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Iksan, South Korea

Seo J.Y.,Kyungpook National University | Kim S.S.,Kyungpook National University | Kim H.J.,Chubu University | Liu K.-H.,Kyungpook National University | And 2 more authors.
Nutrition Research and Practice

Certain phenolic compounds are known to exhibit laxative properties. Seed sprouts, such as those of peanut, are known to promote de novo biosynthesis of phenolic compounds. This study was conducted to examine the potential laxative properties of 80% (v/v) ethanolic extract of peanut sprout (PSE), which contains a high concentration of phenolic compounds such as resveratrol. For this, SD rats were orally administered PSE while a control group was incubated with saline. Laxative effects were examined in both groups of rats. Constipation induced by loperamide in SD rats was improved by administration of PSE. Constipated rats showed increased intestinal movement of BaSO4 upon administration of PSE compared to the control, and the groups administered 100 or 1,000 mg PSE/kg bw were not significantly different in transit time of the indicator. However, colon length was not statistically different among the experimental groups, although it was longer in the group incubated with 1 g PSE/kg bw compared to other groups. Further, there was no significant difference in stool number among the experimental groups. Taken together, these findings show that PSE has a laxative effect in a rat model of loperamide-induced constipation. © 2013 The Korean Nutrition Society and the Korean Society of Community Nutrition. Source

Erkhembaatar M.,Wonkwang University | Choi E.-J.,Wonkwang University | Lee H.-Y.,Huvet Co. | Lee C.H.,Wonkwang University | And 2 more authors.
BMC Complementary and Alternative Medicine

Background: Portulaca oleracea (PO) has been widely used as traditional medicine because of its pharmacological activities. However, the effects of PO on osteoclasts that modulate bone homeostasis are still elusive. Methods: In this study, we examined the effects of PO ethanol extract (POEE) on receptor activator of nuclear factor-kB ligand (RANKL)-mediated Ca2+ mobilization, nuclear factor of activated T-cell c1 (NFATc1) amplification, tartrate-resistant acid phosphatase-positive (TRAP+) multinucleated cell (MNC) formation, and cytotoxicity. Results: Our results demonstrated that POEE suppressed RANKL-induced Ca2+ oscillations by inhibition of Ca2+ release from internal Ca2+ stores, resulting in reduction of NFATc1 amplification. Notably, POEE attenuated RANKL-mediated cytotoxicity and cleavage of polyadenosine 5'-diphosphate-ribose polymerase (PARP), resulted in enhanced formation of TRAP+ MNCs. Conclusions: These results present in vitro effects of POEE on RANKL-mediated osteoclastogenesis and suggest the possible use of PO in treating bone disorders, such as osteopetrosis. © 2015 Erkhembaatar et al. Source

Kim S.S.,Kyungpook National University | Seo J.Y.,Kyungpook National University | Kim B.R.,Kyungpook National University | Kim H.J.,Chubu University | And 2 more authors.
Food Science and Biotechnology

Sprouting of peanut usually promotes de novo biosynthesis of phenolic compounds such as resveratrol. As phenolic compounds have been reported to possess anti-obesity activity, we investigated the effect of peanut sprout extract (PSE) on weight gain induced by high-fat diet (HF) in C57BL/6J mice. Administration of PSE effectively suppressed the body weight gain induced by HF without altering food intake. Furthermore, blood parameters, including levels of TG and total cholesterol, were significantly improved by administration of 0.5 g/kg BW of PSE compared to mice fed HF alone. Although its mechanism of action remains unclear, the anti-obesity activity of PSE appears to be associated with its inhibition of carbohydrate digestion enzymes, as it dose-dependently inhibited the activities of α-amylase and α-glucosidase but not pancreatic lipase while PSE did not have any inhibitory effect against lipid accumulation in differentiated 3T3L1 adipocyte. In conclusion, PSE deserves further study as a health functional ingredient for body weight control. © 2014 The Korean Society of Food Science and Technology and Springer Science+Business Media Dordrecht. Source

Oh H.-G.,Huvet Co. | Moon D.-I.,Huvet Co. | Kim J.-H.,Huvet Co. | Kang Y.-R.,Huvet Co. | And 11 more authors.
Journal of the Korean Society of Food Science and Nutrition

Sea cucumber, Stichopus japonicus, is used not only as an outstanding tonic food but also as a traditional medicine for the treatment of asthma, hypertension, rheumatism, anemia, and sinus congestion. The purpose of this study was to examine sea cucumber as an anti-gastritis and anti-gastric ulcer in HCl-ethanol-induced gastric and H. pylori-infected animal models. Thirty 7-week-old SD rats and Mongolian gerbils were divided into normal (Nor, n=6), control (Con, 60% HCl-ethanol+water, n=6), group I (DSC I, 60% HCl-ethanol+sea cucumber 30 mg/kg, n=6), group II (DSC II, 60% HCl-ethanol+sea cucumber 100 mg/kg, n=6), and group III (DSC III, 60% HCl-ethanol+sea cucumber 300 mg/kg, n=6). Sea cucumber significantly suppressed gastric lesions and ulcers in the 60% HCl-ethanol-induced gastric model. Especially, 100 mg/kg of sea cucumber showed significantly inhibitory effects. In histopathological analysis of the H. pylori model, we found that sea cucumber augmented the eradication rates of H. pylori and attenuated gastric ulcer formation. Our results suggest that sea cucumber has inhibitory effects on gastritis and gastric ulcers. In addition, sea cucumber can be applied for the treatment of H. pylori. Source

Oh H.-G.,Huvet Co. | Kang Y.-R.,Huvet Co. | Kim J.-H.,Huvet Co. | Moon D.-I.,Huvet Co. | And 11 more authors.
Journal of the Korean Society of Food Science and Nutrition

This study was performed to investigate improvements in diabetes mellitus by extracts of yacon in streptozotocin (STZ)-induced diabetic rats. Fifty rats were divided into a normal group and four experimental groups. STZ (45 mg/kg) was injected intraperitoneally to induce type I diabetes in the four experimental groups. Yacon extracts were administered for 5 weeks. Forty-five ICR mice were also divided into one positive control group and four experimental groups for the oral glucose tolerance test (OGTT) after fed yacon extract. The control group did not eat any yacon extracts, while Group 1 (GI) was fed 125 mg/kg of yacon extracts, Group 2 (GII) was fed 250 mg/kg of yacon extracts, and Group 3 (GIII) was fed 500 mg/kg of yacon extracts. After treatment for 5 weeks, blood glucose in GIII group showed decreased tendency at the 5 week. In OGTT by glucose, the glucose level of yacon treatment group in diabetic rats was significantly decreased compared to the glucose level of the control group, but there was no difference in OGTT by maltose. In ICR mice, the glucose level of the experimental group in OGTT by maltose was significantly decreased compared to the control group. The area of the islets of Langerhans was increased by yacon treatment in a dose-dependent manner on diabetic rats. Insulin concentration of the GIII group was also decreased compared to the control group, while the concentration of fructosamine, total cholesterol, and triglycerides in serum showed no difference. OGTT by glucose or maltose in ICR mice or diabetic rats, area of the Islets of Langerhans, and insulin concentration improved. Yacon treatment may be a useful therapeutic and preventive strategy for diabetes mellitus. Source

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