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Di Q.,Nanjing Medical University | Yu N.,Nanjing Medical University | Liu H.,University of Pittsburgh | Hu Y.,Nanjing Medical University | And 4 more authors.
Mediators of Inflammation | Year: 2011

This study was aimed to investigate the effect of NF-B activity on the seizure susceptibility, brain damage, and P-gp expression in kainic acid- (KA-) induced seizure rats. Male SD rats were divided into saline control group (NS group), KA induced epilepsy group (EP group), and epilepsy group intervened with NF-B inhibitor-pyrrolidine dithiocarbamate salt (PDTC group) or with dexamethasone (DEX group). No seizures were observed in the rats of NS group. Compared with NS group, increased P-gp expression and NF-B activation in the rat brain of the EP group were observed after KA micro-injection. Both PDTC and DEX pre-treatment significantly increased the latency to grade III or V seizure onset compared to EP group but failed to show neuron-protective effect as the number of survival neurons didn't significantly differ from that in EP group. Furthermore, PDTC pre-treatment significantly decreased P-gp expression along with NF-B activation in the hippocampus CA3 area and amygdala complex of rats compared with the EP group, implying that NF-B activation involved in the seizure susceptibility and seizure induced brain P-gp over-expression. Additionally, DEX pre-treatment only decreased P-gp expression level without inhibition of NF-B activation, suggesting NF-B independent pathway may also participate in regulating seizure induced P-gp over-expression. Copyright 2011 Nian Yu et al.

Chen M.,Huzhou Central Hospital Huzhou | Fang L.,Huzhou Central Hospital Huzhou | Zhang Q.,Huzhou Central Hospital Huzhou | You J.,Huzhou Central Hospital Huzhou
Shanghai kou qiang yi xue = Shanghai journal of stomatology | Year: 2014

PURPOSE: Applying geometric simulation and finite element analysis to an unilateral mandibular defect reconstructed with rib graft to evaluate the biomechanical properties and guide the implant restoration for this kind of mandibular defect.METHODS: A geometric and finite element analysis mechanic model of mandibular defect reconstructed with rib graft based on CT scan and graphic processing technique was established. Computer-aided simulation of implantation and finite element analysis were carried out to meet the prosthetic requirement. The feasibility and biomechanical properties of this design were also evaluated.RESULTS: Implant restoration on mandibular defect reconstructed with rib graft was feasible. The implant could be inserted perpendicularly to the rib graft and the stress after implantation was concentrated on the mesial aspect of the left mandibular second premolar area. At the later stage, a prosthetic restoration should be applied to adjust the occlusal relationship.CONCLUSIONS: The accuracy and success rate of an implant restoration on a mandibular defect reconstructed with rib graft can be raised via preoperative design of the location and angulation of implants aided by CT scan, graphic processing technique, biomechanical analysis, as well as stress reduction by prosthetic fabrication and occlusal adjustment at the later stage.

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