology, toxicology, chemistry, clinicology, oncology, biochemistry and biotechnology; systemization and compilation of medical information into computer databases; business statistical information all relating to pharmaceuticals, medicine, medicines, vaccines, science, bacteriology, toxicology, chemistry, clinicology, oncology, biochemistry and biotechnology; maintenance of data in computer databases relating to individuals who have been tested for diagnostic purposes; product demonstration services in the field of diagnostic testing; computer database management services, including information storage and retrieval services in the fields of diagnostic testing and preparations for the treatment, monitoring or diagnosis of disease; trade information services in the fields of medical, health, or clinical care; database management of diagnostic testing and results, database management of medical, hospital, insurance or billing records; collation and provision of business information for the purpose of providing referral services in the fields of medical, health or clinical care; collation and provision of business information regarding results from diagnostic testing in relation to medicine and pharmacy; collation and provision of business information regarding medical and pharmaceutical testing procedures; collation and provision of business information regarding disease conditions and disease prevention; collation and provision of business information regarding medical, hospital, insurance or billing records. Medical research laboratory services; conducting clinical trials; medical research laboratory services for the analysis of samples taken from patients; scientific analysis and research services; product development relating to pharmaceuticals, medicines, medicaments and veterinary products; medical and health care research services, namely, clinical testing and diagnostic services; medical health care research services, namely, physician testing services for assisting pharmacists, pharmacy testing services, medical laboratory and testing services; medical research into the causes and treatment of influenza and the common cold.


Trademark
HVIVO SERVICES Ltd | Date: 2015-05-01

Pharmaceutical and medical compositions for human and/or veterinary use; diagnostic preparations and substances; medical diagnostic reagents; antiserums for diagnostic purposes; vaccines for human beings and/or animals; adjuvants for use with vaccines; biological laboratory preparations for medical and/or veterinary purposes; chemical preparations and reagents for medical, pharmaceutical and veterinary purposes; viruses for the treatment of humans and/or animals; diagnostic preparations for medical purposes; in-vitro diagnostics for medical purposes; in-vivo diagnostics for medical purposes. Business investigation and research services relating to cost and business efficiency, all relating to pharmaceuticals, medicine, medicines, vaccines, science, bacteriology, toxicology, chemistry, clinicology, oncology, biochemistry and biotechnology; systemization and compilation of medical information into computer databases; business statistical information all relating to pharmaceuticals, medicine, medicines, vaccines, science, bacteriology, toxicology, chemistry, clinicology, oncology, biochemistry and biotechnology; registration services for diagnostic testing; product demonstration services in the field of diagnostic testing; computer database management services, including information storage and retrieval services in the fields of diagnostic testing and preparations for the treatment, monitoring or diagnosis of disease; trade information services in the fields of medical, health, or clinical care; database management of diagnostic testing and results, database management of medical, hospital, insurance or billing records; collation and provision of business information for the purpose of providing referral services in the fields of medical, health or clinical care; collation and provision of business information regarding results from diagnostic testing in relation to medicine and pharmacy; collation and provision of business information regarding medical and pharmaceutical testing procedures; collation and provision of business information regarding disease conditions and disease prevention; collation and provision of business information regarding medical, hospital, insurance or billing records. Medical research services; conducting clinical trials; medical research laboratory services; scientific analysis and research services; product development relating to pharmaceuticals, medicines, medicaments and veterinary products; medical and health care research services, namely, clinical testing services, physician testing services for assisting pharmacists, pharmacy testing services, medical laboratory and testing services; medical research into the causes and treatment of influenza and the common cold; medical diagnostic services for research purposes; medical laboratory services for the analysis of samples taken from patients for research purposes.

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